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Microneedle technology for potential SARS-CoV-2 vaccine delivery

Megan McNamee, Shuyi Wong, Owen Guy Orcid Logo, Sanjiv Sharma Orcid Logo

Expert Opinion on Drug Delivery, Pages: 1 - 16

Swansea University Authors: Megan McNamee, Shuyi Wong, Owen Guy Orcid Logo, Sanjiv Sharma Orcid Logo

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DOI (Published version): 10.1080/17425247.2023.2209718

Abstract

IntroductionMicroneedle fabrication was conceptualized in the 1970s as devices for painless transdermal drug delivery. The last two decades have seen considerable research and financial investment in this area with SARS-CoV-2 and other vaccines catalyzing their application to in vivo intradermal vac...

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Published in: Expert Opinion on Drug Delivery
ISSN: 1742-5247 1744-7593
Published: Informa UK Limited
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URI: https://cronfa.swan.ac.uk/Record/cronfa63375
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The last two decades have seen considerable research and financial investment in this area with SARS-CoV-2 and other vaccines catalyzing their application to in vivo intradermal vaccine delivery. Microneedle arrays have been fabricated in different shapes, geometries, formats, and out of different materials.Areas coveredThe recent pandemic has offered microneedle platforms the opportunity to be employed as a vehicle for SARS-CoV-2 vaccine administration. Various modes of vaccination delivery and the potential of microneedle array-based vaccines will be presented, with a specific focus placed on recent SARS-CoV-2 research. The advantages of microneedle-based vaccine administration, in addition to the major hurdles to their en masse implementation, will be examined.Expert opinionConsidering the widely acknowledged disadvantages of current vaccine delivery, such as anxiety, pain, and the requirement for professional administration, a large shift in this research sphere is imminent. The SARS-CoV-2 pandemic has catalyzed the development of alternate vaccination platforms, working to avoid the requirement for mass vaccination centers. As microneedle vaccine patches are transitioning through clinical study phases, research will be required to prepare this technology for a more mass production environment.</abstract><type>Journal Article</type><journal>Expert Opinion on Drug Delivery</journal><volume/><journalNumber/><paginationStart>1</paginationStart><paginationEnd>16</paginationEnd><publisher>Informa UK Limited</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1742-5247</issnPrint><issnElectronic>1744-7593</issnElectronic><keywords>Microneedles, skin, vaccine, pain-free, minimally invasive, SARS-CoV-2, vaccination, vaccine patch, theranostics</keywords><publishedDay>0</publishedDay><publishedMonth>0</publishedMonth><publishedYear>0</publishedYear><publishedDate>0001-01-01</publishedDate><doi>10.1080/17425247.2023.2209718</doi><url>http://dx.doi.org/10.1080/17425247.2023.2209718</url><notes/><college>COLLEGE NANME</college><department>The College, Swansea University</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>OICWS</DepartmentCode><institution>Swansea University</institution><apcterm>SU Library paid the OA fee (TA Institutional Deal)</apcterm><funders>Swansea University</funders><projectreference/><lastEdited>2023-06-21T10:03:59.4187740</lastEdited><Created>2023-05-09T14:24:47.6315946</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Biomedical Engineering</level></path><authors><author><firstname>Megan</firstname><surname>McNamee</surname><order>1</order></author><author><firstname>Shuyi</firstname><surname>Wong</surname><order>2</order></author><author><firstname>Owen</firstname><surname>Guy</surname><orcid>0000-0002-6449-4033</orcid><order>3</order></author><author><firstname>Sanjiv</firstname><surname>Sharma</surname><orcid>0000-0003-3828-737X</orcid><order>4</order></author></authors><documents><document><filename>63375__27771__dcaeaa0f4a5e4652a2e436bdbf8acf40.pdf</filename><originalFilename>63375.pdf</originalFilename><uploaded>2023-06-08T15:48:50.2543691</uploaded><type>Output</type><contentLength>2560474</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor &amp; Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by-nc-nd/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling v2 63375 2023-05-09 Microneedle technology for potential SARS-CoV-2 vaccine delivery c3f02aa2478f79f98cd969fbd002dc59 Megan McNamee Megan McNamee true false a9270e65fde82c8d0ea713a408feb44d Shuyi Wong Shuyi Wong true false c7fa5949b8528e048c5b978005f66794 0000-0002-6449-4033 Owen Guy Owen Guy true false b6b7506358522f607b171ec9c94757b7 0000-0003-3828-737X Sanjiv Sharma Sanjiv Sharma true false 2023-05-09 OICWS IntroductionMicroneedle fabrication was conceptualized in the 1970s as devices for painless transdermal drug delivery. The last two decades have seen considerable research and financial investment in this area with SARS-CoV-2 and other vaccines catalyzing their application to in vivo intradermal vaccine delivery. Microneedle arrays have been fabricated in different shapes, geometries, formats, and out of different materials.Areas coveredThe recent pandemic has offered microneedle platforms the opportunity to be employed as a vehicle for SARS-CoV-2 vaccine administration. Various modes of vaccination delivery and the potential of microneedle array-based vaccines will be presented, with a specific focus placed on recent SARS-CoV-2 research. The advantages of microneedle-based vaccine administration, in addition to the major hurdles to their en masse implementation, will be examined.Expert opinionConsidering the widely acknowledged disadvantages of current vaccine delivery, such as anxiety, pain, and the requirement for professional administration, a large shift in this research sphere is imminent. The SARS-CoV-2 pandemic has catalyzed the development of alternate vaccination platforms, working to avoid the requirement for mass vaccination centers. As microneedle vaccine patches are transitioning through clinical study phases, research will be required to prepare this technology for a more mass production environment. Journal Article Expert Opinion on Drug Delivery 1 16 Informa UK Limited 1742-5247 1744-7593 Microneedles, skin, vaccine, pain-free, minimally invasive, SARS-CoV-2, vaccination, vaccine patch, theranostics 0 0 0 0001-01-01 10.1080/17425247.2023.2209718 http://dx.doi.org/10.1080/17425247.2023.2209718 COLLEGE NANME The College, Swansea University COLLEGE CODE OICWS Swansea University SU Library paid the OA fee (TA Institutional Deal) Swansea University 2023-06-21T10:03:59.4187740 2023-05-09T14:24:47.6315946 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Megan McNamee 1 Shuyi Wong 2 Owen Guy 0000-0002-6449-4033 3 Sanjiv Sharma 0000-0003-3828-737X 4 63375__27771__dcaeaa0f4a5e4652a2e436bdbf8acf40.pdf 63375.pdf 2023-06-08T15:48:50.2543691 Output 2560474 application/pdf Version of Record true © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. true eng http://creativecommons.org/licenses/by-nc-nd/4.0/
title Microneedle technology for potential SARS-CoV-2 vaccine delivery
spellingShingle Microneedle technology for potential SARS-CoV-2 vaccine delivery
Megan McNamee
Shuyi Wong
Owen Guy
Sanjiv Sharma
title_short Microneedle technology for potential SARS-CoV-2 vaccine delivery
title_full Microneedle technology for potential SARS-CoV-2 vaccine delivery
title_fullStr Microneedle technology for potential SARS-CoV-2 vaccine delivery
title_full_unstemmed Microneedle technology for potential SARS-CoV-2 vaccine delivery
title_sort Microneedle technology for potential SARS-CoV-2 vaccine delivery
author_id_str_mv c3f02aa2478f79f98cd969fbd002dc59
a9270e65fde82c8d0ea713a408feb44d
c7fa5949b8528e048c5b978005f66794
b6b7506358522f607b171ec9c94757b7
author_id_fullname_str_mv c3f02aa2478f79f98cd969fbd002dc59_***_Megan McNamee
a9270e65fde82c8d0ea713a408feb44d_***_Shuyi Wong
c7fa5949b8528e048c5b978005f66794_***_Owen Guy
b6b7506358522f607b171ec9c94757b7_***_Sanjiv Sharma
author Megan McNamee
Shuyi Wong
Owen Guy
Sanjiv Sharma
author2 Megan McNamee
Shuyi Wong
Owen Guy
Sanjiv Sharma
format Journal article
container_title Expert Opinion on Drug Delivery
container_start_page 1
institution Swansea University
issn 1742-5247
1744-7593
doi_str_mv 10.1080/17425247.2023.2209718
publisher Informa UK Limited
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
url http://dx.doi.org/10.1080/17425247.2023.2209718
document_store_str 1
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description IntroductionMicroneedle fabrication was conceptualized in the 1970s as devices for painless transdermal drug delivery. The last two decades have seen considerable research and financial investment in this area with SARS-CoV-2 and other vaccines catalyzing their application to in vivo intradermal vaccine delivery. Microneedle arrays have been fabricated in different shapes, geometries, formats, and out of different materials.Areas coveredThe recent pandemic has offered microneedle platforms the opportunity to be employed as a vehicle for SARS-CoV-2 vaccine administration. Various modes of vaccination delivery and the potential of microneedle array-based vaccines will be presented, with a specific focus placed on recent SARS-CoV-2 research. The advantages of microneedle-based vaccine administration, in addition to the major hurdles to their en masse implementation, will be examined.Expert opinionConsidering the widely acknowledged disadvantages of current vaccine delivery, such as anxiety, pain, and the requirement for professional administration, a large shift in this research sphere is imminent. The SARS-CoV-2 pandemic has catalyzed the development of alternate vaccination platforms, working to avoid the requirement for mass vaccination centers. As microneedle vaccine patches are transitioning through clinical study phases, research will be required to prepare this technology for a more mass production environment.
published_date 0001-01-01T10:03:58Z
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