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Lung disease characterised via synchrotron radiation micro-CT and digital volume correlation (DVC)

Hari Arora Orcid Logo, Dale Kernot, Louis Giron, David Howells, Michael Darcy, Makoto Hoshino, Kentaro Uesugi, Raoul van Loon Orcid Logo, Gaku Tanaka, Toshihiro Sera

TrAC Trends in Analytical Chemistry, Volume: 172, Start page: 117588

Swansea University Authors: Hari Arora Orcid Logo, Dale Kernot, Louis Giron, David Howells, Michael Darcy, Raoul van Loon Orcid Logo

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DOI (Published version): 10.1016/j.trac.2024.117588

Abstract

The study of lung mechanics is important to futureproof resilience against potential novel threats to lung health. Medical imaging provides insight to lung function. High-resolution, high-speed synchrotron radiation micro-CT imaging at SPring-8 (Japan) and in situ mechanics were used to characterize...

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Published in: TrAC Trends in Analytical Chemistry
ISSN: 0165-9936
Published: Elsevier BV 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa65573
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Medical imaging provides insight to lung function. High-resolution, high-speed synchrotron radiation micro-CT imaging at SPring-8 (Japan) and in situ mechanics were used to characterize healthy and diseased airways. Synchrotron radiation was important to maximize speed and spatial resolution to map the lung architecture clearly. Links between global lung mechanical measurements (pressure-volume) and regional tissue strains were made. Tissue strains were computed from a sequence of tomograms during a respiratory cycle, demonstrating clear differences for the surfactant-free lungs compared to the controls. Poorly ventilated areas were identified within three-dimensional strain maps computed via digital volume correlation. Occluded pathways at low pressures were seen to be opened at higher pressures, augmenting the deformation pathways. The results will aid correlations between microscale and macroscale measurements and the potential impact on patient management guidelines for mechanical ventilation.</abstract><type>Journal Article</type><journal>TrAC Trends in Analytical Chemistry</journal><volume>172</volume><journalNumber/><paginationStart>117588</paginationStart><paginationEnd/><publisher>Elsevier BV</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0165-9936</issnPrint><issnElectronic/><keywords>Lung Mechanics, Synchrotron, Tomography, Digital Volume Correlation (DVC)</keywords><publishedDay>1</publishedDay><publishedMonth>3</publishedMonth><publishedYear>2024</publishedYear><publishedDate>2024-03-01</publishedDate><doi>10.1016/j.trac.2024.117588</doi><url/><notes/><college>COLLEGE NANME</college><department>Engineering and Applied Sciences School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>EAAS</DepartmentCode><institution>Swansea University</institution><apcterm>SU Library paid the OA fee (TA Institutional Deal)</apcterm><funders>This work was supported by the Royal Society International Exchanges IEC\R3\170065, EPSRC EP/V041789/1. 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spelling 2024-04-04T16:19:04.0097013 v2 65573 2024-02-06 Lung disease characterised via synchrotron radiation micro-CT and digital volume correlation (DVC) ed7371c768e9746008a6807f9f7a1555 0000-0002-9790-0907 Hari Arora Hari Arora true false 3d3dda66e219b9d577048cae64a0e365 Dale Kernot Dale Kernot true false 2afc5b9fe0b2fa3fa003d98ced699f0d Louis Giron Louis Giron true false 1e204d7456909eaa1bcd19f5d7415134 David Howells David Howells true false b5aec8101b64f8f9a02f142c2bc91cd6 Michael Darcy Michael Darcy true false 880b30f90841a022f1e5bac32fb12193 0000-0003-3581-5827 Raoul van Loon Raoul van Loon true false 2024-02-06 EAAS The study of lung mechanics is important to futureproof resilience against potential novel threats to lung health. Medical imaging provides insight to lung function. High-resolution, high-speed synchrotron radiation micro-CT imaging at SPring-8 (Japan) and in situ mechanics were used to characterize healthy and diseased airways. Synchrotron radiation was important to maximize speed and spatial resolution to map the lung architecture clearly. Links between global lung mechanical measurements (pressure-volume) and regional tissue strains were made. Tissue strains were computed from a sequence of tomograms during a respiratory cycle, demonstrating clear differences for the surfactant-free lungs compared to the controls. Poorly ventilated areas were identified within three-dimensional strain maps computed via digital volume correlation. Occluded pathways at low pressures were seen to be opened at higher pressures, augmenting the deformation pathways. The results will aid correlations between microscale and macroscale measurements and the potential impact on patient management guidelines for mechanical ventilation. Journal Article TrAC Trends in Analytical Chemistry 172 117588 Elsevier BV 0165-9936 Lung Mechanics, Synchrotron, Tomography, Digital Volume Correlation (DVC) 1 3 2024 2024-03-01 10.1016/j.trac.2024.117588 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University SU Library paid the OA fee (TA Institutional Deal) This work was supported by the Royal Society International Exchanges IEC\R3\170065, EPSRC EP/V041789/1. The synchrotron radiation experiments were performed at BL20B2 of SPring-8 with the approval of the Japan Synchrotron Radiation Research Institute (JASRI) (Proposal No.2019A1310). 2024-04-04T16:19:04.0097013 2024-02-06T09:44:01.7227149 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Hari Arora 0000-0002-9790-0907 1 Dale Kernot 2 Louis Giron 3 David Howells 4 Michael Darcy 5 Makoto Hoshino 6 Kentaro Uesugi 7 Raoul van Loon 0000-0003-3581-5827 8 Gaku Tanaka 9 Toshihiro Sera 10 65573__29925__98013dfee68644b5b1d4aa1fdbfb4eac.pdf 65573.VOR.pdf 2024-04-04T16:17:15.6806955 Output 5939349 application/pdf Version of Record true © 2024 The Authors. This is an open access article under the CC BY license. true eng http://creativecommons.org/licenses/by/4.0/
title Lung disease characterised via synchrotron radiation micro-CT and digital volume correlation (DVC)
spellingShingle Lung disease characterised via synchrotron radiation micro-CT and digital volume correlation (DVC)
Hari Arora
Dale Kernot
Louis Giron
David Howells
Michael Darcy
Raoul van Loon
title_short Lung disease characterised via synchrotron radiation micro-CT and digital volume correlation (DVC)
title_full Lung disease characterised via synchrotron radiation micro-CT and digital volume correlation (DVC)
title_fullStr Lung disease characterised via synchrotron radiation micro-CT and digital volume correlation (DVC)
title_full_unstemmed Lung disease characterised via synchrotron radiation micro-CT and digital volume correlation (DVC)
title_sort Lung disease characterised via synchrotron radiation micro-CT and digital volume correlation (DVC)
author_id_str_mv ed7371c768e9746008a6807f9f7a1555
3d3dda66e219b9d577048cae64a0e365
2afc5b9fe0b2fa3fa003d98ced699f0d
1e204d7456909eaa1bcd19f5d7415134
b5aec8101b64f8f9a02f142c2bc91cd6
880b30f90841a022f1e5bac32fb12193
author_id_fullname_str_mv ed7371c768e9746008a6807f9f7a1555_***_Hari Arora
3d3dda66e219b9d577048cae64a0e365_***_Dale Kernot
2afc5b9fe0b2fa3fa003d98ced699f0d_***_Louis Giron
1e204d7456909eaa1bcd19f5d7415134_***_David Howells
b5aec8101b64f8f9a02f142c2bc91cd6_***_Michael Darcy
880b30f90841a022f1e5bac32fb12193_***_Raoul van Loon
author Hari Arora
Dale Kernot
Louis Giron
David Howells
Michael Darcy
Raoul van Loon
author2 Hari Arora
Dale Kernot
Louis Giron
David Howells
Michael Darcy
Makoto Hoshino
Kentaro Uesugi
Raoul van Loon
Gaku Tanaka
Toshihiro Sera
format Journal article
container_title TrAC Trends in Analytical Chemistry
container_volume 172
container_start_page 117588
publishDate 2024
institution Swansea University
issn 0165-9936
doi_str_mv 10.1016/j.trac.2024.117588
publisher Elsevier BV
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 1
active_str 0
description The study of lung mechanics is important to futureproof resilience against potential novel threats to lung health. Medical imaging provides insight to lung function. High-resolution, high-speed synchrotron radiation micro-CT imaging at SPring-8 (Japan) and in situ mechanics were used to characterize healthy and diseased airways. Synchrotron radiation was important to maximize speed and spatial resolution to map the lung architecture clearly. Links between global lung mechanical measurements (pressure-volume) and regional tissue strains were made. Tissue strains were computed from a sequence of tomograms during a respiratory cycle, demonstrating clear differences for the surfactant-free lungs compared to the controls. Poorly ventilated areas were identified within three-dimensional strain maps computed via digital volume correlation. Occluded pathways at low pressures were seen to be opened at higher pressures, augmenting the deformation pathways. The results will aid correlations between microscale and macroscale measurements and the potential impact on patient management guidelines for mechanical ventilation.
published_date 2024-03-01T14:30:53Z
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