Journal article 773 views 97 downloads
Intestinal microbiota and their metabolic contribution to type 2 diabetes and obesity
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Dean Harris
Journal of Diabetes & Metabolic Disorders, Volume: 20, Issue: 2, Pages: 1855 - 1870
Swansea University Authors:
Andrew Cunningham, Jeffrey Stephens , Dean Harris
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DOI (Published version): 10.1007/s40200-021-00858-4
Abstract
Obesity and type 2 diabetes mellitus (T2DM) are common, chronic metabolic disorders with associated significant long-term health problems at global epidemic levels. It is recognised that gut microbiota play a central role in maintaining host homeostasis and through technological advances in both ani...
| Published in: | Journal of Diabetes & Metabolic Disorders |
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| ISSN: | 2251-6581 |
| Published: |
Springer Science and Business Media LLC
2021
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa58890 |
| Abstract: |
Obesity and type 2 diabetes mellitus (T2DM) are common, chronic metabolic disorders with associated significant long-term health problems at global epidemic levels. It is recognised that gut microbiota play a central role in maintaining host homeostasis and through technological advances in both animal and human models it is becoming clear that gut microbiota are heavily involved in key pathophysiological roles in the aetiology and progression of both conditions. This review will focus on current knowledge regarding microbiota interactions with short chain fatty acids, the host inflammatory response, signaling pathways, integrity of the intestinal barrier, the interaction of the gut-brain axis and the subsequent impact on the metabolic health of the host. |
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| Keywords: |
Gut microbiota; Obesity; Type two diabetes mellitus |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
2 |
| Start Page: |
1855 |
| End Page: |
1870 |