E-Thesis 181 views 108 downloads
Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques / REBECCA HUDSON
Swansea University Author: REBECCA HUDSON
DOI (Published version): 10.23889/SUthesis.58624
Abstract
Characterisation of viscoelastic materials through exploitation of the frequency independent gel point (GP) can be used to study blood clotting anomalies. Information regarding the sol-gel transition can be obtained for gelling systems by employing small amplitude oscillatory shear (SAOS) measuremen...
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Swansea
2021
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Institution: | Swansea University |
Degree level: | Doctoral |
Degree name: | Ph.D |
Supervisor: | Curtis, Daniel J. ; Williams, P. Rhodri |
URI: | https://cronfa.swan.ac.uk/Record/cronfa58624 |
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2021-11-11T16:54:24.3357190 v2 58624 2021-11-11 Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques 0008e36b16fa5bbc35d0bc3e4d41af4b REBECCA HUDSON REBECCA HUDSON true false 2021-11-11 Characterisation of viscoelastic materials through exploitation of the frequency independent gel point (GP) can be used to study blood clotting anomalies. Information regarding the sol-gel transition can be obtained for gelling systems by employing small amplitude oscillatory shear (SAOS) measurements over a range of oscillatory shear frequencies. Analysis of the fractal dimension, , at the GP has previously been used as a biomarker for pathologies related to thromboembolic disease. This thesis investigates the potential adverse clotting characteristics induced by the presence of exhaust particulates using rheometric techniques. SAOS experiments conducted using a combined motor transducer (CMT) rheometer are susceptible to inertial artefacts at high frequencies, leading to potentially significant error in the reported GP. Herein, the development and evaluation of an enhanced rheometer inertia correction procedure (ERIC) is shown to allow valid GP data to be obtained post-acquisition at previously inaccessible frequencies. The potential impact of soot particulates on coagulation is likely to be small due to the weakly elastic gelling systems being studied, thus necessitating the use of the ERIC procedure to remove the presence of any inertial artefacts causing miscalculation of the GP. Fibrin gels were studied as model blood clots to assess the effects of the inclusion of soot particulates on the GP. The impact of the inclusion of increasing concentrations of soot solution on the GP proved inconclusive after the application of ERIC. However, in whole blood clots, the post-ERIC GP data indicated an increase in the density of the clot formed with increasing soot concentration, suggesting an elevated health risk as a possible result of interruption of the clotting cascade due to soot particulates. E-Thesis Swansea Rheology, gel point, particulate matter, fibrin gels, blood 11 11 2021 2021-11-11 10.23889/SUthesis.58624 COLLEGE NANME COLLEGE CODE Swansea University Curtis, Daniel J. ; Williams, P. Rhodri Doctoral Ph.D NRN 2021-11-11T16:54:24.3357190 2021-11-11T16:28:18.4311144 Faculty of Science and Engineering School of Engineering and Applied Sciences - Uncategorised REBECCA HUDSON 1 58624__21500__56053d9dbaca428697884594a9cf74f5.pdf Hudson_Rebecca_PhD_Thesis_Final_Redacted_Signature.pdf 2021-11-11T16:46:16.6722978 Output 6778317 application/pdf E-Thesis – open access true Copyright: The author, Rebecca Hudson, 2021. true eng |
title |
Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques |
spellingShingle |
Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques REBECCA HUDSON |
title_short |
Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques |
title_full |
Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques |
title_fullStr |
Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques |
title_full_unstemmed |
Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques |
title_sort |
Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques |
author_id_str_mv |
0008e36b16fa5bbc35d0bc3e4d41af4b |
author_id_fullname_str_mv |
0008e36b16fa5bbc35d0bc3e4d41af4b_***_REBECCA HUDSON |
author |
REBECCA HUDSON |
author2 |
REBECCA HUDSON |
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E-Thesis |
publishDate |
2021 |
institution |
Swansea University |
doi_str_mv |
10.23889/SUthesis.58624 |
college_str |
Faculty of Science and Engineering |
hierarchytype |
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facultyofscienceandengineering |
hierarchy_top_title |
Faculty of Science and Engineering |
hierarchy_parent_id |
facultyofscienceandengineering |
hierarchy_parent_title |
Faculty of Science and Engineering |
department_str |
School of Engineering and Applied Sciences - Uncategorised{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Uncategorised |
document_store_str |
1 |
active_str |
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description |
Characterisation of viscoelastic materials through exploitation of the frequency independent gel point (GP) can be used to study blood clotting anomalies. Information regarding the sol-gel transition can be obtained for gelling systems by employing small amplitude oscillatory shear (SAOS) measurements over a range of oscillatory shear frequencies. Analysis of the fractal dimension, , at the GP has previously been used as a biomarker for pathologies related to thromboembolic disease. This thesis investigates the potential adverse clotting characteristics induced by the presence of exhaust particulates using rheometric techniques. SAOS experiments conducted using a combined motor transducer (CMT) rheometer are susceptible to inertial artefacts at high frequencies, leading to potentially significant error in the reported GP. Herein, the development and evaluation of an enhanced rheometer inertia correction procedure (ERIC) is shown to allow valid GP data to be obtained post-acquisition at previously inaccessible frequencies. The potential impact of soot particulates on coagulation is likely to be small due to the weakly elastic gelling systems being studied, thus necessitating the use of the ERIC procedure to remove the presence of any inertial artefacts causing miscalculation of the GP. Fibrin gels were studied as model blood clots to assess the effects of the inclusion of soot particulates on the GP. The impact of the inclusion of increasing concentrations of soot solution on the GP proved inconclusive after the application of ERIC. However, in whole blood clots, the post-ERIC GP data indicated an increase in the density of the clot formed with increasing soot concentration, suggesting an elevated health risk as a possible result of interruption of the clotting cascade due to soot particulates. |
published_date |
2021-11-11T04:15:17Z |
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1763754028867518464 |
score |
11.02167 |