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Topology‐Matching Design of an Influenza‐Neutralizing Spiky Nanoparticle‐Based Inhibitor with a Dual Mode of Action

Chuanxiong Nie, Badri Parshad, Sumati Bhatia Orcid Logo, Chong Cheng, Marlena Stadtmüller, Alexander Oehrl, Yannic Kerkhoff, Thorsten Wolff, Rainer Haag Orcid Logo

Angewandte Chemie International Edition, Volume: 59, Issue: 36, Pages: 15532 - 15536

Swansea University Author: Sumati Bhatia Orcid Logo

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DOI (Published version): 10.1002/anie.202004832

Abstract

In this study, we demonstrate the concept of “topology-matching design” for virus inhibitors. With the current knowledge of influenza A virus (IAV), we designed a nanoparticle-based inhibitor (nano-inhibitor) that has a matched nanotopology to IAV virions and shows heteromultivalent inhibitory effec...

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Published in: Angewandte Chemie International Edition
ISSN: 1433-7851 1521-3773
Published: Wiley 2020
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa64863
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Abstract: In this study, we demonstrate the concept of “topology-matching design” for virus inhibitors. With the current knowledge of influenza A virus (IAV), we designed a nanoparticle-based inhibitor (nano-inhibitor) that has a matched nanotopology to IAV virions and shows heteromultivalent inhibitory effects on hemagglutinin and neuraminidase. The synthesized nano-inhibitor can neutralize the viral particle extracellularly and block its attachment and entry to the host cells. The virus replication was significantly reduced by 6 orders of magnitude in the presence of the reverse designed nano-inhibitors. Even when used 24 hours after the infection, more than 99.999 % inhibition is still achieved, which indicates such a nano-inhibitor might be a potent antiviral for the treatment of influenza infection.
Keywords: Antiviral agents, inhibitors, influenza, nanoparticles, topology matching
College: Faculty of Science and Engineering
Funders: The authors gratefully acknowledge financial support from Deutsche Forschungsgemeinschaft (DFG) through grants within the Collaborative Research Center (SFB) 765. C.N. acknowledges the support from China Scholarship Council (CSC). We would like to acknowledge the assistance of the Core Facility BioSupraMol supported by the DFG. Open access funding enabled and organized by Projekt DEAL.
Issue: 36
Start Page: 15532
End Page: 15536

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