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United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): a retrospective cohort study using linked routinely collected data, study protocol
,
Laura J Gray ,
Carl Melbourne ,
Chris Orton ,
David Ford ,
Christopher A Martin ,
David McAllister,
Kamlesh Khunti ,
Martin Tobin ,
Catherine John ,
Keith R Abrams ,
Manish Pareek
BMJ Open, Volume: 11, Issue: 6, Start page: e046392
Swansea University Authors:
Chris Orton , David Ford
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DOI (Published version): 10.1136/bmjopen-2020-046392
Abstract
Introduction COVID-19 has spread rapidly worldwide, causing significant morbidity and mortality. People from ethnic minorities, particularly those working in healthcare settings, have been disproportionately affected. Current evidence of the association between ethnicity and COVID-19 outcomes in peo...
| Published in: | BMJ Open |
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| ISSN: | 2044-6055 2044-6055 |
| Published: |
BMJ
2021
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa60383 |
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| Abstract: |
Introduction COVID-19 has spread rapidly worldwide, causing significant morbidity and mortality. People from ethnic minorities, particularly those working in healthcare settings, have been disproportionately affected. Current evidence of the association between ethnicity and COVID-19 outcomes in people working in healthcare settings is insufficient to inform plans to address health inequalities.Methods and analysis This study combines anonymised human resource databases with professional registration and National Health Service data sets to assess associations between ethnicity and COVID-19 diagnosis, hospitalisation and death in healthcare workers in the UK. Adverse COVID-19 outcomes will be assessed between 1 February 2020 (date following first confirmed COVID-19 case in UK) and study end date (31 January 2021), allowing 1-year of follow-up. Planned analyses include multivariable Poisson, logistic and flexible parametric time-to-event regression within each country, adjusting for core predictors, followed by meta-analysis of country-specific results to produce combined effect estimates for the UK. Mediation analysis methods will be explored to examine the direct, indirect and mediated interactive effects between ethnicity, occupational group and COVID-19 outcomes.Ethics and dissemination Ethical approval for the UK-REACH programme has been obtained via the expedited HRA COVID-19 processes (REC ref: 20/HRA/4718, IRAS ID: 288316). Research information will be anonymised via the Secure Anonymised Information Linkage Databank before release to researchers. Study results will be submitted for publication in an open access peer-reviewed journal and made available on our dedicated website (https://uk-reach.org/).Trial registration number ISRCTN11811602. |
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| Keywords: |
COVID-19, healthcare, public health protocol |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
e MRC-UK Research and Innovation (MR/V027549/1) and the Department
of Health and Social Care through the National Institute for Health Research (NIHR)
rapid response panel to tackle COVID-19. Core funding was also provided by NIHR
Biomedical Research Centres. The views expressed in this publication are those
of the authors and not necessarily those of the National Health Service (NHS), the
MRC, the NIHR or the Department of Health and Social Care. This work is carried
out with the support of BREATHE—The Health Data Research Hub for Respiratory
Health (MC_PC_19004) in partnership with SAIL Databank through the UK Research and Innovation Industrial Strategy Challenge Fund and delivered through Health Data Research UK. |
| Issue: |
6 |
| Start Page: |
e046392 |