A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness

Journal article 571 views

Manon F. Pritchard, Lydia Powell

, Alison A. Jack, Kate Powell, Konrad Beck, Hannah Florance, Julian Forton, Philip D. Rye, Arne Dessen, Katja E. Hill, David W. Thomas

Antimicrobial Agents and Chemotherapy, Volume: 61, Issue: 9

Swansea University Author: Lydia Powell

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DOI (Published version): 10.1128/aac.00762-17

Published in:	Antimicrobial Agents and Chemotherapy
ISSN:	0066-4804 1098-6596
Published:	American Society for Microbiology 2017
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa61619

Item Description:	Accepted Post-Print Version available at https://orca.cardiff.ac.uk/id/eprint/101264/
Keywords:	Pseudomonas aeruginosa, colistin, cystic fibrosis, alginate, OligoG CF-5/20
College:	Faculty of Medicine, Health and Life Sciences
Funders:	This study was supported by funding from the European Union via the Eurostars Programme and the European Social Fund, Research Council of Norway, Cystic Fibrosis Foundation US, and AlgiPharma AS. We thank N. Høiby for P. aeruginosa strain NH57388A, E. Mahenthiralingam for the IPARP strains, and Debbie Salmon for technical support for the LC-MS. We thank Gudmund Skjåk-Bræk for providing the high-Mw pseudomonal alginate for the CD studies. We also thank Damian Farnell for his support with statistical analysis. D.W.T. has a consultancy relationship with and, along with K.E.H., has received research funding from AlgiPharma AS. A.D. and P.D.R. are director/owners of AlgiPharma AS. We have no other conflicts of interest to disclose.
Issue:	9