Journal article 292 views 52 downloads
Data-driven calculation of porous geometry-dependent permeability and fluid-induced wall shear stress within tissue engineering scaffolds
,
Bjornar Sandnes ,
Paul Egan,
Feihu Zhao
Journal of Engineering Design, Pages: 1 - 15
Swansea University Authors:
Matt Bedding, Perumal Nithiarasu , Bjornar Sandnes , Feihu Zhao
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DOI (Published version): 10.1080/09544828.2024.2321224
Abstract
It is commonly known that mechanical stimulation, for example, wall shear stress (WSS), can affect cellular behaviours. In vitro experiments have been performed by applying fluid-induced WSS to investigate the cell physiology and pathology. Porous scaffolds are used in these experiments for housing...
| Published in: | Journal of Engineering Design |
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| ISSN: | 0954-4828 1466-1837 |
| Published: |
Informa UK Limited
2024
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa65980 |
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| Abstract: |
It is commonly known that mechanical stimulation, for example, wall shear stress (WSS), can affect cellular behaviours. In vitro experiments have been performed by applying fluid-induced WSS to investigate the cell physiology and pathology. Porous scaffolds are used in these experiments for housing and facilitating the micro-physical/chemical environment on cells during 3-dimensional (3D) cell culturing. It is known that scaffold porous geometries influence scaffold permeability and internal WSS. Computational simulations are commonly employed to determine the WSS; however, these simulations can be computationally expensive and may not be readily accessible to everyone due to a knowledge gap. To address this limitation, this study proposes an empirical equation for calculating the scaffold permeability based on the Kozeny-Carman equation. The new equation considers the porous geometric features, providing an accurate estimation of the scaffold permeability. Furthermore, the study introduces a new correlation between WSS and permeability, aiming to establish an efficient and precise estimation of internal WSS. This correlation enables efficient estimation of the WSS within porous scaffolds without relying on computationally demanding simulations. Therefore, the output from this study can negate the issues of using computational simulation for determining scaffold permeability and internal WSS under perfusion flow by providing empirical equations. |
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| Keywords: |
TPMS scaffold permeability; empirical model; perfusion bioreactor; wall shear stress |
| College: |
Faculty of Science and Engineering |
| Funders: |
This study was supported by Royal Society Research Grant (reference code: RGS\R2\212280). MBT was funded by EPSRC-DTP scholarship (reference code: EP/T517987/1 - 2573181). |
| Start Page: |
1 |
| End Page: |
15 |