Journal article 265 views
Exercise training induces thrombogenic benefits in recent but not late postmenopausal women
,
Jens Bangsbo
American Journal of Physiology-Heart and Circulatory Physiology, Volume: 325, Issue: 2, Pages: H346 - H361
Swansea University Author:
Adrian Evans
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DOI (Published version): 10.1152/ajpheart.00054.2023
Abstract
Although regular physical activity is known to improve cardiovascular health in men, evidence for its beneficial effects in postmenopausal females is less convincing and it remains unclear whether initiation of exercise training soon after, rather than manyyears after menopause impacts the magnitude...
| Published in: | American Journal of Physiology-Heart and Circulatory Physiology |
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| ISSN: | 0363-6135 1522-1539 |
| Published: |
American Physiological Society
2023
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa63903 |
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| Abstract: |
Although regular physical activity is known to improve cardiovascular health in men, evidence for its beneficial effects in postmenopausal females is less convincing and it remains unclear whether initiation of exercise training soon after, rather than manyyears after menopause impacts the magnitude of training-induced adaptations. We evaluated exercise-induced changes inmarkers of thrombotic risk and conduit artery function in recent5yr compared with late10yr postmenopausal females. Fourteenrecent5yr and 13 late10yr healthy postmenopausal females completed 8 wk of regular intensive exercise training, consisting offloorball and cycling. Markers of thrombotic risk and vascular health were assessed before and after the intervention, and datawere analyzed using a linear mixed model. Exercise training reduced markers of thrombotic risk, including an 11% reduction (P ¼0.007) in agonist-induced platelet reactivity and a reduction (P ¼ 0.027) in incipient clot microstructure (40% reduction in clotmass) in the recent5yr but not the late10yr (P ¼ 0.380; P ¼ 0.739, respectively) postmenopausal females. There was no changein conduit artery function, as measured by brachial (recent5yr, P ¼ 0.804; late10yr, P ¼ 0.311) and popliteal artery (recent5yr,P ¼ 0.130; late10yr, P ¼ 0.434) flow-mediated dilation. Only the late10yr postmenopausal females exhibited an increase (by9.6%, P ¼ 0.022) in intracellular adhesion molecule-1 levels after training, which may have impacted the thrombogenic adaptation in this group. These findings suggest that 8 wk of high-intensity exercise training reduces thrombotic risk in recent5yr, butnot late10yr postmenopausal females. Thus, regular physical activity initiated soon after, rather than many years after menopause and at a higher age, may be more efficient for reducing thrombogenic risk.NEW & NOTEWORTHY Eight weeks of high-intensity exercise training reduces platelet reactivity as well as blood clot densityand strength in females 5 yr past menopause but not in females 10 yr past menopause. The divergent response in the latepostmenopausal females may be explained by training-induced low-grade systemic inflammation. These findings suggest thatregular physical activity initiated soon after menopause, compared with many years after menopause, may be more efficient forreducing the risk of blood clots. |
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| Keywords: |
Exercise training; menopause; platelets; thrombosis; vascular function |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
Nordea Foundation, Helsefonden; the Danish Ministry of Culture Fund for Sports Research |
| Issue: |
2 |
| Start Page: |
H346 |
| End Page: |
H361 |