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United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): a retrospective cohort study using linked routinely collected data, study protocol

Lucy Teece Orcid Logo, Laura J Gray Orcid Logo, Carl Melbourne Orcid Logo, Chris Orton Orcid Logo, David Ford Orcid Logo, Christopher A Martin Orcid Logo, David McAllister, Kamlesh Khunti Orcid Logo, Martin Tobin Orcid Logo, Catherine John Orcid Logo, Keith R Abrams Orcid Logo, Manish Pareek Orcid Logo

BMJ Open, Volume: 11, Issue: 6, Start page: e046392

Swansea University Authors: Chris Orton Orcid Logo, David Ford Orcid Logo

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DOI (Published version): 10.1136/bmjopen-2020-046392

Abstract

Introduction COVID-19 has spread rapidly worldwide, causing significant morbidity and mortality. People from ethnic minorities, particularly those working in healthcare settings, have been disproportionately affected. Current evidence of the association between ethnicity and COVID-19 outcomes in peo...

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Published in: BMJ Open
ISSN: 2044-6055 2044-6055
Published: BMJ 2021
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People from ethnic minorities, particularly those working in healthcare settings, have been disproportionately affected. Current evidence of the association between ethnicity and COVID-19 outcomes in people working in healthcare settings is insufficient to inform plans to address health inequalities.Methods and analysis This study combines anonymised human resource databases with professional registration and National Health Service data sets to assess associations between ethnicity and COVID-19 diagnosis, hospitalisation and death in healthcare workers in the UK. Adverse COVID-19 outcomes will be assessed between 1 February 2020 (date following first confirmed COVID-19 case in UK) and study end date (31 January 2021), allowing 1-year of follow-up. Planned analyses include multivariable Poisson, logistic and flexible parametric time-to-event regression within each country, adjusting for core predictors, followed by meta-analysis of country-specific results to produce combined effect estimates for the UK. Mediation analysis methods will be explored to examine the direct, indirect and mediated interactive effects between ethnicity, occupational group and COVID-19 outcomes.Ethics and dissemination Ethical approval for the UK-REACH programme has been obtained via the expedited HRA COVID-19 processes (REC ref: 20/HRA/4718, IRAS ID: 288316). Research information will be anonymised via the Secure Anonymised Information Linkage Databank before release to researchers. 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Core funding was also provided by NIHR Biomedical Research Centres. The views expressed in this publication are those of the authors and not necessarily those of the National Health Service (NHS), the MRC, the NIHR or the Department of Health and Social Care. 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spelling 2022-08-03T15:52:04.2079623 v2 60383 2022-07-05 United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): a retrospective cohort study using linked routinely collected data, study protocol 555c622e1f7bd9d2e0341f2ebbfd3e7f 0000-0002-9561-2493 Chris Orton Chris Orton true false 52fc0c473b0da1b7218d87f9fc68a3e6 0000-0001-6551-721X David Ford David Ford true false 2022-07-05 HDAT Introduction COVID-19 has spread rapidly worldwide, causing significant morbidity and mortality. People from ethnic minorities, particularly those working in healthcare settings, have been disproportionately affected. Current evidence of the association between ethnicity and COVID-19 outcomes in people working in healthcare settings is insufficient to inform plans to address health inequalities.Methods and analysis This study combines anonymised human resource databases with professional registration and National Health Service data sets to assess associations between ethnicity and COVID-19 diagnosis, hospitalisation and death in healthcare workers in the UK. Adverse COVID-19 outcomes will be assessed between 1 February 2020 (date following first confirmed COVID-19 case in UK) and study end date (31 January 2021), allowing 1-year of follow-up. Planned analyses include multivariable Poisson, logistic and flexible parametric time-to-event regression within each country, adjusting for core predictors, followed by meta-analysis of country-specific results to produce combined effect estimates for the UK. Mediation analysis methods will be explored to examine the direct, indirect and mediated interactive effects between ethnicity, occupational group and COVID-19 outcomes.Ethics and dissemination Ethical approval for the UK-REACH programme has been obtained via the expedited HRA COVID-19 processes (REC ref: 20/HRA/4718, IRAS ID: 288316). Research information will be anonymised via the Secure Anonymised Information Linkage Databank before release to researchers. Study results will be submitted for publication in an open access peer-reviewed journal and made available on our dedicated website (https://uk-reach.org/).Trial registration number ISRCTN11811602. Journal Article BMJ Open 11 6 e046392 BMJ 2044-6055 2044-6055 COVID-19, healthcare, public health protocol 28 6 2021 2021-06-28 10.1136/bmjopen-2020-046392 COLLEGE NANME Health Data Science COLLEGE CODE HDAT Swansea University Another institution paid the OA fee e MRC-UK Research and Innovation (MR/V027549/1) and the Department of Health and Social Care through the National Institute for Health Research (NIHR) rapid response panel to tackle COVID-19. Core funding was also provided by NIHR Biomedical Research Centres. The views expressed in this publication are those of the authors and not necessarily those of the National Health Service (NHS), the MRC, the NIHR or the Department of Health and Social Care. This work is carried out with the support of BREATHE—The Health Data Research Hub for Respiratory Health (MC_PC_19004) in partnership with SAIL Databank through the UK Research and Innovation Industrial Strategy Challenge Fund and delivered through Health Data Research UK. 2022-08-03T15:52:04.2079623 2022-07-05T13:20:27.4178137 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Lucy Teece 0000-0001-6669-8534 1 Laura J Gray 0000-0002-9284-9321 2 Carl Melbourne 0000-0001-7216-4547 3 Chris Orton 0000-0002-9561-2493 4 David Ford 0000-0001-6551-721X 5 Christopher A Martin 0000-0002-2337-4799 6 David McAllister 7 Kamlesh Khunti 0000-0003-2343-7099 8 Martin Tobin 0000-0002-3596-7874 9 Catherine John 0000-0002-6057-2073 10 Keith R Abrams 0000-0002-7557-1567 11 Manish Pareek 0000-0003-1521-9964 12 60383__24451__528f639fa45c4e16abecc8ccbfa4c996.pdf 60383.VOR.e046392.full.pdf 2022-07-05T13:26:16.4989787 Output 651290 application/pdf Version of Record true This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. true eng https://creativecommons.org/licenses/by/4.0/
title United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): a retrospective cohort study using linked routinely collected data, study protocol
spellingShingle United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): a retrospective cohort study using linked routinely collected data, study protocol
Chris Orton
David Ford
title_short United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): a retrospective cohort study using linked routinely collected data, study protocol
title_full United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): a retrospective cohort study using linked routinely collected data, study protocol
title_fullStr United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): a retrospective cohort study using linked routinely collected data, study protocol
title_full_unstemmed United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): a retrospective cohort study using linked routinely collected data, study protocol
title_sort United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): a retrospective cohort study using linked routinely collected data, study protocol
author_id_str_mv 555c622e1f7bd9d2e0341f2ebbfd3e7f
52fc0c473b0da1b7218d87f9fc68a3e6
author_id_fullname_str_mv 555c622e1f7bd9d2e0341f2ebbfd3e7f_***_Chris Orton
52fc0c473b0da1b7218d87f9fc68a3e6_***_David Ford
author Chris Orton
David Ford
author2 Lucy Teece
Laura J Gray
Carl Melbourne
Chris Orton
David Ford
Christopher A Martin
David McAllister
Kamlesh Khunti
Martin Tobin
Catherine John
Keith R Abrams
Manish Pareek
format Journal article
container_title BMJ Open
container_volume 11
container_issue 6
container_start_page e046392
publishDate 2021
institution Swansea University
issn 2044-6055
2044-6055
doi_str_mv 10.1136/bmjopen-2020-046392
publisher BMJ
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
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description Introduction COVID-19 has spread rapidly worldwide, causing significant morbidity and mortality. People from ethnic minorities, particularly those working in healthcare settings, have been disproportionately affected. Current evidence of the association between ethnicity and COVID-19 outcomes in people working in healthcare settings is insufficient to inform plans to address health inequalities.Methods and analysis This study combines anonymised human resource databases with professional registration and National Health Service data sets to assess associations between ethnicity and COVID-19 diagnosis, hospitalisation and death in healthcare workers in the UK. Adverse COVID-19 outcomes will be assessed between 1 February 2020 (date following first confirmed COVID-19 case in UK) and study end date (31 January 2021), allowing 1-year of follow-up. Planned analyses include multivariable Poisson, logistic and flexible parametric time-to-event regression within each country, adjusting for core predictors, followed by meta-analysis of country-specific results to produce combined effect estimates for the UK. Mediation analysis methods will be explored to examine the direct, indirect and mediated interactive effects between ethnicity, occupational group and COVID-19 outcomes.Ethics and dissemination Ethical approval for the UK-REACH programme has been obtained via the expedited HRA COVID-19 processes (REC ref: 20/HRA/4718, IRAS ID: 288316). Research information will be anonymised via the Secure Anonymised Information Linkage Databank before release to researchers. Study results will be submitted for publication in an open access peer-reviewed journal and made available on our dedicated website (https://uk-reach.org/).Trial registration number ISRCTN11811602.
published_date 2021-06-28T04:18:27Z
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