IL‐10 differentially controls the infiltration of inflammatory macrophages and antigen‐presenting cells during inflammation

Liao, Chia‐Te; Rosas, Marcela; Davies, Luke; Giles, Peter J.; Tyrrell, Victoria J.; O'Donnell, Valerie B.; Topley, Nicholas; Humphreys, Ian R.; Fraser, Donald J.; Jones, Simon A.; Taylor, Philip R.

doi:10.1002/eji.201646528

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IL‐10 differentially controls the infiltration of inflammatory macrophages and antigen‐presenting cells during inflammation

Chia‐Te Liao, Marcela Rosas, Luke Davies

, Peter J. Giles, Victoria J. Tyrrell, Valerie B. O'Donnell, Nicholas Topley, Ian R. Humphreys, Donald J. Fraser, Simon A. Jones, Philip R. Taylor

European Journal of Immunology, Volume: 46, Issue: 9, Pages: 2222 - 2232

Swansea University Author: Luke Davies

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DOI (Published version): 10.1002/eji.201646528

Abstract

The inflammatory activation and recruitment of defined myeloid populations is essential for controlling the bridge between innate and adaptive immunity and shaping the immune response to microbial challenge. However, these cells exhibit significant functional heterogeneity and the inflammatory signa...

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Published in:	European Journal of Immunology
ISSN:	0014-2980 1521-4141
Published:	Wiley 2016
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URI:	https://cronfa.swan.ac.uk/Record/cronfa61705
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spelling	2022-11-07T11:05:33.1827876 v2 61705 2022-10-31 IL‐10 differentially controls the infiltration of inflammatory macrophages and antigen‐presenting cells during inflammation ff080296775381560053d5e3a6e81745 0000-0001-7767-4060 Luke Davies Luke Davies true false 2022-10-31 BMS The inflammatory activation and recruitment of defined myeloid populations is essential for controlling the bridge between innate and adaptive immunity and shaping the immune response to microbial challenge. However, these cells exhibit significant functional heterogeneity and the inflammatory signals that differentially influence their effector characteristics are poorly characterized. In this study, we defined the phenotype of discrete subsets of effective antigen-presenting cells (APCs) in the peritoneal cavity during peritonitis. When the functional properties of these cells were compared to inflammatory monocyte-derived macrophages we noted differential responses to the immune-modulatory cytokine IL-10. In contrast to the suppressive actions of IL-10 on inflammatory macrophages, the recruitment of APCs was relatively refractory and we found no evidence for selective inhibition of APC differentiation. This differential response of myeloid cell subsets to IL-10 may thus have limited impact on development of potentially tissue-damaging adaptive immune responses, while restricting the magnitude of the inflammatory response. These findings may have clinical relevance in the context of peritoneal dialysis patients, where recurrent infections are associated with immune-mediated membrane dysfunction, treatment failure, and increased morbidity. Journal Article European Journal of Immunology 46 9 2222 2232 Wiley 0014-2980 1521-4141 Antigen presenting; Antigen processing; Dendritic cells; Fate-mapping; Inflammation; Macrophages; Monocytes 7 9 2016 2016-09-07 10.1002/eji.201646528 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University Wellcome Trust. Grant Numbers: 094143/Z/10/Z, WT107964MA; Medical Research Council. Grant Numbers: G0601617/1, MR/K02003X1 2022-11-07T11:05:33.1827876 2022-10-31T12:40:23.2092409 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Chia‐Te Liao 1 Marcela Rosas 2 Luke Davies 0000-0001-7767-4060 3 Peter J. Giles 4 Victoria J. Tyrrell 5 Valerie B. O'Donnell 6 Nicholas Topley 7 Ian R. Humphreys 8 Donald J. Fraser 9 Simon A. Jones 10 Philip R. Taylor 11 61705__25664__470f59e7120f4750b9102b8894878979.pdf 61705.pdf 2022-11-07T11:04:08.6745596 Output 2193353 application/pdf Version of Record true Copyright 2016 The Authors. This is an open access article under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title	IL‐10 differentially controls the infiltration of inflammatory macrophages and antigen‐presenting cells during inflammation
spellingShingle	IL‐10 differentially controls the infiltration of inflammatory macrophages and antigen‐presenting cells during inflammation Luke Davies
title_short	IL‐10 differentially controls the infiltration of inflammatory macrophages and antigen‐presenting cells during inflammation
title_full	IL‐10 differentially controls the infiltration of inflammatory macrophages and antigen‐presenting cells during inflammation
title_fullStr	IL‐10 differentially controls the infiltration of inflammatory macrophages and antigen‐presenting cells during inflammation
title_full_unstemmed	IL‐10 differentially controls the infiltration of inflammatory macrophages and antigen‐presenting cells during inflammation
title_sort	IL‐10 differentially controls the infiltration of inflammatory macrophages and antigen‐presenting cells during inflammation
author_id_str_mv	ff080296775381560053d5e3a6e81745
author_id_fullname_str_mv	ff080296775381560053d5e3a6e81745_***_Luke Davies
author	Luke Davies
author2	Chia‐Te Liao Marcela Rosas Luke Davies Peter J. Giles Victoria J. Tyrrell Valerie B. O'Donnell Nicholas Topley Ian R. Humphreys Donald J. Fraser Simon A. Jones Philip R. Taylor
format	Journal article
container_title	European Journal of Immunology
container_volume	46
container_issue	9
container_start_page	2222
publishDate	2016
institution	Swansea University
issn	0014-2980 1521-4141
doi_str_mv	10.1002/eji.201646528
publisher	Wiley
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description	The inflammatory activation and recruitment of defined myeloid populations is essential for controlling the bridge between innate and adaptive immunity and shaping the immune response to microbial challenge. However, these cells exhibit significant functional heterogeneity and the inflammatory signals that differentially influence their effector characteristics are poorly characterized. In this study, we defined the phenotype of discrete subsets of effective antigen-presenting cells (APCs) in the peritoneal cavity during peritonitis. When the functional properties of these cells were compared to inflammatory monocyte-derived macrophages we noted differential responses to the immune-modulatory cytokine IL-10. In contrast to the suppressive actions of IL-10 on inflammatory macrophages, the recruitment of APCs was relatively refractory and we found no evidence for selective inhibition of APC differentiation. This differential response of myeloid cell subsets to IL-10 may thus have limited impact on development of potentially tissue-damaging adaptive immune responses, while restricting the magnitude of the inflammatory response. These findings may have clinical relevance in the context of peritoneal dialysis patients, where recurrent infections are associated with immune-mediated membrane dysfunction, treatment failure, and increased morbidity.
published_date	2016-09-07T04:20:43Z
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IL‐10 differentially controls the infiltration of inflammatory macrophages and antigen‐presenting cells during inflammation

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