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Incidence determinants and serological correlates of reactive symptoms following SARS-CoV-2 vaccination
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David A. Jolliffe,
Mohammad Talaei ,
Sian Faustini,
Giulia Vivaldi ,
Matthew Greenig,
Alex G. Richter,
Ronan Lyons ,
Christopher J. Griffiths,
Frank Kee,
Aziz Sheikh,
Gwyneth Davies ,
Seif O. Shaheen,
Adrian R. Martineau
npj Vaccines, Volume: 8, Issue: 1
Swansea University Authors:
Ronan Lyons , Gwyneth Davies
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DOI (Published version): 10.1038/s41541-023-00614-0
Abstract
Prospective population-based studies investigating associations between reactive symptoms following SARS-CoV-2 vaccination and serologic responses to vaccination are lacking. We therefore conducted a study in 9003 adults from the UK general population receiving SARS-CoV-2 vaccines as part of the nat...
| Published in: | npj Vaccines |
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| ISSN: | 2059-0105 |
| Published: |
Springer Science and Business Media LLC
2023
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa63120 |
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| Abstract: |
Prospective population-based studies investigating associations between reactive symptoms following SARS-CoV-2 vaccination and serologic responses to vaccination are lacking. We therefore conducted a study in 9003 adults from the UK general population receiving SARS-CoV-2 vaccines as part of the national vaccination programme. Titres of combined IgG/IgA/IgM responses to SARS-CoV-2 spike (S) glycoprotein were determined in eluates of dried blood spots collected from all participants before and after vaccination. 4262 (47.3%) participants experienced systemic reactive symptoms after a first vaccine dose. Factors associating with lower risk of such symptoms included older age (aOR per additional 10 years of age 0.85, 95% CI: 0.81–0.90), male vs. female sex (0.59, 0.53–0.65) and receipt of an mRNA vaccine vs. ChAdOx1 nCoV-19 (0.29, 0.26–0.32 for BNT162b2; 0.06, 0.01–0.26 for mRNA-1273). Higher risk of such symptoms was associated with SARS-CoV-2 seropositivity and COVID-19 symptoms prior to vaccination (2.23, 1.78–2.81), but not with SARS-CoV-2 seropositivity in the absence of COVID-19 symptoms (0.94, 0.81–1.09). Presence vs. absence of self-reported anxiety or depression at enrolment associated with higher risk of such symptoms (1.24, 1.12–1.39). Post-vaccination anti-S titres were higher among participants who experienced reactive symptoms after vaccination vs. those who did not (P < 0.001). We conclude that factors influencing risk of systemic symptoms after SARS-CoV-2 vaccination include demographic characteristics, pre-vaccination SARS-CoV-2 serostatus and vaccine type. Participants experiencing reactive symptoms following SARS-CoV-2 vaccination had higher post-vaccination titres of IgG/A/M anti-S antibodies. Improved public understanding of the frequency of reactogenic symptoms and their positive association with vaccine immunogenicity could potentially increase vaccine uptake. |
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| Keywords: |
Fever, Risk factors, RNA vaccines |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
Barts Charity |
| Issue: |
1 |