Journal article 637 views 80 downloads
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Nature Genetics, Volume: 54, Issue: 4, Pages: 412 - 436
Swansea University Author: Vanessa Burholt
-
PDF | Version of Record
This article is licensed under a Creative Commons Attribution 4.0 International License
Download (4.92MB)
DOI (Published version): 10.1038/s41588-022-01024-z
Abstract
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘pro...
Published in: | Nature Genetics |
---|---|
ISSN: | 1061-4036 1546-1718 |
Published: |
Springer Science and Business Media LLC
2022
|
Online Access: |
Check full text
|
URI: | https://cronfa.swan.ac.uk/Record/cronfa60592 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
first_indexed |
2022-07-21T23:43:23Z |
---|---|
last_indexed |
2023-02-03T04:14:26Z |
id |
cronfa60592 |
recordtype |
SURis |
fullrecord |
<?xml version="1.0"?><rfc1807><datestamp>2023-02-02T19:22:47.0989485</datestamp><bib-version>v2</bib-version><id>60592</id><entry>2022-07-22</entry><title>New insights into the genetic etiology of Alzheimer’s disease and related dementias</title><swanseaauthors><author><sid>cf7fe9863906cd54df5b0a99904d535e</sid><ORCID>0000-0002-6789-127X</ORCID><firstname>Vanessa</firstname><surname>Burholt</surname><name>Vanessa Burholt</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2022-07-22</date><deptcode>PHAC</deptcode><abstract>Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.</abstract><type>Journal Article</type><journal>Nature Genetics</journal><volume>54</volume><journalNumber>4</journalNumber><paginationStart>412</paginationStart><paginationEnd>436</paginationEnd><publisher>Springer Science and Business Media LLC</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1061-4036</issnPrint><issnElectronic>1546-1718</issnElectronic><keywords/><publishedDay>4</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2022</publishedYear><publishedDate>2022-04-04</publishedDate><doi>10.1038/s41588-022-01024-z</doi><url/><notes/><college>COLLEGE NANME</college><department>Public Health</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>PHAC</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>This work was funded by a grant (EADB) from the EU Joint Programme – Neurodegenerative Disease Research. INSERM UMR1167 is also funded by the INSERM, Institut Pasteur de Lille, Lille Métropole Communauté Urbaine and French government’s LABEX DISTALZ program (development of innovative strategies for a transdisciplinary approach to AD).</funders><projectreference/><lastEdited>2023-02-02T19:22:47.0989485</lastEdited><Created>2022-07-22T00:35:51.2392001</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">The Centre for Innovative Ageing</level></path><authors><author><firstname>Céline</firstname><surname>Bellenguez</surname><orcid>0000-0002-1240-7874</orcid><order>1</order></author><author><firstname>Fahri</firstname><surname>Küçükali</surname><orcid>0000-0002-3835-9639</orcid><order>2</order></author><author><firstname>Iris E.</firstname><surname>Jansen</surname><order>3</order></author><author><firstname>Luca</firstname><surname>Kleineidam</surname><order>4</order></author><author><firstname>Sonia</firstname><surname>Moreno-Grau</surname><order>5</order></author><author><firstname>Najaf</firstname><surname>Amin</surname><orcid>0000-0002-8944-1771</orcid><order>6</order></author><author><firstname>Adam C.</firstname><surname>Naj</surname><order>7</order></author><author><firstname>Rafael</firstname><surname>Campos-Martin</surname><order>8</order></author><author><firstname>Benjamin</firstname><surname>Grenier-Boley</surname><order>9</order></author><author><firstname>Victor</firstname><surname>Andrade</surname><order>10</order></author><author><firstname>Peter A.</firstname><surname>Holmans</surname><orcid>0000-0003-0870-9412</orcid><order>11</order></author><author><firstname>Anne</firstname><surname>Boland</surname><order>12</order></author><author><firstname>Vincent</firstname><surname>Damotte</surname><order>13</order></author><author><firstname>Sven J. van der</firstname><surname>Lee</surname><orcid>0000-0003-1606-8643</orcid><order>14</order></author><author><firstname>Marcos R.</firstname><surname>Costa</surname><orcid>0000-0002-4928-2163</orcid><order>15</order></author><author><firstname>Teemu</firstname><surname>Kuulasmaa</surname><orcid>0000-0002-1795-7314</orcid><order>16</order></author><author><firstname>Qiong</firstname><surname>Yang</surname><orcid>0000-0002-3658-1375</orcid><order>17</order></author><author><firstname>Itziar de</firstname><surname>Rojas</surname><orcid>0000-0002-2148-381x</orcid><order>18</order></author><author><firstname>Joshua C.</firstname><surname>Bis</surname><orcid>0000-0002-3409-1110</orcid><order>19</order></author><author><firstname>Amber</firstname><surname>Yaqub</surname><orcid>0000-0002-3579-8054</orcid><order>20</order></author><author><firstname>Ivana</firstname><surname>Prokic</surname><orcid>0000-0002-0370-1473</orcid><order>21</order></author><author><firstname>Julien</firstname><surname>Chapuis</surname><orcid>0000-0002-5802-2857</orcid><order>22</order></author><author><firstname>Shahzad</firstname><surname>Ahmad</surname><orcid>0000-0002-8658-3790</orcid><order>23</order></author><author><firstname>Vilmantas</firstname><surname>Giedraitis</surname><orcid>0000-0003-3423-2021</orcid><order>24</order></author><author><firstname>Dag</firstname><surname>Aarsland</surname><order>25</order></author><author><firstname>Pablo</firstname><surname>Garcia-Gonzalez</surname><orcid>0000-0003-0125-5403</orcid><order>26</order></author><author><firstname>Carla</firstname><surname>Abdelnour</surname><order>27</order></author><author><firstname>Emilio</firstname><surname>Alarcón-Martín</surname><order>28</order></author><author><firstname>Daniel</firstname><surname>Alcolea</surname><orcid>0000-0002-3819-3245</orcid><order>29</order></author><author><firstname>Montserrat</firstname><surname>Alegret</surname><order>30</order></author><author><firstname>Ignacio</firstname><surname>Alvarez</surname><orcid>0000-0002-8537-3935</orcid><order>31</order></author><author><firstname>Victoria</firstname><surname>Álvarez</surname><order>32</order></author><author><firstname>Nicola J.</firstname><surname>Armstrong</surname><order>33</order></author><author><firstname>Anthoula</firstname><surname>Tsolaki</surname><orcid>0000-0002-5563-7776</orcid><order>34</order></author><author><firstname>Carmen</firstname><surname>Antúnez</surname><order>35</order></author><author><firstname>Ildebrando</firstname><surname>Appollonio</surname><order>36</order></author><author><firstname>Marina</firstname><surname>Arcaro</surname><order>37</order></author><author><firstname>Silvana</firstname><surname>Archetti</surname><order>38</order></author><author><firstname>Alfonso Arias</firstname><surname>Pastor</surname><order>39</order></author><author><firstname>Beatrice</firstname><surname>Arosio</surname><order>40</order></author><author><firstname>Lavinia</firstname><surname>Athanasiu</surname><order>41</order></author><author><firstname>Henri</firstname><surname>Bailly</surname><order>42</order></author><author><firstname>Nerisa</firstname><surname>Banaj</surname><order>43</order></author><author><firstname>Miquel</firstname><surname>Baquero</surname><orcid>0000-0002-6861-1831</orcid><order>44</order></author><author><firstname>Sandra</firstname><surname>Barral</surname><order>45</order></author><author><firstname>Alexa</firstname><surname>Beiser</surname><order>46</order></author><author><firstname>Ana Belén</firstname><surname>Pastor</surname><orcid>0000-0001-9637-4688</orcid><order>47</order></author><author><firstname>Jennifer E.</firstname><surname>Below</surname><order>48</order></author><author><firstname>Penelope</firstname><surname>Benchek</surname><order>49</order></author><author><firstname>Luisa</firstname><surname>Benussi</surname><order>50</order></author><author><firstname>Claudine</firstname><surname>Berr</surname><orcid>0000-0001-5254-7655</orcid><order>51</order></author><author><firstname>Céline</firstname><surname>Besse</surname><order>52</order></author><author><firstname>Valentina</firstname><surname>Bessi</surname><orcid>0000-0002-6176-3584</orcid><order>53</order></author><author><firstname>Giuliano</firstname><surname>Binetti</surname><order>54</order></author><author><firstname>Alessandra</firstname><surname>Bizarro</surname><order>55</order></author><author><firstname>Rafael</firstname><surname>Blesa</surname><order>56</order></author><author><firstname>Mercè</firstname><surname>Boada</surname><orcid>0000-0003-2617-3009</orcid><order>57</order></author><author><firstname>Eric</firstname><surname>Boerwinkle</surname><order>58</order></author><author><firstname>Barbara</firstname><surname>Borroni</surname><order>59</order></author><author><firstname>Silvia</firstname><surname>Boschi</surname><order>60</order></author><author><firstname>Paola</firstname><surname>Bossù</surname><orcid>0000-0002-1432-0078</orcid><order>61</order></author><author><firstname>Geir</firstname><surname>Bråthen</surname><orcid>0000-0003-3224-7983</orcid><order>62</order></author><author><firstname>Jan</firstname><surname>Bressler</surname><orcid>0000-0001-6578-4772</orcid><order>63</order></author><author><firstname>Catherine</firstname><surname>Bresner</surname><orcid>0000-0003-2673-9762</orcid><order>64</order></author><author><firstname>Henry</firstname><surname>Brodaty</surname><orcid>0000-0001-9487-6617</orcid><order>65</order></author><author><firstname>Keeley J.</firstname><surname>Brookes</surname><orcid>0000-0003-2427-2513</orcid><order>66</order></author><author><firstname>Luis Ignacio</firstname><surname>Brusco</surname><order>67</order></author><author><firstname>Dolores</firstname><surname>Buiza-Rueda</surname><order>68</order></author><author><firstname>Katharina</firstname><surname>Bûrger</surname><order>69</order></author><author><firstname>Vanessa</firstname><surname>Burholt</surname><orcid>0000-0002-6789-127X</orcid><order>70</order></author><author><firstname>William S.</firstname><surname>Bush</surname><orcid>0000-0002-9729-6519</orcid><order>71</order></author><author><firstname>Miguel</firstname><surname>Calero</surname><orcid>0000-0001-5366-3324</orcid><order>72</order></author><author><firstname>Laura B.</firstname><surname>Cantwell</surname><order>73</order></author><author><firstname>Geneviève</firstname><surname>Chene</surname><order>74</order></author><author><firstname>Jaeyoon</firstname><surname>Chung</surname><orcid>0000-0002-6431-9454</orcid><order>75</order></author><author><firstname>Michael L.</firstname><surname>Cuccaro</surname><order>76</order></author><author><firstname>Ángel</firstname><surname>Carracedo</surname><order>77</order></author><author><firstname>Roberta</firstname><surname>Cecchetti</surname><order>78</order></author><author><firstname>Laura</firstname><surname>Cervera-Carles</surname><orcid>0000-0003-2286-200x</orcid><order>79</order></author><author><firstname>Camille</firstname><surname>Charbonnier</surname><order>80</order></author><author><firstname>Hung-Hsin</firstname><surname>Chen</surname><order>81</order></author><author><firstname>Caterina</firstname><surname>Chillotti</surname><order>82</order></author><author><firstname>Simona</firstname><surname>Ciccone</surname><order>83</order></author><author><firstname>Jurgen A. H. R.</firstname><surname>Claassen</surname><order>84</order></author><author><firstname>Christopher</firstname><surname>Clark</surname><order>85</order></author><author><firstname>Elisa</firstname><surname>Conti</surname><order>86</order></author><author><firstname>Anaïs</firstname><surname>Corma-Gómez</surname><order>87</order></author><author><firstname>Emanuele</firstname><surname>Costantini</surname><orcid>0000-0002-1096-8221</orcid><order>88</order></author><author><firstname>Carlo</firstname><surname>Custodero</surname><order>89</order></author><author><firstname>Delphine</firstname><surname>Daian</surname><order>90</order></author><author><firstname>Maria Carolina</firstname><surname>Dalmasso</surname><orcid>0000-0002-4901-9955</orcid><order>91</order></author><author><firstname>Antonio</firstname><surname>Daniele</surname><order>92</order></author><author><firstname>Efthimios</firstname><surname>Dardiotis</surname><order>93</order></author><author><firstname>Jean-François</firstname><surname>Dartigues</surname><order>94</order></author><author><firstname>Peter Paul de</firstname><surname>Deyn</surname><order>95</order></author><author><firstname>Katia de Paiva</firstname><surname>Lopes</surname><orcid>0000-0002-0240-0126</orcid><order>96</order></author><author><firstname>Lot D. de</firstname><surname>Witte</surname><orcid>0000-0002-7235-9958</orcid><order>97</order></author><author><firstname>Stéphanie</firstname><surname>Debette</surname><orcid>0000-0001-8675-7968</orcid><order>98</order></author><author><firstname>Jürgen</firstname><surname>Deckert</surname><order>99</order></author><author><firstname>Teodoro del</firstname><surname>Ser</surname><orcid>0000-0001-9806-7083</orcid><order>100</order></author><author><firstname>Nicola</firstname><surname>Denning</surname><order>101</order></author><author><firstname>Anita</firstname><surname>DeStefano</surname><order>102</order></author><author><firstname>Martin</firstname><surname>Dichgans</surname><orcid>0000-0002-0654-387x</orcid><order>103</order></author><author><firstname>Janine</firstname><surname>Diehl-Schmid</surname><orcid>0000-0002-7745-1382</orcid><order>104</order></author><author><firstname>Mónica</firstname><surname>Diez-Fairen</surname><orcid>0000-0003-1882-0309</orcid><order>105</order></author><author><firstname>Paolo Dionigi</firstname><surname>Rossi</surname><order>106</order></author><author><firstname>Srdjan</firstname><surname>Djurovic</surname><orcid>0000-0002-8140-8061</orcid><order>107</order></author><author><firstname>Emmanuelle</firstname><surname>Duron</surname><order>108</order></author><author><firstname>Emrah</firstname><surname>Düzel</surname><order>109</order></author><author><firstname>Carole</firstname><surname>Dufouil</surname><orcid>0000-0003-2442-4476</orcid><order>110</order></author><author><firstname>Gudny</firstname><surname>Eiriksdottir</surname><order>111</order></author><author><firstname>Sebastiaan</firstname><surname>Engelborghs</surname><order>112</order></author><author><firstname>Valentina</firstname><surname>Escott-Price</surname><orcid>0000-0003-1784-5483</orcid><order>113</order></author><author><firstname>Ana</firstname><surname>Espinosa</surname><order>114</order></author><author><firstname>Michael</firstname><surname>Ewers</surname><orcid>0000-0001-5231-1714</orcid><order>115</order></author><author><firstname>Kelley M.</firstname><surname>Faber</surname><order>116</order></author><author><firstname>Tagliavini</firstname><surname>Fabrizio</surname><orcid>0000-0003-1039-7315</orcid><order>117</order></author><author><firstname>Sune Fallgaard</firstname><surname>Nielsen</surname><order>118</order></author><author><firstname>David W.</firstname><surname>Fardo</surname><order>119</order></author><author><firstname>Lucia</firstname><surname>Farotti</surname><order>120</order></author><author><firstname>Chiara</firstname><surname>Fenoglio</surname><order>121</order></author><author><firstname>Marta</firstname><surname>Fernández-Fuertes</surname><order>122</order></author><author><firstname>Raffaele</firstname><surname>Ferrari</surname><order>123</order></author><author><firstname>Catarina B.</firstname><surname>Ferreira</surname><order>124</order></author><author><firstname>Evelyn</firstname><surname>Ferri</surname><order>125</order></author><author><firstname>Bertrand</firstname><surname>Fin</surname><order>126</order></author><author><firstname>Peter</firstname><surname>Fischer</surname><order>127</order></author><author><firstname>Tormod</firstname><surname>Fladby</surname><orcid>0000-0002-9984-9797</orcid><order>128</order></author><author><firstname>Klaus</firstname><surname>Fließbach</surname><order>129</order></author><author><firstname>Bernard</firstname><surname>Fongang</surname><order>130</order></author><author><firstname>Myriam</firstname><surname>Fornage</surname><orcid>0000-0003-0677-8158</orcid><order>131</order></author><author><firstname>Juan</firstname><surname>Fortea</surname><order>132</order></author><author><firstname>Tatiana M.</firstname><surname>Foroud</surname><order>133</order></author><author><firstname>Silvia</firstname><surname>Fostinelli</surname><order>134</order></author><author><firstname>Nick C.</firstname><surname>Fox</surname><orcid>0000-0002-6660-657x</orcid><order>135</order></author><author><firstname>Emlio</firstname><surname>Franco-Macías</surname><order>136</order></author><author><firstname>María J.</firstname><surname>Bullido</surname><orcid>0000-0002-6477-1117</orcid><order>137</order></author><author><firstname>Ana</firstname><surname>Frank-García</surname><order>138</order></author><author><firstname>Lutz</firstname><surname>Froelich</surname><orcid>0000-0003-1494-0813</orcid><order>139</order></author><author><firstname>Brian</firstname><surname>Fulton-Howard</surname><order>140</order></author><author><firstname>Daniela</firstname><surname>Galimberti</surname><orcid>0000-0002-9284-5953</orcid><order>141</order></author><author><firstname>Jose Maria</firstname><surname>García-Alberca</surname><orcid>0000-0003-2951-6644</orcid><order>142</order></author><author><firstname>Pablo</firstname><surname>García-González</surname><order>143</order></author><author><firstname>Sebastian</firstname><surname>Garcia-Madrona</surname><order>144</order></author><author><firstname>Guillermo</firstname><surname>Garcia-Ribas</surname><order>145</order></author><author><firstname>Roberta</firstname><surname>Ghidoni</surname><order>146</order></author><author><firstname>Ina</firstname><surname>Giegling</surname><order>147</order></author><author><firstname>Giaccone</firstname><surname>Giorgio</surname><order>148</order></author><author><firstname>Alison M.</firstname><surname>Goate</surname><orcid>0000-0002-0576-2472</orcid><order>149</order></author><author><firstname>Oliver</firstname><surname>Goldhardt</surname><order>150</order></author><author><firstname>Duber</firstname><surname>Gomez-Fonseca</surname><order>151</order></author><author><firstname>Antonio</firstname><surname>González-Pérez</surname><orcid>0000-0001-9771-5982</orcid><order>152</order></author><author><firstname>Caroline</firstname><surname>Graff</surname><order>153</order></author><author><firstname>Giulia</firstname><surname>Grande</surname><order>154</order></author><author><firstname>Emma</firstname><surname>Green</surname><orcid>0000-0002-8687-5590</orcid><order>155</order></author><author><firstname>Timo</firstname><surname>Grimmer</surname><order>156</order></author><author><firstname>Edna</firstname><surname>Grünblatt</surname><orcid>0000-0001-8505-7265</orcid><order>157</order></author><author><firstname>Michelle</firstname><surname>Grunin</surname><order>158</order></author><author><firstname>Vilmundur</firstname><surname>Gudnason</surname><orcid>0000-0001-5696-0084</orcid><order>159</order></author><author><firstname>Tamar</firstname><surname>Guetta-Baranes</surname><order>160</order></author><author><firstname>Annakaisa</firstname><surname>Haapasalo</surname><orcid>0000-0003-0959-2957</orcid><order>161</order></author><author><firstname>Georgios</firstname><surname>Hadjigeorgiou</surname><order>162</order></author><author><firstname>Jonathan L.</firstname><surname>Haines</surname><order>163</order></author><author><firstname>Kara L.</firstname><surname>Hamilton-Nelson</surname><order>164</order></author><author><firstname>Harald</firstname><surname>Hampel</surname><order>165</order></author><author><firstname>Olivier</firstname><surname>Hanon</surname><order>166</order></author><author><firstname>John</firstname><surname>Hardy</surname><order>167</order></author><author><firstname>Annette M.</firstname><surname>Hartmann</surname><order>168</order></author><author><firstname>Lucrezia</firstname><surname>Hausner</surname><order>169</order></author><author><firstname>Janet</firstname><surname>Harwood</surname><orcid>0000-0002-3225-0069</orcid><order>170</order></author><author><firstname>Stefanie</firstname><surname>Heilmann-Heimbach</surname><orcid>0000-0003-1057-465x</orcid><order>171</order></author><author><firstname>Seppo</firstname><surname>Helisalmi</surname><order>172</order></author><author><firstname>Michael T.</firstname><surname>Heneka</surname><order>173</order></author><author><firstname>Isabel</firstname><surname>Hernández</surname><order>174</order></author><author><firstname>Martin J.</firstname><surname>Herrmann</surname><orcid>0000-0001-9970-2122</orcid><order>175</order></author><author><firstname>Per</firstname><surname>Hoffmann</surname><order>176</order></author><author><firstname>Clive</firstname><surname>Holmes</surname><order>177</order></author><author><firstname>Henne</firstname><surname>Holstege</surname><orcid>0000-0002-7688-3087</orcid><order>178</order></author><author><firstname>Raquel Huerto</firstname><surname>Vilas</surname><order>179</order></author><author><firstname>Marc</firstname><surname>Hulsman</surname><order>180</order></author><author><firstname>Jack</firstname><surname>Humphrey</surname><order>181</order></author><author><firstname>Geert Jan</firstname><surname>Biessels</surname><orcid>0000-0001-6862-2496</orcid><order>182</order></author><author><firstname>Xueqiu</firstname><surname>Jian</surname><orcid>0000-0002-0313-6494</orcid><order>183</order></author><author><firstname>Charlotte</firstname><surname>Johansson</surname><orcid>0000-0002-5351-1950</orcid><order>184</order></author><author><firstname>Gyungah R.</firstname><surname>Jun</surname><orcid>0000-0002-3230-8697</orcid><order>185</order></author><author><firstname>Yuriko</firstname><surname>Kastumata</surname><orcid>0000-0002-0188-8094</orcid><order>186</order></author><author><firstname>John</firstname><surname>Kauwe</surname><order>187</order></author><author><firstname>Patrick G.</firstname><surname>Kehoe</surname><orcid>0000-0002-7542-1139</orcid><order>188</order></author><author><firstname>Lena</firstname><surname>Kilander</surname><order>189</order></author><author><firstname>Anne Kinhult</firstname><surname>Ståhlbom</surname><order>190</order></author><author><firstname>Miia</firstname><surname>Kivipelto</surname><order>191</order></author><author><firstname>Anne</firstname><surname>Koivisto</surname><order>192</order></author><author><firstname>Johannes</firstname><surname>Kornhuber</surname><orcid>0000-0002-8096-3987</orcid><order>193</order></author><author><firstname>Mary H.</firstname><surname>Kosmidis</surname><orcid>0000-0001-8790-1220</orcid><order>194</order></author><author><firstname>Walter A.</firstname><surname>Kukull</surname><order>195</order></author><author><firstname>Pavel P.</firstname><surname>Kuksa</surname><order>196</order></author><author><firstname>Brian W.</firstname><surname>Kunkle</surname><order>197</order></author><author><firstname>Amanda B.</firstname><surname>Kuzma</surname><order>198</order></author><author><firstname>Carmen</firstname><surname>Lage</surname><orcid>0000-0003-1703-121x</orcid><order>199</order></author><author><firstname>Erika J.</firstname><surname>Laukka</surname><order>200</order></author><author><firstname>Lenore</firstname><surname>Launer</surname><orcid>0000-0002-3238-7612</orcid><order>201</order></author><author><firstname>Alessandra</firstname><surname>Lauria</surname><order>202</order></author><author><firstname>Chien-Yueh</firstname><surname>Lee</surname><orcid>0000-0002-4304-974x</orcid><order>203</order></author><author><firstname>Jenni</firstname><surname>Lehtisalo</surname><order>204</order></author><author><firstname>Ondrej</firstname><surname>Lerch</surname><order>205</order></author><author><firstname>Alberto</firstname><surname>Lleó</surname><orcid>0000-0002-2568-5478</orcid><order>206</order></author><author><firstname>William</firstname><surname>Longstreth</surname><order>207</order></author><author><firstname>Oscar</firstname><surname>Lopez</surname><orcid>0000-0002-8546-8256</orcid><order>208</order></author><author><firstname>Adolfo Lopez de</firstname><surname>Munain</surname><orcid>0000-0002-9509-4032</orcid><order>209</order></author><author><firstname>Seth</firstname><surname>Love</surname><order>210</order></author><author><firstname>Malin</firstname><surname>Löwemark</surname><order>211</order></author><author><firstname>Lauren</firstname><surname>Luckcuck</surname><order>212</order></author><author><firstname>Kathryn L.</firstname><surname>Lunetta</surname><orcid>0000-0002-9268-810x</orcid><order>213</order></author><author><firstname>Yiyi</firstname><surname>Ma</surname><orcid>0000-0002-3609-8877</orcid><order>214</order></author><author><firstname>Juan</firstname><surname>Macías</surname><order>215</order></author><author><firstname>Catherine A.</firstname><surname>MacLeod</surname><orcid>0000-0002-9314-7380</orcid><order>216</order></author><author><firstname>Wolfgang</firstname><surname>Maier</surname><order>217</order></author><author><firstname>Francesca</firstname><surname>Mangialasche</surname><order>218</order></author><author><firstname>Marco</firstname><surname>Spallazzi</surname><order>219</order></author><author><firstname>Marta</firstname><surname>Marquié</surname><orcid>0000-0002-0660-0950</orcid><order>220</order></author><author><firstname>Rachel</firstname><surname>Marshall</surname><order>221</order></author><author><firstname>Eden R.</firstname><surname>Martin</surname><order>222</order></author><author><firstname>Angel Martín</firstname><surname>Montes</surname><orcid>0000-0002-1694-786x</orcid><order>223</order></author><author><firstname>Carmen Martínez</firstname><surname>Rodríguez</surname><order>224</order></author><author><firstname>Carlo</firstname><surname>Masullo</surname><order>225</order></author><author><firstname>Richard</firstname><surname>Mayeux</surname><order>226</order></author><author><firstname>Simon</firstname><surname>Mead</surname><orcid>0000-0002-4326-1468</orcid><order>227</order></author><author><firstname>Patrizia</firstname><surname>Mecocci</surname><order>228</order></author><author><firstname>Miguel</firstname><surname>Medina</surname><orcid>0000-0002-7016-5340</orcid><order>229</order></author><author><firstname>Alun</firstname><surname>Meggy</surname><order>230</order></author><author><firstname>Shima</firstname><surname>Mehrabian</surname><order>231</order></author><author><firstname>Silvia</firstname><surname>Mendoza</surname><order>232</order></author><author><firstname>Manuel</firstname><surname>Menéndez-González</surname><orcid>0000-0002-5218-0774</orcid><order>233</order></author><author><firstname>Pablo</firstname><surname>Mir</surname><order>234</order></author><author><firstname>Susanne</firstname><surname>Moebus</surname><order>235</order></author><author><firstname>Merel</firstname><surname>Mol</surname><orcid>0000-0003-2533-2530</orcid><order>236</order></author><author><firstname>Laura</firstname><surname>Molina-Porcel</surname><order>237</order></author><author><firstname>Laura</firstname><surname>Montrreal</surname><order>238</order></author><author><firstname>Laura</firstname><surname>Morelli</surname><order>239</order></author><author><firstname>Fermin</firstname><surname>Moreno</surname><order>240</order></author><author><firstname>Kevin</firstname><surname>Morgan</surname><orcid>0000-0002-8217-2396</orcid><order>241</order></author><author><firstname>Thomas</firstname><surname>Mosley</surname><order>242</order></author><author><firstname>Markus M.</firstname><surname>Nöthen</surname><orcid>0000-0002-8770-2464</orcid><order>243</order></author><author><firstname>Carolina</firstname><surname>Muchnik</surname><orcid>0000-0002-1542-3706</orcid><order>244</order></author><author><firstname>Shubhabrata</firstname><surname>Mukherjee</surname><order>245</order></author><author><firstname>Benedetta</firstname><surname>Nacmias</surname><orcid>0000-0001-9338-9040</orcid><order>246</order></author><author><firstname>Tiia</firstname><surname>Ngandu</surname><order>247</order></author><author><firstname>Gael</firstname><surname>Nicolas</surname><orcid>0000-0001-9391-7800</orcid><order>248</order></author><author><firstname>Børge G.</firstname><surname>Nordestgaard</surname><orcid>0000-0002-1954-7220</orcid><order>249</order></author><author><firstname>Robert</firstname><surname>Olaso</surname><order>250</order></author><author><firstname>Adelina</firstname><surname>Orellana</surname><order>251</order></author><author><firstname>Michela</firstname><surname>Orsini</surname><order>252</order></author><author><firstname>Gemma</firstname><surname>Ortega</surname><order>253</order></author><author><firstname>Alessandro</firstname><surname>Padovani</surname><order>254</order></author><author><firstname>Caffarra</firstname><surname>Paolo</surname><order>255</order></author><author><firstname>Goran</firstname><surname>Papenberg</surname><order>256</order></author><author><firstname>Lucilla</firstname><surname>Parnetti</surname><order>257</order></author><author><firstname>Florence</firstname><surname>Pasquier</surname><orcid>0000-0001-9880-9788</orcid><order>258</order></author><author><firstname>Pau</firstname><surname>Pastor</surname><orcid>0000-0002-7493-8777</orcid><order>259</order></author><author><firstname>Gina</firstname><surname>Peloso</surname><orcid>0000-0002-5355-8636</orcid><order>260</order></author><author><firstname>Alba</firstname><surname>Pérez-Cordón</surname><orcid>0000-0002-6028-0791</orcid><order>261</order></author><author><firstname>Jordi</firstname><surname>Pérez-Tur</surname><orcid>0000-0002-9111-1712</orcid><order>262</order></author><author><firstname>Pierre</firstname><surname>Pericard</surname><orcid>0000-0001-8167-6448</orcid><order>263</order></author><author><firstname>Oliver</firstname><surname>Peters</surname><order>264</order></author><author><firstname>Yolande A. L.</firstname><surname>Pijnenburg</surname><order>265</order></author><author><firstname>Juan A.</firstname><surname>Pineda</surname><orcid>0000-0002-3751-0296</orcid><order>266</order></author><author><firstname>Gerard</firstname><surname>Piñol-Ripoll</surname><order>267</order></author><author><firstname>Claudia</firstname><surname>Pisanu</surname><orcid>0000-0002-9151-4319</orcid><order>268</order></author><author><firstname>Thomas</firstname><surname>Polak</surname><order>269</order></author><author><firstname>Julius</firstname><surname>Popp</surname><order>270</order></author><author><firstname>Danielle</firstname><surname>Posthuma</surname><orcid>0000-0001-7582-2365</orcid><order>271</order></author><author><firstname>Josef</firstname><surname>Priller</surname><order>272</order></author><author><firstname>Raquel</firstname><surname>Puerta</surname><orcid>0000-0002-1191-5893</orcid><order>273</order></author><author><firstname>Olivier</firstname><surname>Quenez</surname><orcid>0000-0002-8273-8505</orcid><order>274</order></author><author><firstname>Inés</firstname><surname>Quintela</surname><order>275</order></author><author><firstname>Jesper Qvist</firstname><surname>Thomassen</surname><orcid>0000-0003-3484-9531</orcid><order>276</order></author><author><firstname>Alberto</firstname><surname>Rábano</surname><order>277</order></author><author><firstname>Innocenzo</firstname><surname>Rainero</surname><order>278</order></author><author><firstname>Farid</firstname><surname>Rajabli</surname><order>279</order></author><author><firstname>Inez</firstname><surname>Ramakers</surname><order>280</order></author><author><firstname>Luis M.</firstname><surname>Real</surname><orcid>0000-0003-4932-7429</orcid><order>281</order></author><author><firstname>Marcel J. T.</firstname><surname>Reinders</surname><orcid>0000-0002-1148-1562</orcid><order>282</order></author><author><firstname>Christiane</firstname><surname>Reitz</surname><orcid>0000-0001-8757-7889</orcid><order>283</order></author><author><firstname>Dolly</firstname><surname>Reyes-Dumeyer</surname><order>284</order></author><author><firstname>Perry</firstname><surname>Ridge</surname><order>285</order></author><author><firstname>Steffi</firstname><surname>Riedel-Heller</surname><orcid>0000-0003-4321-6090</orcid><order>286</order></author><author><firstname>Peter</firstname><surname>Riederer</surname><order>287</order></author><author><firstname>Natalia</firstname><surname>Roberto</surname><order>288</order></author><author><firstname>Eloy</firstname><surname>Rodriguez-Rodriguez</surname><orcid>0000-0001-7742-677x</orcid><order>289</order></author><author><firstname>Arvid</firstname><surname>Rongve</surname><orcid>0000-0002-0476-4134</orcid><order>290</order></author><author><firstname>Irene Rosas</firstname><surname>Allende</surname><order>291</order></author><author><firstname>Maitée</firstname><surname>Rosende-Roca</surname><order>292</order></author><author><firstname>Jose Luis</firstname><surname>Royo</surname><order>293</order></author><author><firstname>Elisa</firstname><surname>Rubino</surname><order>294</order></author><author><firstname>Dan</firstname><surname>Rujescu</surname><order>295</order></author><author><firstname>María Eugenia</firstname><surname>Sáez</surname><orcid>0000-0001-9299-2534</orcid><order>296</order></author><author><firstname>Paraskevi</firstname><surname>Sakka</surname><order>297</order></author><author><firstname>Ingvild</firstname><surname>Saltvedt</surname><orcid>0000-0002-7897-9808</orcid><order>298</order></author><author><firstname>Ángela</firstname><surname>Sanabria</surname><order>299</order></author><author><firstname>María Bernal</firstname><surname>Sánchez-Arjona</surname><order>300</order></author><author><firstname>Florentino</firstname><surname>Sanchez-Garcia</surname><order>301</order></author><author><firstname>Pascual Sánchez</firstname><surname>Juan</surname><orcid>0000-0002-6081-8037</orcid><order>302</order></author><author><firstname>Raquel</firstname><surname>Sánchez-Valle</surname><order>303</order></author><author><firstname>Sigrid B.</firstname><surname>Sando</surname><order>304</order></author><author><firstname>Chloé</firstname><surname>Sarnowski</surname><orcid>0000-0002-6090-7099</orcid><order>305</order></author><author><firstname>Claudia L.</firstname><surname>Satizabal</surname><orcid>0000-0002-1115-4430</orcid><order>306</order></author><author><firstname>Michela</firstname><surname>Scamosci</surname><order>307</order></author><author><firstname>Nikolaos</firstname><surname>Scarmeas</surname><order>308</order></author><author><firstname>Elio</firstname><surname>Scarpini</surname><order>309</order></author><author><firstname>Philip</firstname><surname>Scheltens</surname><order>310</order></author><author><firstname>Norbert</firstname><surname>Scherbaum</surname><order>311</order></author><author><firstname>Martin</firstname><surname>Scherer</surname><order>312</order></author><author><firstname>Matthias</firstname><surname>Schmid</surname><order>313</order></author><author><firstname>Anja</firstname><surname>Schneider</surname><order>314</order></author><author><firstname>Jonathan M.</firstname><surname>Schott</surname><orcid>0000-0003-2059-024x</orcid><order>315</order></author><author><firstname>Geir</firstname><surname>Selbæk</surname><orcid>0000-0001-6511-8219</orcid><order>316</order></author><author><firstname>Davide</firstname><surname>Seripa</surname><order>317</order></author><author><firstname>Manuel</firstname><surname>Serrano</surname><order>318</order></author><author><firstname>Jin</firstname><surname>Sha</surname><order>319</order></author><author><firstname>Alexey A.</firstname><surname>Shadrin</surname><orcid>0000-0002-7467-250x</orcid><order>320</order></author><author><firstname>Olivia</firstname><surname>Skrobot</surname><order>321</order></author><author><firstname>Susan</firstname><surname>Slifer</surname><order>322</order></author><author><firstname>Gijsje J. L.</firstname><surname>Snijders</surname><order>323</order></author><author><firstname>Hilkka</firstname><surname>Soininen</surname><orcid>0000-0002-2785-9937</orcid><order>324</order></author><author><firstname>Vincenzo</firstname><surname>Solfrizzi</surname><orcid>0000-0002-8524-0315</orcid><order>325</order></author><author><firstname>Alina</firstname><surname>Solomon</surname><order>326</order></author><author><firstname>Yeunjoo</firstname><surname>Song</surname><orcid>0000-0002-7452-3731</orcid><order>327</order></author><author><firstname>Sandro</firstname><surname>Sorbi</surname><order>328</order></author><author><firstname>Oscar</firstname><surname>Sotolongo-Grau</surname><orcid>0000-0002-9679-0670</orcid><order>329</order></author><author><firstname>Gianfranco</firstname><surname>Spalletta</surname><orcid>0000-0002-7432-4249</orcid><order>330</order></author><author><firstname>Annika</firstname><surname>Spottke</surname><order>331</order></author><author><firstname>Alessio</firstname><surname>Squassina</surname><orcid>0000-0001-7415-7607</orcid><order>332</order></author><author><firstname>Eystein</firstname><surname>Stordal</surname><orcid>0000-0002-2443-7923</orcid><order>333</order></author><author><firstname>Juan Pablo</firstname><surname>Tartan</surname><order>334</order></author><author><firstname>Lluís</firstname><surname>Tárraga</surname><order>335</order></author><author><firstname>Niccolo</firstname><surname>Tesí</surname><order>336</order></author><author><firstname>Anbupalam</firstname><surname>Thalamuthu</surname><order>337</order></author><author><firstname>Tegos</firstname><surname>Thomas</surname><order>338</order></author><author><firstname>Giuseppe</firstname><surname>Tosto</surname><orcid>0000-0001-7075-8245</orcid><order>339</order></author><author><firstname>Latchezar</firstname><surname>Traykov</surname><order>340</order></author><author><firstname>Lucio</firstname><surname>Tremolizzo</surname><order>341</order></author><author><firstname>Anne</firstname><surname>Tybjærg-Hansen</surname><order>342</order></author><author><firstname>Andre</firstname><surname>Uitterlinden</surname><orcid>0000-0002-7276-3387</orcid><order>343</order></author><author><firstname>Abbe</firstname><surname>Ullgren</surname><order>344</order></author><author><firstname>Ingun</firstname><surname>Ulstein</surname><order>345</order></author><author><firstname>Sergi</firstname><surname>Valero</surname><order>346</order></author><author><firstname>Otto</firstname><surname>Valladares</surname><orcid>0000-0001-8055-2187</orcid><order>347</order></author><author><firstname>Christine Van</firstname><surname>Broeckhoven</surname><orcid>0000-0003-0183-7665</orcid><order>348</order></author><author><firstname>Jeffery</firstname><surname>Vance</surname><order>349</order></author><author><firstname>Badri N.</firstname><surname>Vardarajan</surname><order>350</order></author><author><firstname>Aad van der</firstname><surname>Lugt</surname><order>351</order></author><author><firstname>Jasper Van</firstname><surname>Dongen</surname><order>352</order></author><author><firstname>Jeroen van</firstname><surname>Rooij</surname><order>353</order></author><author><firstname>John van</firstname><surname>Swieten</surname><order>354</order></author><author><firstname>Rik</firstname><surname>Vandenberghe</surname><order>355</order></author><author><firstname>Frans</firstname><surname>Verhey</surname><order>356</order></author><author><firstname>Jean-Sébastien</firstname><surname>Vidal</surname><orcid>0000-0001-6770-0720</orcid><order>357</order></author><author><firstname>Jonathan</firstname><surname>Vogelgsang</surname><orcid>0000-0001-9326-8193</orcid><order>358</order></author><author><firstname>Martin</firstname><surname>Vyhnalek</surname><order>359</order></author><author><firstname>Michael</firstname><surname>Wagner</surname><orcid>0000-0003-2589-6440</orcid><order>360</order></author><author><firstname>David</firstname><surname>Wallon</surname><orcid>0000-0002-2634-7198</orcid><order>361</order></author><author><firstname>Li-San</firstname><surname>Wang</surname><order>362</order></author><author><firstname>Ruiqi</firstname><surname>Wang</surname><order>363</order></author><author><firstname>Leonie</firstname><surname>Weinhold</surname><order>364</order></author><author><firstname>Jens</firstname><surname>Wiltfang</surname><orcid>0000-0003-1492-5330</orcid><order>365</order></author><author><firstname>Gill</firstname><surname>Windle</surname><order>366</order></author><author><firstname>Bob</firstname><surname>Woods</surname><orcid>0000-0002-6781-651x</orcid><order>367</order></author><author><firstname>Mary</firstname><surname>Yannakoulia</surname><orcid>0000-0003-2171-7337</orcid><order>368</order></author><author><firstname>Habil</firstname><surname>Zare</surname><orcid>0000-0001-5902-6238</orcid><order>369</order></author><author><firstname>Yi</firstname><surname>Zhao</surname><order>370</order></author><author><firstname>Xiaoling</firstname><surname>Zhang</surname><orcid>0000-0001-8237-1857</orcid><order>371</order></author><author><firstname>Congcong</firstname><surname>Zhu</surname><order>372</order></author><author><firstname>Miren</firstname><surname>Zulaica</surname><order>373</order></author><author><firstname>Jan</firstname><surname>Laczo</surname><order>374</order></author><author><firstname>Vaclav</firstname><surname>Matoska</surname><order>375</order></author><author><firstname>Maria</firstname><surname>Serpente</surname><order>376</order></author><author><firstname>Francesca</firstname><surname>Assogna</surname><order>377</order></author><author><firstname>Fabrizio</firstname><surname>Piras</surname><order>378</order></author><author><firstname>Federica</firstname><surname>Piras</surname><order>379</order></author><author><firstname>Valentina</firstname><surname>Ciullo</surname><order>380</order></author><author><firstname>Jacob</firstname><surname>Shofany</surname><order>381</order></author><author><firstname>Carlo</firstname><surname>Ferrarese</surname><order>382</order></author><author><firstname>Simona</firstname><surname>Andreoni</surname><order>383</order></author><author><firstname>Gessica</firstname><surname>Sala</surname><order>384</order></author><author><firstname>Chiara Paola</firstname><surname>Zoia</surname><order>385</order></author><author><firstname>Maria Del</firstname><surname>Zompo</surname><order>386</order></author><author><firstname>Alberto</firstname><surname>Benussi</surname><order>387</order></author><author><firstname>Patrizia</firstname><surname>Bastiani</surname><order>388</order></author><author><firstname>Mari</firstname><surname>Takalo</surname><order>389</order></author><author><firstname>Teemu</firstname><surname>Natunen</surname><order>390</order></author><author><firstname>Tiina</firstname><surname>Laatikainen</surname><order>391</order></author><author><firstname>Jaakko</firstname><surname>Tuomilehto</surname><order>392</order></author><author><firstname>Riitta</firstname><surname>Antikainen</surname><order>393</order></author><author><firstname>Timo</firstname><surname>Strandberg</surname><order>394</order></author><author><firstname>Jaana</firstname><surname>Lindström</surname><order>395</order></author><author><firstname>Markku</firstname><surname>Peltonen</surname><order>396</order></author><author><firstname>Richard</firstname><surname>Abraham</surname><order>397</order></author><author><firstname>Ammar</firstname><surname>Al-Chalabi</surname><order>398</order></author><author><firstname>Nicholas J.</firstname><surname>Bass</surname><order>399</order></author><author><firstname>Carol</firstname><surname>Brayne</surname><order>400</order></author><author><firstname>Kristelle S.</firstname><surname>Brown</surname><order>401</order></author><author><firstname>John</firstname><surname>Collinge</surname><order>402</order></author><author><firstname>David</firstname><surname>Craig</surname><order>403</order></author><author><firstname>Pangiotis</firstname><surname>Deloukas</surname><order>404</order></author><author><firstname>Nick</firstname><surname>Fox</surname><order>405</order></author><author><firstname>Amy</firstname><surname>Gerrish</surname><order>406</order></author><author><firstname>Michael</firstname><surname>Gill</surname><order>407</order></author><author><firstname>Rhian</firstname><surname>Gwilliam</surname><order>408</order></author><author><firstname>Denise</firstname><surname>Harold</surname><order>409</order></author><author><firstname>Paul</firstname><surname>Hollingworth</surname><order>410</order></author><author><firstname>Jarret A.</firstname><surname>Johnston</surname><order>411</order></author><author><firstname>Lesley</firstname><surname>Jones</surname><order>412</order></author><author><firstname>Brian</firstname><surname>Lawlor</surname><order>413</order></author><author><firstname>Gill</firstname><surname>Livingston</surname><order>414</order></author><author><firstname>Simon</firstname><surname>Lovestone</surname><order>415</order></author><author><firstname>Michelle</firstname><surname>Lupton</surname><order>416</order></author><author><firstname>Aoibhinn</firstname><surname>Lynch</surname><order>417</order></author><author><firstname>David</firstname><surname>Mann</surname><order>418</order></author><author><firstname>Bernadette</firstname><surname>McGuinness</surname><order>419</order></author><author><firstname>Andrew</firstname><surname>McQuillin</surname><order>420</order></author><author><firstname>Michael C.</firstname><surname>O’Donovan</surname><order>421</order></author><author><firstname>Michael J.</firstname><surname>Owen</surname><order>422</order></author><author><firstname>Peter</firstname><surname>Passmore</surname><order>423</order></author><author><firstname>John F.</firstname><surname>Powell</surname><order>424</order></author><author><firstname>Petra</firstname><surname>Proitsi</surname><order>425</order></author><author><firstname>Martin</firstname><surname>Rossor</surname><order>426</order></author><author><firstname>Christopher E.</firstname><surname>Shaw</surname><order>427</order></author><author><firstname>A. David</firstname><surname>Smith</surname><order>428</order></author><author><firstname>Hugh</firstname><surname>Gurling</surname><order>429</order></author><author><firstname>Stephen</firstname><surname>Todd</surname><order>430</order></author><author><firstname>Catherine</firstname><surname>Mummery</surname><order>431</order></author><author><firstname>Nathalie</firstname><surname>Ryan</surname><order>432</order></author><author><firstname>Giordano</firstname><surname>Lacidogna</surname><order>433</order></author><author><firstname>Ad</firstname><surname>Adarmes-Gómez</surname><order>434</order></author><author><firstname>Ana</firstname><surname>Mauleón</surname><order>435</order></author><author><firstname>Ana</firstname><surname>Pancho</surname><order>436</order></author><author><firstname>Anna</firstname><surname>Gailhajenet</surname><order>437</order></author><author><firstname>Asunción</firstname><surname>Lafuente</surname><order>438</order></author><author><firstname>D.</firstname><surname>Macias-García</surname><order>439</order></author><author><firstname>Elvira</firstname><surname>Martín</surname><order>440</order></author><author><firstname>Esther</firstname><surname>Pelejà</surname><order>441</order></author><author><firstname>F.</firstname><surname>Carrillo</surname><order>442</order></author><author><firstname>Isabel Sastre</firstname><surname>Merlín</surname><order>443</order></author><author><firstname>L.</firstname><surname>Garrote-Espina</surname><order>444</order></author><author><firstname>Liliana</firstname><surname>Vargas</surname><order>445</order></author><author><firstname>M.</firstname><surname>Carrion-Claro</surname><order>446</order></author><author><firstname>M.</firstname><surname>Marín</surname><order>447</order></author><author><firstname>Ma</firstname><surname>Labrador</surname><order>448</order></author><author><firstname>Mar</firstname><surname>Buendia</surname><order>449</order></author><author><firstname>María Dolores</firstname><surname>Alonso</surname><order>450</order></author><author><firstname>Marina</firstname><surname>Guitart</surname><order>451</order></author><author><firstname>Mariona</firstname><surname>Moreno</surname><order>452</order></author><author><firstname>Marta</firstname><surname>Ibarria</surname><order>453</order></author><author><firstname>Mt</firstname><surname>Periñán</surname><order>454</order></author><author><firstname>Nuria</firstname><surname>Aguilera</surname><order>455</order></author><author><firstname>P.</firstname><surname>Gómez-Garre</surname><order>456</order></author><author><firstname>Pilar</firstname><surname>Cañabate</surname><order>457</order></author><author><firstname>R.</firstname><surname>Escuela</surname><order>458</order></author><author><firstname>R.</firstname><surname>Pineda-Sánchez</surname><order>459</order></author><author><firstname>R.</firstname><surname>Vigo-Ortega</surname><order>460</order></author><author><firstname>S.</firstname><surname>Jesús</surname><order>461</order></author><author><firstname>Silvia</firstname><surname>Preckler</surname><order>462</order></author><author><firstname>Silvia</firstname><surname>Rodrigo-Herrero</surname><order>463</order></author><author><firstname>Susana</firstname><surname>Diego</surname><order>464</order></author><author><firstname>Alessandro</firstname><surname>Vacca</surname><order>465</order></author><author><firstname>Fausto</firstname><surname>Roveta</surname><order>466</order></author><author><firstname>Nicola</firstname><surname>Salvadori</surname><order>467</order></author><author><firstname>Elena</firstname><surname>Chipi</surname><order>468</order></author><author><firstname>Henning</firstname><surname>Boecker</surname><order>469</order></author><author><firstname>Christoph</firstname><surname>Laske</surname><order>470</order></author><author><firstname>Robert</firstname><surname>Perneczky</surname><order>471</order></author><author><firstname>Costas</firstname><surname>Anastasiou</surname><order>472</order></author><author><firstname>Daniel</firstname><surname>Janowitz</surname><order>473</order></author><author><firstname>Rainer</firstname><surname>Malik</surname><order>474</order></author><author><firstname>Anna</firstname><surname>Anastasiou</surname><order>475</order></author><author><firstname>Kayenat</firstname><surname>Parveen</surname><order>476</order></author><author><firstname>Carmen</firstname><surname>Lage</surname><order>477</order></author><author><firstname>Sara</firstname><surname>López-García</surname><order>478</order></author><author><firstname>Anna</firstname><surname>Antonell</surname><order>479</order></author><author><firstname>Kalina Yonkova</firstname><surname>Mihova</surname><order>480</order></author><author><firstname>Diyana</firstname><surname>Belezhanska</surname><order>481</order></author><author><firstname>Heike</firstname><surname>Weber</surname><order>482</order></author><author><firstname>Silvia</firstname><surname>Kochen</surname><order>483</order></author><author><firstname>Patricia</firstname><surname>Solis</surname><order>484</order></author><author><firstname>Nancy</firstname><surname>Medel</surname><order>485</order></author><author><firstname>Julieta</firstname><surname>Lisso</surname><order>486</order></author><author><firstname>Zulma</firstname><surname>Sevillano</surname><order>487</order></author><author><firstname>Daniel G.</firstname><surname>Politis</surname><order>488</order></author><author><firstname>Valeria</firstname><surname>Cores</surname><order>489</order></author><author><firstname>Carolina</firstname><surname>Cuesta</surname><order>490</order></author><author><firstname>Cecilia</firstname><surname>Ortiz</surname><order>491</order></author><author><firstname>Juan Ignacio</firstname><surname>Bacha</surname><order>492</order></author><author><firstname>Mario</firstname><surname>Rios</surname><order>493</order></author><author><firstname>Aldo</firstname><surname>Saenz</surname><order>494</order></author><author><firstname>Mariana Sanchez</firstname><surname>Abalos</surname><order>495</order></author><author><firstname>Eduardo</firstname><surname>Kohler</surname><order>496</order></author><author><firstname>Dana Lis</firstname><surname>Palacio</surname><order>497</order></author><author><firstname>Ignacio</firstname><surname>Etchepareborda</surname><order>498</order></author><author><firstname>Matias</firstname><surname>Kohler</surname><order>499</order></author><author><firstname>Gisela</firstname><surname>Novack</surname><order>500</order></author><author><firstname>Federico Ariel</firstname><surname>Prestia</surname><order>501</order></author><author><firstname>Pablo</firstname><surname>Galeano</surname><order>502</order></author><author><firstname>Eduardo M.</firstname><surname>Castaño</surname><order>503</order></author><author><firstname>Sandra</firstname><surname>Germani</surname><order>504</order></author><author><firstname>Carlos Reyes</firstname><surname>Toso</surname><order>505</order></author><author><firstname>Matias</firstname><surname>Rojo</surname><order>506</order></author><author><firstname>Carlos</firstname><surname>Ingino</surname><order>507</order></author><author><firstname>Carlos</firstname><surname>Mangone</surname><order>508</order></author><author><firstname>David C.</firstname><surname>Rubinsztein</surname><order>509</order></author><author><firstname>Stefan</firstname><surname>Teipel</surname><order>510</order></author><author><firstname>Nathalie</firstname><surname>Fievet</surname><order>511</order></author><author><firstname>Vincent</firstname><surname>Deramerourt</surname><order>512</order></author><author><firstname>Charlotte</firstname><surname>Forsell</surname><order>513</order></author><author><firstname>Håkan</firstname><surname>Thonberg</surname><order>514</order></author><author><firstname>Maria</firstname><surname>Bjerke</surname><order>515</order></author><author><firstname>Ellen De</firstname><surname>Roeck</surname><order>516</order></author><author><firstname>María Teresa</firstname><surname>Martínez-Larrad</surname><order>517</order></author><author><firstname>Natividad</firstname><surname>Olivar</surname><order>518</order></author><author><firstname>Nuria</firstname><surname>Aguilera</surname><order>519</order></author><author><firstname>Amanda</firstname><surname>Cano</surname><order>520</order></author><author><firstname>Pilar</firstname><surname>Cañabate</surname><order>521</order></author><author><firstname>Juan</firstname><surname>Macias</surname><order>522</order></author><author><firstname>Olalla</firstname><surname>Maroñas</surname><order>523</order></author><author><firstname>Raúl</firstname><surname>Nuñez-Llaves</surname><order>524</order></author><author><firstname>Clàudia</firstname><surname>Olivé</surname><order>525</order></author><author><firstname>Ester</firstname><surname>Pelejá</surname><order>526</order></author><author><firstname>Astrid D.</firstname><surname>Adarmes-Gómez</surname><order>527</order></author><author><firstname>María Dolores</firstname><surname>Alonso</surname><order>528</order></author><author><firstname>Guillermo</firstname><surname>Amer-Ferrer</surname><order>529</order></author><author><firstname>Martirio</firstname><surname>Antequera</surname><order>530</order></author><author><firstname>Juan Andrés</firstname><surname>Burguera</surname><order>531</order></author><author><firstname>Fátima</firstname><surname>Carrillo</surname><order>532</order></author><author><firstname>Mario</firstname><surname>Carrión-Claro</surname><order>533</order></author><author><firstname>María José</firstname><surname>Casajeros</surname><order>534</order></author><author><firstname>Marian Martinez de</firstname><surname>Pancorbo</surname><order>535</order></author><author><firstname>Rocío</firstname><surname>Escuela</surname><order>536</order></author><author><firstname>Lorena</firstname><surname>Garrote-Espina</surname><order>537</order></author><author><firstname>Pilar</firstname><surname>Gómez-Garre</surname><order>538</order></author><author><firstname>Saray</firstname><surname>Hevilla</surname><order>539</order></author><author><firstname>Silvia</firstname><surname>Jesús</surname><order>540</order></author><author><firstname>Miguel Angel Labrador</firstname><surname>Espinosa</surname><order>541</order></author><author><firstname>Agustina</firstname><surname>Legaz</surname><order>542</order></author><author><firstname>Sara</firstname><surname>López-García</surname><order>543</order></author><author><firstname>Daniel</firstname><surname>Macias-García</surname><order>544</order></author><author><firstname>Salvadora</firstname><surname>Manzanares</surname><order>545</order></author><author><firstname>Marta</firstname><surname>Marín</surname><order>546</order></author><author><firstname>Juan</firstname><surname>Marín-Muñoz</surname><order>547</order></author><author><firstname>Tamara</firstname><surname>Marín</surname><order>548</order></author><author><firstname>Begoña</firstname><surname>Martínez</surname><order>549</order></author><author><firstname>Victoriana</firstname><surname>Martínez</surname><order>550</order></author><author><firstname>Pablo Martínez-Lage</firstname><surname>Álvarez</surname><order>551</order></author><author><firstname>Maite Mendioroz</firstname><surname>Iriarte</surname><order>552</order></author><author><firstname>María Teresa</firstname><surname>Periñán-Tocino</surname><order>553</order></author><author><firstname>Rocío</firstname><surname>Pineda-Sánchez</surname><order>554</order></author><author><firstname>Diego Real de</firstname><surname>Asúa</surname><order>555</order></author><author><firstname>Silvia</firstname><surname>Rodrigo</surname><order>556</order></author><author><firstname>Isabel</firstname><surname>Sastre</surname><order>557</order></author><author><firstname>Maria Pilar</firstname><surname>Vicente</surname><order>558</order></author><author><firstname>Rosario</firstname><surname>Vigo-Ortega</surname><order>559</order></author><author><firstname>Liliana</firstname><surname>Vivancos</surname><order>560</order></author><author><firstname>Jacques</firstname><surname>Epelbaum</surname><order>561</order></author><author><firstname>Didier</firstname><surname>Hannequin</surname><order>562</order></author><author><firstname>Dominique</firstname><surname>campion</surname><order>563</order></author><author><firstname>Vincent</firstname><surname>Deramecourt</surname><order>564</order></author><author><firstname>Christophe</firstname><surname>Tzourio</surname><order>565</order></author><author><firstname>Alexis</firstname><surname>Brice</surname><order>566</order></author><author><firstname>Bruno</firstname><surname>Dubois</surname><order>567</order></author><author><firstname>Amy</firstname><surname>Williams</surname><order>568</order></author><author><firstname>Charlene</firstname><surname>Thomas</surname><order>569</order></author><author><firstname>Chloe</firstname><surname>Davies</surname><order>570</order></author><author><firstname>William</firstname><surname>Nash</surname><order>571</order></author><author><firstname>Kimberley</firstname><surname>Dowzell</surname><order>572</order></author><author><firstname>Atahualpa Castillo</firstname><surname>Morales</surname><order>573</order></author><author><firstname>Mateus</firstname><surname>Bernardo-Harrington</surname><order>574</order></author><author><firstname>James</firstname><surname>Turton</surname><order>575</order></author><author><firstname>Jenny</firstname><surname>Lord</surname><order>576</order></author><author><firstname>Kristelle</firstname><surname>Brown</surname><order>577</order></author><author><firstname>Emma</firstname><surname>Vardy</surname><order>578</order></author><author><firstname>Elizabeth</firstname><surname>Fisher</surname><order>579</order></author><author><firstname>Jason D.</firstname><surname>Warren</surname><order>580</order></author><author><firstname>Martin</firstname><surname>Rossor</surname><order>581</order></author><author><firstname>Natalie S.</firstname><surname>Ryan</surname><order>582</order></author><author><firstname>Rita</firstname><surname>Guerreiro</surname><order>583</order></author><author><firstname>James</firstname><surname>Uphill</surname><order>584</order></author><author><firstname>Nick</firstname><surname>Bass</surname><order>585</order></author><author><firstname>Reinhard</firstname><surname>Heun</surname><order>586</order></author><author><firstname>Heike</firstname><surname>Kölsch</surname><order>587</order></author><author><firstname>Britta</firstname><surname>Schürmann</surname><order>588</order></author><author><firstname>André</firstname><surname>Lacour</surname><order>589</order></author><author><firstname>Christine</firstname><surname>Herold</surname><order>590</order></author><author><firstname>Janet A.</firstname><surname>Johnston</surname><order>591</order></author><author><firstname>Peter</firstname><surname>Passmore</surname><order>592</order></author><author><firstname>John</firstname><surname>Powell</surname><order>593</order></author><author><firstname>Yogen</firstname><surname>Patel</surname><order>594</order></author><author><firstname>Angela</firstname><surname>Hodges</surname><order>595</order></author><author><firstname>Tim</firstname><surname>Becker</surname><order>596</order></author><author><firstname>Donald</firstname><surname>Warden</surname><order>597</order></author><author><firstname>Gordon</firstname><surname>Wilcock</surname><order>598</order></author><author><firstname>Robert</firstname><surname>Clarke</surname><order>599</order></author><author><firstname>Panagiotis</firstname><surname>Deloukas</surname><order>600</order></author><author><firstname>Yoav</firstname><surname>Ben-Shlomo</surname><order>601</order></author><author><firstname>Nigel M.</firstname><surname>Hooper</surname><order>602</order></author><author><firstname>Stuart</firstname><surname>Pickering-Brown</surname><order>603</order></author><author><firstname>Rebecca</firstname><surname>Sussams</surname><order>604</order></author><author><firstname>Nick</firstname><surname>Warner</surname><order>605</order></author><author><firstname>Anthony</firstname><surname>Bayer</surname><order>606</order></author><author><firstname>Isabella</firstname><surname>Heuser</surname><order>607</order></author><author><firstname>Dmitriy</firstname><surname>Drichel</surname><order>608</order></author><author><firstname>Norman</firstname><surname>Klopp</surname><order>609</order></author><author><firstname>Manuel</firstname><surname>Mayhaus</surname><order>610</order></author><author><firstname>Matthias</firstname><surname>Riemenschneider</surname><order>611</order></author><author><firstname>Sabrina</firstname><surname>Pinchler</surname><order>612</order></author><author><firstname>Thomas</firstname><surname>Feulner</surname><order>613</order></author><author><firstname>Wei</firstname><surname>Gu</surname><order>614</order></author><author><firstname>Hendrik van den</firstname><surname>Bussche</surname><order>615</order></author><author><firstname>Michael</firstname><surname>Hüll</surname><order>616</order></author><author><firstname>Lutz</firstname><surname>Frölich</surname><order>617</order></author><author><firstname>H-Erich</firstname><surname>Wichmann</surname><order>618</order></author><author><firstname>Karl-Heinz</firstname><surname>Jöckel</surname><order>619</order></author><author><firstname>Michael</firstname><surname>O’Donovan</surname><order>620</order></author><author><firstname>Michael</firstname><surname>Owen</surname><order>621</order></author><author><firstname>Shahram</firstname><surname>Bahrami</surname><order>622</order></author><author><firstname>Ingunn</firstname><surname>Bosnes</surname><order>623</order></author><author><firstname>Per</firstname><surname>Selnes</surname><order>624</order></author><author><firstname>Sverre</firstname><surname>Bergh</surname><order>625</order></author><author><firstname>Aarno</firstname><surname>Palotie</surname><order>626</order></author><author><firstname>Mark</firstname><surname>Daly</surname><order>627</order></author><author><firstname>Howard</firstname><surname>Jacob</surname><order>628</order></author><author><firstname>Athena</firstname><surname>Matakidou</surname><order>629</order></author><author><firstname>Heiko</firstname><surname>Runz</surname><order>630</order></author><author><firstname>Sally</firstname><surname>John</surname><order>631</order></author><author><firstname>Robert</firstname><surname>Plenge</surname><order>632</order></author><author><firstname>Mark</firstname><surname>McCarthy</surname><order>633</order></author><author><firstname>Julie</firstname><surname>Hunkapiller</surname><order>634</order></author><author><firstname>Meg</firstname><surname>Ehm</surname><order>635</order></author><author><firstname>Dawn</firstname><surname>Waterworth</surname><order>636</order></author><author><firstname>Caroline</firstname><surname>Fox</surname><order>637</order></author><author><firstname>Anders</firstname><surname>Malarstig</surname><order>638</order></author><author><firstname>Kathy</firstname><surname>Klinger</surname><order>639</order></author><author><firstname>Kathy</firstname><surname>Call</surname><order>640</order></author><author><firstname>Tim</firstname><surname>Behrens</surname><order>641</order></author><author><firstname>Patrick</firstname><surname>Loerch</surname><order>642</order></author><author><firstname>Tomi</firstname><surname>Mäkelä</surname><order>643</order></author><author><firstname>Jaakko</firstname><surname>Kaprio</surname><order>644</order></author><author><firstname>Petri</firstname><surname>Virolainen</surname><order>645</order></author><author><firstname>Kari</firstname><surname>Pulkki</surname><order>646</order></author><author><firstname>Terhi</firstname><surname>Kilpi</surname><order>647</order></author><author><firstname>Markus</firstname><surname>Perola</surname><order>648</order></author><author><firstname>Jukka</firstname><surname>Partanen</surname><order>649</order></author><author><firstname>Anne</firstname><surname>Pitkäranta</surname><order>650</order></author><author><firstname>Riitta</firstname><surname>Kaarteenaho</surname><order>651</order></author><author><firstname>Seppo</firstname><surname>Vainio</surname><order>652</order></author><author><firstname>Miia</firstname><surname>Turpeinen</surname><order>653</order></author><author><firstname>Raisa</firstname><surname>Serpi</surname><order>654</order></author><author><firstname>Tarja</firstname><surname>Laitinen</surname><order>655</order></author><author><firstname>Johanna</firstname><surname>Mäkelä</surname><order>656</order></author><author><firstname>Veli-Matti</firstname><surname>Kosma</surname><order>657</order></author><author><firstname>Urho</firstname><surname>Kujala</surname><order>658</order></author><author><firstname>Outi</firstname><surname>Tuovila</surname><order>659</order></author><author><firstname>Minna</firstname><surname>Hendolin</surname><order>660</order></author><author><firstname>Raimo</firstname><surname>Pakkanen</surname><order>661</order></author><author><firstname>Jeff</firstname><surname>Waring</surname><order>662</order></author><author><firstname>Bridget</firstname><surname>Riley-Gillis</surname><order>663</order></author><author><firstname>Jimmy</firstname><surname>Liu</surname><order>664</order></author><author><firstname>Shameek</firstname><surname>Biswas</surname><order>665</order></author><author><firstname>Dorothee</firstname><surname>Diogo</surname><order>666</order></author><author><firstname>Catherine</firstname><surname>Marshall</surname><order>667</order></author><author><firstname>Xinli</firstname><surname>Hu</surname><order>668</order></author><author><firstname>Matthias</firstname><surname>Gossel</surname><order>669</order></author><author><firstname>Robert</firstname><surname>Graham</surname><order>670</order></author><author><firstname>Beryl</firstname><surname>Cummings</surname><order>671</order></author><author><firstname>Samuli</firstname><surname>Ripatti</surname><order>672</order></author><author><firstname>Johanna</firstname><surname>Schleutker</surname><order>673</order></author><author><firstname>Mikko</firstname><surname>Arvas</surname><order>674</order></author><author><firstname>Olli</firstname><surname>Carpén</surname><order>675</order></author><author><firstname>Reetta</firstname><surname>Hinttala</surname><order>676</order></author><author><firstname>Johannes</firstname><surname>Kettunen</surname><order>677</order></author><author><firstname>Arto</firstname><surname>Mannermaa</surname><order>678</order></author><author><firstname>Jari</firstname><surname>Laukkanen</surname><order>679</order></author><author><firstname>Valtteri</firstname><surname>Julkunen</surname><order>680</order></author><author><firstname>Anne</firstname><surname>Remes</surname><order>681</order></author><author><firstname>Reetta</firstname><surname>Kälviäinen</surname><order>682</order></author><author><firstname>Jukka</firstname><surname>Peltola</surname><order>683</order></author><author><firstname>Pentti</firstname><surname>Tienari</surname><order>684</order></author><author><firstname>Juha</firstname><surname>Rinne</surname><order>685</order></author><author><firstname>Adam</firstname><surname>Ziemann</surname><order>686</order></author><author><firstname>Jeffrey</firstname><surname>Waring</surname><order>687</order></author><author><firstname>Sahar</firstname><surname>Esmaeeli</surname><order>688</order></author><author><firstname>Nizar</firstname><surname>Smaoui</surname><order>689</order></author><author><firstname>Anne</firstname><surname>Lehtonen</surname><order>690</order></author><author><firstname>Susan</firstname><surname>Eaton</surname><order>691</order></author><author><firstname>Sanni</firstname><surname>Lahdenperä</surname><order>692</order></author><author><firstname>Janet van</firstname><surname>Adelsberg</surname><order>693</order></author><author><firstname>John</firstname><surname>Michon</surname><order>694</order></author><author><firstname>Geoff</firstname><surname>Kerchner</surname><order>695</order></author><author><firstname>Natalie</firstname><surname>Bowers</surname><order>696</order></author><author><firstname>Edmond</firstname><surname>Teng</surname><order>697</order></author><author><firstname>John</firstname><surname>Eicher</surname><order>698</order></author><author><firstname>Vinay</firstname><surname>Mehta</surname><order>699</order></author><author><firstname>Padhraig</firstname><surname>Gormley</surname><order>700</order></author><author><firstname>Kari</firstname><surname>Linden</surname><order>701</order></author><author><firstname>Christopher</firstname><surname>Whelan</surname><order>702</order></author><author><firstname>Fanli</firstname><surname>Xu</surname><order>703</order></author><author><firstname>David</firstname><surname>Pulford</surname><order>704</order></author><author><firstname>Martti</firstname><surname>Färkkilä</surname><order>705</order></author><author><firstname>Sampsa</firstname><surname>Pikkarainen</surname><order>706</order></author><author><firstname>Airi</firstname><surname>Jussila</surname><order>707</order></author><author><firstname>Timo</firstname><surname>Blomster</surname><order>708</order></author><author><firstname>Mikko</firstname><surname>Kiviniemi</surname><order>709</order></author><author><firstname>Markku</firstname><surname>Voutilainen</surname><order>710</order></author><author><firstname>Bob</firstname><surname>Georgantas</surname><order>711</order></author><author><firstname>Graham</firstname><surname>Heap</surname><order>712</order></author><author><firstname>Fedik</firstname><surname>Rahimov</surname><order>713</order></author><author><firstname>Keith</firstname><surname>Usiskin</surname><order>714</order></author><author><firstname>Tim</firstname><surname>Lu</surname><order>715</order></author><author><firstname>Danny</firstname><surname>Oh</surname><order>716</order></author><author><firstname>Kirsi</firstname><surname>Kalpala</surname><order>717</order></author><author><firstname>Melissa</firstname><surname>Miller</surname><order>718</order></author><author><firstname>Linda</firstname><surname>McCarthy</surname><order>719</order></author><author><firstname>Kari</firstname><surname>Eklund</surname><order>720</order></author><author><firstname>Antti</firstname><surname>Palomäki</surname><order>721</order></author><author><firstname>Pia</firstname><surname>Isomäki</surname><order>722</order></author><author><firstname>Laura</firstname><surname>Pirilä</surname><order>723</order></author><author><firstname>Oili</firstname><surname>Kaipiainen-Seppänen</surname><order>724</order></author><author><firstname>Johanna</firstname><surname>Huhtakangas</surname><order>725</order></author><author><firstname>Apinya</firstname><surname>Lertratanakul</surname><order>726</order></author><author><firstname>Marla</firstname><surname>Hochfeld</surname><order>727</order></author><author><firstname>Nan</firstname><surname>Bing</surname><order>728</order></author><author><firstname>Jorge Esparza</firstname><surname>Gordillo</surname><order>729</order></author><author><firstname>Nina</firstname><surname>Mars</surname><order>730</order></author><author><firstname>Margit</firstname><surname>Pelkonen</surname><order>731</order></author><author><firstname>Paula</firstname><surname>Kauppi</surname><order>732</order></author><author><firstname>Hannu</firstname><surname>Kankaanranta</surname><order>733</order></author><author><firstname>Terttu</firstname><surname>Harju</surname><order>734</order></author><author><firstname>David</firstname><surname>Close</surname><order>735</order></author><author><firstname>Steven</firstname><surname>Greenberg</surname><order>736</order></author><author><firstname>Hubert</firstname><surname>Chen</surname><order>737</order></author><author><firstname>Jo</firstname><surname>Betts</surname><order>738</order></author><author><firstname>Soumitra</firstname><surname>Ghosh</surname><order>739</order></author><author><firstname>Veikko</firstname><surname>Salomaa</surname><order>740</order></author><author><firstname>Teemu</firstname><surname>Niiranen</surname><order>741</order></author><author><firstname>Markus</firstname><surname>Juonala</surname><order>742</order></author><author><firstname>Kaj</firstname><surname>Metsärinne</surname><order>743</order></author><author><firstname>Mika</firstname><surname>Kähönen</surname><order>744</order></author><author><firstname>Juhani</firstname><surname>Junttila</surname><order>745</order></author><author><firstname>Markku</firstname><surname>Laakso</surname><order>746</order></author><author><firstname>Jussi</firstname><surname>Pihlajamäki</surname><order>747</order></author><author><firstname>Juha</firstname><surname>Sinisalo</surname><order>748</order></author><author><firstname>Marja-Riitta</firstname><surname>Taskinen</surname><order>749</order></author><author><firstname>Tiinamaija</firstname><surname>Tuomi</surname><order>750</order></author><author><firstname>Ben</firstname><surname>Challis</surname><order>751</order></author><author><firstname>Andrew</firstname><surname>Peterson</surname><order>752</order></author><author><firstname>Audrey</firstname><surname>Chu</surname><order>753</order></author><author><firstname>Jaakko</firstname><surname>Parkkinen</surname><order>754</order></author><author><firstname>Anthony</firstname><surname>Muslin</surname><order>755</order></author><author><firstname>Heikki</firstname><surname>Joensuu</surname><order>756</order></author><author><firstname>Tuomo</firstname><surname>Meretoja</surname><order>757</order></author><author><firstname>Lauri</firstname><surname>Aaltonen</surname><order>758</order></author><author><firstname>Johanna</firstname><surname>Mattson</surname><order>759</order></author><author><firstname>Annika</firstname><surname>Auranen</surname><order>760</order></author><author><firstname>Peeter</firstname><surname>Karihtala</surname><order>761</order></author><author><firstname>Saila</firstname><surname>Kauppila</surname><order>762</order></author><author><firstname>Päivi</firstname><surname>Auvinen</surname><order>763</order></author><author><firstname>Klaus</firstname><surname>Elenius</surname><order>764</order></author><author><firstname>Relja</firstname><surname>Popovic</surname><order>765</order></author><author><firstname>Jennifer</firstname><surname>Schutzman</surname><order>766</order></author><author><firstname>Andrey</firstname><surname>Loboda</surname><order>767</order></author><author><firstname>Aparna</firstname><surname>Chhibber</surname><order>768</order></author><author><firstname>Heli</firstname><surname>Lehtonen</surname><order>769</order></author><author><firstname>Stefan</firstname><surname>McDonough</surname><order>770</order></author><author><firstname>Marika</firstname><surname>Crohns</surname><order>771</order></author><author><firstname>Diptee</firstname><surname>Kulkarni</surname><order>772</order></author><author><firstname>Kai</firstname><surname>Kaarniranta</surname><order>773</order></author><author><firstname>Joni A.</firstname><surname>Turunen</surname><order>774</order></author><author><firstname>Terhi</firstname><surname>Ollila</surname><order>775</order></author><author><firstname>Sanna</firstname><surname>Seitsonen</surname><order>776</order></author><author><firstname>Hannu</firstname><surname>Uusitalo</surname><order>777</order></author><author><firstname>Vesa</firstname><surname>Aaltonen</surname><order>778</order></author><author><firstname>Hannele</firstname><surname>Uusitalo-Järvinen</surname><order>779</order></author><author><firstname>Marja</firstname><surname>Luodonpää</surname><order>780</order></author><author><firstname>Nina</firstname><surname>Hautala</surname><order>781</order></author><author><firstname>Stephanie</firstname><surname>Loomis</surname><order>782</order></author><author><firstname>Erich</firstname><surname>Strauss</surname><order>783</order></author><author><firstname>Hao</firstname><surname>Chen</surname><order>784</order></author><author><firstname>Anna</firstname><surname>Podgornaia</surname><order>785</order></author><author><firstname>Joshua</firstname><surname>Hoffman</surname><order>786</order></author><author><firstname>Kaisa</firstname><surname>Tasanen</surname><order>787</order></author><author><firstname>Laura</firstname><surname>Huilaja</surname><order>788</order></author><author><firstname>Katariina</firstname><surname>Hannula-Jouppi</surname><order>789</order></author><author><firstname>Teea</firstname><surname>Salmi</surname><order>790</order></author><author><firstname>Sirkku</firstname><surname>Peltonen</surname><order>791</order></author><author><firstname>Leena</firstname><surname>Koulu</surname><order>792</order></author><author><firstname>Ilkka</firstname><surname>Harvima</surname><order>793</order></author><author><firstname>Ying</firstname><surname>Wu</surname><order>794</order></author><author><firstname>David</firstname><surname>Choy</surname><order>795</order></author><author><firstname>Pirkko</firstname><surname>Pussinen</surname><order>796</order></author><author><firstname>Aino</firstname><surname>Salminen</surname><order>797</order></author><author><firstname>Tuula</firstname><surname>Salo</surname><order>798</order></author><author><firstname>David</firstname><surname>Rice</surname><order>799</order></author><author><firstname>Pekka</firstname><surname>Nieminen</surname><order>800</order></author><author><firstname>Ulla</firstname><surname>Palotie</surname><order>801</order></author><author><firstname>Maria</firstname><surname>Siponen</surname><order>802</order></author><author><firstname>Liisa</firstname><surname>Suominen</surname><order>803</order></author><author><firstname>Päivi</firstname><surname>Mäntylä</surname><order>804</order></author><author><firstname>Ulvi</firstname><surname>Gursoy</surname><order>805</order></author><author><firstname>Vuokko</firstname><surname>Anttonen</surname><order>806</order></author><author><firstname>Kirsi</firstname><surname>Sipilä</surname><order>807</order></author><author><firstname>Justin Wade</firstname><surname>Davis</surname><order>808</order></author><author><firstname>Danjuma</firstname><surname>Quarless</surname><order>809</order></author><author><firstname>Slavé</firstname><surname>Petrovski</surname><order>810</order></author><author><firstname>Eleonor</firstname><surname>Wigmore</surname><order>811</order></author><author><firstname>Chia-Yen</firstname><surname>Chen</surname><order>812</order></author><author><firstname>Paola</firstname><surname>Bronson</surname><order>813</order></author><author><firstname>Ellen</firstname><surname>Tsai</surname><order>814</order></author><author><firstname>Yunfeng</firstname><surname>Huang</surname><order>815</order></author><author><firstname>Joseph</firstname><surname>Maranville</surname><order>816</order></author><author><firstname>Elmutaz</firstname><surname>Shaikho</surname><order>817</order></author><author><firstname>Elhaj</firstname><surname>Mohammed</surname><order>818</order></author><author><firstname>Samir</firstname><surname>Wadhawan</surname><order>819</order></author><author><firstname>Erika</firstname><surname>Kvikstad</surname><order>820</order></author><author><firstname>Minal</firstname><surname>Caliskan</surname><order>821</order></author><author><firstname>Diana</firstname><surname>Chang</surname><order>822</order></author><author><firstname>Tushar</firstname><surname>Bhangale</surname><order>823</order></author><author><firstname>Sarah</firstname><surname>Pendergrass</surname><order>824</order></author><author><firstname>Emily</firstname><surname>Holzinger</surname><order>825</order></author><author><firstname>Xing</firstname><surname>Chen</surname><order>826</order></author><author><firstname>Åsa</firstname><surname>Hedman</surname><order>827</order></author><author><firstname>Karen S.</firstname><surname>King</surname><order>828</order></author><author><firstname>Clarence</firstname><surname>Wang</surname><order>829</order></author><author><firstname>Ethan</firstname><surname>Xu</surname><order>830</order></author><author><firstname>Franck</firstname><surname>Auge</surname><order>831</order></author><author><firstname>Clement</firstname><surname>Chatelain</surname><order>832</order></author><author><firstname>Deepak</firstname><surname>Rajpal</surname><order>833</order></author><author><firstname>Dongyu</firstname><surname>Liu</surname><order>834</order></author><author><firstname>Katherine</firstname><surname>Call</surname><order>835</order></author><author><firstname>Tai-he</firstname><surname>Xia</surname><order>836</order></author><author><firstname>Matt</firstname><surname>Brauer</surname><order>837</order></author><author><firstname>Mitja</firstname><surname>Kurki</surname><order>838</order></author><author><firstname>Juha</firstname><surname>Karjalainen</surname><order>839</order></author><author><firstname>Aki</firstname><surname>Havulinna</surname><order>840</order></author><author><firstname>Anu</firstname><surname>Jalanko</surname><order>841</order></author><author><firstname>Priit</firstname><surname>Palta</surname><order>842</order></author><author><firstname>Pietro della Briotta</firstname><surname>Parolo</surname><order>843</order></author><author><firstname>Wei</firstname><surname>Zhou</surname><order>844</order></author><author><firstname>Susanna</firstname><surname>Lemmelä</surname><order>845</order></author><author><firstname>Manuel</firstname><surname>Rivas</surname><order>846</order></author><author><firstname>Jarmo</firstname><surname>Harju</surname><order>847</order></author><author><firstname>Arto</firstname><surname>Lehisto</surname><order>848</order></author><author><firstname>Andrea</firstname><surname>Ganna</surname><order>849</order></author><author><firstname>Vincent</firstname><surname>Llorens</surname><order>850</order></author><author><firstname>Hannele</firstname><surname>Laivuori</surname><order>851</order></author><author><firstname>Sina</firstname><surname>Rüeger</surname><order>852</order></author><author><firstname>Mari E.</firstname><surname>Niemi</surname><order>853</order></author><author><firstname>Taru</firstname><surname>Tukiainen</surname><order>854</order></author><author><firstname>Mary Pat</firstname><surname>Reeve</surname><order>855</order></author><author><firstname>Henrike</firstname><surname>Heyne</surname><order>856</order></author><author><firstname>Kimmo</firstname><surname>Palin</surname><order>857</order></author><author><firstname>Javier</firstname><surname>Garcia-Tabuenca</surname><order>858</order></author><author><firstname>Harri</firstname><surname>Siirtola</surname><order>859</order></author><author><firstname>Tuomo</firstname><surname>Kiiskinen</surname><order>860</order></author><author><firstname>Jiwoo</firstname><surname>Lee</surname><order>861</order></author><author><firstname>Kristin</firstname><surname>Tsuo</surname><order>862</order></author><author><firstname>Amanda</firstname><surname>Elliott</surname><order>863</order></author><author><firstname>Kati</firstname><surname>Kristiansson</surname><order>864</order></author><author><firstname>Kati</firstname><surname>Hyvärinen</surname><order>865</order></author><author><firstname>Jarmo</firstname><surname>Ritari</surname><order>866</order></author><author><firstname>Miika</firstname><surname>Koskinen</surname><order>867</order></author><author><firstname>Katri</firstname><surname>Pylkäs</surname><order>868</order></author><author><firstname>Marita</firstname><surname>Kalaoja</surname><order>869</order></author><author><firstname>Minna</firstname><surname>Karjalainen</surname><order>870</order></author><author><firstname>Tuomo</firstname><surname>Mantere</surname><order>871</order></author><author><firstname>Eeva</firstname><surname>Kangasniemi</surname><order>872</order></author><author><firstname>Sami</firstname><surname>Heikkinen</surname><order>873</order></author><author><firstname>Eija</firstname><surname>Laakkonen</surname><order>874</order></author><author><firstname>Csilla</firstname><surname>Sipeky</surname><order>875</order></author><author><firstname>Samuel</firstname><surname>Heron</surname><order>876</order></author><author><firstname>Antti</firstname><surname>Karlsson</surname><order>877</order></author><author><firstname>Dhanaprakash</firstname><surname>Jambulingam</surname><order>878</order></author><author><firstname>Venkat Subramaniam</firstname><surname>Rathinakannan</surname><order>879</order></author><author><firstname>Risto</firstname><surname>Kajanne</surname><order>880</order></author><author><firstname>Mervi</firstname><surname>Aavikko</surname><order>881</order></author><author><firstname>Manuel González</firstname><surname>Jiménez</surname><order>882</order></author><author><firstname>Pietro della Briotta</firstname><surname>Parola</surname><order>883</order></author><author><firstname>Arto</firstname><surname>Lehistö</surname><order>884</order></author><author><firstname>Masahiro</firstname><surname>Kanai</surname><order>885</order></author><author><firstname>Mari</firstname><surname>Kaunisto</surname><order>886</order></author><author><firstname>Elina</firstname><surname>Kilpeläinen</surname><order>887</order></author><author><firstname>Timo P.</firstname><surname>Sipilä</surname><order>888</order></author><author><firstname>Georg</firstname><surname>Brein</surname><order>889</order></author><author><firstname>Ghazal</firstname><surname>Awaisa</surname><order>890</order></author><author><firstname>Anastasia</firstname><surname>Shcherban</surname><order>891</order></author><author><firstname>Kati</firstname><surname>Donner</surname><order>892</order></author><author><firstname>Anu</firstname><surname>Loukola</surname><order>893</order></author><author><firstname>Päivi</firstname><surname>Laiho</surname><order>894</order></author><author><firstname>Tuuli</firstname><surname>Sistonen</surname><order>895</order></author><author><firstname>Essi</firstname><surname>Kaiharju</surname><order>896</order></author><author><firstname>Markku</firstname><surname>Laukkanen</surname><order>897</order></author><author><firstname>Elina</firstname><surname>Järvensivu</surname><order>898</order></author><author><firstname>Sini</firstname><surname>Lähteenmäki</surname><order>899</order></author><author><firstname>Lotta</firstname><surname>Männikkö</surname><order>900</order></author><author><firstname>Regis</firstname><surname>Wong</surname><order>901</order></author><author><firstname>Hannele</firstname><surname>Mattsson</surname><order>902</order></author><author><firstname>Tero</firstname><surname>Hiekkalinna</surname><order>903</order></author><author><firstname>Teemu</firstname><surname>Paajanen</surname><order>904</order></author><author><firstname>Kalle</firstname><surname>Pärn</surname><order>905</order></author><author><firstname>Javier</firstname><surname>Gracia-Tabuenca</surname><order>906</order></author><author><firstname>Erin</firstname><surname>Abner</surname><order>907</order></author><author><firstname>Perrie M.</firstname><surname>Adams</surname><order>908</order></author><author><firstname>Alyssa</firstname><surname>Aguirre</surname><order>909</order></author><author><firstname>Marilyn S.</firstname><surname>Albert</surname><order>910</order></author><author><firstname>Roger L.</firstname><surname>Albin</surname><order>911</order></author><author><firstname>Mariet</firstname><surname>Allen</surname><order>912</order></author><author><firstname>Lisa</firstname><surname>Alvarez</surname><order>913</order></author><author><firstname>Liana G.</firstname><surname>Apostolova</surname><order>914</order></author><author><firstname>Steven E.</firstname><surname>Arnold</surname><order>915</order></author><author><firstname>Sanjay</firstname><surname>Asthana</surname><order>916</order></author><author><firstname>Craig S.</firstname><surname>Atwood</surname><order>917</order></author><author><firstname>Gayle</firstname><surname>Ayres</surname><order>918</order></author><author><firstname>Clinton T.</firstname><surname>Baldwin</surname><order>919</order></author><author><firstname>Robert C.</firstname><surname>Barber</surname><order>920</order></author><author><firstname>Lisa L.</firstname><surname>Barnes</surname><order>921</order></author><author><firstname>Sandra</firstname><surname>Barral</surname><order>922</order></author><author><firstname>Thomas G.</firstname><surname>Beach</surname><order>923</order></author><author><firstname>James T.</firstname><surname>Becker</surname><order>924</order></author><author><firstname>Gary W.</firstname><surname>Beecham</surname><order>925</order></author><author><firstname>Duane</firstname><surname>Beekly</surname><order>926</order></author><author><firstname>Jennifer E.</firstname><surname>Below</surname><orcid>0000-0002-1346-1872</orcid><order>927</order></author><author><firstname>Penelope</firstname><surname>Benchek</surname><order>928</order></author><author><firstname>Bruno A.</firstname><surname>Benitez</surname><order>929</order></author><author><firstname>David</firstname><surname>Bennett</surname><order>930</order></author><author><firstname>John</firstname><surname>Bertelson</surname><order>931</order></author><author><firstname>Flanagan E.</firstname><surname>Margaret</surname><order>932</order></author><author><firstname>Thomas D.</firstname><surname>Bird</surname><order>933</order></author><author><firstname>Deborah</firstname><surname>Blacker</surname><order>934</order></author><author><firstname>Bradley F.</firstname><surname>Boeve</surname><order>935</order></author><author><firstname>James D.</firstname><surname>Bowen</surname><order>936</order></author><author><firstname>Adam</firstname><surname>Boxer</surname><order>937</order></author><author><firstname>James</firstname><surname>Brewer</surname><order>938</order></author><author><firstname>James R.</firstname><surname>Burke</surname><order>939</order></author><author><firstname>Jeffrey M.</firstname><surname>Burns</surname><order>940</order></author><author><firstname>Will S.</firstname><surname>Bush</surname><order>941</order></author><author><firstname>Joseph D.</firstname><surname>Buxbaum</surname><order>942</order></author><author><firstname>Nigel J.</firstname><surname>Cairns</surname><order>943</order></author><author><firstname>Chuanhai</firstname><surname>Cao</surname><order>944</order></author><author><firstname>Christopher S.</firstname><surname>Carlson</surname><order>945</order></author><author><firstname>Cynthia M.</firstname><surname>Carlsson</surname><order>946</order></author><author><firstname>Regina M.</firstname><surname>Carney</surname><order>947</order></author><author><firstname>Minerva M.</firstname><surname>Carrasquillo</surname><order>948</order></author><author><firstname>Scott</firstname><surname>Chasse</surname><order>949</order></author><author><firstname>Marie-Francoise</firstname><surname>Chesselet</surname><order>950</order></author><author><firstname>Alessandra</firstname><surname>Chesi</surname><order>951</order></author><author><firstname>Nathaniel A.</firstname><surname>Chin</surname><order>952</order></author><author><firstname>Helena C.</firstname><surname>Chui</surname><order>953</order></author><author><firstname>Jaeyoon</firstname><surname>Chung</surname><order>954</order></author><author><firstname>Suzanne</firstname><surname>Craft</surname><order>955</order></author><author><firstname>Paul K.</firstname><surname>Crane</surname><order>956</order></author><author><firstname>David H.</firstname><surname>Cribbs</surname><order>957</order></author><author><firstname>Elizabeth A.</firstname><surname>Crocco</surname><order>958</order></author><author><firstname>Carlos</firstname><surname>Cruchaga</surname><order>959</order></author><author><firstname>Michael L.</firstname><surname>Cuccaro</surname><order>960</order></author><author><firstname>Munro</firstname><surname>Cullum</surname><order>961</order></author><author><firstname>Eveleen</firstname><surname>Darby</surname><order>962</order></author><author><firstname>Barbara</firstname><surname>Davis</surname><order>963</order></author><author><firstname>Philip L. De</firstname><surname>Jager</surname><order>964</order></author><author><firstname>Charles</firstname><surname>DeCarli</surname><order>965</order></author><author><firstname>John</firstname><surname>DeToledo</surname><order>966</order></author><author><firstname>Malcolm</firstname><surname>Dick</surname><order>967</order></author><author><firstname>Dennis W.</firstname><surname>Dickson</surname><order>968</order></author><author><firstname>Beth A.</firstname><surname>Dombroski</surname><order>969</order></author><author><firstname>Rachelle S.</firstname><surname>Doody</surname><order>970</order></author><author><firstname>Ranjan</firstname><surname>Duara</surname><order>971</order></author><author><firstname>Nilüfer</firstname><surname>Ertekin-Taner</surname><order>972</order></author><author><firstname>Denis A.</firstname><surname>Evans</surname><order>973</order></author><author><firstname>Thomas J.</firstname><surname>Fairchild</surname><order>974</order></author><author><firstname>Kenneth B.</firstname><surname>Fallon</surname><order>975</order></author><author><firstname>Martin R.</firstname><surname>Farlow</surname><order>976</order></author><author><firstname>John J.</firstname><surname>Farrell</surname><order>977</order></author><author><firstname>Victoria</firstname><surname>Fernandez-Hernandez</surname><order>978</order></author><author><firstname>Steven</firstname><surname>Ferris</surname><order>979</order></author><author><firstname>Matthew P.</firstname><surname>Frosch</surname><order>980</order></author><author><firstname>Brian</firstname><surname>Fulton-Howard</surname><order>981</order></author><author><firstname>Douglas R.</firstname><surname>Galasko</surname><order>982</order></author><author><firstname>Adriana</firstname><surname>Gamboa</surname><order>983</order></author><author><firstname>Marla</firstname><surname>Gearing</surname><order>984</order></author><author><firstname>Daniel H.</firstname><surname>Geschwind</surname><order>985</order></author><author><firstname>Bernardino</firstname><surname>Ghetti</surname><order>986</order></author><author><firstname>John R.</firstname><surname>Gilbert</surname><order>987</order></author><author><firstname>Thomas J.</firstname><surname>Grabowski</surname><order>988</order></author><author><firstname>Neill R.</firstname><surname>Graff-Radford</surname><order>989</order></author><author><firstname>Struan F. A.</firstname><surname>Grant</surname><order>990</order></author><author><firstname>Robert C.</firstname><surname>Green</surname><order>991</order></author><author><firstname>John H.</firstname><surname>Growdon</surname><order>992</order></author><author><firstname>Jonathan L.</firstname><surname>Haines</surname><order>993</order></author><author><firstname>Hakon</firstname><surname>Hakonarson</surname><order>994</order></author><author><firstname>James</firstname><surname>Hall</surname><order>995</order></author><author><firstname>Ronald L.</firstname><surname>Hamilton</surname><order>996</order></author><author><firstname>Oscar</firstname><surname>Harari</surname><order>997</order></author><author><firstname>Lindy E.</firstname><surname>Harrell</surname><order>998</order></author><author><firstname>Jacob</firstname><surname>Haut</surname><order>999</order></author><author><firstname>Elizabeth</firstname><surname>Head</surname><order>1000</order></author><author><firstname>Victor W.</firstname><surname>Henderson</surname><order>1001</order></author><author><firstname>Michelle</firstname><surname>Hernandez</surname><order>1002</order></author><author><firstname>Timothy</firstname><surname>Hohman</surname><order>1003</order></author><author><firstname>Lawrence S.</firstname><surname>Honig</surname><order>1004</order></author><author><firstname>Ryan M.</firstname><surname>Huebinger</surname><order>1005</order></author><author><firstname>Matthew J.</firstname><surname>Huentelman</surname><order>1006</order></author><author><firstname>Christine M.</firstname><surname>Hulette</surname><order>1007</order></author><author><firstname>Bradley T.</firstname><surname>Hyman</surname><order>1008</order></author><author><firstname>Linda S.</firstname><surname>Hynan</surname><order>1009</order></author><author><firstname>Laura</firstname><surname>Ibanez</surname><order>1010</order></author><author><firstname>Gail P.</firstname><surname>Jarvik</surname><order>1011</order></author><author><firstname>Suman</firstname><surname>Jayadev</surname><order>1012</order></author><author><firstname>Lee-Way</firstname><surname>Jin</surname><order>1013</order></author><author><firstname>Kim</firstname><surname>Johnson</surname><order>1014</order></author><author><firstname>Leigh</firstname><surname>Johnson</surname><order>1015</order></author><author><firstname>M. Ilyas</firstname><surname>Kamboh</surname><order>1016</order></author><author><firstname>Anna M.</firstname><surname>Karydas</surname><order>1017</order></author><author><firstname>Mindy J.</firstname><surname>Katz</surname><order>1018</order></author><author><firstname>Jeffrey A.</firstname><surname>Kaye</surname><order>1019</order></author><author><firstname>C. Dirk</firstname><surname>Keene</surname><order>1020</order></author><author><firstname>Aisha</firstname><surname>Khaleeq</surname><order>1021</order></author><author><firstname>Ronald</firstname><surname>Kim</surname><order>1022</order></author><author><firstname>Janice</firstname><surname>Knebl</surname><order>1023</order></author><author><firstname>Neil W.</firstname><surname>Kowall</surname><order>1024</order></author><author><firstname>Joel H.</firstname><surname>Kramer</surname><order>1025</order></author><author><firstname>Pavel P.</firstname><surname>Kuksa</surname><order>1026</order></author><author><firstname>Frank M.</firstname><surname>LaFerla</surname><order>1027</order></author><author><firstname>James J.</firstname><surname>Lah</surname><order>1028</order></author><author><firstname>Eric B.</firstname><surname>Larson</surname><order>1029</order></author><author><firstname>Chien-Yueh</firstname><surname>Lee</surname><order>1030</order></author><author><firstname>Edward B.</firstname><surname>Lee</surname><order>1031</order></author><author><firstname>Alan</firstname><surname>Lerner</surname><order>1032</order></author><author><firstname>Yuk Yee</firstname><surname>Leung</surname><order>1033</order></author><author><firstname>James B.</firstname><surname>Leverenz</surname><order>1034</order></author><author><firstname>Allan I.</firstname><surname>Levey</surname><order>1035</order></author><author><firstname>Mingyao</firstname><surname>Li</surname><order>1036</order></author><author><firstname>Andrew P.</firstname><surname>Lieberman</surname><order>1037</order></author><author><firstname>Richard B.</firstname><surname>Lipton</surname><order>1038</order></author><author><firstname>Mark</firstname><surname>Logue</surname><order>1039</order></author><author><firstname>Constantine G.</firstname><surname>Lyketsos</surname><order>1040</order></author><author><firstname>John</firstname><surname>Malamon</surname><order>1041</order></author><author><firstname>Douglas</firstname><surname>Mains</surname><order>1042</order></author><author><firstname>Daniel C.</firstname><surname>Marson</surname><order>1043</order></author><author><firstname>Frank</firstname><surname>Martiniuk</surname><order>1044</order></author><author><firstname>Deborah C.</firstname><surname>Mash</surname><order>1045</order></author><author><firstname>Eliezer</firstname><surname>Masliah</surname><order>1046</order></author><author><firstname>Paul</firstname><surname>Massman</surname><order>1047</order></author><author><firstname>Arjun</firstname><surname>Masurkar</surname><order>1048</order></author><author><firstname>Wayne C.</firstname><surname>McCormick</surname><order>1049</order></author><author><firstname>Susan M.</firstname><surname>McCurry</surname><order>1050</order></author><author><firstname>Andrew N.</firstname><surname>McDavid</surname><order>1051</order></author><author><firstname>Stefan</firstname><surname>McDonough</surname><order>1052</order></author><author><firstname>Ann C.</firstname><surname>McKee</surname><order>1053</order></author><author><firstname>Marsel</firstname><surname>Mesulam</surname><order>1054</order></author><author><firstname>Jesse</firstname><surname>Mez</surname><order>1055</order></author><author><firstname>Bruce L.</firstname><surname>Miller</surname><order>1056</order></author><author><firstname>Carol A.</firstname><surname>Miller</surname><order>1057</order></author><author><firstname>Joshua W.</firstname><surname>Miller</surname><order>1058</order></author><author><firstname>Thomas J.</firstname><surname>Montine</surname><order>1059</order></author><author><firstname>Edwin S.</firstname><surname>Monuki</surname><order>1060</order></author><author><firstname>John C.</firstname><surname>Morris</surname><order>1061</order></author><author><firstname>Amanda J.</firstname><surname>Myers</surname><order>1062</order></author><author><firstname>Trung</firstname><surname>Nguyen</surname><order>1063</order></author><author><firstname>Sid</firstname><surname>O’Bryant</surname><order>1064</order></author><author><firstname>John M.</firstname><surname>Olichney</surname><order>1065</order></author><author><firstname>Marcia</firstname><surname>Ory</surname><order>1066</order></author><author><firstname>Raymond</firstname><surname>Palmer</surname><order>1067</order></author><author><firstname>Joseph E.</firstname><surname>Parisi</surname><order>1068</order></author><author><firstname>Henry L.</firstname><surname>Paulson</surname><order>1069</order></author><author><firstname>Valory</firstname><surname>Pavlik</surname><order>1070</order></author><author><firstname>David</firstname><surname>Paydarfar</surname><order>1071</order></author><author><firstname>Victoria</firstname><surname>Perez</surname><order>1072</order></author><author><firstname>Elaine</firstname><surname>Peskind</surname><order>1073</order></author><author><firstname>Ronald C.</firstname><surname>Petersen</surname><order>1074</order></author><author><firstname>Jennifer E.</firstname><surname>Phillips-Cremins</surname><order>1075</order></author><author><firstname>Aimee</firstname><surname>Pierce</surname><order>1076</order></author><author><firstname>Marsha</firstname><surname>Polk</surname><order>1077</order></author><author><firstname>Wayne W.</firstname><surname>Poon</surname><order>1078</order></author><author><firstname>Huntington</firstname><surname>Potter</surname><order>1079</order></author><author><firstname>Liming</firstname><surname>Qu</surname><order>1080</order></author><author><firstname>Mary</firstname><surname>Quiceno</surname><order>1081</order></author><author><firstname>Joseph F.</firstname><surname>Quinn</surname><order>1082</order></author><author><firstname>Ashok</firstname><surname>Raj</surname><order>1083</order></author><author><firstname>Murray</firstname><surname>Raskind</surname><order>1084</order></author><author><firstname>Eric M.</firstname><surname>Reiman</surname><order>1085</order></author><author><firstname>Barry</firstname><surname>Reisberg</surname><order>1086</order></author><author><firstname>Joan S.</firstname><surname>Reisch</surname><order>1087</order></author><author><firstname>John M.</firstname><surname>Ringman</surname><order>1088</order></author><author><firstname>Erik D.</firstname><surname>Roberson</surname><order>1089</order></author><author><firstname>Monica</firstname><surname>Rodriguear</surname><order>1090</order></author><author><firstname>Ekaterina</firstname><surname>Rogaeva</surname><order>1091</order></author><author><firstname>Howard J.</firstname><surname>Rosen</surname><order>1092</order></author><author><firstname>Roger N.</firstname><surname>Rosenberg</surname><order>1093</order></author><author><firstname>Donald R.</firstname><surname>Royall</surname><order>1094</order></author><author><firstname>Mark A.</firstname><surname>Sager</surname><order>1095</order></author><author><firstname>Mary</firstname><surname>Sano</surname><order>1096</order></author><author><firstname>Andrew J.</firstname><surname>Saykin</surname><order>1097</order></author><author><firstname>Julie A.</firstname><surname>Schneider</surname><order>1098</order></author><author><firstname>Lon S.</firstname><surname>Schneider</surname><order>1099</order></author><author><firstname>William W.</firstname><surname>Seeley</surname><order>1100</order></author><author><firstname>Susan H.</firstname><surname>Slifer</surname><order>1101</order></author><author><firstname>Scott</firstname><surname>Small</surname><order>1102</order></author><author><firstname>Amanda G.</firstname><surname>Smith</surname><order>1103</order></author><author><firstname>Janet P.</firstname><surname>Smith</surname><order>1104</order></author><author><firstname>Yeunjoo E.</firstname><surname>Song</surname><order>1105</order></author><author><firstname>Joshua A.</firstname><surname>Sonnen</surname><order>1106</order></author><author><firstname>Salvatore</firstname><surname>Spina</surname><order>1107</order></author><author><firstname>Peter St</firstname><surname>George-Hyslop</surname><order>1108</order></author><author><firstname>Robert A.</firstname><surname>Stern</surname><order>1109</order></author><author><firstname>Alan B.</firstname><surname>Stevens</surname><order>1110</order></author><author><firstname>Stephen M.</firstname><surname>Strittmatter</surname><order>1111</order></author><author><firstname>David</firstname><surname>Sultzer</surname><order>1112</order></author><author><firstname>Russell H.</firstname><surname>Swerdlow</surname><order>1113</order></author><author><firstname>Rudolph E.</firstname><surname>Tanzi</surname><order>1114</order></author><author><firstname>Jeffrey L.</firstname><surname>Tilson</surname><order>1115</order></author><author><firstname>John Q.</firstname><surname>Trojanowski</surname><order>1116</order></author><author><firstname>Juan C.</firstname><surname>Troncoso</surname><order>1117</order></author><author><firstname>Debby W.</firstname><surname>Tsuang</surname><order>1118</order></author><author><firstname>Otto</firstname><surname>Valladares</surname><order>1119</order></author><author><firstname>Vivianna M. Van</firstname><surname>Deerlin</surname><order>1120</order></author><author><firstname>Linda J. van</firstname><surname>Eldik</surname><order>1121</order></author><author><firstname>Robert</firstname><surname>Vassar</surname><order>1122</order></author><author><firstname>Harry V.</firstname><surname>Vinters</surname><order>1123</order></author><author><firstname>Jean-Paul</firstname><surname>Vonsattel</surname><order>1124</order></author><author><firstname>Sandra</firstname><surname>Weintraub</surname><order>1125</order></author><author><firstname>Kathleen A.</firstname><surname>Welsh-Bohmer</surname><order>1126</order></author><author><firstname>Patrice L.</firstname><surname>Whitehead</surname><order>1127</order></author><author><firstname>Ellen M.</firstname><surname>Wijsman</surname><order>1128</order></author><author><firstname>Kirk C.</firstname><surname>Wilhelmsen</surname><order>1129</order></author><author><firstname>Benjamin</firstname><surname>Williams</surname><order>1130</order></author><author><firstname>Jennifer</firstname><surname>Williamson</surname><order>1131</order></author><author><firstname>Henrik</firstname><surname>Wilms</surname><order>1132</order></author><author><firstname>Thomas S.</firstname><surname>Wingo</surname><order>1133</order></author><author><firstname>Thomas</firstname><surname>Wisniewski</surname><order>1134</order></author><author><firstname>Randall L.</firstname><surname>Woltjer</surname><order>1135</order></author><author><firstname>Martin</firstname><surname>Woon</surname><order>1136</order></author><author><firstname>Clinton B.</firstname><surname>Wright</surname><order>1137</order></author><author><firstname>Chuang-Kuo</firstname><surname>Wu</surname><order>1138</order></author><author><firstname>Steven G.</firstname><surname>Younkin</surname><order>1139</order></author><author><firstname>Chang-En</firstname><surname>Yu</surname><order>1140</order></author><author><firstname>Lei</firstname><surname>Yu</surname><order>1141</order></author><author><firstname>Yuanchao</firstname><surname>Zhang</surname><order>1142</order></author><author><firstname>Yi</firstname><surname>Zhao</surname><order>1143</order></author><author><firstname>Xiongwei</firstname><surname>Zhu</surname><order>1144</order></author><author><firstname>Hieab</firstname><surname>Adams</surname><order>1145</order></author><author><firstname>Rufus O.</firstname><surname>Akinyemi</surname><order>1146</order></author><author><firstname>Muhammad</firstname><surname>Ali</surname><order>1147</order></author><author><firstname>Nicola</firstname><surname>Armstrong</surname><order>1148</order></author><author><firstname>Hugo J.</firstname><surname>Aparicio</surname><order>1149</order></author><author><firstname>Maryam</firstname><surname>Bahadori</surname><order>1150</order></author><author><firstname>James T.</firstname><surname>Becker</surname><order>1151</order></author><author><firstname>Monique</firstname><surname>Breteler</surname><order>1152</order></author><author><firstname>Daniel</firstname><surname>Chasman</surname><order>1153</order></author><author><firstname>Ganesh</firstname><surname>Chauhan</surname><order>1154</order></author><author><firstname>Hata</firstname><surname>Comic</surname><order>1155</order></author><author><firstname>Simon</firstname><surname>Cox</surname><order>1156</order></author><author><firstname>Adrienne L.</firstname><surname>Cupples</surname><order>1157</order></author><author><firstname>Gail</firstname><surname>Davies</surname><order>1158</order></author><author><firstname>Charles S.</firstname><surname>DeCarli</surname><order>1159</order></author><author><firstname>Marie-Gabrielle</firstname><surname>Duperron</surname><order>1160</order></author><author><firstname>Josée</firstname><surname>Dupuis</surname><order>1161</order></author><author><firstname>Tavia</firstname><surname>Evans</surname><order>1162</order></author><author><firstname>Frank</firstname><surname>Fan</surname><order>1163</order></author><author><firstname>Annette</firstname><surname>Fitzpatrick</surname><order>1164</order></author><author><firstname>Alison E.</firstname><surname>Fohner</surname><order>1165</order></author><author><firstname>Mary</firstname><surname>Ganguli</surname><order>1166</order></author><author><firstname>Mirjam</firstname><surname>Geerlings</surname><order>1167</order></author><author><firstname>Stephen J.</firstname><surname>Glatt</surname><order>1168</order></author><author><firstname>Hector M.</firstname><surname>Gonzalez</surname><order>1169</order></author><author><firstname>Monica</firstname><surname>Goss</surname><order>1170</order></author><author><firstname>Hans</firstname><surname>Grabe</surname><order>1171</order></author><author><firstname>Mohamad</firstname><surname>Habes</surname><order>1172</order></author><author><firstname>Susan R.</firstname><surname>Heckbert</surname><order>1173</order></author><author><firstname>Edith</firstname><surname>Hofer</surname><order>1174</order></author><author><firstname>Elliot</firstname><surname>Hong</surname><order>1175</order></author><author><firstname>Timothy</firstname><surname>Hughes</surname><order>1176</order></author><author><firstname>Tiffany F.</firstname><surname>Kautz</surname><order>1177</order></author><author><firstname>Maria</firstname><surname>Knol</surname><order>1178</order></author><author><firstname>William</firstname><surname>Kremen</surname><order>1179</order></author><author><firstname>Paul</firstname><surname>Lacaze</surname><order>1180</order></author><author><firstname>Jari</firstname><surname>Lahti</surname><order>1181</order></author><author><firstname>Quentin Le</firstname><surname>Grand</surname><order>1182</order></author><author><firstname>Elizabeth</firstname><surname>Litkowski</surname><order>1183</order></author><author><firstname>Shuo</firstname><surname>Li</surname><order>1184</order></author><author><firstname>Dan</firstname><surname>Liu</surname><order>1185</order></author><author><firstname>Xuan</firstname><surname>Liu</surname><order>1186</order></author><author><firstname>Marisa</firstname><surname>Loitfelder</surname><order>1187</order></author><author><firstname>Alisa</firstname><surname>Manning</surname><order>1188</order></author><author><firstname>Pauline</firstname><surname>Maillard</surname><order>1189</order></author><author><firstname>Riccardo</firstname><surname>Marioni</surname><order>1190</order></author><author><firstname>Bernard</firstname><surname>Mazoyer</surname><order>1191</order></author><author><firstname>Debora Melo van</firstname><surname>Lent</surname><order>1192</order></author><author><firstname>Hao</firstname><surname>Mei</surname><order>1193</order></author><author><firstname>Aniket</firstname><surname>Mishra</surname><order>1194</order></author><author><firstname>Paul</firstname><surname>Nyquist</surname><order>1195</order></author><author><firstname>Jeffrey</firstname><surname>O’Connell</surname><order>1196</order></author><author><firstname>Yash</firstname><surname>Patel</surname><order>1197</order></author><author><firstname>Tomas</firstname><surname>Paus</surname><order>1198</order></author><author><firstname>Zdenka</firstname><surname>Pausova</surname><order>1199</order></author><author><firstname>Katri</firstname><surname>Raikkonen-Talvitie</surname><order>1200</order></author><author><firstname>Moeen</firstname><surname>Riaz</surname><order>1201</order></author><author><firstname>Stephen</firstname><surname>Rich</surname><order>1202</order></author><author><firstname>Jerome</firstname><surname>Rotter</surname><order>1203</order></author><author><firstname>Jose</firstname><surname>Romero</surname><order>1204</order></author><author><firstname>Gena</firstname><surname>Roshchupkin</surname><order>1205</order></author><author><firstname>Yasaman</firstname><surname>Saba</surname><order>1206</order></author><author><firstname>Murali</firstname><surname>Sargurupremraj</surname><order>1207</order></author><author><firstname>Helena</firstname><surname>Schmidt</surname><order>1208</order></author><author><firstname>Reinhold</firstname><surname>Schmidt</surname><order>1209</order></author><author><firstname>Joshua M.</firstname><surname>Shulman</surname><order>1210</order></author><author><firstname>Jennifer</firstname><surname>Smith</surname><order>1211</order></author><author><firstname>Hema</firstname><surname>Sekhar</surname><order>1212</order></author><author><firstname>Reddy</firstname><surname>Rajula</surname><order>1213</order></author><author><firstname>Jean</firstname><surname>Shin</surname><order>1214</order></author><author><firstname>Jeannette</firstname><surname>Simino</surname><order>1215</order></author><author><firstname>Eeva</firstname><surname>Sliz</surname><order>1216</order></author><author><firstname>Alexander</firstname><surname>Teumer</surname><order>1217</order></author><author><firstname>Alvin</firstname><surname>Thomas</surname><order>1218</order></author><author><firstname>Adrienne</firstname><surname>Tin</surname><order>1219</order></author><author><firstname>Elliot</firstname><surname>Tucker-Drob</surname><order>1220</order></author><author><firstname>Dina</firstname><surname>Vojinovic</surname><order>1221</order></author><author><firstname>Yanbing</firstname><surname>Wang</surname><order>1222</order></author><author><firstname>Galit</firstname><surname>Weinstein</surname><order>1223</order></author><author><firstname>Dylan</firstname><surname>Williams</surname><order>1224</order></author><author><firstname>Katharina</firstname><surname>Wittfeld</surname><order>1225</order></author><author><firstname>Lisa</firstname><surname>Yanek</surname><order>1226</order></author><author><firstname>Yunju</firstname><surname>Yang</surname><order>1227</order></author><author><firstname>Lindsay A.</firstname><surname>Farrer</surname><orcid>0000-0001-5533-4225</orcid><order>1228</order></author><author><firstname>Bruce M.</firstname><surname>Psaty</surname><orcid>0000-0002-7278-2190</orcid><order>1229</order></author><author><firstname>Mohsen</firstname><surname>Ghanbari</surname><orcid>0000-0002-9476-7143</orcid><order>1230</order></author><author><firstname>Towfique</firstname><surname>Raj</surname><orcid>0000-0002-9355-5704</orcid><order>1231</order></author><author><firstname>Perminder</firstname><surname>Sachdev</surname><orcid>0000-0002-9595-3220</orcid><order>1232</order></author><author><firstname>Karen</firstname><surname>Mather</surname><orcid>0000-0003-4143-8941</orcid><order>1233</order></author><author><firstname>Frank</firstname><surname>Jessen</surname><order>1234</order></author><author><firstname>M. Arfan</firstname><surname>Ikram</surname><orcid>0000-0003-0372-8585</orcid><order>1235</order></author><author><firstname>Alexandre de</firstname><surname>Mendonça</surname><order>1236</order></author><author><firstname>Jakub</firstname><surname>Hort</surname><order>1237</order></author><author><firstname>Magda</firstname><surname>Tsolaki</surname><orcid>0000-0002-2072-8010</orcid><order>1238</order></author><author><firstname>Margaret A.</firstname><surname>Pericak-Vance</surname><orcid>0000-0001-7283-8804</orcid><order>1239</order></author><author><firstname>Philippe</firstname><surname>Amouyel</surname><orcid>0000-0001-9088-234x</orcid><order>1240</order></author><author><firstname>Julie</firstname><surname>Williams</surname><orcid>0000-0002-4069-0259</orcid><order>1241</order></author><author><firstname>Ruth</firstname><surname>Frikke-Schmidt</surname><orcid>0000-0003-4084-5027</orcid><order>1242</order></author><author><firstname>Jordi</firstname><surname>Clarimon</surname><order>1243</order></author><author><firstname>Jean-François</firstname><surname>Deleuze</surname><order>1244</order></author><author><firstname>Giacomina</firstname><surname>Rossi</surname><order>1245</order></author><author><firstname>Sudha</firstname><surname>Seshadri</surname><orcid>0000-0001-6135-2622</orcid><order>1246</order></author><author><firstname>Ole A.</firstname><surname>Andreassen</surname><orcid>0000-0002-4461-3568</orcid><order>1247</order></author><author><firstname>Martin</firstname><surname>Ingelsson</surname><order>1248</order></author><author><firstname>Mikko</firstname><surname>Hiltunen</surname><order>1249</order></author><author><firstname>Kristel</firstname><surname>Sleegers</surname><orcid>0000-0002-0283-2332</orcid><order>1250</order></author><author><firstname>Gerard D.</firstname><surname>Schellenberg</surname><order>1251</order></author><author><firstname>Cornelia M. van</firstname><surname>Duijn</surname><orcid>0000-0002-2374-9204</orcid><order>1252</order></author><author><firstname>Rebecca</firstname><surname>Sims</surname><orcid>0000-0002-3885-1199</orcid><order>1253</order></author><author><firstname>Wiesje M. van der</firstname><surname>Flier</surname><orcid>0000-0001-8766-6224</orcid><order>1254</order></author><author><firstname>Agustín</firstname><surname>Ruiz</surname><order>1255</order></author><author><firstname>Alfredo</firstname><surname>Ramirez</surname><orcid>0000-0003-4991-763x</orcid><order>1256</order></author><author><firstname>Jean-Charles</firstname><surname>Lambert</surname><orcid>0000-0003-0829-7817</orcid><order>1257</order></author><author><firstname></firstname><surname>(EADB)</surname><order>1258</order></author><author><firstname></firstname><surname>(GR@ACE)</surname><order>1259</order></author><author><firstname></firstname><surname>(DEGESCO)</surname><order>1260</order></author><author><firstname></firstname><surname>(EADI)</surname><order>1261</order></author><author><firstname></firstname><surname>(GERAD)</surname><order>1262</order></author><author><firstname></firstname><surname>(Demgene)</surname><order>1263</order></author><author><firstname></firstname><surname>(FinnGen)</surname><order>1264</order></author><author><firstname></firstname><surname>(ADGC)</surname><order>1265</order></author><author><firstname></firstname><surname>(CHARGE)</surname><order>1266</order></author></authors><documents><document><filename>60592__24701__607010dbc38d49ec97f23e93bc54faa6.pdf</filename><originalFilename>New insights into the genetic etiology ADRD.pdf</originalFilename><uploaded>2022-07-22T00:42:45.0712012</uploaded><type>Output</type><contentLength>5163465</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>This article is licensed under a Creative Commons Attribution 4.0 International License</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807> |
spelling |
2023-02-02T19:22:47.0989485 v2 60592 2022-07-22 New insights into the genetic etiology of Alzheimer’s disease and related dementias cf7fe9863906cd54df5b0a99904d535e 0000-0002-6789-127X Vanessa Burholt Vanessa Burholt true false 2022-07-22 PHAC Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. Journal Article Nature Genetics 54 4 412 436 Springer Science and Business Media LLC 1061-4036 1546-1718 4 4 2022 2022-04-04 10.1038/s41588-022-01024-z COLLEGE NANME Public Health COLLEGE CODE PHAC Swansea University Another institution paid the OA fee This work was funded by a grant (EADB) from the EU Joint Programme – Neurodegenerative Disease Research. INSERM UMR1167 is also funded by the INSERM, Institut Pasteur de Lille, Lille Métropole Communauté Urbaine and French government’s LABEX DISTALZ program (development of innovative strategies for a transdisciplinary approach to AD). 2023-02-02T19:22:47.0989485 2022-07-22T00:35:51.2392001 Faculty of Medicine, Health and Life Sciences The Centre for Innovative Ageing Céline Bellenguez 0000-0002-1240-7874 1 Fahri Küçükali 0000-0002-3835-9639 2 Iris E. Jansen 3 Luca Kleineidam 4 Sonia Moreno-Grau 5 Najaf Amin 0000-0002-8944-1771 6 Adam C. Naj 7 Rafael Campos-Martin 8 Benjamin Grenier-Boley 9 Victor Andrade 10 Peter A. Holmans 0000-0003-0870-9412 11 Anne Boland 12 Vincent Damotte 13 Sven J. van der Lee 0000-0003-1606-8643 14 Marcos R. Costa 0000-0002-4928-2163 15 Teemu Kuulasmaa 0000-0002-1795-7314 16 Qiong Yang 0000-0002-3658-1375 17 Itziar de Rojas 0000-0002-2148-381x 18 Joshua C. Bis 0000-0002-3409-1110 19 Amber Yaqub 0000-0002-3579-8054 20 Ivana Prokic 0000-0002-0370-1473 21 Julien Chapuis 0000-0002-5802-2857 22 Shahzad Ahmad 0000-0002-8658-3790 23 Vilmantas Giedraitis 0000-0003-3423-2021 24 Dag Aarsland 25 Pablo Garcia-Gonzalez 0000-0003-0125-5403 26 Carla Abdelnour 27 Emilio Alarcón-Martín 28 Daniel Alcolea 0000-0002-3819-3245 29 Montserrat Alegret 30 Ignacio Alvarez 0000-0002-8537-3935 31 Victoria Álvarez 32 Nicola J. Armstrong 33 Anthoula Tsolaki 0000-0002-5563-7776 34 Carmen Antúnez 35 Ildebrando Appollonio 36 Marina Arcaro 37 Silvana Archetti 38 Alfonso Arias Pastor 39 Beatrice Arosio 40 Lavinia Athanasiu 41 Henri Bailly 42 Nerisa Banaj 43 Miquel Baquero 0000-0002-6861-1831 44 Sandra Barral 45 Alexa Beiser 46 Ana Belén Pastor 0000-0001-9637-4688 47 Jennifer E. Below 48 Penelope Benchek 49 Luisa Benussi 50 Claudine Berr 0000-0001-5254-7655 51 Céline Besse 52 Valentina Bessi 0000-0002-6176-3584 53 Giuliano Binetti 54 Alessandra Bizarro 55 Rafael Blesa 56 Mercè Boada 0000-0003-2617-3009 57 Eric Boerwinkle 58 Barbara Borroni 59 Silvia Boschi 60 Paola Bossù 0000-0002-1432-0078 61 Geir Bråthen 0000-0003-3224-7983 62 Jan Bressler 0000-0001-6578-4772 63 Catherine Bresner 0000-0003-2673-9762 64 Henry Brodaty 0000-0001-9487-6617 65 Keeley J. Brookes 0000-0003-2427-2513 66 Luis Ignacio Brusco 67 Dolores Buiza-Rueda 68 Katharina Bûrger 69 Vanessa Burholt 0000-0002-6789-127X 70 William S. Bush 0000-0002-9729-6519 71 Miguel Calero 0000-0001-5366-3324 72 Laura B. Cantwell 73 Geneviève Chene 74 Jaeyoon Chung 0000-0002-6431-9454 75 Michael L. Cuccaro 76 Ángel Carracedo 77 Roberta Cecchetti 78 Laura Cervera-Carles 0000-0003-2286-200x 79 Camille Charbonnier 80 Hung-Hsin Chen 81 Caterina Chillotti 82 Simona Ciccone 83 Jurgen A. H. R. Claassen 84 Christopher Clark 85 Elisa Conti 86 Anaïs Corma-Gómez 87 Emanuele Costantini 0000-0002-1096-8221 88 Carlo Custodero 89 Delphine Daian 90 Maria Carolina Dalmasso 0000-0002-4901-9955 91 Antonio Daniele 92 Efthimios Dardiotis 93 Jean-François Dartigues 94 Peter Paul de Deyn 95 Katia de Paiva Lopes 0000-0002-0240-0126 96 Lot D. de Witte 0000-0002-7235-9958 97 Stéphanie Debette 0000-0001-8675-7968 98 Jürgen Deckert 99 Teodoro del Ser 0000-0001-9806-7083 100 Nicola Denning 101 Anita DeStefano 102 Martin Dichgans 0000-0002-0654-387x 103 Janine Diehl-Schmid 0000-0002-7745-1382 104 Mónica Diez-Fairen 0000-0003-1882-0309 105 Paolo Dionigi Rossi 106 Srdjan Djurovic 0000-0002-8140-8061 107 Emmanuelle Duron 108 Emrah Düzel 109 Carole Dufouil 0000-0003-2442-4476 110 Gudny Eiriksdottir 111 Sebastiaan Engelborghs 112 Valentina Escott-Price 0000-0003-1784-5483 113 Ana Espinosa 114 Michael Ewers 0000-0001-5231-1714 115 Kelley M. Faber 116 Tagliavini Fabrizio 0000-0003-1039-7315 117 Sune Fallgaard Nielsen 118 David W. Fardo 119 Lucia Farotti 120 Chiara Fenoglio 121 Marta Fernández-Fuertes 122 Raffaele Ferrari 123 Catarina B. Ferreira 124 Evelyn Ferri 125 Bertrand Fin 126 Peter Fischer 127 Tormod Fladby 0000-0002-9984-9797 128 Klaus Fließbach 129 Bernard Fongang 130 Myriam Fornage 0000-0003-0677-8158 131 Juan Fortea 132 Tatiana M. Foroud 133 Silvia Fostinelli 134 Nick C. Fox 0000-0002-6660-657x 135 Emlio Franco-Macías 136 María J. Bullido 0000-0002-6477-1117 137 Ana Frank-García 138 Lutz Froelich 0000-0003-1494-0813 139 Brian Fulton-Howard 140 Daniela Galimberti 0000-0002-9284-5953 141 Jose Maria García-Alberca 0000-0003-2951-6644 142 Pablo García-González 143 Sebastian Garcia-Madrona 144 Guillermo Garcia-Ribas 145 Roberta Ghidoni 146 Ina Giegling 147 Giaccone Giorgio 148 Alison M. Goate 0000-0002-0576-2472 149 Oliver Goldhardt 150 Duber Gomez-Fonseca 151 Antonio González-Pérez 0000-0001-9771-5982 152 Caroline Graff 153 Giulia Grande 154 Emma Green 0000-0002-8687-5590 155 Timo Grimmer 156 Edna Grünblatt 0000-0001-8505-7265 157 Michelle Grunin 158 Vilmundur Gudnason 0000-0001-5696-0084 159 Tamar Guetta-Baranes 160 Annakaisa Haapasalo 0000-0003-0959-2957 161 Georgios Hadjigeorgiou 162 Jonathan L. Haines 163 Kara L. Hamilton-Nelson 164 Harald Hampel 165 Olivier Hanon 166 John Hardy 167 Annette M. Hartmann 168 Lucrezia Hausner 169 Janet Harwood 0000-0002-3225-0069 170 Stefanie Heilmann-Heimbach 0000-0003-1057-465x 171 Seppo Helisalmi 172 Michael T. Heneka 173 Isabel Hernández 174 Martin J. Herrmann 0000-0001-9970-2122 175 Per Hoffmann 176 Clive Holmes 177 Henne Holstege 0000-0002-7688-3087 178 Raquel Huerto Vilas 179 Marc Hulsman 180 Jack Humphrey 181 Geert Jan Biessels 0000-0001-6862-2496 182 Xueqiu Jian 0000-0002-0313-6494 183 Charlotte Johansson 0000-0002-5351-1950 184 Gyungah R. Jun 0000-0002-3230-8697 185 Yuriko Kastumata 0000-0002-0188-8094 186 John Kauwe 187 Patrick G. Kehoe 0000-0002-7542-1139 188 Lena Kilander 189 Anne Kinhult Ståhlbom 190 Miia Kivipelto 191 Anne Koivisto 192 Johannes Kornhuber 0000-0002-8096-3987 193 Mary H. Kosmidis 0000-0001-8790-1220 194 Walter A. Kukull 195 Pavel P. Kuksa 196 Brian W. Kunkle 197 Amanda B. Kuzma 198 Carmen Lage 0000-0003-1703-121x 199 Erika J. Laukka 200 Lenore Launer 0000-0002-3238-7612 201 Alessandra Lauria 202 Chien-Yueh Lee 0000-0002-4304-974x 203 Jenni Lehtisalo 204 Ondrej Lerch 205 Alberto Lleó 0000-0002-2568-5478 206 William Longstreth 207 Oscar Lopez 0000-0002-8546-8256 208 Adolfo Lopez de Munain 0000-0002-9509-4032 209 Seth Love 210 Malin Löwemark 211 Lauren Luckcuck 212 Kathryn L. Lunetta 0000-0002-9268-810x 213 Yiyi Ma 0000-0002-3609-8877 214 Juan Macías 215 Catherine A. MacLeod 0000-0002-9314-7380 216 Wolfgang Maier 217 Francesca Mangialasche 218 Marco Spallazzi 219 Marta Marquié 0000-0002-0660-0950 220 Rachel Marshall 221 Eden R. Martin 222 Angel Martín Montes 0000-0002-1694-786x 223 Carmen Martínez Rodríguez 224 Carlo Masullo 225 Richard Mayeux 226 Simon Mead 0000-0002-4326-1468 227 Patrizia Mecocci 228 Miguel Medina 0000-0002-7016-5340 229 Alun Meggy 230 Shima Mehrabian 231 Silvia Mendoza 232 Manuel Menéndez-González 0000-0002-5218-0774 233 Pablo Mir 234 Susanne Moebus 235 Merel Mol 0000-0003-2533-2530 236 Laura Molina-Porcel 237 Laura Montrreal 238 Laura Morelli 239 Fermin Moreno 240 Kevin Morgan 0000-0002-8217-2396 241 Thomas Mosley 242 Markus M. Nöthen 0000-0002-8770-2464 243 Carolina Muchnik 0000-0002-1542-3706 244 Shubhabrata Mukherjee 245 Benedetta Nacmias 0000-0001-9338-9040 246 Tiia Ngandu 247 Gael Nicolas 0000-0001-9391-7800 248 Børge G. Nordestgaard 0000-0002-1954-7220 249 Robert Olaso 250 Adelina Orellana 251 Michela Orsini 252 Gemma Ortega 253 Alessandro Padovani 254 Caffarra Paolo 255 Goran Papenberg 256 Lucilla Parnetti 257 Florence Pasquier 0000-0001-9880-9788 258 Pau Pastor 0000-0002-7493-8777 259 Gina Peloso 0000-0002-5355-8636 260 Alba Pérez-Cordón 0000-0002-6028-0791 261 Jordi Pérez-Tur 0000-0002-9111-1712 262 Pierre Pericard 0000-0001-8167-6448 263 Oliver Peters 264 Yolande A. L. Pijnenburg 265 Juan A. Pineda 0000-0002-3751-0296 266 Gerard Piñol-Ripoll 267 Claudia Pisanu 0000-0002-9151-4319 268 Thomas Polak 269 Julius Popp 270 Danielle Posthuma 0000-0001-7582-2365 271 Josef Priller 272 Raquel Puerta 0000-0002-1191-5893 273 Olivier Quenez 0000-0002-8273-8505 274 Inés Quintela 275 Jesper Qvist Thomassen 0000-0003-3484-9531 276 Alberto Rábano 277 Innocenzo Rainero 278 Farid Rajabli 279 Inez Ramakers 280 Luis M. Real 0000-0003-4932-7429 281 Marcel J. T. Reinders 0000-0002-1148-1562 282 Christiane Reitz 0000-0001-8757-7889 283 Dolly Reyes-Dumeyer 284 Perry Ridge 285 Steffi Riedel-Heller 0000-0003-4321-6090 286 Peter Riederer 287 Natalia Roberto 288 Eloy Rodriguez-Rodriguez 0000-0001-7742-677x 289 Arvid Rongve 0000-0002-0476-4134 290 Irene Rosas Allende 291 Maitée Rosende-Roca 292 Jose Luis Royo 293 Elisa Rubino 294 Dan Rujescu 295 María Eugenia Sáez 0000-0001-9299-2534 296 Paraskevi Sakka 297 Ingvild Saltvedt 0000-0002-7897-9808 298 Ángela Sanabria 299 María Bernal Sánchez-Arjona 300 Florentino Sanchez-Garcia 301 Pascual Sánchez Juan 0000-0002-6081-8037 302 Raquel Sánchez-Valle 303 Sigrid B. Sando 304 Chloé Sarnowski 0000-0002-6090-7099 305 Claudia L. Satizabal 0000-0002-1115-4430 306 Michela Scamosci 307 Nikolaos Scarmeas 308 Elio Scarpini 309 Philip Scheltens 310 Norbert Scherbaum 311 Martin Scherer 312 Matthias Schmid 313 Anja Schneider 314 Jonathan M. Schott 0000-0003-2059-024x 315 Geir Selbæk 0000-0001-6511-8219 316 Davide Seripa 317 Manuel Serrano 318 Jin Sha 319 Alexey A. Shadrin 0000-0002-7467-250x 320 Olivia Skrobot 321 Susan Slifer 322 Gijsje J. L. Snijders 323 Hilkka Soininen 0000-0002-2785-9937 324 Vincenzo Solfrizzi 0000-0002-8524-0315 325 Alina Solomon 326 Yeunjoo Song 0000-0002-7452-3731 327 Sandro Sorbi 328 Oscar Sotolongo-Grau 0000-0002-9679-0670 329 Gianfranco Spalletta 0000-0002-7432-4249 330 Annika Spottke 331 Alessio Squassina 0000-0001-7415-7607 332 Eystein Stordal 0000-0002-2443-7923 333 Juan Pablo Tartan 334 Lluís Tárraga 335 Niccolo Tesí 336 Anbupalam Thalamuthu 337 Tegos Thomas 338 Giuseppe Tosto 0000-0001-7075-8245 339 Latchezar Traykov 340 Lucio Tremolizzo 341 Anne Tybjærg-Hansen 342 Andre Uitterlinden 0000-0002-7276-3387 343 Abbe Ullgren 344 Ingun Ulstein 345 Sergi Valero 346 Otto Valladares 0000-0001-8055-2187 347 Christine Van Broeckhoven 0000-0003-0183-7665 348 Jeffery Vance 349 Badri N. Vardarajan 350 Aad van der Lugt 351 Jasper Van Dongen 352 Jeroen van Rooij 353 John van Swieten 354 Rik Vandenberghe 355 Frans Verhey 356 Jean-Sébastien Vidal 0000-0001-6770-0720 357 Jonathan Vogelgsang 0000-0001-9326-8193 358 Martin Vyhnalek 359 Michael Wagner 0000-0003-2589-6440 360 David Wallon 0000-0002-2634-7198 361 Li-San Wang 362 Ruiqi Wang 363 Leonie Weinhold 364 Jens Wiltfang 0000-0003-1492-5330 365 Gill Windle 366 Bob Woods 0000-0002-6781-651x 367 Mary Yannakoulia 0000-0003-2171-7337 368 Habil Zare 0000-0001-5902-6238 369 Yi Zhao 370 Xiaoling Zhang 0000-0001-8237-1857 371 Congcong Zhu 372 Miren Zulaica 373 Jan Laczo 374 Vaclav Matoska 375 Maria Serpente 376 Francesca Assogna 377 Fabrizio Piras 378 Federica Piras 379 Valentina Ciullo 380 Jacob Shofany 381 Carlo Ferrarese 382 Simona Andreoni 383 Gessica Sala 384 Chiara Paola Zoia 385 Maria Del Zompo 386 Alberto Benussi 387 Patrizia Bastiani 388 Mari Takalo 389 Teemu Natunen 390 Tiina Laatikainen 391 Jaakko Tuomilehto 392 Riitta Antikainen 393 Timo Strandberg 394 Jaana Lindström 395 Markku Peltonen 396 Richard Abraham 397 Ammar Al-Chalabi 398 Nicholas J. Bass 399 Carol Brayne 400 Kristelle S. Brown 401 John Collinge 402 David Craig 403 Pangiotis Deloukas 404 Nick Fox 405 Amy Gerrish 406 Michael Gill 407 Rhian Gwilliam 408 Denise Harold 409 Paul Hollingworth 410 Jarret A. Johnston 411 Lesley Jones 412 Brian Lawlor 413 Gill Livingston 414 Simon Lovestone 415 Michelle Lupton 416 Aoibhinn Lynch 417 David Mann 418 Bernadette McGuinness 419 Andrew McQuillin 420 Michael C. O’Donovan 421 Michael J. Owen 422 Peter Passmore 423 John F. Powell 424 Petra Proitsi 425 Martin Rossor 426 Christopher E. Shaw 427 A. David Smith 428 Hugh Gurling 429 Stephen Todd 430 Catherine Mummery 431 Nathalie Ryan 432 Giordano Lacidogna 433 Ad Adarmes-Gómez 434 Ana Mauleón 435 Ana Pancho 436 Anna Gailhajenet 437 Asunción Lafuente 438 D. Macias-García 439 Elvira Martín 440 Esther Pelejà 441 F. Carrillo 442 Isabel Sastre Merlín 443 L. Garrote-Espina 444 Liliana Vargas 445 M. Carrion-Claro 446 M. Marín 447 Ma Labrador 448 Mar Buendia 449 María Dolores Alonso 450 Marina Guitart 451 Mariona Moreno 452 Marta Ibarria 453 Mt Periñán 454 Nuria Aguilera 455 P. Gómez-Garre 456 Pilar Cañabate 457 R. Escuela 458 R. Pineda-Sánchez 459 R. Vigo-Ortega 460 S. Jesús 461 Silvia Preckler 462 Silvia Rodrigo-Herrero 463 Susana Diego 464 Alessandro Vacca 465 Fausto Roveta 466 Nicola Salvadori 467 Elena Chipi 468 Henning Boecker 469 Christoph Laske 470 Robert Perneczky 471 Costas Anastasiou 472 Daniel Janowitz 473 Rainer Malik 474 Anna Anastasiou 475 Kayenat Parveen 476 Carmen Lage 477 Sara López-García 478 Anna Antonell 479 Kalina Yonkova Mihova 480 Diyana Belezhanska 481 Heike Weber 482 Silvia Kochen 483 Patricia Solis 484 Nancy Medel 485 Julieta Lisso 486 Zulma Sevillano 487 Daniel G. Politis 488 Valeria Cores 489 Carolina Cuesta 490 Cecilia Ortiz 491 Juan Ignacio Bacha 492 Mario Rios 493 Aldo Saenz 494 Mariana Sanchez Abalos 495 Eduardo Kohler 496 Dana Lis Palacio 497 Ignacio Etchepareborda 498 Matias Kohler 499 Gisela Novack 500 Federico Ariel Prestia 501 Pablo Galeano 502 Eduardo M. Castaño 503 Sandra Germani 504 Carlos Reyes Toso 505 Matias Rojo 506 Carlos Ingino 507 Carlos Mangone 508 David C. Rubinsztein 509 Stefan Teipel 510 Nathalie Fievet 511 Vincent Deramerourt 512 Charlotte Forsell 513 Håkan Thonberg 514 Maria Bjerke 515 Ellen De Roeck 516 María Teresa Martínez-Larrad 517 Natividad Olivar 518 Nuria Aguilera 519 Amanda Cano 520 Pilar Cañabate 521 Juan Macias 522 Olalla Maroñas 523 Raúl Nuñez-Llaves 524 Clàudia Olivé 525 Ester Pelejá 526 Astrid D. Adarmes-Gómez 527 María Dolores Alonso 528 Guillermo Amer-Ferrer 529 Martirio Antequera 530 Juan Andrés Burguera 531 Fátima Carrillo 532 Mario Carrión-Claro 533 María José Casajeros 534 Marian Martinez de Pancorbo 535 Rocío Escuela 536 Lorena Garrote-Espina 537 Pilar Gómez-Garre 538 Saray Hevilla 539 Silvia Jesús 540 Miguel Angel Labrador Espinosa 541 Agustina Legaz 542 Sara López-García 543 Daniel Macias-García 544 Salvadora Manzanares 545 Marta Marín 546 Juan Marín-Muñoz 547 Tamara Marín 548 Begoña Martínez 549 Victoriana Martínez 550 Pablo Martínez-Lage Álvarez 551 Maite Mendioroz Iriarte 552 María Teresa Periñán-Tocino 553 Rocío Pineda-Sánchez 554 Diego Real de Asúa 555 Silvia Rodrigo 556 Isabel Sastre 557 Maria Pilar Vicente 558 Rosario Vigo-Ortega 559 Liliana Vivancos 560 Jacques Epelbaum 561 Didier Hannequin 562 Dominique campion 563 Vincent Deramecourt 564 Christophe Tzourio 565 Alexis Brice 566 Bruno Dubois 567 Amy Williams 568 Charlene Thomas 569 Chloe Davies 570 William Nash 571 Kimberley Dowzell 572 Atahualpa Castillo Morales 573 Mateus Bernardo-Harrington 574 James Turton 575 Jenny Lord 576 Kristelle Brown 577 Emma Vardy 578 Elizabeth Fisher 579 Jason D. Warren 580 Martin Rossor 581 Natalie S. Ryan 582 Rita Guerreiro 583 James Uphill 584 Nick Bass 585 Reinhard Heun 586 Heike Kölsch 587 Britta Schürmann 588 André Lacour 589 Christine Herold 590 Janet A. Johnston 591 Peter Passmore 592 John Powell 593 Yogen Patel 594 Angela Hodges 595 Tim Becker 596 Donald Warden 597 Gordon Wilcock 598 Robert Clarke 599 Panagiotis Deloukas 600 Yoav Ben-Shlomo 601 Nigel M. Hooper 602 Stuart Pickering-Brown 603 Rebecca Sussams 604 Nick Warner 605 Anthony Bayer 606 Isabella Heuser 607 Dmitriy Drichel 608 Norman Klopp 609 Manuel Mayhaus 610 Matthias Riemenschneider 611 Sabrina Pinchler 612 Thomas Feulner 613 Wei Gu 614 Hendrik van den Bussche 615 Michael Hüll 616 Lutz Frölich 617 H-Erich Wichmann 618 Karl-Heinz Jöckel 619 Michael O’Donovan 620 Michael Owen 621 Shahram Bahrami 622 Ingunn Bosnes 623 Per Selnes 624 Sverre Bergh 625 Aarno Palotie 626 Mark Daly 627 Howard Jacob 628 Athena Matakidou 629 Heiko Runz 630 Sally John 631 Robert Plenge 632 Mark McCarthy 633 Julie Hunkapiller 634 Meg Ehm 635 Dawn Waterworth 636 Caroline Fox 637 Anders Malarstig 638 Kathy Klinger 639 Kathy Call 640 Tim Behrens 641 Patrick Loerch 642 Tomi Mäkelä 643 Jaakko Kaprio 644 Petri Virolainen 645 Kari Pulkki 646 Terhi Kilpi 647 Markus Perola 648 Jukka Partanen 649 Anne Pitkäranta 650 Riitta Kaarteenaho 651 Seppo Vainio 652 Miia Turpeinen 653 Raisa Serpi 654 Tarja Laitinen 655 Johanna Mäkelä 656 Veli-Matti Kosma 657 Urho Kujala 658 Outi Tuovila 659 Minna Hendolin 660 Raimo Pakkanen 661 Jeff Waring 662 Bridget Riley-Gillis 663 Jimmy Liu 664 Shameek Biswas 665 Dorothee Diogo 666 Catherine Marshall 667 Xinli Hu 668 Matthias Gossel 669 Robert Graham 670 Beryl Cummings 671 Samuli Ripatti 672 Johanna Schleutker 673 Mikko Arvas 674 Olli Carpén 675 Reetta Hinttala 676 Johannes Kettunen 677 Arto Mannermaa 678 Jari Laukkanen 679 Valtteri Julkunen 680 Anne Remes 681 Reetta Kälviäinen 682 Jukka Peltola 683 Pentti Tienari 684 Juha Rinne 685 Adam Ziemann 686 Jeffrey Waring 687 Sahar Esmaeeli 688 Nizar Smaoui 689 Anne Lehtonen 690 Susan Eaton 691 Sanni Lahdenperä 692 Janet van Adelsberg 693 John Michon 694 Geoff Kerchner 695 Natalie Bowers 696 Edmond Teng 697 John Eicher 698 Vinay Mehta 699 Padhraig Gormley 700 Kari Linden 701 Christopher Whelan 702 Fanli Xu 703 David Pulford 704 Martti Färkkilä 705 Sampsa Pikkarainen 706 Airi Jussila 707 Timo Blomster 708 Mikko Kiviniemi 709 Markku Voutilainen 710 Bob Georgantas 711 Graham Heap 712 Fedik Rahimov 713 Keith Usiskin 714 Tim Lu 715 Danny Oh 716 Kirsi Kalpala 717 Melissa Miller 718 Linda McCarthy 719 Kari Eklund 720 Antti Palomäki 721 Pia Isomäki 722 Laura Pirilä 723 Oili Kaipiainen-Seppänen 724 Johanna Huhtakangas 725 Apinya Lertratanakul 726 Marla Hochfeld 727 Nan Bing 728 Jorge Esparza Gordillo 729 Nina Mars 730 Margit Pelkonen 731 Paula Kauppi 732 Hannu Kankaanranta 733 Terttu Harju 734 David Close 735 Steven Greenberg 736 Hubert Chen 737 Jo Betts 738 Soumitra Ghosh 739 Veikko Salomaa 740 Teemu Niiranen 741 Markus Juonala 742 Kaj Metsärinne 743 Mika Kähönen 744 Juhani Junttila 745 Markku Laakso 746 Jussi Pihlajamäki 747 Juha Sinisalo 748 Marja-Riitta Taskinen 749 Tiinamaija Tuomi 750 Ben Challis 751 Andrew Peterson 752 Audrey Chu 753 Jaakko Parkkinen 754 Anthony Muslin 755 Heikki Joensuu 756 Tuomo Meretoja 757 Lauri Aaltonen 758 Johanna Mattson 759 Annika Auranen 760 Peeter Karihtala 761 Saila Kauppila 762 Päivi Auvinen 763 Klaus Elenius 764 Relja Popovic 765 Jennifer Schutzman 766 Andrey Loboda 767 Aparna Chhibber 768 Heli Lehtonen 769 Stefan McDonough 770 Marika Crohns 771 Diptee Kulkarni 772 Kai Kaarniranta 773 Joni A. Turunen 774 Terhi Ollila 775 Sanna Seitsonen 776 Hannu Uusitalo 777 Vesa Aaltonen 778 Hannele Uusitalo-Järvinen 779 Marja Luodonpää 780 Nina Hautala 781 Stephanie Loomis 782 Erich Strauss 783 Hao Chen 784 Anna Podgornaia 785 Joshua Hoffman 786 Kaisa Tasanen 787 Laura Huilaja 788 Katariina Hannula-Jouppi 789 Teea Salmi 790 Sirkku Peltonen 791 Leena Koulu 792 Ilkka Harvima 793 Ying Wu 794 David Choy 795 Pirkko Pussinen 796 Aino Salminen 797 Tuula Salo 798 David Rice 799 Pekka Nieminen 800 Ulla Palotie 801 Maria Siponen 802 Liisa Suominen 803 Päivi Mäntylä 804 Ulvi Gursoy 805 Vuokko Anttonen 806 Kirsi Sipilä 807 Justin Wade Davis 808 Danjuma Quarless 809 Slavé Petrovski 810 Eleonor Wigmore 811 Chia-Yen Chen 812 Paola Bronson 813 Ellen Tsai 814 Yunfeng Huang 815 Joseph Maranville 816 Elmutaz Shaikho 817 Elhaj Mohammed 818 Samir Wadhawan 819 Erika Kvikstad 820 Minal Caliskan 821 Diana Chang 822 Tushar Bhangale 823 Sarah Pendergrass 824 Emily Holzinger 825 Xing Chen 826 Åsa Hedman 827 Karen S. King 828 Clarence Wang 829 Ethan Xu 830 Franck Auge 831 Clement Chatelain 832 Deepak Rajpal 833 Dongyu Liu 834 Katherine Call 835 Tai-he Xia 836 Matt Brauer 837 Mitja Kurki 838 Juha Karjalainen 839 Aki Havulinna 840 Anu Jalanko 841 Priit Palta 842 Pietro della Briotta Parolo 843 Wei Zhou 844 Susanna Lemmelä 845 Manuel Rivas 846 Jarmo Harju 847 Arto Lehisto 848 Andrea Ganna 849 Vincent Llorens 850 Hannele Laivuori 851 Sina Rüeger 852 Mari E. Niemi 853 Taru Tukiainen 854 Mary Pat Reeve 855 Henrike Heyne 856 Kimmo Palin 857 Javier Garcia-Tabuenca 858 Harri Siirtola 859 Tuomo Kiiskinen 860 Jiwoo Lee 861 Kristin Tsuo 862 Amanda Elliott 863 Kati Kristiansson 864 Kati Hyvärinen 865 Jarmo Ritari 866 Miika Koskinen 867 Katri Pylkäs 868 Marita Kalaoja 869 Minna Karjalainen 870 Tuomo Mantere 871 Eeva Kangasniemi 872 Sami Heikkinen 873 Eija Laakkonen 874 Csilla Sipeky 875 Samuel Heron 876 Antti Karlsson 877 Dhanaprakash Jambulingam 878 Venkat Subramaniam Rathinakannan 879 Risto Kajanne 880 Mervi Aavikko 881 Manuel González Jiménez 882 Pietro della Briotta Parola 883 Arto Lehistö 884 Masahiro Kanai 885 Mari Kaunisto 886 Elina Kilpeläinen 887 Timo P. Sipilä 888 Georg Brein 889 Ghazal Awaisa 890 Anastasia Shcherban 891 Kati Donner 892 Anu Loukola 893 Päivi Laiho 894 Tuuli Sistonen 895 Essi Kaiharju 896 Markku Laukkanen 897 Elina Järvensivu 898 Sini Lähteenmäki 899 Lotta Männikkö 900 Regis Wong 901 Hannele Mattsson 902 Tero Hiekkalinna 903 Teemu Paajanen 904 Kalle Pärn 905 Javier Gracia-Tabuenca 906 Erin Abner 907 Perrie M. Adams 908 Alyssa Aguirre 909 Marilyn S. Albert 910 Roger L. Albin 911 Mariet Allen 912 Lisa Alvarez 913 Liana G. Apostolova 914 Steven E. Arnold 915 Sanjay Asthana 916 Craig S. Atwood 917 Gayle Ayres 918 Clinton T. Baldwin 919 Robert C. Barber 920 Lisa L. Barnes 921 Sandra Barral 922 Thomas G. Beach 923 James T. Becker 924 Gary W. Beecham 925 Duane Beekly 926 Jennifer E. Below 0000-0002-1346-1872 927 Penelope Benchek 928 Bruno A. Benitez 929 David Bennett 930 John Bertelson 931 Flanagan E. Margaret 932 Thomas D. Bird 933 Deborah Blacker 934 Bradley F. Boeve 935 James D. Bowen 936 Adam Boxer 937 James Brewer 938 James R. Burke 939 Jeffrey M. Burns 940 Will S. Bush 941 Joseph D. Buxbaum 942 Nigel J. Cairns 943 Chuanhai Cao 944 Christopher S. Carlson 945 Cynthia M. Carlsson 946 Regina M. Carney 947 Minerva M. Carrasquillo 948 Scott Chasse 949 Marie-Francoise Chesselet 950 Alessandra Chesi 951 Nathaniel A. Chin 952 Helena C. Chui 953 Jaeyoon Chung 954 Suzanne Craft 955 Paul K. Crane 956 David H. Cribbs 957 Elizabeth A. Crocco 958 Carlos Cruchaga 959 Michael L. Cuccaro 960 Munro Cullum 961 Eveleen Darby 962 Barbara Davis 963 Philip L. De Jager 964 Charles DeCarli 965 John DeToledo 966 Malcolm Dick 967 Dennis W. Dickson 968 Beth A. Dombroski 969 Rachelle S. Doody 970 Ranjan Duara 971 Nilüfer Ertekin-Taner 972 Denis A. Evans 973 Thomas J. Fairchild 974 Kenneth B. Fallon 975 Martin R. Farlow 976 John J. Farrell 977 Victoria Fernandez-Hernandez 978 Steven Ferris 979 Matthew P. Frosch 980 Brian Fulton-Howard 981 Douglas R. Galasko 982 Adriana Gamboa 983 Marla Gearing 984 Daniel H. Geschwind 985 Bernardino Ghetti 986 John R. Gilbert 987 Thomas J. Grabowski 988 Neill R. Graff-Radford 989 Struan F. A. Grant 990 Robert C. Green 991 John H. Growdon 992 Jonathan L. Haines 993 Hakon Hakonarson 994 James Hall 995 Ronald L. Hamilton 996 Oscar Harari 997 Lindy E. Harrell 998 Jacob Haut 999 Elizabeth Head 1000 Victor W. Henderson 1001 Michelle Hernandez 1002 Timothy Hohman 1003 Lawrence S. Honig 1004 Ryan M. Huebinger 1005 Matthew J. Huentelman 1006 Christine M. Hulette 1007 Bradley T. Hyman 1008 Linda S. Hynan 1009 Laura Ibanez 1010 Gail P. Jarvik 1011 Suman Jayadev 1012 Lee-Way Jin 1013 Kim Johnson 1014 Leigh Johnson 1015 M. Ilyas Kamboh 1016 Anna M. Karydas 1017 Mindy J. Katz 1018 Jeffrey A. Kaye 1019 C. Dirk Keene 1020 Aisha Khaleeq 1021 Ronald Kim 1022 Janice Knebl 1023 Neil W. Kowall 1024 Joel H. Kramer 1025 Pavel P. Kuksa 1026 Frank M. LaFerla 1027 James J. Lah 1028 Eric B. Larson 1029 Chien-Yueh Lee 1030 Edward B. Lee 1031 Alan Lerner 1032 Yuk Yee Leung 1033 James B. Leverenz 1034 Allan I. Levey 1035 Mingyao Li 1036 Andrew P. Lieberman 1037 Richard B. Lipton 1038 Mark Logue 1039 Constantine G. Lyketsos 1040 John Malamon 1041 Douglas Mains 1042 Daniel C. Marson 1043 Frank Martiniuk 1044 Deborah C. Mash 1045 Eliezer Masliah 1046 Paul Massman 1047 Arjun Masurkar 1048 Wayne C. McCormick 1049 Susan M. McCurry 1050 Andrew N. McDavid 1051 Stefan McDonough 1052 Ann C. McKee 1053 Marsel Mesulam 1054 Jesse Mez 1055 Bruce L. Miller 1056 Carol A. Miller 1057 Joshua W. Miller 1058 Thomas J. Montine 1059 Edwin S. Monuki 1060 John C. Morris 1061 Amanda J. Myers 1062 Trung Nguyen 1063 Sid O’Bryant 1064 John M. Olichney 1065 Marcia Ory 1066 Raymond Palmer 1067 Joseph E. Parisi 1068 Henry L. Paulson 1069 Valory Pavlik 1070 David Paydarfar 1071 Victoria Perez 1072 Elaine Peskind 1073 Ronald C. Petersen 1074 Jennifer E. Phillips-Cremins 1075 Aimee Pierce 1076 Marsha Polk 1077 Wayne W. Poon 1078 Huntington Potter 1079 Liming Qu 1080 Mary Quiceno 1081 Joseph F. Quinn 1082 Ashok Raj 1083 Murray Raskind 1084 Eric M. Reiman 1085 Barry Reisberg 1086 Joan S. Reisch 1087 John M. Ringman 1088 Erik D. Roberson 1089 Monica Rodriguear 1090 Ekaterina Rogaeva 1091 Howard J. Rosen 1092 Roger N. Rosenberg 1093 Donald R. Royall 1094 Mark A. Sager 1095 Mary Sano 1096 Andrew J. Saykin 1097 Julie A. Schneider 1098 Lon S. Schneider 1099 William W. Seeley 1100 Susan H. Slifer 1101 Scott Small 1102 Amanda G. Smith 1103 Janet P. Smith 1104 Yeunjoo E. Song 1105 Joshua A. Sonnen 1106 Salvatore Spina 1107 Peter St George-Hyslop 1108 Robert A. Stern 1109 Alan B. Stevens 1110 Stephen M. Strittmatter 1111 David Sultzer 1112 Russell H. Swerdlow 1113 Rudolph E. Tanzi 1114 Jeffrey L. Tilson 1115 John Q. Trojanowski 1116 Juan C. Troncoso 1117 Debby W. Tsuang 1118 Otto Valladares 1119 Vivianna M. Van Deerlin 1120 Linda J. van Eldik 1121 Robert Vassar 1122 Harry V. Vinters 1123 Jean-Paul Vonsattel 1124 Sandra Weintraub 1125 Kathleen A. Welsh-Bohmer 1126 Patrice L. Whitehead 1127 Ellen M. Wijsman 1128 Kirk C. Wilhelmsen 1129 Benjamin Williams 1130 Jennifer Williamson 1131 Henrik Wilms 1132 Thomas S. Wingo 1133 Thomas Wisniewski 1134 Randall L. Woltjer 1135 Martin Woon 1136 Clinton B. Wright 1137 Chuang-Kuo Wu 1138 Steven G. Younkin 1139 Chang-En Yu 1140 Lei Yu 1141 Yuanchao Zhang 1142 Yi Zhao 1143 Xiongwei Zhu 1144 Hieab Adams 1145 Rufus O. Akinyemi 1146 Muhammad Ali 1147 Nicola Armstrong 1148 Hugo J. Aparicio 1149 Maryam Bahadori 1150 James T. Becker 1151 Monique Breteler 1152 Daniel Chasman 1153 Ganesh Chauhan 1154 Hata Comic 1155 Simon Cox 1156 Adrienne L. Cupples 1157 Gail Davies 1158 Charles S. DeCarli 1159 Marie-Gabrielle Duperron 1160 Josée Dupuis 1161 Tavia Evans 1162 Frank Fan 1163 Annette Fitzpatrick 1164 Alison E. Fohner 1165 Mary Ganguli 1166 Mirjam Geerlings 1167 Stephen J. Glatt 1168 Hector M. Gonzalez 1169 Monica Goss 1170 Hans Grabe 1171 Mohamad Habes 1172 Susan R. Heckbert 1173 Edith Hofer 1174 Elliot Hong 1175 Timothy Hughes 1176 Tiffany F. Kautz 1177 Maria Knol 1178 William Kremen 1179 Paul Lacaze 1180 Jari Lahti 1181 Quentin Le Grand 1182 Elizabeth Litkowski 1183 Shuo Li 1184 Dan Liu 1185 Xuan Liu 1186 Marisa Loitfelder 1187 Alisa Manning 1188 Pauline Maillard 1189 Riccardo Marioni 1190 Bernard Mazoyer 1191 Debora Melo van Lent 1192 Hao Mei 1193 Aniket Mishra 1194 Paul Nyquist 1195 Jeffrey O’Connell 1196 Yash Patel 1197 Tomas Paus 1198 Zdenka Pausova 1199 Katri Raikkonen-Talvitie 1200 Moeen Riaz 1201 Stephen Rich 1202 Jerome Rotter 1203 Jose Romero 1204 Gena Roshchupkin 1205 Yasaman Saba 1206 Murali Sargurupremraj 1207 Helena Schmidt 1208 Reinhold Schmidt 1209 Joshua M. Shulman 1210 Jennifer Smith 1211 Hema Sekhar 1212 Reddy Rajula 1213 Jean Shin 1214 Jeannette Simino 1215 Eeva Sliz 1216 Alexander Teumer 1217 Alvin Thomas 1218 Adrienne Tin 1219 Elliot Tucker-Drob 1220 Dina Vojinovic 1221 Yanbing Wang 1222 Galit Weinstein 1223 Dylan Williams 1224 Katharina Wittfeld 1225 Lisa Yanek 1226 Yunju Yang 1227 Lindsay A. Farrer 0000-0001-5533-4225 1228 Bruce M. Psaty 0000-0002-7278-2190 1229 Mohsen Ghanbari 0000-0002-9476-7143 1230 Towfique Raj 0000-0002-9355-5704 1231 Perminder Sachdev 0000-0002-9595-3220 1232 Karen Mather 0000-0003-4143-8941 1233 Frank Jessen 1234 M. Arfan Ikram 0000-0003-0372-8585 1235 Alexandre de Mendonça 1236 Jakub Hort 1237 Magda Tsolaki 0000-0002-2072-8010 1238 Margaret A. Pericak-Vance 0000-0001-7283-8804 1239 Philippe Amouyel 0000-0001-9088-234x 1240 Julie Williams 0000-0002-4069-0259 1241 Ruth Frikke-Schmidt 0000-0003-4084-5027 1242 Jordi Clarimon 1243 Jean-François Deleuze 1244 Giacomina Rossi 1245 Sudha Seshadri 0000-0001-6135-2622 1246 Ole A. Andreassen 0000-0002-4461-3568 1247 Martin Ingelsson 1248 Mikko Hiltunen 1249 Kristel Sleegers 0000-0002-0283-2332 1250 Gerard D. Schellenberg 1251 Cornelia M. van Duijn 0000-0002-2374-9204 1252 Rebecca Sims 0000-0002-3885-1199 1253 Wiesje M. van der Flier 0000-0001-8766-6224 1254 Agustín Ruiz 1255 Alfredo Ramirez 0000-0003-4991-763x 1256 Jean-Charles Lambert 0000-0003-0829-7817 1257 (EADB) 1258 (GR@ACE) 1259 (DEGESCO) 1260 (EADI) 1261 (GERAD) 1262 (Demgene) 1263 (FinnGen) 1264 (ADGC) 1265 (CHARGE) 1266 60592__24701__607010dbc38d49ec97f23e93bc54faa6.pdf New insights into the genetic etiology ADRD.pdf 2022-07-22T00:42:45.0712012 Output 5163465 application/pdf Version of Record true This article is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/ |
title |
New insights into the genetic etiology of Alzheimer’s disease and related dementias |
spellingShingle |
New insights into the genetic etiology of Alzheimer’s disease and related dementias Vanessa Burholt |
title_short |
New insights into the genetic etiology of Alzheimer’s disease and related dementias |
title_full |
New insights into the genetic etiology of Alzheimer’s disease and related dementias |
title_fullStr |
New insights into the genetic etiology of Alzheimer’s disease and related dementias |
title_full_unstemmed |
New insights into the genetic etiology of Alzheimer’s disease and related dementias |
title_sort |
New insights into the genetic etiology of Alzheimer’s disease and related dementias |
author_id_str_mv |
cf7fe9863906cd54df5b0a99904d535e |
author_id_fullname_str_mv |
cf7fe9863906cd54df5b0a99904d535e_***_Vanessa Burholt |
author |
Vanessa Burholt |
author2 |
Céline Bellenguez Fahri Küçükali Iris E. Jansen Luca Kleineidam Sonia Moreno-Grau Najaf Amin Adam C. Naj Rafael Campos-Martin Benjamin Grenier-Boley Victor Andrade Peter A. Holmans Anne Boland Vincent Damotte Sven J. van der Lee Marcos R. Costa Teemu Kuulasmaa Qiong Yang Itziar de Rojas Joshua C. Bis Amber Yaqub Ivana Prokic Julien Chapuis Shahzad Ahmad Vilmantas Giedraitis Dag Aarsland Pablo Garcia-Gonzalez Carla Abdelnour Emilio Alarcón-Martín Daniel Alcolea Montserrat Alegret Ignacio Alvarez Victoria Álvarez Nicola J. Armstrong Anthoula Tsolaki Carmen Antúnez Ildebrando Appollonio Marina Arcaro Silvana Archetti Alfonso Arias Pastor Beatrice Arosio Lavinia Athanasiu Henri Bailly Nerisa Banaj Miquel Baquero Sandra Barral Alexa Beiser Ana Belén Pastor Jennifer E. Below Penelope Benchek Luisa Benussi Claudine Berr Céline Besse Valentina Bessi Giuliano Binetti Alessandra Bizarro Rafael Blesa Mercè Boada Eric Boerwinkle Barbara Borroni Silvia Boschi Paola Bossù Geir Bråthen Jan Bressler Catherine Bresner Henry Brodaty Keeley J. Brookes Luis Ignacio Brusco Dolores Buiza-Rueda Katharina Bûrger Vanessa Burholt William S. Bush Miguel Calero Laura B. Cantwell Geneviève Chene Jaeyoon Chung Michael L. Cuccaro Ángel Carracedo Roberta Cecchetti Laura Cervera-Carles Camille Charbonnier Hung-Hsin Chen Caterina Chillotti Simona Ciccone Jurgen A. H. R. Claassen Christopher Clark Elisa Conti Anaïs Corma-Gómez Emanuele Costantini Carlo Custodero Delphine Daian Maria Carolina Dalmasso Antonio Daniele Efthimios Dardiotis Jean-François Dartigues Peter Paul de Deyn Katia de Paiva Lopes Lot D. de Witte Stéphanie Debette Jürgen Deckert Teodoro del Ser Nicola Denning Anita DeStefano Martin Dichgans Janine Diehl-Schmid Mónica Diez-Fairen Paolo Dionigi Rossi Srdjan Djurovic Emmanuelle Duron Emrah Düzel Carole Dufouil Gudny Eiriksdottir Sebastiaan Engelborghs Valentina Escott-Price Ana Espinosa Michael Ewers Kelley M. Faber Tagliavini Fabrizio Sune Fallgaard Nielsen David W. Fardo Lucia Farotti Chiara Fenoglio Marta Fernández-Fuertes Raffaele Ferrari Catarina B. Ferreira Evelyn Ferri Bertrand Fin Peter Fischer Tormod Fladby Klaus Fließbach Bernard Fongang Myriam Fornage Juan Fortea Tatiana M. Foroud Silvia Fostinelli Nick C. Fox Emlio Franco-Macías María J. Bullido Ana Frank-García Lutz Froelich Brian Fulton-Howard Daniela Galimberti Jose Maria García-Alberca Pablo García-González Sebastian Garcia-Madrona Guillermo Garcia-Ribas Roberta Ghidoni Ina Giegling Giaccone Giorgio Alison M. Goate Oliver Goldhardt Duber Gomez-Fonseca Antonio González-Pérez Caroline Graff Giulia Grande Emma Green Timo Grimmer Edna Grünblatt Michelle Grunin Vilmundur Gudnason Tamar Guetta-Baranes Annakaisa Haapasalo Georgios Hadjigeorgiou Jonathan L. Haines Kara L. Hamilton-Nelson Harald Hampel Olivier Hanon John Hardy Annette M. Hartmann Lucrezia Hausner Janet Harwood Stefanie Heilmann-Heimbach Seppo Helisalmi Michael T. Heneka Isabel Hernández Martin J. Herrmann Per Hoffmann Clive Holmes Henne Holstege Raquel Huerto Vilas Marc Hulsman Jack Humphrey Geert Jan Biessels Xueqiu Jian Charlotte Johansson Gyungah R. Jun Yuriko Kastumata John Kauwe Patrick G. Kehoe Lena Kilander Anne Kinhult Ståhlbom Miia Kivipelto Anne Koivisto Johannes Kornhuber Mary H. Kosmidis Walter A. Kukull Pavel P. Kuksa Brian W. Kunkle Amanda B. Kuzma Carmen Lage Erika J. Laukka Lenore Launer Alessandra Lauria Chien-Yueh Lee Jenni Lehtisalo Ondrej Lerch Alberto Lleó William Longstreth Oscar Lopez Adolfo Lopez de Munain Seth Love Malin Löwemark Lauren Luckcuck Kathryn L. Lunetta Yiyi Ma Juan Macías Catherine A. MacLeod Wolfgang Maier Francesca Mangialasche Marco Spallazzi Marta Marquié Rachel Marshall Eden R. Martin Angel Martín Montes Carmen Martínez Rodríguez Carlo Masullo Richard Mayeux Simon Mead Patrizia Mecocci Miguel Medina Alun Meggy Shima Mehrabian Silvia Mendoza Manuel Menéndez-González Pablo Mir Susanne Moebus Merel Mol Laura Molina-Porcel Laura Montrreal Laura Morelli Fermin Moreno Kevin Morgan Thomas Mosley Markus M. Nöthen Carolina Muchnik Shubhabrata Mukherjee Benedetta Nacmias Tiia Ngandu Gael Nicolas Børge G. Nordestgaard Robert Olaso Adelina Orellana Michela Orsini Gemma Ortega Alessandro Padovani Caffarra Paolo Goran Papenberg Lucilla Parnetti Florence Pasquier Pau Pastor Gina Peloso Alba Pérez-Cordón Jordi Pérez-Tur Pierre Pericard Oliver Peters Yolande A. L. Pijnenburg Juan A. Pineda Gerard Piñol-Ripoll Claudia Pisanu Thomas Polak Julius Popp Danielle Posthuma Josef Priller Raquel Puerta Olivier Quenez Inés Quintela Jesper Qvist Thomassen Alberto Rábano Innocenzo Rainero Farid Rajabli Inez Ramakers Luis M. Real Marcel J. T. Reinders Christiane Reitz Dolly Reyes-Dumeyer Perry Ridge Steffi Riedel-Heller Peter Riederer Natalia Roberto Eloy Rodriguez-Rodriguez Arvid Rongve Irene Rosas Allende Maitée Rosende-Roca Jose Luis Royo Elisa Rubino Dan Rujescu María Eugenia Sáez Paraskevi Sakka Ingvild Saltvedt Ángela Sanabria María Bernal Sánchez-Arjona Florentino Sanchez-Garcia Pascual Sánchez Juan Raquel Sánchez-Valle Sigrid B. Sando Chloé Sarnowski Claudia L. Satizabal Michela Scamosci Nikolaos Scarmeas Elio Scarpini Philip Scheltens Norbert Scherbaum Martin Scherer Matthias Schmid Anja Schneider Jonathan M. Schott Geir Selbæk Davide Seripa Manuel Serrano Jin Sha Alexey A. Shadrin Olivia Skrobot Susan Slifer Gijsje J. L. Snijders Hilkka Soininen Vincenzo Solfrizzi Alina Solomon Yeunjoo Song Sandro Sorbi Oscar Sotolongo-Grau Gianfranco Spalletta Annika Spottke Alessio Squassina Eystein Stordal Juan Pablo Tartan Lluís Tárraga Niccolo Tesí Anbupalam Thalamuthu Tegos Thomas Giuseppe Tosto Latchezar Traykov Lucio Tremolizzo Anne Tybjærg-Hansen Andre Uitterlinden Abbe Ullgren Ingun Ulstein Sergi Valero Otto Valladares Christine Van Broeckhoven Jeffery Vance Badri N. Vardarajan Aad van der Lugt Jasper Van Dongen Jeroen van Rooij John van Swieten Rik Vandenberghe Frans Verhey Jean-Sébastien Vidal Jonathan Vogelgsang Martin Vyhnalek Michael Wagner David Wallon Li-San Wang Ruiqi Wang Leonie Weinhold Jens Wiltfang Gill Windle Bob Woods Mary Yannakoulia Habil Zare Yi Zhao Xiaoling Zhang Congcong Zhu Miren Zulaica Jan Laczo Vaclav Matoska Maria Serpente Francesca Assogna Fabrizio Piras Federica Piras Valentina Ciullo Jacob Shofany Carlo Ferrarese Simona Andreoni Gessica Sala Chiara Paola Zoia Maria Del Zompo Alberto Benussi Patrizia Bastiani Mari Takalo Teemu Natunen Tiina Laatikainen Jaakko Tuomilehto Riitta Antikainen Timo Strandberg Jaana Lindström Markku Peltonen Richard Abraham Ammar Al-Chalabi Nicholas J. Bass Carol Brayne Kristelle S. Brown John Collinge David Craig Pangiotis Deloukas Nick Fox Amy Gerrish Michael Gill Rhian Gwilliam Denise Harold Paul Hollingworth Jarret A. Johnston Lesley Jones Brian Lawlor Gill Livingston Simon Lovestone Michelle Lupton Aoibhinn Lynch David Mann Bernadette McGuinness Andrew McQuillin Michael C. O’Donovan Michael J. Owen Peter Passmore John F. Powell Petra Proitsi Martin Rossor Christopher E. Shaw A. David Smith Hugh Gurling Stephen Todd Catherine Mummery Nathalie Ryan Giordano Lacidogna Ad Adarmes-Gómez Ana Mauleón Ana Pancho Anna Gailhajenet Asunción Lafuente D. Macias-García Elvira Martín Esther Pelejà F. Carrillo Isabel Sastre Merlín L. Garrote-Espina Liliana Vargas M. Carrion-Claro M. Marín Ma Labrador Mar Buendia María Dolores Alonso Marina Guitart Mariona Moreno Marta Ibarria Mt Periñán Nuria Aguilera P. Gómez-Garre Pilar Cañabate R. Escuela R. Pineda-Sánchez R. Vigo-Ortega S. Jesús Silvia Preckler Silvia Rodrigo-Herrero Susana Diego Alessandro Vacca Fausto Roveta Nicola Salvadori Elena Chipi Henning Boecker Christoph Laske Robert Perneczky Costas Anastasiou Daniel Janowitz Rainer Malik Anna Anastasiou Kayenat Parveen Carmen Lage Sara López-García Anna Antonell Kalina Yonkova Mihova Diyana Belezhanska Heike Weber Silvia Kochen Patricia Solis Nancy Medel Julieta Lisso Zulma Sevillano Daniel G. Politis Valeria Cores Carolina Cuesta Cecilia Ortiz Juan Ignacio Bacha Mario Rios Aldo Saenz Mariana Sanchez Abalos Eduardo Kohler Dana Lis Palacio Ignacio Etchepareborda Matias Kohler Gisela Novack Federico Ariel Prestia Pablo Galeano Eduardo M. Castaño Sandra Germani Carlos Reyes Toso Matias Rojo Carlos Ingino Carlos Mangone David C. Rubinsztein Stefan Teipel Nathalie Fievet Vincent Deramerourt Charlotte Forsell Håkan Thonberg Maria Bjerke Ellen De Roeck María Teresa Martínez-Larrad Natividad Olivar Nuria Aguilera Amanda Cano Pilar Cañabate Juan Macias Olalla Maroñas Raúl Nuñez-Llaves Clàudia Olivé Ester Pelejá Astrid D. Adarmes-Gómez María Dolores Alonso Guillermo Amer-Ferrer Martirio Antequera Juan Andrés Burguera Fátima Carrillo Mario Carrión-Claro María José Casajeros Marian Martinez de Pancorbo Rocío Escuela Lorena Garrote-Espina Pilar Gómez-Garre Saray Hevilla Silvia Jesús Miguel Angel Labrador Espinosa Agustina Legaz Sara López-García Daniel Macias-García Salvadora Manzanares Marta Marín Juan Marín-Muñoz Tamara Marín Begoña Martínez Victoriana Martínez Pablo Martínez-Lage Álvarez Maite Mendioroz Iriarte María Teresa Periñán-Tocino Rocío Pineda-Sánchez Diego Real de Asúa Silvia Rodrigo Isabel Sastre Maria Pilar Vicente Rosario Vigo-Ortega Liliana Vivancos Jacques Epelbaum Didier Hannequin Dominique campion Vincent Deramecourt Christophe Tzourio Alexis Brice Bruno Dubois Amy Williams Charlene Thomas Chloe Davies William Nash Kimberley Dowzell Atahualpa Castillo Morales Mateus Bernardo-Harrington James Turton Jenny Lord Kristelle Brown Emma Vardy Elizabeth Fisher Jason D. Warren Martin Rossor Natalie S. Ryan Rita Guerreiro James Uphill Nick Bass Reinhard Heun Heike Kölsch Britta Schürmann André Lacour Christine Herold Janet A. Johnston Peter Passmore John Powell Yogen Patel Angela Hodges Tim Becker Donald Warden Gordon Wilcock Robert Clarke Panagiotis Deloukas Yoav Ben-Shlomo Nigel M. Hooper Stuart Pickering-Brown Rebecca Sussams Nick Warner Anthony Bayer Isabella Heuser Dmitriy Drichel Norman Klopp Manuel Mayhaus Matthias Riemenschneider Sabrina Pinchler Thomas Feulner Wei Gu Hendrik van den Bussche Michael Hüll Lutz Frölich H-Erich Wichmann Karl-Heinz Jöckel Michael O’Donovan Michael Owen Shahram Bahrami Ingunn Bosnes Per Selnes Sverre Bergh Aarno Palotie Mark Daly Howard Jacob Athena Matakidou Heiko Runz Sally John Robert Plenge Mark McCarthy Julie Hunkapiller Meg Ehm Dawn Waterworth Caroline Fox Anders Malarstig Kathy Klinger Kathy Call Tim Behrens Patrick Loerch Tomi Mäkelä Jaakko Kaprio Petri Virolainen Kari Pulkki Terhi Kilpi Markus Perola Jukka Partanen Anne Pitkäranta Riitta Kaarteenaho Seppo Vainio Miia Turpeinen Raisa Serpi Tarja Laitinen Johanna Mäkelä Veli-Matti Kosma Urho Kujala Outi Tuovila Minna Hendolin Raimo Pakkanen Jeff Waring Bridget Riley-Gillis Jimmy Liu Shameek Biswas Dorothee Diogo Catherine Marshall Xinli Hu Matthias Gossel Robert Graham Beryl Cummings Samuli Ripatti Johanna Schleutker Mikko Arvas Olli Carpén Reetta Hinttala Johannes Kettunen Arto Mannermaa Jari Laukkanen Valtteri Julkunen Anne Remes Reetta Kälviäinen Jukka Peltola Pentti Tienari Juha Rinne Adam Ziemann Jeffrey Waring Sahar Esmaeeli Nizar Smaoui Anne Lehtonen Susan Eaton Sanni Lahdenperä Janet van Adelsberg John Michon Geoff Kerchner Natalie Bowers Edmond Teng John Eicher Vinay Mehta Padhraig Gormley Kari Linden Christopher Whelan Fanli Xu David Pulford Martti Färkkilä Sampsa Pikkarainen Airi Jussila Timo Blomster Mikko Kiviniemi Markku Voutilainen Bob Georgantas Graham Heap Fedik Rahimov Keith Usiskin Tim Lu Danny Oh Kirsi Kalpala Melissa Miller Linda McCarthy Kari Eklund Antti Palomäki Pia Isomäki Laura Pirilä Oili Kaipiainen-Seppänen Johanna Huhtakangas Apinya Lertratanakul Marla Hochfeld Nan Bing Jorge Esparza Gordillo Nina Mars Margit Pelkonen Paula Kauppi Hannu Kankaanranta Terttu Harju David Close Steven Greenberg Hubert Chen Jo Betts Soumitra Ghosh Veikko Salomaa Teemu Niiranen Markus Juonala Kaj Metsärinne Mika Kähönen Juhani Junttila Markku Laakso Jussi Pihlajamäki Juha Sinisalo Marja-Riitta Taskinen Tiinamaija Tuomi Ben Challis Andrew Peterson Audrey Chu Jaakko Parkkinen Anthony Muslin Heikki Joensuu Tuomo Meretoja Lauri Aaltonen Johanna Mattson Annika Auranen Peeter Karihtala Saila Kauppila Päivi Auvinen Klaus Elenius Relja Popovic Jennifer Schutzman Andrey Loboda Aparna Chhibber Heli Lehtonen Stefan McDonough Marika Crohns Diptee Kulkarni Kai Kaarniranta Joni A. Turunen Terhi Ollila Sanna Seitsonen Hannu Uusitalo Vesa Aaltonen Hannele Uusitalo-Järvinen Marja Luodonpää Nina Hautala Stephanie Loomis Erich Strauss Hao Chen Anna Podgornaia Joshua Hoffman Kaisa Tasanen Laura Huilaja Katariina Hannula-Jouppi Teea Salmi Sirkku Peltonen Leena Koulu Ilkka Harvima Ying Wu David Choy Pirkko Pussinen Aino Salminen Tuula Salo David Rice Pekka Nieminen Ulla Palotie Maria Siponen Liisa Suominen Päivi Mäntylä Ulvi Gursoy Vuokko Anttonen Kirsi Sipilä Justin Wade Davis Danjuma Quarless Slavé Petrovski Eleonor Wigmore Chia-Yen Chen Paola Bronson Ellen Tsai Yunfeng Huang Joseph Maranville Elmutaz Shaikho Elhaj Mohammed Samir Wadhawan Erika Kvikstad Minal Caliskan Diana Chang Tushar Bhangale Sarah Pendergrass Emily Holzinger Xing Chen Åsa Hedman Karen S. King Clarence Wang Ethan Xu Franck Auge Clement Chatelain Deepak Rajpal Dongyu Liu Katherine Call Tai-he Xia Matt Brauer Mitja Kurki Juha Karjalainen Aki Havulinna Anu Jalanko Priit Palta Pietro della Briotta Parolo Wei Zhou Susanna Lemmelä Manuel Rivas Jarmo Harju Arto Lehisto Andrea Ganna Vincent Llorens Hannele Laivuori Sina Rüeger Mari E. Niemi Taru Tukiainen Mary Pat Reeve Henrike Heyne Kimmo Palin Javier Garcia-Tabuenca Harri Siirtola Tuomo Kiiskinen Jiwoo Lee Kristin Tsuo Amanda Elliott Kati Kristiansson Kati Hyvärinen Jarmo Ritari Miika Koskinen Katri Pylkäs Marita Kalaoja Minna Karjalainen Tuomo Mantere Eeva Kangasniemi Sami Heikkinen Eija Laakkonen Csilla Sipeky Samuel Heron Antti Karlsson Dhanaprakash Jambulingam Venkat Subramaniam Rathinakannan Risto Kajanne Mervi Aavikko Manuel González Jiménez Pietro della Briotta Parola Arto Lehistö Masahiro Kanai Mari Kaunisto Elina Kilpeläinen Timo P. Sipilä Georg Brein Ghazal Awaisa Anastasia Shcherban Kati Donner Anu Loukola Päivi Laiho Tuuli Sistonen Essi Kaiharju Markku Laukkanen Elina Järvensivu Sini Lähteenmäki Lotta Männikkö Regis Wong Hannele Mattsson Tero Hiekkalinna Teemu Paajanen Kalle Pärn Javier Gracia-Tabuenca Erin Abner Perrie M. Adams Alyssa Aguirre Marilyn S. Albert Roger L. Albin Mariet Allen Lisa Alvarez Liana G. Apostolova Steven E. Arnold Sanjay Asthana Craig S. Atwood Gayle Ayres Clinton T. Baldwin Robert C. Barber Lisa L. Barnes Sandra Barral Thomas G. Beach James T. Becker Gary W. Beecham Duane Beekly Jennifer E. Below Penelope Benchek Bruno A. Benitez David Bennett John Bertelson Flanagan E. Margaret Thomas D. Bird Deborah Blacker Bradley F. Boeve James D. Bowen Adam Boxer James Brewer James R. Burke Jeffrey M. Burns Will S. Bush Joseph D. Buxbaum Nigel J. Cairns Chuanhai Cao Christopher S. Carlson Cynthia M. Carlsson Regina M. Carney Minerva M. Carrasquillo Scott Chasse Marie-Francoise Chesselet Alessandra Chesi Nathaniel A. Chin Helena C. Chui Jaeyoon Chung Suzanne Craft Paul K. Crane David H. Cribbs Elizabeth A. Crocco Carlos Cruchaga Michael L. Cuccaro Munro Cullum Eveleen Darby Barbara Davis Philip L. De Jager Charles DeCarli John DeToledo Malcolm Dick Dennis W. Dickson Beth A. Dombroski Rachelle S. Doody Ranjan Duara Nilüfer Ertekin-Taner Denis A. Evans Thomas J. Fairchild Kenneth B. Fallon Martin R. Farlow John J. Farrell Victoria Fernandez-Hernandez Steven Ferris Matthew P. Frosch Brian Fulton-Howard Douglas R. Galasko Adriana Gamboa Marla Gearing Daniel H. Geschwind Bernardino Ghetti John R. Gilbert Thomas J. Grabowski Neill R. Graff-Radford Struan F. A. Grant Robert C. Green John H. Growdon Jonathan L. Haines Hakon Hakonarson James Hall Ronald L. Hamilton Oscar Harari Lindy E. Harrell Jacob Haut Elizabeth Head Victor W. Henderson Michelle Hernandez Timothy Hohman Lawrence S. Honig Ryan M. Huebinger Matthew J. Huentelman Christine M. Hulette Bradley T. Hyman Linda S. Hynan Laura Ibanez Gail P. Jarvik Suman Jayadev Lee-Way Jin Kim Johnson Leigh Johnson M. Ilyas Kamboh Anna M. Karydas Mindy J. Katz Jeffrey A. Kaye C. Dirk Keene Aisha Khaleeq Ronald Kim Janice Knebl Neil W. Kowall Joel H. Kramer Pavel P. Kuksa Frank M. LaFerla James J. Lah Eric B. Larson Chien-Yueh Lee Edward B. Lee Alan Lerner Yuk Yee Leung James B. Leverenz Allan I. Levey Mingyao Li Andrew P. Lieberman Richard B. Lipton Mark Logue Constantine G. Lyketsos John Malamon Douglas Mains Daniel C. Marson Frank Martiniuk Deborah C. Mash Eliezer Masliah Paul Massman Arjun Masurkar Wayne C. McCormick Susan M. McCurry Andrew N. McDavid Stefan McDonough Ann C. McKee Marsel Mesulam Jesse Mez Bruce L. Miller Carol A. Miller Joshua W. Miller Thomas J. Montine Edwin S. Monuki John C. Morris Amanda J. Myers Trung Nguyen Sid O’Bryant John M. Olichney Marcia Ory Raymond Palmer Joseph E. Parisi Henry L. Paulson Valory Pavlik David Paydarfar Victoria Perez Elaine Peskind Ronald C. Petersen Jennifer E. Phillips-Cremins Aimee Pierce Marsha Polk Wayne W. Poon Huntington Potter Liming Qu Mary Quiceno Joseph F. Quinn Ashok Raj Murray Raskind Eric M. Reiman Barry Reisberg Joan S. Reisch John M. Ringman Erik D. Roberson Monica Rodriguear Ekaterina Rogaeva Howard J. Rosen Roger N. Rosenberg Donald R. Royall Mark A. Sager Mary Sano Andrew J. Saykin Julie A. Schneider Lon S. Schneider William W. Seeley Susan H. Slifer Scott Small Amanda G. Smith Janet P. Smith Yeunjoo E. Song Joshua A. Sonnen Salvatore Spina Peter St George-Hyslop Robert A. Stern Alan B. Stevens Stephen M. Strittmatter David Sultzer Russell H. Swerdlow Rudolph E. Tanzi Jeffrey L. Tilson John Q. Trojanowski Juan C. Troncoso Debby W. Tsuang Otto Valladares Vivianna M. Van Deerlin Linda J. van Eldik Robert Vassar Harry V. Vinters Jean-Paul Vonsattel Sandra Weintraub Kathleen A. Welsh-Bohmer Patrice L. Whitehead Ellen M. Wijsman Kirk C. Wilhelmsen Benjamin Williams Jennifer Williamson Henrik Wilms Thomas S. Wingo Thomas Wisniewski Randall L. Woltjer Martin Woon Clinton B. Wright Chuang-Kuo Wu Steven G. Younkin Chang-En Yu Lei Yu Yuanchao Zhang Yi Zhao Xiongwei Zhu Hieab Adams Rufus O. Akinyemi Muhammad Ali Nicola Armstrong Hugo J. Aparicio Maryam Bahadori James T. Becker Monique Breteler Daniel Chasman Ganesh Chauhan Hata Comic Simon Cox Adrienne L. Cupples Gail Davies Charles S. DeCarli Marie-Gabrielle Duperron Josée Dupuis Tavia Evans Frank Fan Annette Fitzpatrick Alison E. Fohner Mary Ganguli Mirjam Geerlings Stephen J. Glatt Hector M. Gonzalez Monica Goss Hans Grabe Mohamad Habes Susan R. Heckbert Edith Hofer Elliot Hong Timothy Hughes Tiffany F. Kautz Maria Knol William Kremen Paul Lacaze Jari Lahti Quentin Le Grand Elizabeth Litkowski Shuo Li Dan Liu Xuan Liu Marisa Loitfelder Alisa Manning Pauline Maillard Riccardo Marioni Bernard Mazoyer Debora Melo van Lent Hao Mei Aniket Mishra Paul Nyquist Jeffrey O’Connell Yash Patel Tomas Paus Zdenka Pausova Katri Raikkonen-Talvitie Moeen Riaz Stephen Rich Jerome Rotter Jose Romero Gena Roshchupkin Yasaman Saba Murali Sargurupremraj Helena Schmidt Reinhold Schmidt Joshua M. Shulman Jennifer Smith Hema Sekhar Reddy Rajula Jean Shin Jeannette Simino Eeva Sliz Alexander Teumer Alvin Thomas Adrienne Tin Elliot Tucker-Drob Dina Vojinovic Yanbing Wang Galit Weinstein Dylan Williams Katharina Wittfeld Lisa Yanek Yunju Yang Lindsay A. Farrer Bruce M. Psaty Mohsen Ghanbari Towfique Raj Perminder Sachdev Karen Mather Frank Jessen M. Arfan Ikram Alexandre de Mendonça Jakub Hort Magda Tsolaki Margaret A. Pericak-Vance Philippe Amouyel Julie Williams Ruth Frikke-Schmidt Jordi Clarimon Jean-François Deleuze Giacomina Rossi Sudha Seshadri Ole A. Andreassen Martin Ingelsson Mikko Hiltunen Kristel Sleegers Gerard D. Schellenberg Cornelia M. van Duijn Rebecca Sims Wiesje M. van der Flier Agustín Ruiz Alfredo Ramirez Jean-Charles Lambert (EADB) (GR@ACE) (DEGESCO) (EADI) (GERAD) (Demgene) (FinnGen) (ADGC) (CHARGE) |
format |
Journal article |
container_title |
Nature Genetics |
container_volume |
54 |
container_issue |
4 |
container_start_page |
412 |
publishDate |
2022 |
institution |
Swansea University |
issn |
1061-4036 1546-1718 |
doi_str_mv |
10.1038/s41588-022-01024-z |
publisher |
Springer Science and Business Media LLC |
college_str |
Faculty of Medicine, Health and Life Sciences |
hierarchytype |
|
hierarchy_top_id |
facultyofmedicinehealthandlifesciences |
hierarchy_top_title |
Faculty of Medicine, Health and Life Sciences |
hierarchy_parent_id |
facultyofmedicinehealthandlifesciences |
hierarchy_parent_title |
Faculty of Medicine, Health and Life Sciences |
department_str |
The Centre for Innovative Ageing{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}The Centre for Innovative Ageing |
document_store_str |
1 |
active_str |
0 |
description |
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. |
published_date |
2022-04-04T04:18:50Z |
_version_ |
1763754251612323840 |
score |
11.037056 |