No Cover Image

Journal article 500 views 58 downloads

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Céline Bellenguez Orcid Logo, Fahri Küçükali Orcid Logo, Iris E. Jansen, Luca Kleineidam, Sonia Moreno-Grau, Najaf Amin Orcid Logo, Adam C. Naj, Rafael Campos-Martin, Benjamin Grenier-Boley, Victor Andrade, Peter A. Holmans Orcid Logo, Anne Boland, Vincent Damotte, Sven J. van der Lee Orcid Logo, Marcos R. Costa Orcid Logo, Teemu Kuulasmaa Orcid Logo, Qiong Yang Orcid Logo, Itziar de Rojas Orcid Logo, Joshua C. Bis Orcid Logo, Amber Yaqub Orcid Logo, Ivana Prokic Orcid Logo, Julien Chapuis Orcid Logo, Shahzad Ahmad Orcid Logo, Vilmantas Giedraitis Orcid Logo, Dag Aarsland, Pablo Garcia-Gonzalez Orcid Logo, Carla Abdelnour, Emilio Alarcón-Martín, Daniel Alcolea Orcid Logo, Montserrat Alegret, Ignacio Alvarez Orcid Logo, Victoria Álvarez, Nicola J. Armstrong, Anthoula Tsolaki Orcid Logo, Carmen Antúnez, Ildebrando Appollonio, Marina Arcaro, Silvana Archetti, Alfonso Arias Pastor, Beatrice Arosio, Lavinia Athanasiu, Henri Bailly, Nerisa Banaj, Miquel Baquero Orcid Logo, Sandra Barral, Alexa Beiser, Ana Belén Pastor Orcid Logo, Jennifer E. Below, Penelope Benchek, Luisa Benussi, Claudine Berr Orcid Logo, Céline Besse, Valentina Bessi Orcid Logo, Giuliano Binetti, Alessandra Bizarro, Rafael Blesa, Mercè Boada Orcid Logo, Eric Boerwinkle, Barbara Borroni, Silvia Boschi, Paola Bossù Orcid Logo, Geir Bråthen Orcid Logo, Jan Bressler Orcid Logo, Catherine Bresner Orcid Logo, Henry Brodaty Orcid Logo, Keeley J. Brookes Orcid Logo, Luis Ignacio Brusco, Dolores Buiza-Rueda, Katharina Bûrger, Vanessa Burholt Orcid Logo, William S. Bush Orcid Logo, Miguel Calero Orcid Logo, Laura B. Cantwell, Geneviève Chene, Jaeyoon Chung Orcid Logo, Michael L. Cuccaro, Ángel Carracedo, Roberta Cecchetti, Laura Cervera-Carles Orcid Logo, Camille Charbonnier, Hung-Hsin Chen, Caterina Chillotti, Simona Ciccone, Jurgen A. H. R. Claassen, Christopher Clark, Elisa Conti, Anaïs Corma-Gómez, Emanuele Costantini Orcid Logo, Carlo Custodero, Delphine Daian, Maria Carolina Dalmasso Orcid Logo, Antonio Daniele, Efthimios Dardiotis, Jean-François Dartigues, Peter Paul de Deyn, Katia de Paiva Lopes Orcid Logo, Lot D. de Witte Orcid Logo, Stéphanie Debette Orcid Logo, Jürgen Deckert, Teodoro del Ser Orcid Logo, Nicola Denning, Anita DeStefano, Martin Dichgans Orcid Logo, Janine Diehl-Schmid Orcid Logo, Mónica Diez-Fairen Orcid Logo, Paolo Dionigi Rossi, Srdjan Djurovic Orcid Logo, Emmanuelle Duron, Emrah Düzel, Carole Dufouil Orcid Logo, Gudny Eiriksdottir, Sebastiaan Engelborghs, Valentina Escott-Price Orcid Logo, Ana Espinosa, Michael Ewers Orcid Logo, Kelley M. Faber, Tagliavini Fabrizio Orcid Logo, Sune Fallgaard Nielsen, David W. Fardo, Lucia Farotti, Chiara Fenoglio, Marta Fernández-Fuertes, Raffaele Ferrari, Catarina B. Ferreira, Evelyn Ferri, Bertrand Fin, Peter Fischer, Tormod Fladby Orcid Logo, Klaus Fließbach, Bernard Fongang, Myriam Fornage Orcid Logo, Juan Fortea, Tatiana M. Foroud, Silvia Fostinelli, Nick C. Fox Orcid Logo, Emlio Franco-Macías, María J. Bullido Orcid Logo, Ana Frank-García, Lutz Froelich Orcid Logo, Brian Fulton-Howard, Daniela Galimberti Orcid Logo, Jose Maria García-Alberca Orcid Logo, Pablo García-González, Sebastian Garcia-Madrona, Guillermo Garcia-Ribas, Roberta Ghidoni, Ina Giegling, Giaccone Giorgio, Alison M. Goate Orcid Logo, Oliver Goldhardt, Duber Gomez-Fonseca, Antonio González-Pérez Orcid Logo, Caroline Graff, Giulia Grande, Emma Green Orcid Logo, Timo Grimmer, Edna Grünblatt Orcid Logo, Michelle Grunin, Vilmundur Gudnason Orcid Logo, Tamar Guetta-Baranes, Annakaisa Haapasalo Orcid Logo, Georgios Hadjigeorgiou, Jonathan L. Haines, Kara L. Hamilton-Nelson, Harald Hampel, Olivier Hanon, John Hardy, Annette M. Hartmann, Lucrezia Hausner, Janet Harwood Orcid Logo, Stefanie Heilmann-Heimbach Orcid Logo, Seppo Helisalmi, Michael T. Heneka, Isabel Hernández, Martin J. Herrmann Orcid Logo, Per Hoffmann, Clive Holmes, Henne Holstege Orcid Logo, Raquel Huerto Vilas, Marc Hulsman, Jack Humphrey, Geert Jan Biessels Orcid Logo, Xueqiu Jian Orcid Logo, Charlotte Johansson Orcid Logo, Gyungah R. Jun Orcid Logo, Yuriko Kastumata Orcid Logo, John Kauwe, Patrick G. Kehoe Orcid Logo, Lena Kilander, Anne Kinhult Ståhlbom, Miia Kivipelto, Anne Koivisto, Johannes Kornhuber Orcid Logo, Mary H. Kosmidis Orcid Logo, Walter A. Kukull, Pavel P. Kuksa, Brian W. Kunkle, Amanda B. Kuzma, Carmen Lage Orcid Logo, Erika J. Laukka, Lenore Launer Orcid Logo, Alessandra Lauria, Chien-Yueh Lee Orcid Logo, Jenni Lehtisalo, Ondrej Lerch, Alberto Lleó Orcid Logo, William Longstreth, Oscar Lopez Orcid Logo, Adolfo Lopez de Munain Orcid Logo, Seth Love, Malin Löwemark, Lauren Luckcuck, Kathryn L. Lunetta Orcid Logo, Yiyi Ma Orcid Logo, Juan Macías, Catherine A. MacLeod Orcid Logo, Wolfgang Maier, Francesca Mangialasche, Marco Spallazzi, Marta Marquié Orcid Logo, Rachel Marshall, Eden R. Martin, Angel Martín Montes Orcid Logo, Carmen Martínez Rodríguez, Carlo Masullo, Richard Mayeux, Simon Mead Orcid Logo, Patrizia Mecocci, Miguel Medina Orcid Logo, Alun Meggy, Shima Mehrabian, Silvia Mendoza, Manuel Menéndez-González Orcid Logo, Pablo Mir, Susanne Moebus, Merel Mol Orcid Logo, Laura Molina-Porcel, Laura Montrreal, Laura Morelli, Fermin Moreno, Kevin Morgan Orcid Logo, Thomas Mosley, Markus M. Nöthen Orcid Logo, Carolina Muchnik Orcid Logo, Shubhabrata Mukherjee, Benedetta Nacmias Orcid Logo, Tiia Ngandu, Gael Nicolas Orcid Logo, Børge G. Nordestgaard Orcid Logo, Robert Olaso, Adelina Orellana, Michela Orsini, Gemma Ortega, Alessandro Padovani, Caffarra Paolo, Goran Papenberg, Lucilla Parnetti, Florence Pasquier Orcid Logo, Pau Pastor Orcid Logo, Gina Peloso Orcid Logo, Alba Pérez-Cordón Orcid Logo, Jordi Pérez-Tur Orcid Logo, Pierre Pericard Orcid Logo, Oliver Peters, Yolande A. L. Pijnenburg, Juan A. Pineda Orcid Logo, Gerard Piñol-Ripoll, Claudia Pisanu Orcid Logo, Thomas Polak, Julius Popp, Danielle Posthuma Orcid Logo, Josef Priller, Raquel Puerta Orcid Logo, Olivier Quenez Orcid Logo, Inés Quintela, Jesper Qvist Thomassen Orcid Logo, Alberto Rábano, Innocenzo Rainero, Farid Rajabli, Inez Ramakers, Luis M. Real Orcid Logo, Marcel J. T. Reinders Orcid Logo, Christiane Reitz Orcid Logo, Dolly Reyes-Dumeyer, Perry Ridge, Steffi Riedel-Heller Orcid Logo, Peter Riederer, Natalia Roberto, Eloy Rodriguez-Rodriguez Orcid Logo, Arvid Rongve Orcid Logo, Irene Rosas Allende, Maitée Rosende-Roca, Jose Luis Royo, Elisa Rubino, Dan Rujescu, María Eugenia Sáez Orcid Logo, Paraskevi Sakka, Ingvild Saltvedt Orcid Logo, Ángela Sanabria, María Bernal Sánchez-Arjona, Florentino Sanchez-Garcia, Pascual Sánchez Juan Orcid Logo, Raquel Sánchez-Valle, Sigrid B. Sando, Chloé Sarnowski Orcid Logo, Claudia L. Satizabal Orcid Logo, Michela Scamosci, Nikolaos Scarmeas, Elio Scarpini, Philip Scheltens, Norbert Scherbaum, Martin Scherer, Matthias Schmid, Anja Schneider, Jonathan M. Schott Orcid Logo, Geir Selbæk Orcid Logo, Davide Seripa, Manuel Serrano, Jin Sha, Alexey A. Shadrin Orcid Logo, Olivia Skrobot, Susan Slifer, Gijsje J. L. Snijders, Hilkka Soininen Orcid Logo, Vincenzo Solfrizzi Orcid Logo, Alina Solomon, Yeunjoo Song Orcid Logo, Sandro Sorbi, Oscar Sotolongo-Grau Orcid Logo, Gianfranco Spalletta Orcid Logo, Annika Spottke, Alessio Squassina Orcid Logo, Eystein Stordal Orcid Logo, Juan Pablo Tartan, Lluís Tárraga, Niccolo Tesí, Anbupalam Thalamuthu, Tegos Thomas, Giuseppe Tosto Orcid Logo, Latchezar Traykov, Lucio Tremolizzo, Anne Tybjærg-Hansen, Andre Uitterlinden Orcid Logo, Abbe Ullgren, Ingun Ulstein, Sergi Valero, Otto Valladares Orcid Logo, Christine Van Broeckhoven Orcid Logo, Jeffery Vance, Badri N. Vardarajan, Aad van der Lugt, Jasper Van Dongen, Jeroen van Rooij, John van Swieten, Rik Vandenberghe, Frans Verhey, Jean-Sébastien Vidal Orcid Logo, Jonathan Vogelgsang Orcid Logo, Martin Vyhnalek, Michael Wagner Orcid Logo, David Wallon Orcid Logo, Li-San Wang, Ruiqi Wang, Leonie Weinhold, Jens Wiltfang Orcid Logo, Gill Windle, Bob Woods Orcid Logo, Mary Yannakoulia Orcid Logo, Habil Zare Orcid Logo, Yi Zhao, Xiaoling Zhang Orcid Logo, Congcong Zhu, Miren Zulaica, Jan Laczo, Vaclav Matoska, Maria Serpente, Francesca Assogna, Fabrizio Piras, Federica Piras, Valentina Ciullo, Jacob Shofany, Carlo Ferrarese, Simona Andreoni, Gessica Sala, Chiara Paola Zoia, Maria Del Zompo, Alberto Benussi, Patrizia Bastiani, Mari Takalo, Teemu Natunen, Tiina Laatikainen, Jaakko Tuomilehto, Riitta Antikainen, Timo Strandberg, Jaana Lindström, Markku Peltonen, Richard Abraham, Ammar Al-Chalabi, Nicholas J. Bass, Carol Brayne, Kristelle S. Brown, John Collinge, David Craig, Pangiotis Deloukas, Nick Fox, Amy Gerrish, Michael Gill, Rhian Gwilliam, Denise Harold, Paul Hollingworth, Jarret A. Johnston, Lesley Jones, Brian Lawlor, Gill Livingston, Simon Lovestone, Michelle Lupton, Aoibhinn Lynch, David Mann, Bernadette McGuinness, Andrew McQuillin, Michael C. O’Donovan, Michael J. Owen, Peter Passmore, John F. Powell, Petra Proitsi, Martin Rossor, Christopher E. Shaw, A. David Smith, Hugh Gurling, Stephen Todd, Catherine Mummery, Nathalie Ryan, Giordano Lacidogna, Ad Adarmes-Gómez, Ana Mauleón, Ana Pancho, Anna Gailhajenet, Asunción Lafuente, D. Macias-García, Elvira Martín, Esther Pelejà, F. Carrillo, Isabel Sastre Merlín, L. Garrote-Espina, Liliana Vargas, M. Carrion-Claro, M. Marín, Ma Labrador, Mar Buendia, María Dolores Alonso, Marina Guitart, Mariona Moreno, Marta Ibarria, Mt Periñán, Nuria Aguilera, P. Gómez-Garre, Pilar Cañabate, R. Escuela, R. Pineda-Sánchez, R. Vigo-Ortega, S. Jesús, Silvia Preckler, Silvia Rodrigo-Herrero, Susana Diego, Alessandro Vacca, Fausto Roveta, Nicola Salvadori, Elena Chipi, Henning Boecker, Christoph Laske, Robert Perneczky, Costas Anastasiou, Daniel Janowitz, Rainer Malik, Anna Anastasiou, Kayenat Parveen, Carmen Lage, Sara López-García, Anna Antonell, Kalina Yonkova Mihova, Diyana Belezhanska, Heike Weber, Silvia Kochen, Patricia Solis, Nancy Medel, Julieta Lisso, Zulma Sevillano, Daniel G. Politis, Valeria Cores, Carolina Cuesta, Cecilia Ortiz, Juan Ignacio Bacha, Mario Rios, Aldo Saenz, Mariana Sanchez Abalos, Eduardo Kohler, Dana Lis Palacio, Ignacio Etchepareborda, Matias Kohler, Gisela Novack, Federico Ariel Prestia, Pablo Galeano, Eduardo M. Castaño, Sandra Germani, Carlos Reyes Toso, Matias Rojo, Carlos Ingino, Carlos Mangone, David C. Rubinsztein, Stefan Teipel, Nathalie Fievet, Vincent Deramerourt, Charlotte Forsell, Håkan Thonberg, Maria Bjerke, Ellen De Roeck, María Teresa Martínez-Larrad, Natividad Olivar, Nuria Aguilera, Amanda Cano, Pilar Cañabate, Juan Macias, Olalla Maroñas, Raúl Nuñez-Llaves, Clàudia Olivé, Ester Pelejá, Astrid D. Adarmes-Gómez, María Dolores Alonso, Guillermo Amer-Ferrer, Martirio Antequera, Juan Andrés Burguera, Fátima Carrillo, Mario Carrión-Claro, María José Casajeros, Marian Martinez de Pancorbo, Rocío Escuela, Lorena Garrote-Espina, Pilar Gómez-Garre, Saray Hevilla, Silvia Jesús, Miguel Angel Labrador Espinosa, Agustina Legaz, Sara López-García, Daniel Macias-García, Salvadora Manzanares, Marta Marín, Juan Marín-Muñoz, Tamara Marín, Begoña Martínez, Victoriana Martínez, Pablo Martínez-Lage Álvarez, Maite Mendioroz Iriarte, María Teresa Periñán-Tocino, Rocío Pineda-Sánchez, Diego Real de Asúa, Silvia Rodrigo, Isabel Sastre, Maria Pilar Vicente, Rosario Vigo-Ortega, Liliana Vivancos, Jacques Epelbaum, Didier Hannequin, Dominique campion, Vincent Deramecourt, Christophe Tzourio, Alexis Brice, Bruno Dubois, Amy Williams, Charlene Thomas, Chloe Davies, William Nash, Kimberley Dowzell, Atahualpa Castillo Morales, Mateus Bernardo-Harrington, James Turton, Jenny Lord, Kristelle Brown, Emma Vardy, Elizabeth Fisher, Jason D. Warren, Martin Rossor, Natalie S. Ryan, Rita Guerreiro, James Uphill, Nick Bass, Reinhard Heun, Heike Kölsch, Britta Schürmann, André Lacour, Christine Herold, Janet A. Johnston, Peter Passmore, John Powell, Yogen Patel, Angela Hodges, Tim Becker, Donald Warden, Gordon Wilcock, Robert Clarke, Panagiotis Deloukas, Yoav Ben-Shlomo, Nigel M. Hooper, Stuart Pickering-Brown, Rebecca Sussams, Nick Warner, Anthony Bayer, Isabella Heuser, Dmitriy Drichel, Norman Klopp, Manuel Mayhaus, Matthias Riemenschneider, Sabrina Pinchler, Thomas Feulner, Wei Gu, Hendrik van den Bussche, Michael Hüll, Lutz Frölich, H-Erich Wichmann, Karl-Heinz Jöckel, Michael O’Donovan, Michael Owen, Shahram Bahrami, Ingunn Bosnes, Per Selnes, Sverre Bergh, Aarno Palotie, Mark Daly, Howard Jacob, Athena Matakidou, Heiko Runz, Sally John, Robert Plenge, Mark McCarthy, Julie Hunkapiller, Meg Ehm, Dawn Waterworth, Caroline Fox, Anders Malarstig, Kathy Klinger, Kathy Call, Tim Behrens, Patrick Loerch, Tomi Mäkelä, Jaakko Kaprio, Petri Virolainen, Kari Pulkki, Terhi Kilpi, Markus Perola, Jukka Partanen, Anne Pitkäranta, Riitta Kaarteenaho, Seppo Vainio, Miia Turpeinen, Raisa Serpi, Tarja Laitinen, Johanna Mäkelä, Veli-Matti Kosma, Urho Kujala, Outi Tuovila, Minna Hendolin, Raimo Pakkanen, Jeff Waring, Bridget Riley-Gillis, Jimmy Liu, Shameek Biswas, Dorothee Diogo, Catherine Marshall, Xinli Hu, Matthias Gossel, Robert Graham, Beryl Cummings, Samuli Ripatti, Johanna Schleutker, Mikko Arvas, Olli Carpén, Reetta Hinttala, Johannes Kettunen, Arto Mannermaa, Jari Laukkanen, Valtteri Julkunen, Anne Remes, Reetta Kälviäinen, Jukka Peltola, Pentti Tienari, Juha Rinne, Adam Ziemann, Jeffrey Waring, Sahar Esmaeeli, Nizar Smaoui, Anne Lehtonen, Susan Eaton, Sanni Lahdenperä, Janet van Adelsberg, John Michon, Geoff Kerchner, Natalie Bowers, Edmond Teng, John Eicher, Vinay Mehta, Padhraig Gormley, Kari Linden, Christopher Whelan, Fanli Xu, David Pulford, Martti Färkkilä, Sampsa Pikkarainen, Airi Jussila, Timo Blomster, Mikko Kiviniemi, Markku Voutilainen, Bob Georgantas, Graham Heap, Fedik Rahimov, Keith Usiskin, Tim Lu, Danny Oh, Kirsi Kalpala, Melissa Miller, Linda McCarthy, Kari Eklund, Antti Palomäki, Pia Isomäki, Laura Pirilä, Oili Kaipiainen-Seppänen, Johanna Huhtakangas, Apinya Lertratanakul, Marla Hochfeld, Nan Bing, Jorge Esparza Gordillo, Nina Mars, Margit Pelkonen, Paula Kauppi, Hannu Kankaanranta, Terttu Harju, David Close, Steven Greenberg, Hubert Chen, Jo Betts, Soumitra Ghosh, Veikko Salomaa, Teemu Niiranen, Markus Juonala, Kaj Metsärinne, Mika Kähönen, Juhani Junttila, Markku Laakso, Jussi Pihlajamäki, Juha Sinisalo, Marja-Riitta Taskinen, Tiinamaija Tuomi, Ben Challis, Andrew Peterson, Audrey Chu, Jaakko Parkkinen, Anthony Muslin, Heikki Joensuu, Tuomo Meretoja, Lauri Aaltonen, Johanna Mattson, Annika Auranen, Peeter Karihtala, Saila Kauppila, Päivi Auvinen, Klaus Elenius, Relja Popovic, Jennifer Schutzman, Andrey Loboda, Aparna Chhibber, Heli Lehtonen, Stefan McDonough, Marika Crohns, Diptee Kulkarni, Kai Kaarniranta, Joni A. Turunen, Terhi Ollila, Sanna Seitsonen, Hannu Uusitalo, Vesa Aaltonen, Hannele Uusitalo-Järvinen, Marja Luodonpää, Nina Hautala, Stephanie Loomis, Erich Strauss, Hao Chen, Anna Podgornaia, Joshua Hoffman, Kaisa Tasanen, Laura Huilaja, Katariina Hannula-Jouppi, Teea Salmi, Sirkku Peltonen, Leena Koulu, Ilkka Harvima, Ying Wu, David Choy, Pirkko Pussinen, Aino Salminen, Tuula Salo, David Rice, Pekka Nieminen, Ulla Palotie, Maria Siponen, Liisa Suominen, Päivi Mäntylä, Ulvi Gursoy, Vuokko Anttonen, Kirsi Sipilä, Justin Wade Davis, Danjuma Quarless, Slavé Petrovski, Eleonor Wigmore, Chia-Yen Chen, Paola Bronson, Ellen Tsai, Yunfeng Huang, Joseph Maranville, Elmutaz Shaikho, Elhaj Mohammed, Samir Wadhawan, Erika Kvikstad, Minal Caliskan, Diana Chang, Tushar Bhangale, Sarah Pendergrass, Emily Holzinger, Xing Chen, Åsa Hedman, Karen S. King, Clarence Wang, Ethan Xu, Franck Auge, Clement Chatelain, Deepak Rajpal, Dongyu Liu, Katherine Call, Tai-he Xia, Matt Brauer, Mitja Kurki, Juha Karjalainen, Aki Havulinna, Anu Jalanko, Priit Palta, Pietro della Briotta Parolo, Wei Zhou, Susanna Lemmelä, Manuel Rivas, Jarmo Harju, Arto Lehisto, Andrea Ganna, Vincent Llorens, Hannele Laivuori, Sina Rüeger, Mari E. Niemi, Taru Tukiainen, Mary Pat Reeve, Henrike Heyne, Kimmo Palin, Javier Garcia-Tabuenca, Harri Siirtola, Tuomo Kiiskinen, Jiwoo Lee, Kristin Tsuo, Amanda Elliott, Kati Kristiansson, Kati Hyvärinen, Jarmo Ritari, Miika Koskinen, Katri Pylkäs, Marita Kalaoja, Minna Karjalainen, Tuomo Mantere, Eeva Kangasniemi, Sami Heikkinen, Eija Laakkonen, Csilla Sipeky, Samuel Heron, Antti Karlsson, Dhanaprakash Jambulingam, Venkat Subramaniam Rathinakannan, Risto Kajanne, Mervi Aavikko, Manuel González Jiménez, Pietro della Briotta Parola, Arto Lehistö, Masahiro Kanai, Mari Kaunisto, Elina Kilpeläinen, Timo P. Sipilä, Georg Brein, Ghazal Awaisa, Anastasia Shcherban, Kati Donner, Anu Loukola, Päivi Laiho, Tuuli Sistonen, Essi Kaiharju, Markku Laukkanen, Elina Järvensivu, Sini Lähteenmäki, Lotta Männikkö, Regis Wong, Hannele Mattsson, Tero Hiekkalinna, Teemu Paajanen, Kalle Pärn, Javier Gracia-Tabuenca, Erin Abner, Perrie M. Adams, Alyssa Aguirre, Marilyn S. Albert, Roger L. Albin, Mariet Allen, Lisa Alvarez, Liana G. Apostolova, Steven E. Arnold, Sanjay Asthana, Craig S. Atwood, Gayle Ayres, Clinton T. Baldwin, Robert C. Barber, Lisa L. Barnes, Sandra Barral, Thomas G. Beach, James T. Becker, Gary W. Beecham, Duane Beekly, Jennifer E. Below Orcid Logo, Penelope Benchek, Bruno A. Benitez, David Bennett, John Bertelson, Flanagan E. Margaret, Thomas D. Bird, Deborah Blacker, Bradley F. Boeve, James D. Bowen, Adam Boxer, James Brewer, James R. Burke, Jeffrey M. Burns, Will S. Bush, Joseph D. Buxbaum, Nigel J. Cairns, Chuanhai Cao, Christopher S. Carlson, Cynthia M. Carlsson, Regina M. Carney, Minerva M. Carrasquillo, Scott Chasse, Marie-Francoise Chesselet, Alessandra Chesi, Nathaniel A. Chin, Helena C. Chui, Jaeyoon Chung, Suzanne Craft, Paul K. Crane, David H. Cribbs, Elizabeth A. Crocco, Carlos Cruchaga, Michael L. Cuccaro, Munro Cullum, Eveleen Darby, Barbara Davis, Philip L. De Jager, Charles DeCarli, John DeToledo, Malcolm Dick, Dennis W. Dickson, Beth A. Dombroski, Rachelle S. Doody, Ranjan Duara, Nilüfer Ertekin-Taner, Denis A. Evans, Thomas J. Fairchild, Kenneth B. Fallon, Martin R. Farlow, John J. Farrell, Victoria Fernandez-Hernandez, Steven Ferris, Matthew P. Frosch, Brian Fulton-Howard, Douglas R. Galasko, Adriana Gamboa, Marla Gearing, Daniel H. Geschwind, Bernardino Ghetti, John R. Gilbert, Thomas J. Grabowski, Neill R. Graff-Radford, Struan F. A. Grant, Robert C. Green, John H. Growdon, Jonathan L. Haines, Hakon Hakonarson, James Hall, Ronald L. Hamilton, Oscar Harari, Lindy E. Harrell, Jacob Haut, Elizabeth Head, Victor W. Henderson, Michelle Hernandez, Timothy Hohman, Lawrence S. Honig, Ryan M. Huebinger, Matthew J. Huentelman, Christine M. Hulette, Bradley T. Hyman, Linda S. Hynan, Laura Ibanez, Gail P. Jarvik, Suman Jayadev, Lee-Way Jin, Kim Johnson, Leigh Johnson, M. Ilyas Kamboh, Anna M. Karydas, Mindy J. Katz, Jeffrey A. Kaye, C. Dirk Keene, Aisha Khaleeq, Ronald Kim, Janice Knebl, Neil W. Kowall, Joel H. Kramer, Pavel P. Kuksa, Frank M. LaFerla, James J. Lah, Eric B. Larson, Chien-Yueh Lee, Edward B. Lee, Alan Lerner, Yuk Yee Leung, James B. Leverenz, Allan I. Levey, Mingyao Li, Andrew P. Lieberman, Richard B. Lipton, Mark Logue, Constantine G. Lyketsos, John Malamon, Douglas Mains, Daniel C. Marson, Frank Martiniuk, Deborah C. Mash, Eliezer Masliah, Paul Massman, Arjun Masurkar, Wayne C. McCormick, Susan M. McCurry, Andrew N. McDavid, Stefan McDonough, Ann C. McKee, Marsel Mesulam, Jesse Mez, Bruce L. Miller, Carol A. Miller, Joshua W. Miller, Thomas J. Montine, Edwin S. Monuki, John C. Morris, Amanda J. Myers, Trung Nguyen, Sid O’Bryant, John M. Olichney, Marcia Ory, Raymond Palmer, Joseph E. Parisi, Henry L. Paulson, Valory Pavlik, David Paydarfar, Victoria Perez, Elaine Peskind, Ronald C. Petersen, Jennifer E. Phillips-Cremins, Aimee Pierce, Marsha Polk, Wayne W. Poon, Huntington Potter, Liming Qu, Mary Quiceno, Joseph F. Quinn, Ashok Raj, Murray Raskind, Eric M. Reiman, Barry Reisberg, Joan S. Reisch, John M. Ringman, Erik D. Roberson, Monica Rodriguear, Ekaterina Rogaeva, Howard J. Rosen, Roger N. Rosenberg, Donald R. Royall, Mark A. Sager, Mary Sano, Andrew J. Saykin, Julie A. Schneider, Lon S. Schneider, William W. Seeley, Susan H. Slifer, Scott Small, Amanda G. Smith, Janet P. Smith, Yeunjoo E. Song, Joshua A. Sonnen, Salvatore Spina, Peter St George-Hyslop, Robert A. Stern, Alan B. Stevens, Stephen M. Strittmatter, David Sultzer, Russell H. Swerdlow, Rudolph E. Tanzi, Jeffrey L. Tilson, John Q. Trojanowski, Juan C. Troncoso, Debby W. Tsuang, Otto Valladares, Vivianna M. Van Deerlin, Linda J. van Eldik, Robert Vassar, Harry V. Vinters, Jean-Paul Vonsattel, Sandra Weintraub, Kathleen A. Welsh-Bohmer, Patrice L. Whitehead, Ellen M. Wijsman, Kirk C. Wilhelmsen, Benjamin Williams, Jennifer Williamson, Henrik Wilms, Thomas S. Wingo, Thomas Wisniewski, Randall L. Woltjer, Martin Woon, Clinton B. Wright, Chuang-Kuo Wu, Steven G. Younkin, Chang-En Yu, Lei Yu, Yuanchao Zhang, Yi Zhao, Xiongwei Zhu, Hieab Adams, Rufus O. Akinyemi, Muhammad Ali, Nicola Armstrong, Hugo J. Aparicio, Maryam Bahadori, James T. Becker, Monique Breteler, Daniel Chasman, Ganesh Chauhan, Hata Comic, Simon Cox, Adrienne L. Cupples, Gail Davies, Charles S. DeCarli, Marie-Gabrielle Duperron, Josée Dupuis, Tavia Evans, Frank Fan, Annette Fitzpatrick, Alison E. Fohner, Mary Ganguli, Mirjam Geerlings, Stephen J. Glatt, Hector M. Gonzalez, Monica Goss, Hans Grabe, Mohamad Habes, Susan R. Heckbert, Edith Hofer, Elliot Hong, Timothy Hughes, Tiffany F. Kautz, Maria Knol, William Kremen, Paul Lacaze, Jari Lahti, Quentin Le Grand, Elizabeth Litkowski, Shuo Li, Dan Liu, Xuan Liu, Marisa Loitfelder, Alisa Manning, Pauline Maillard, Riccardo Marioni, Bernard Mazoyer, Debora Melo van Lent, Hao Mei, Aniket Mishra, Paul Nyquist, Jeffrey O’Connell, Yash Patel, Tomas Paus, Zdenka Pausova, Katri Raikkonen-Talvitie, Moeen Riaz, Stephen Rich, Jerome Rotter, Jose Romero, Gena Roshchupkin, Yasaman Saba, Murali Sargurupremraj, Helena Schmidt, Reinhold Schmidt, Joshua M. Shulman, Jennifer Smith, Hema Sekhar, Reddy Rajula, Jean Shin, Jeannette Simino, Eeva Sliz, Alexander Teumer, Alvin Thomas, Adrienne Tin, Elliot Tucker-Drob, Dina Vojinovic, Yanbing Wang, Galit Weinstein, Dylan Williams, Katharina Wittfeld, Lisa Yanek, Yunju Yang, Lindsay A. Farrer Orcid Logo, Bruce M. Psaty Orcid Logo, Mohsen Ghanbari Orcid Logo, Towfique Raj Orcid Logo, Perminder Sachdev Orcid Logo, Karen Mather Orcid Logo, Frank Jessen, M. Arfan Ikram Orcid Logo, Alexandre de Mendonça, Jakub Hort, Magda Tsolaki Orcid Logo, Margaret A. Pericak-Vance Orcid Logo, Philippe Amouyel Orcid Logo, Julie Williams Orcid Logo, Ruth Frikke-Schmidt Orcid Logo, Jordi Clarimon, Jean-François Deleuze, Giacomina Rossi, Sudha Seshadri Orcid Logo, Ole A. Andreassen Orcid Logo, Martin Ingelsson, Mikko Hiltunen, Kristel Sleegers Orcid Logo, Gerard D. Schellenberg, Cornelia M. van Duijn Orcid Logo, Rebecca Sims Orcid Logo, Wiesje M. van der Flier Orcid Logo, Agustín Ruiz, Alfredo Ramirez Orcid Logo, Jean-Charles Lambert Orcid Logo, (EADB), (GR@ACE), (DEGESCO), (EADI), (GERAD), (Demgene), (FinnGen), (ADGC), (CHARGE)

Nature Genetics, Volume: 54, Issue: 4, Pages: 412 - 436

Swansea University Author: Vanessa Burholt Orcid Logo

  • New insights into the genetic etiology ADRD.pdf

    PDF | Version of Record

    This article is licensed under a Creative Commons Attribution 4.0 International License

    Download (4.92MB)

Abstract

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘pro...

Full description

Published in: Nature Genetics
ISSN: 1061-4036 1546-1718
Published: Springer Science and Business Media LLC 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa60592
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract: Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.
College: Faculty of Medicine, Health and Life Sciences
Funders: This work was funded by a grant (EADB) from the EU Joint Programme – Neurodegenerative Disease Research. INSERM UMR1167 is also funded by the INSERM, Institut Pasteur de Lille, Lille Métropole Communauté Urbaine and French government’s LABEX DISTALZ program (development of innovative strategies for a transdisciplinary approach to AD).
Issue: 4
Start Page: 412
End Page: 436