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A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness

Manon F. Pritchard, Lydia Powell Orcid Logo, Alison A. Jack, Kate Powell, Konrad Beck, Hannah Florance, Julian Forton, Philip D. Rye, Arne Dessen, Katja E. Hill, David W. Thomas

Antimicrobial Agents and Chemotherapy, Volume: 61, Issue: 9

Swansea University Author: Lydia Powell Orcid Logo

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DOI (Published version): 10.1128/aac.00762-17

Published in: Antimicrobial Agents and Chemotherapy
ISSN: 0066-4804 1098-6596
Published: American Society for Microbiology 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa61619
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first_indexed 2022-11-09T11:48:12Z
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2022-11-09T11:56:48.5318018</datestamp><bib-version>v2</bib-version><id>61619</id><entry>2022-10-20</entry><title>A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness</title><swanseaauthors><author><sid>0e7e702952672bcbfdfd4974199202fb</sid><ORCID>0000-0002-8641-0160</ORCID><firstname>Lydia</firstname><surname>Powell</surname><name>Lydia Powell</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2022-10-20</date><deptcode>BMS</deptcode><abstract/><type>Journal Article</type><journal>Antimicrobial Agents and Chemotherapy</journal><volume>61</volume><journalNumber>9</journalNumber><paginationStart/><paginationEnd/><publisher>American Society for Microbiology</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0066-4804</issnPrint><issnElectronic>1098-6596</issnElectronic><keywords>Pseudomonas aeruginosa, colistin, cystic fibrosis, alginate, OligoG CF-5/20</keywords><publishedDay>1</publishedDay><publishedMonth>9</publishedMonth><publishedYear>2017</publishedYear><publishedDate>2017-09-01</publishedDate><doi>10.1128/aac.00762-17</doi><url/><notes>Accepted Post-Print Version available at https://orca.cardiff.ac.uk/id/eprint/101264/</notes><college>COLLEGE NANME</college><department>Biomedical Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BMS</DepartmentCode><institution>Swansea University</institution><apcterm/><funders>This study was supported by funding from the European Union via the Eurostars Programme and the European Social Fund, Research Council of Norway, Cystic Fibrosis Foundation US, and AlgiPharma AS. We thank N. H&#xF8;iby for P. aeruginosa strain NH57388A, E. Mahenthiralingam for the IPARP strains, and Debbie Salmon for technical support for the LC-MS. We thank Gudmund Skj&#xE5;k-Br&#xE6;k for providing the high-Mw pseudomonal alginate for the CD studies. We also thank Damian Farnell for his support with statistical analysis. D.W.T. has a consultancy relationship with and, along with K.E.H., has received research funding from AlgiPharma AS. A.D. and P.D.R. are director/owners of AlgiPharma AS. We have no other conflicts of interest to disclose.</funders><projectreference/><lastEdited>2022-11-09T11:56:48.5318018</lastEdited><Created>2022-10-20T14:36:19.9119770</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Manon F.</firstname><surname>Pritchard</surname><order>1</order></author><author><firstname>Lydia</firstname><surname>Powell</surname><orcid>0000-0002-8641-0160</orcid><order>2</order></author><author><firstname>Alison A.</firstname><surname>Jack</surname><order>3</order></author><author><firstname>Kate</firstname><surname>Powell</surname><order>4</order></author><author><firstname>Konrad</firstname><surname>Beck</surname><order>5</order></author><author><firstname>Hannah</firstname><surname>Florance</surname><order>6</order></author><author><firstname>Julian</firstname><surname>Forton</surname><order>7</order></author><author><firstname>Philip D.</firstname><surname>Rye</surname><order>8</order></author><author><firstname>Arne</firstname><surname>Dessen</surname><order>9</order></author><author><firstname>Katja E.</firstname><surname>Hill</surname><order>10</order></author><author><firstname>David W.</firstname><surname>Thomas</surname><order>11</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2022-11-09T11:56:48.5318018 v2 61619 2022-10-20 A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness 0e7e702952672bcbfdfd4974199202fb 0000-0002-8641-0160 Lydia Powell Lydia Powell true false 2022-10-20 BMS Journal Article Antimicrobial Agents and Chemotherapy 61 9 American Society for Microbiology 0066-4804 1098-6596 Pseudomonas aeruginosa, colistin, cystic fibrosis, alginate, OligoG CF-5/20 1 9 2017 2017-09-01 10.1128/aac.00762-17 Accepted Post-Print Version available at https://orca.cardiff.ac.uk/id/eprint/101264/ COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University This study was supported by funding from the European Union via the Eurostars Programme and the European Social Fund, Research Council of Norway, Cystic Fibrosis Foundation US, and AlgiPharma AS. We thank N. Høiby for P. aeruginosa strain NH57388A, E. Mahenthiralingam for the IPARP strains, and Debbie Salmon for technical support for the LC-MS. We thank Gudmund Skjåk-Bræk for providing the high-Mw pseudomonal alginate for the CD studies. We also thank Damian Farnell for his support with statistical analysis. D.W.T. has a consultancy relationship with and, along with K.E.H., has received research funding from AlgiPharma AS. A.D. and P.D.R. are director/owners of AlgiPharma AS. We have no other conflicts of interest to disclose. 2022-11-09T11:56:48.5318018 2022-10-20T14:36:19.9119770 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Manon F. Pritchard 1 Lydia Powell 0000-0002-8641-0160 2 Alison A. Jack 3 Kate Powell 4 Konrad Beck 5 Hannah Florance 6 Julian Forton 7 Philip D. Rye 8 Arne Dessen 9 Katja E. Hill 10 David W. Thomas 11
title A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness
spellingShingle A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness
Lydia Powell
title_short A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness
title_full A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness
title_fullStr A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness
title_full_unstemmed A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness
title_sort A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness
author_id_str_mv 0e7e702952672bcbfdfd4974199202fb
author_id_fullname_str_mv 0e7e702952672bcbfdfd4974199202fb_***_Lydia Powell
author Lydia Powell
author2 Manon F. Pritchard
Lydia Powell
Alison A. Jack
Kate Powell
Konrad Beck
Hannah Florance
Julian Forton
Philip D. Rye
Arne Dessen
Katja E. Hill
David W. Thomas
format Journal article
container_title Antimicrobial Agents and Chemotherapy
container_volume 61
container_issue 9
publishDate 2017
institution Swansea University
issn 0066-4804
1098-6596
doi_str_mv 10.1128/aac.00762-17
publisher American Society for Microbiology
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
active_str 0
published_date 2017-09-01T04:20:34Z
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score 11.013148

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