E-Thesis 408 views
Therapeutic Exosomes as Novel Treatment for Ovarian Cancer / CLAIRE DONNELLY
Swansea University Author: CLAIRE DONNELLY
DOI (Published version): 10.23889/SUthesis.62107
Abstract
Ovarian cancer (OC) has the highest mortality rate of all gynecological cancers, with a low 5-year survival rate. This is in part due to resistance to chemotherapy drugs and recurrence, which causes OC treatments to become inadequate. Exosomes are a type of extracellular vesicle (EV), along with mic...
| Published: |
Swansea
2022
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| Institution: | Swansea University |
| Degree level: | Doctoral |
| Degree name: | Ph.D |
| Supervisor: | Gonzalez, Deyarina |
| URI: | https://cronfa.swan.ac.uk/Record/cronfa62107 |
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| Abstract: |
Ovarian cancer (OC) has the highest mortality rate of all gynecological cancers, with a low 5-year survival rate. This is in part due to resistance to chemotherapy drugs and recurrence, which causes OC treatments to become inadequate. Exosomes are a type of extracellular vesicle (EV), along with microvesicles and apoptotic bodies. Exosomes act as key mediators of intercellular communication. This leads to the involvement of exosomes in many normal physiological processes including immune responses. However, exosomes derived from tumour cells are implicated in pathological processes, such as cancer progression and metastasis. This study evaluated the role of tumour derived exosomes in OC. This included assessing their biomarker potential. In contrast, non-tumour derived exosomes were evaluated to determine therapeutic ability. |
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| Keywords: |
Exosomes, Extracellular Vesicles, Ovarian Cancer, Therapeutic, 3D Culture |
| College: |
Faculty of Medicine, Health and Life Sciences |