Journal article 583 views
A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness
Manon F. Pritchard,
Lydia Powell ,
Alison A. Jack,
Kate Powell,
Konrad Beck,
Hannah Florance,
Julian Forton,
Philip D. Rye,
Arne Dessen,
Katja E. Hill,
David W. Thomas
Antimicrobial Agents and Chemotherapy, Volume: 61, Issue: 9
Swansea University Author: Lydia Powell
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DOI (Published version): 10.1128/aac.00762-17
Abstract
A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness
Published in: | Antimicrobial Agents and Chemotherapy |
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ISSN: | 0066-4804 1098-6596 |
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American Society for Microbiology
2017
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Online Access: |
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URI: | https://cronfa.swan.ac.uk/Record/cronfa61619 |
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We thank N. Høiby for P. aeruginosa strain NH57388A, E. Mahenthiralingam for the IPARP strains, and Debbie Salmon for technical support for the LC-MS. We thank Gudmund Skjåk-Bræk for providing the high-Mw pseudomonal alginate for the CD studies. We also thank Damian Farnell for his support with statistical analysis.
D.W.T. has a consultancy relationship with and, along with K.E.H., has received research funding from AlgiPharma AS. A.D. and P.D.R. are director/owners of AlgiPharma AS. We have no other conflicts of interest to disclose.</funders><projectreference/><lastEdited>2022-11-09T11:56:48.5318018</lastEdited><Created>2022-10-20T14:36:19.9119770</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Manon F.</firstname><surname>Pritchard</surname><order>1</order></author><author><firstname>Lydia</firstname><surname>Powell</surname><orcid>0000-0002-8641-0160</orcid><order>2</order></author><author><firstname>Alison A.</firstname><surname>Jack</surname><order>3</order></author><author><firstname>Kate</firstname><surname>Powell</surname><order>4</order></author><author><firstname>Konrad</firstname><surname>Beck</surname><order>5</order></author><author><firstname>Hannah</firstname><surname>Florance</surname><order>6</order></author><author><firstname>Julian</firstname><surname>Forton</surname><order>7</order></author><author><firstname>Philip D.</firstname><surname>Rye</surname><order>8</order></author><author><firstname>Arne</firstname><surname>Dessen</surname><order>9</order></author><author><firstname>Katja E.</firstname><surname>Hill</surname><order>10</order></author><author><firstname>David W.</firstname><surname>Thomas</surname><order>11</order></author></authors><documents/><OutputDurs/></rfc1807> |
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2022-11-09T11:56:48.5318018 v2 61619 2022-10-20 A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness 0e7e702952672bcbfdfd4974199202fb 0000-0002-8641-0160 Lydia Powell Lydia Powell true false 2022-10-20 MEDS Journal Article Antimicrobial Agents and Chemotherapy 61 9 American Society for Microbiology 0066-4804 1098-6596 Pseudomonas aeruginosa, colistin, cystic fibrosis, alginate, OligoG CF-5/20 1 9 2017 2017-09-01 10.1128/aac.00762-17 Accepted Post-Print Version available at https://orca.cardiff.ac.uk/id/eprint/101264/ COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University This study was supported by funding from the European Union via the Eurostars Programme and the European Social Fund, Research Council of Norway, Cystic Fibrosis Foundation US, and AlgiPharma AS. We thank N. Høiby for P. aeruginosa strain NH57388A, E. Mahenthiralingam for the IPARP strains, and Debbie Salmon for technical support for the LC-MS. We thank Gudmund Skjåk-Bræk for providing the high-Mw pseudomonal alginate for the CD studies. We also thank Damian Farnell for his support with statistical analysis. D.W.T. has a consultancy relationship with and, along with K.E.H., has received research funding from AlgiPharma AS. A.D. and P.D.R. are director/owners of AlgiPharma AS. We have no other conflicts of interest to disclose. 2022-11-09T11:56:48.5318018 2022-10-20T14:36:19.9119770 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Manon F. Pritchard 1 Lydia Powell 0000-0002-8641-0160 2 Alison A. Jack 3 Kate Powell 4 Konrad Beck 5 Hannah Florance 6 Julian Forton 7 Philip D. Rye 8 Arne Dessen 9 Katja E. Hill 10 David W. Thomas 11 |
title |
A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness |
spellingShingle |
A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness Lydia Powell |
title_short |
A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness |
title_full |
A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness |
title_fullStr |
A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness |
title_full_unstemmed |
A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness |
title_sort |
A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness |
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0e7e702952672bcbfdfd4974199202fb |
author_id_fullname_str_mv |
0e7e702952672bcbfdfd4974199202fb_***_Lydia Powell |
author |
Lydia Powell |
author2 |
Manon F. Pritchard Lydia Powell Alison A. Jack Kate Powell Konrad Beck Hannah Florance Julian Forton Philip D. Rye Arne Dessen Katja E. Hill David W. Thomas |
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Journal article |
container_title |
Antimicrobial Agents and Chemotherapy |
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61 |
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9 |
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2017 |
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Swansea University |
issn |
0066-4804 1098-6596 |
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10.1128/aac.00762-17 |
publisher |
American Society for Microbiology |
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Faculty of Medicine, Health and Life Sciences |
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facultyofmedicinehealthandlifesciences |
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Faculty of Medicine, Health and Life Sciences |
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Faculty of Medicine, Health and Life Sciences |
department_str |
Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine |
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2017-09-01T14:14:35Z |
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