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Silicone 3D Printing: Process Optimization, Product Biocompatibility, and Reliability of Silicone Meniscus Implants

Eric Luis, Houwen Matthew Pan, Swee Leong Sing, Anil Bastola, Guo Dong Goh, Guo Liang Goh, Heang Kuan Joel Tan, Ram Bajpai, Juha Song, Wai Yee Yeong

3D Printing and Additive Manufacturing, Volume: 6, Issue: 6, Pages: 319 - 332

Swansea University Author: Anil Bastola

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DOI (Published version): 10.1089/3dp.2018.0226

Abstract

A novel custom-made 3D silicone printer and two-part Ecoflex silicone resins were used to 3D-print standard-shaped silicone coupon and irregular-shaped meniscus structures via a heat-cured extrusion-based method. This article is segmented into three parts: (1) study on the effect of 3D printing para...

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Published in: 3D Printing and Additive Manufacturing
ISSN: 2329-7662 2329-7670
Published: Mary Ann Liebert Inc 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa65753
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spelling v2 65753 2024-03-05 Silicone 3D Printing: Process Optimization, Product Biocompatibility, and Reliability of Silicone Meniscus Implants 6775d40c935b36b92058eb10d6454f1a Anil Bastola Anil Bastola true false 2024-03-05 MECH A novel custom-made 3D silicone printer and two-part Ecoflex silicone resins were used to 3D-print standard-shaped silicone coupon and irregular-shaped meniscus structures via a heat-cured extrusion-based method. This article is segmented into three parts: (1) study on the effect of 3D printing parameters on dimensional accuracy and mechanical properties of 3D-printed silicone, (2) reliability and failure analysis of 3D-printed silicone according to ASTM D575 standards under monotonic and cyclic compressive loading, and (3) cytotoxicity of 3D-printed silicone by extraction method according to ISO 10993-12 for different extraction time and extract volume/surface area ratios. Based on analysis using regression method and analysis of variance, we found that the dimensional accuracy of lengths and widths is sensitive to both nozzle diameters and bed temperatures (BTs), while the height is only sensitive to BTs. Failure results were analyzed using the two-parameter Weibull probability distribution model and Weibull regression analysis and revealed that the Weibull modulus had a value greater than 1 in all groups, indicating an increasing failure rate with time for Ecoflex 30 and 50 meniscus implants. Results from quantitative cell proliferative assay exhibit statistically insignificant differences for all samples, pointing to the low cytotoxicity and excellent biocompatibility of printed silicone. Journal Article 3D Printing and Additive Manufacturing 6 6 319 332 Mary Ann Liebert Inc 2329-7662 2329-7670 16 12 2019 2019-12-16 10.1089/3dp.2018.0226 COLLEGE NANME Mechanical Engineering COLLEGE CODE MECH Swansea University Other This research is supported by the National Research Foundation, Prime Minister's Office, Singapore, under its Medium-Sized Centre funding scheme and by the NTU Start-Up Grant. 2024-04-28T14:42:58.8143126 2024-03-05T21:56:01.5617441 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering Eric Luis 1 Houwen Matthew Pan 2 Swee Leong Sing 3 Anil Bastola 4 Guo Dong Goh 5 Guo Liang Goh 6 Heang Kuan Joel Tan 7 Ram Bajpai 8 Juha Song 9 Wai Yee Yeong 10
title Silicone 3D Printing: Process Optimization, Product Biocompatibility, and Reliability of Silicone Meniscus Implants
spellingShingle Silicone 3D Printing: Process Optimization, Product Biocompatibility, and Reliability of Silicone Meniscus Implants
Anil Bastola
title_short Silicone 3D Printing: Process Optimization, Product Biocompatibility, and Reliability of Silicone Meniscus Implants
title_full Silicone 3D Printing: Process Optimization, Product Biocompatibility, and Reliability of Silicone Meniscus Implants
title_fullStr Silicone 3D Printing: Process Optimization, Product Biocompatibility, and Reliability of Silicone Meniscus Implants
title_full_unstemmed Silicone 3D Printing: Process Optimization, Product Biocompatibility, and Reliability of Silicone Meniscus Implants
title_sort Silicone 3D Printing: Process Optimization, Product Biocompatibility, and Reliability of Silicone Meniscus Implants
author_id_str_mv 6775d40c935b36b92058eb10d6454f1a
author_id_fullname_str_mv 6775d40c935b36b92058eb10d6454f1a_***_Anil Bastola
author Anil Bastola
author2 Eric Luis
Houwen Matthew Pan
Swee Leong Sing
Anil Bastola
Guo Dong Goh
Guo Liang Goh
Heang Kuan Joel Tan
Ram Bajpai
Juha Song
Wai Yee Yeong
format Journal article
container_title 3D Printing and Additive Manufacturing
container_volume 6
container_issue 6
container_start_page 319
publishDate 2019
institution Swansea University
issn 2329-7662
2329-7670
doi_str_mv 10.1089/3dp.2018.0226
publisher Mary Ann Liebert Inc
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering
document_store_str 0
active_str 0
description A novel custom-made 3D silicone printer and two-part Ecoflex silicone resins were used to 3D-print standard-shaped silicone coupon and irregular-shaped meniscus structures via a heat-cured extrusion-based method. This article is segmented into three parts: (1) study on the effect of 3D printing parameters on dimensional accuracy and mechanical properties of 3D-printed silicone, (2) reliability and failure analysis of 3D-printed silicone according to ASTM D575 standards under monotonic and cyclic compressive loading, and (3) cytotoxicity of 3D-printed silicone by extraction method according to ISO 10993-12 for different extraction time and extract volume/surface area ratios. Based on analysis using regression method and analysis of variance, we found that the dimensional accuracy of lengths and widths is sensitive to both nozzle diameters and bed temperatures (BTs), while the height is only sensitive to BTs. Failure results were analyzed using the two-parameter Weibull probability distribution model and Weibull regression analysis and revealed that the Weibull modulus had a value greater than 1 in all groups, indicating an increasing failure rate with time for Ecoflex 30 and 50 meniscus implants. Results from quantitative cell proliferative assay exhibit statistically insignificant differences for all samples, pointing to the low cytotoxicity and excellent biocompatibility of printed silicone.
published_date 2019-12-16T14:42:57Z
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score 11.013148

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