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Therapeutic Exosomes as Novel Treatment for Ovarian Cancer / CLAIRE DONNELLY

Swansea University Author: CLAIRE DONNELLY

  • E-Thesis – open access under embargo until: 26th October 2027

DOI (Published version): 10.23889/SUthesis.62107

Abstract

Ovarian cancer (OC) has the highest mortality rate of all gynecological cancers, with a low 5-year survival rate. This is in part due to resistance to chemotherapy drugs and recurrence, which causes OC treatments to become inadequate. Exosomes are a type of extracellular vesicle (EV), along with mic...

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Published: Swansea 2022
Institution: Swansea University
Degree level: Doctoral
Degree name: Ph.D
Supervisor: Gonzalez, Deyarina
URI: https://cronfa.swan.ac.uk/Record/cronfa62107
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first_indexed 2022-12-02T10:47:29Z
last_indexed 2023-01-13T19:23:20Z
id cronfa62107
recordtype RisThesis
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spelling 2022-12-02T11:17:44.9526677 v2 62107 2022-12-02 Therapeutic Exosomes as Novel Treatment for Ovarian Cancer 5124376ab7d92dbf15f427262e7f2ce5 CLAIRE DONNELLY CLAIRE DONNELLY true false 2022-12-02 Ovarian cancer (OC) has the highest mortality rate of all gynecological cancers, with a low 5-year survival rate. This is in part due to resistance to chemotherapy drugs and recurrence, which causes OC treatments to become inadequate. Exosomes are a type of extracellular vesicle (EV), along with microvesicles and apoptotic bodies. Exosomes act as key mediators of intercellular communication. This leads to the involvement of exosomes in many normal physiological processes including immune responses. However, exosomes derived from tumour cells are implicated in pathological processes, such as cancer progression and metastasis. This study evaluated the role of tumour derived exosomes in OC. This included assessing their biomarker potential. In contrast, non-tumour derived exosomes were evaluated to determine therapeutic ability. E-Thesis Swansea Exosomes, Extracellular Vesicles, Ovarian Cancer, Therapeutic, 3D Culture 26 10 2022 2022-10-26 10.23889/SUthesis.62107 COLLEGE NANME COLLEGE CODE Swansea University Gonzalez, Deyarina Doctoral Ph.D HCRW 2022-12-02T11:17:44.9526677 2022-12-02T10:43:46.2267542 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine CLAIRE DONNELLY 1 Under embargo Under embargo 2022-12-02T11:00:23.7360487 Output 12037464 application/pdf E-Thesis – open access true 2027-10-26T00:00:00.0000000 Copyright: The author, Claire Ailsa Donnelly, 2022. true eng
title Therapeutic Exosomes as Novel Treatment for Ovarian Cancer
spellingShingle Therapeutic Exosomes as Novel Treatment for Ovarian Cancer
CLAIRE DONNELLY
title_short Therapeutic Exosomes as Novel Treatment for Ovarian Cancer
title_full Therapeutic Exosomes as Novel Treatment for Ovarian Cancer
title_fullStr Therapeutic Exosomes as Novel Treatment for Ovarian Cancer
title_full_unstemmed Therapeutic Exosomes as Novel Treatment for Ovarian Cancer
title_sort Therapeutic Exosomes as Novel Treatment for Ovarian Cancer
author_id_str_mv 5124376ab7d92dbf15f427262e7f2ce5
author_id_fullname_str_mv 5124376ab7d92dbf15f427262e7f2ce5_***_CLAIRE DONNELLY
author CLAIRE DONNELLY
author2 CLAIRE DONNELLY
format E-Thesis
publishDate 2022
institution Swansea University
doi_str_mv 10.23889/SUthesis.62107
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
active_str 0
description Ovarian cancer (OC) has the highest mortality rate of all gynecological cancers, with a low 5-year survival rate. This is in part due to resistance to chemotherapy drugs and recurrence, which causes OC treatments to become inadequate. Exosomes are a type of extracellular vesicle (EV), along with microvesicles and apoptotic bodies. Exosomes act as key mediators of intercellular communication. This leads to the involvement of exosomes in many normal physiological processes including immune responses. However, exosomes derived from tumour cells are implicated in pathological processes, such as cancer progression and metastasis. This study evaluated the role of tumour derived exosomes in OC. This included assessing their biomarker potential. In contrast, non-tumour derived exosomes were evaluated to determine therapeutic ability.
published_date 2022-10-26T04:21:28Z
_version_ 1763754417525358592
score 11.037319

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