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Modeling Reactive Hyperemia to Better Understand and Assess Microvascular Function: A Review of Techniques

Alberto Coccarelli Orcid Logo, Michael D. Nelson

Annals of Biomedical Engineering, Volume: 51, Issue: 3, Pages: 479 - 492

Swansea University Author: Alberto Coccarelli Orcid Logo

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DOI (Published version): 10.1007/s10439-022-03134-5

Abstract

Reactive hyperemia is a well-established technique for the non-invasive evaluation of the peripheral microcirculatory function, measured as the magnitude of limb re-perfusion after a brief period of ischemia. Despite widespread adoption by researchers and clinicians alike, many uncertainties remain...

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Published in: Annals of Biomedical Engineering
ISSN: 0090-6964 1573-9686
Published: Springer Science and Business Media LLC 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa62578
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spelling 2023-02-27T16:08:53.0307651 v2 62578 2023-02-06 Modeling Reactive Hyperemia to Better Understand and Assess Microvascular Function: A Review of Techniques 06fd3332e5eb3cf4bb4e75a24f49149d 0000-0003-1511-9015 Alberto Coccarelli Alberto Coccarelli true false 2023-02-06 ACEM Reactive hyperemia is a well-established technique for the non-invasive evaluation of the peripheral microcirculatory function, measured as the magnitude of limb re-perfusion after a brief period of ischemia. Despite widespread adoption by researchers and clinicians alike, many uncertainties remain surrounding interpretation, compounded by patient-specific confounding factors (such as blood pressure or the metabolic rate of the ischemic limb). Mathematical modeling can accelerate our understanding of the physiology underlying the reactive hyperemia response and guide in the estimation of quantities which are difficult to measure experimentally. In this work, we aim to provide a comprehensive guide for mathematical modeling techniques that can be used for describing the key phenomena involved in the reactive hyperemia response, alongside their limitations and advantages. The reported methodologies can be used for investigating specific reactive hyperemia aspects alone, or can be combined into a computational framework to be used in (pre-)clinical settings. Journal Article Annals of Biomedical Engineering 51 3 479 492 Springer Science and Business Media LLC 0090-6964 1573-9686 Reactive hyperemia; Microvascular function; Non-invasive testing; Peripheral circulation; Computational haemodynamics; Multi-scale modeling 1 3 2023 2023-03-01 10.1007/s10439-022-03134-5 COLLEGE NANME Aerospace, Civil, Electrical, and Mechanical Engineering COLLEGE CODE ACEM Swansea University 2023-02-27T16:08:53.0307651 2023-02-06T08:46:25.0833614 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering Alberto Coccarelli 0000-0003-1511-9015 1 Michael D. Nelson 2 62578__26682__1f713733ba974f5f8b16090b49ae591d.pdf 62578.pdf 2023-02-27T16:06:39.7530951 Output 745153 application/pdf Version of Record true This article is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/
title Modeling Reactive Hyperemia to Better Understand and Assess Microvascular Function: A Review of Techniques
spellingShingle Modeling Reactive Hyperemia to Better Understand and Assess Microvascular Function: A Review of Techniques
Alberto Coccarelli
title_short Modeling Reactive Hyperemia to Better Understand and Assess Microvascular Function: A Review of Techniques
title_full Modeling Reactive Hyperemia to Better Understand and Assess Microvascular Function: A Review of Techniques
title_fullStr Modeling Reactive Hyperemia to Better Understand and Assess Microvascular Function: A Review of Techniques
title_full_unstemmed Modeling Reactive Hyperemia to Better Understand and Assess Microvascular Function: A Review of Techniques
title_sort Modeling Reactive Hyperemia to Better Understand and Assess Microvascular Function: A Review of Techniques
author_id_str_mv 06fd3332e5eb3cf4bb4e75a24f49149d
author_id_fullname_str_mv 06fd3332e5eb3cf4bb4e75a24f49149d_***_Alberto Coccarelli
author Alberto Coccarelli
author2 Alberto Coccarelli
Michael D. Nelson
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container_title Annals of Biomedical Engineering
container_volume 51
container_issue 3
container_start_page 479
publishDate 2023
institution Swansea University
issn 0090-6964
1573-9686
doi_str_mv 10.1007/s10439-022-03134-5
publisher Springer Science and Business Media LLC
college_str Faculty of Science and Engineering
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hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering
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description Reactive hyperemia is a well-established technique for the non-invasive evaluation of the peripheral microcirculatory function, measured as the magnitude of limb re-perfusion after a brief period of ischemia. Despite widespread adoption by researchers and clinicians alike, many uncertainties remain surrounding interpretation, compounded by patient-specific confounding factors (such as blood pressure or the metabolic rate of the ischemic limb). Mathematical modeling can accelerate our understanding of the physiology underlying the reactive hyperemia response and guide in the estimation of quantities which are difficult to measure experimentally. In this work, we aim to provide a comprehensive guide for mathematical modeling techniques that can be used for describing the key phenomena involved in the reactive hyperemia response, alongside their limitations and advantages. The reported methodologies can be used for investigating specific reactive hyperemia aspects alone, or can be combined into a computational framework to be used in (pre-)clinical settings.
published_date 2023-03-01T20:32:07Z
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