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Adaptation of Left Ventricular Twist Mechanics in Exercise-Trained Children Is Only Evident after the Adolescent Growth Spurt

Dean R. Perkins Orcid Logo, Jack S. Talbot, Rachel N. Lord, Tony G. Dawkins, Aaron L. Baggish, Abbas Zaidi, Orhan Uzun, Kelly Mackintosh Orcid Logo, Melitta McNarry Orcid Logo, Stephen-Mark Cooper, Rhodri S. Lloyd, Jon L. Oliver, Rob E. Shave, Mike Stembridge

Journal of the American Society of Echocardiography

Swansea University Authors: Kelly Mackintosh Orcid Logo, Melitta McNarry Orcid Logo

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DOI (Published version): 10.1016/j.echo.2023.11.024

Abstract

BackgroundThe extent of structural cardiac remodeling in response to endurance training is maturity dependent. In adults, this structural adaptation is often associated with the adaptation of left ventricular (LV) twist mechanics. For example, an increase in LV twist often follows an expansion in en...

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Published in: Journal of the American Society of Echocardiography
ISSN: 0894-7317
Published: Elsevier BV 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa65224
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fullrecord <?xml version="1.0" encoding="utf-8"?><rfc1807 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><bib-version>v2</bib-version><id>65224</id><entry>2023-12-06</entry><title>Adaptation of Left Ventricular Twist Mechanics in Exercise-Trained Children Is Only Evident after the Adolescent Growth Spurt</title><swanseaauthors><author><sid>bdb20e3f31bcccf95c7bc116070c4214</sid><ORCID>0000-0003-0355-6357</ORCID><firstname>Kelly</firstname><surname>Mackintosh</surname><name>Kelly Mackintosh</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>062f5697ff59f004bc8c713955988398</sid><ORCID>0000-0003-0813-7477</ORCID><firstname>Melitta</firstname><surname>McNarry</surname><name>Melitta McNarry</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2023-12-06</date><deptcode>STSC</deptcode><abstract>BackgroundThe extent of structural cardiac remodeling in response to endurance training is maturity dependent. In adults, this structural adaptation is often associated with the adaptation of left ventricular (LV) twist mechanics. For example, an increase in LV twist often follows an expansion in end-diastolic volume, whereas a reduction in twist may follow a thickening of the LV walls. While structural cardiac remodeling has been shown to be more prominent post–peak height velocity (PHV), it remains to be determined how this maturation-dependent structural remodeling influences LV twist. Therefore, we aimed to (1) compare LV twist mechanics between trained and untrained children pre- and post-PHV and (2) investigate how LV structural variables relate to LV twist mechanics pre- and post-PHV.MethodsLeft ventricular function and morphology were assessed (echocardiography) in endurance-trained and untrained boys (n = 38 and n = 28, respectively) and girls (n = 39 and n = 34, respectively). Participants were categorized as either pre- or post-PHV using maturity offset to estimate somatic maturation.ResultsPre-PHV, there were no differences in LV twist or torsion between trained and untrained boys (twist: P = .630; torsion: P = .382) or girls (twist: P = .502; torsion: P = .316), and LV twist mechanics were not related with any LV structural variables (P &gt; .05). Post-PHV, LV twist was lower in trained versus untrained boys (P = .004), with torsion lower in trained groups, irrespective of sex (boys: P &lt; .001; girls: P = .017). Moreover, LV torsion was inversely related to LV mass (boys: r = −0.55, P = .001; girls: r = −0.46, P = .003) and end-diastolic volume (boys: r = −0.64, P &lt; .001; girls: r = −0.36, P = .025) in both sexes.ConclusionsA difference in LV twist mechanics between endurance-trained and untrained cohorts is only apparent post-PHV, where structural and functional remodeling were related.</abstract><type>Journal Article</type><journal>Journal of the American Society of Echocardiography</journal><volume>0</volume><journalNumber/><paginationStart/><paginationEnd/><publisher>Elsevier BV</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0894-7317</issnPrint><issnElectronic/><keywords>echocardiography, myocardium, twist, youth, exercise</keywords><publishedDay>4</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2023</publishedYear><publishedDate>2023-12-04</publishedDate><doi>10.1016/j.echo.2023.11.024</doi><url/><notes/><college>COLLEGE NANME</college><department>Sport and Exercise Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><apcterm/><funders/><projectreference/><lastEdited>2024-04-09T16:29:37.6237765</lastEdited><Created>2023-12-06T10:47:38.7881591</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Sport and Exercise Sciences</level></path><authors><author><firstname>Dean R.</firstname><surname>Perkins</surname><orcid>0000-0002-9044-8508</orcid><order>1</order></author><author><firstname>Jack S.</firstname><surname>Talbot</surname><order>2</order></author><author><firstname>Rachel N.</firstname><surname>Lord</surname><order>3</order></author><author><firstname>Tony G.</firstname><surname>Dawkins</surname><order>4</order></author><author><firstname>Aaron L.</firstname><surname>Baggish</surname><order>5</order></author><author><firstname>Abbas</firstname><surname>Zaidi</surname><order>6</order></author><author><firstname>Orhan</firstname><surname>Uzun</surname><order>7</order></author><author><firstname>Kelly</firstname><surname>Mackintosh</surname><orcid>0000-0003-0355-6357</orcid><order>8</order></author><author><firstname>Melitta</firstname><surname>McNarry</surname><orcid>0000-0003-0813-7477</orcid><order>9</order></author><author><firstname>Stephen-Mark</firstname><surname>Cooper</surname><order>10</order></author><author><firstname>Rhodri S.</firstname><surname>Lloyd</surname><order>11</order></author><author><firstname>Jon L.</firstname><surname>Oliver</surname><order>12</order></author><author><firstname>Rob E.</firstname><surname>Shave</surname><order>13</order></author><author><firstname>Mike</firstname><surname>Stembridge</surname><order>14</order></author></authors><documents><document><filename>65224__29219__8ae87ebfd2b34a60908675b2b3f7ac66.pdf</filename><originalFilename>65224 AAM.pdf</originalFilename><uploaded>2023-12-06T11:22:41.2770755</uploaded><type>Output</type><contentLength>1128088</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><documentNotes>Author accepted manuscript document released under the terms of a Creative Commons CC-BY licence using the Swansea University Research Publications Policy (rights retention).</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>https://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling v2 65224 2023-12-06 Adaptation of Left Ventricular Twist Mechanics in Exercise-Trained Children Is Only Evident after the Adolescent Growth Spurt bdb20e3f31bcccf95c7bc116070c4214 0000-0003-0355-6357 Kelly Mackintosh Kelly Mackintosh true false 062f5697ff59f004bc8c713955988398 0000-0003-0813-7477 Melitta McNarry Melitta McNarry true false 2023-12-06 STSC BackgroundThe extent of structural cardiac remodeling in response to endurance training is maturity dependent. In adults, this structural adaptation is often associated with the adaptation of left ventricular (LV) twist mechanics. For example, an increase in LV twist often follows an expansion in end-diastolic volume, whereas a reduction in twist may follow a thickening of the LV walls. While structural cardiac remodeling has been shown to be more prominent post–peak height velocity (PHV), it remains to be determined how this maturation-dependent structural remodeling influences LV twist. Therefore, we aimed to (1) compare LV twist mechanics between trained and untrained children pre- and post-PHV and (2) investigate how LV structural variables relate to LV twist mechanics pre- and post-PHV.MethodsLeft ventricular function and morphology were assessed (echocardiography) in endurance-trained and untrained boys (n = 38 and n = 28, respectively) and girls (n = 39 and n = 34, respectively). Participants were categorized as either pre- or post-PHV using maturity offset to estimate somatic maturation.ResultsPre-PHV, there were no differences in LV twist or torsion between trained and untrained boys (twist: P = .630; torsion: P = .382) or girls (twist: P = .502; torsion: P = .316), and LV twist mechanics were not related with any LV structural variables (P > .05). Post-PHV, LV twist was lower in trained versus untrained boys (P = .004), with torsion lower in trained groups, irrespective of sex (boys: P < .001; girls: P = .017). Moreover, LV torsion was inversely related to LV mass (boys: r = −0.55, P = .001; girls: r = −0.46, P = .003) and end-diastolic volume (boys: r = −0.64, P < .001; girls: r = −0.36, P = .025) in both sexes.ConclusionsA difference in LV twist mechanics between endurance-trained and untrained cohorts is only apparent post-PHV, where structural and functional remodeling were related. Journal Article Journal of the American Society of Echocardiography 0 Elsevier BV 0894-7317 echocardiography, myocardium, twist, youth, exercise 4 12 2023 2023-12-04 10.1016/j.echo.2023.11.024 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2024-04-09T16:29:37.6237765 2023-12-06T10:47:38.7881591 Faculty of Science and Engineering School of Engineering and Applied Sciences - Sport and Exercise Sciences Dean R. Perkins 0000-0002-9044-8508 1 Jack S. Talbot 2 Rachel N. Lord 3 Tony G. Dawkins 4 Aaron L. Baggish 5 Abbas Zaidi 6 Orhan Uzun 7 Kelly Mackintosh 0000-0003-0355-6357 8 Melitta McNarry 0000-0003-0813-7477 9 Stephen-Mark Cooper 10 Rhodri S. Lloyd 11 Jon L. Oliver 12 Rob E. Shave 13 Mike Stembridge 14 65224__29219__8ae87ebfd2b34a60908675b2b3f7ac66.pdf 65224 AAM.pdf 2023-12-06T11:22:41.2770755 Output 1128088 application/pdf Accepted Manuscript true Author accepted manuscript document released under the terms of a Creative Commons CC-BY licence using the Swansea University Research Publications Policy (rights retention). true eng https://creativecommons.org/licenses/by/4.0/
title Adaptation of Left Ventricular Twist Mechanics in Exercise-Trained Children Is Only Evident after the Adolescent Growth Spurt
spellingShingle Adaptation of Left Ventricular Twist Mechanics in Exercise-Trained Children Is Only Evident after the Adolescent Growth Spurt
Kelly Mackintosh
Melitta McNarry
title_short Adaptation of Left Ventricular Twist Mechanics in Exercise-Trained Children Is Only Evident after the Adolescent Growth Spurt
title_full Adaptation of Left Ventricular Twist Mechanics in Exercise-Trained Children Is Only Evident after the Adolescent Growth Spurt
title_fullStr Adaptation of Left Ventricular Twist Mechanics in Exercise-Trained Children Is Only Evident after the Adolescent Growth Spurt
title_full_unstemmed Adaptation of Left Ventricular Twist Mechanics in Exercise-Trained Children Is Only Evident after the Adolescent Growth Spurt
title_sort Adaptation of Left Ventricular Twist Mechanics in Exercise-Trained Children Is Only Evident after the Adolescent Growth Spurt
author_id_str_mv bdb20e3f31bcccf95c7bc116070c4214
062f5697ff59f004bc8c713955988398
author_id_fullname_str_mv bdb20e3f31bcccf95c7bc116070c4214_***_Kelly Mackintosh
062f5697ff59f004bc8c713955988398_***_Melitta McNarry
author Kelly Mackintosh
Melitta McNarry
author2 Dean R. Perkins
Jack S. Talbot
Rachel N. Lord
Tony G. Dawkins
Aaron L. Baggish
Abbas Zaidi
Orhan Uzun
Kelly Mackintosh
Melitta McNarry
Stephen-Mark Cooper
Rhodri S. Lloyd
Jon L. Oliver
Rob E. Shave
Mike Stembridge
format Journal article
container_title Journal of the American Society of Echocardiography
container_volume 0
publishDate 2023
institution Swansea University
issn 0894-7317
doi_str_mv 10.1016/j.echo.2023.11.024
publisher Elsevier BV
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Sport and Exercise Sciences
document_store_str 1
active_str 0
description BackgroundThe extent of structural cardiac remodeling in response to endurance training is maturity dependent. In adults, this structural adaptation is often associated with the adaptation of left ventricular (LV) twist mechanics. For example, an increase in LV twist often follows an expansion in end-diastolic volume, whereas a reduction in twist may follow a thickening of the LV walls. While structural cardiac remodeling has been shown to be more prominent post–peak height velocity (PHV), it remains to be determined how this maturation-dependent structural remodeling influences LV twist. Therefore, we aimed to (1) compare LV twist mechanics between trained and untrained children pre- and post-PHV and (2) investigate how LV structural variables relate to LV twist mechanics pre- and post-PHV.MethodsLeft ventricular function and morphology were assessed (echocardiography) in endurance-trained and untrained boys (n = 38 and n = 28, respectively) and girls (n = 39 and n = 34, respectively). Participants were categorized as either pre- or post-PHV using maturity offset to estimate somatic maturation.ResultsPre-PHV, there were no differences in LV twist or torsion between trained and untrained boys (twist: P = .630; torsion: P = .382) or girls (twist: P = .502; torsion: P = .316), and LV twist mechanics were not related with any LV structural variables (P > .05). Post-PHV, LV twist was lower in trained versus untrained boys (P = .004), with torsion lower in trained groups, irrespective of sex (boys: P < .001; girls: P = .017). Moreover, LV torsion was inversely related to LV mass (boys: r = −0.55, P = .001; girls: r = −0.46, P = .003) and end-diastolic volume (boys: r = −0.64, P < .001; girls: r = −0.36, P = .025) in both sexes.ConclusionsA difference in LV twist mechanics between endurance-trained and untrained cohorts is only apparent post-PHV, where structural and functional remodeling were related.
published_date 2023-12-04T16:29:33Z
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score 11.013731

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