Journal article 263 views
Synthesis and comparison of linear and hyperbranched multivalent glycosides for C-type lectin binding
Pallavi Kiran,
Shalini Kumari,
Jens Dernedde,
Rainer Haag 
,
Sumati Bhatia
,
Sumati Bhatia
New Journal of Chemistry, Volume: 43, Issue: 40, Pages: 16012 - 16016
Swansea University Author:
Sumati Bhatia
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1039/c9nj02018g
Abstract
Linear and hyperbranched polyglycerol-based mannosides and fucosyllactosides were developed as nanomolar binders of mannose binding lectin (MBL) and DC-SIGN using label free microscale thermophoresis (MST) and surface plasmon resonance (SPR) techniques, respectively. While there was a small preferen...
| Published in: | New Journal of Chemistry |
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| ISSN: | 1144-0546 1369-9261 |
| Published: |
Royal Society of Chemistry (RSC)
2019
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa64871 |
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| Abstract: |
Linear and hyperbranched polyglycerol-based mannosides and fucosyllactosides were developed as nanomolar binders of mannose binding lectin (MBL) and DC-SIGN using label free microscale thermophoresis (MST) and surface plasmon resonance (SPR) techniques, respectively. While there was a small preference for hyperbranched polyglycerols in the case of MBL inhibitors, a clear advantage of ligand presentation on linear polyglycerol scaffolds was observed for DC-SIGN. |
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| College: |
Faculty of Science and Engineering |
| Issue: |
40 |
| Start Page: |
16012 |
| End Page: |
16016 |