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Lung disease characterised via synchrotron radiation micro-CT and digital volume correlation (DVC)
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Dale Kernot,
Louis Giron,
David Howells,
Michael Darcy,
Makoto Hoshino,
Kentaro Uesugi,
Raoul van Loon ,
Gaku Tanaka,
Toshihiro Sera
TrAC Trends in Analytical Chemistry, Volume: 172, Start page: 117588
Swansea University Authors:
Hari Arora , Dale Kernot, Louis Giron, David Howells, Michael Darcy, Raoul van Loon
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DOI (Published version): 10.1016/j.trac.2024.117588
Abstract
The study of lung mechanics is important to futureproof resilience against potential novel threats to lung health. Medical imaging provides insight to lung function. High-resolution, high-speed synchrotron radiation micro-CT imaging at SPring-8 (Japan) and in situ mechanics were used to characterize...
| Published in: | TrAC Trends in Analytical Chemistry |
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| ISSN: | 0165-9936 |
| Published: |
Elsevier BV
2024
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa65573 |
| Abstract: |
The study of lung mechanics is important to futureproof resilience against potential novel threats to lung health. Medical imaging provides insight to lung function. High-resolution, high-speed synchrotron radiation micro-CT imaging at SPring-8 (Japan) and in situ mechanics were used to characterize healthy and diseased airways. Synchrotron radiation was important to maximize speed and spatial resolution to map the lung architecture clearly. Links between global lung mechanical measurements (pressure-volume) and regional tissue strains were made. Tissue strains were computed from a sequence of tomograms during a respiratory cycle, demonstrating clear differences for the surfactant-free lungs compared to the controls. Poorly ventilated areas were identified within three-dimensional strain maps computed via digital volume correlation. Occluded pathways at low pressures were seen to be opened at higher pressures, augmenting the deformation pathways. The results will aid correlations between microscale and macroscale measurements and the potential impact on patient management guidelines for mechanical ventilation. |
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| Keywords: |
Lung Mechanics, Synchrotron, Tomography, Digital Volume Correlation (DVC) |
| College: |
Faculty of Science and Engineering |
| Funders: |
This work was supported by the Royal Society International Exchanges IEC\R3\170065, EPSRC EP/V041789/1. The synchrotron radiation experiments were performed at BL20B2 of SPring-8 with the approval of the Japan Synchrotron Radiation Research Institute (JASRI) (Proposal No.2019A1310). |
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