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Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques / REBECCA HUDSON

Swansea University Author: REBECCA HUDSON

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DOI (Published version): 10.23889/SUthesis.58624

Abstract

Characterisation of viscoelastic materials through exploitation of the frequency independent gel point (GP) can be used to study blood clotting anomalies. Information regarding the sol-gel transition can be obtained for gelling systems by employing small amplitude oscillatory shear (SAOS) measuremen...

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Published: Swansea 2021
Institution: Swansea University
Degree level: Doctoral
Degree name: Ph.D
Supervisor: Curtis, Daniel J. ; Williams, P. Rhodri
URI: https://cronfa.swan.ac.uk/Record/cronfa58624
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first_indexed 2021-11-11T16:34:27Z
last_indexed 2021-11-12T04:26:10Z
id cronfa58624
recordtype RisThesis
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spelling 2021-11-11T16:54:24.3357190 v2 58624 2021-11-11 Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques 0008e36b16fa5bbc35d0bc3e4d41af4b REBECCA HUDSON REBECCA HUDSON true false 2021-11-11 Characterisation of viscoelastic materials through exploitation of the frequency independent gel point (GP) can be used to study blood clotting anomalies. Information regarding the sol-gel transition can be obtained for gelling systems by employing small amplitude oscillatory shear (SAOS) measurements over a range of oscillatory shear frequencies. Analysis of the fractal dimension, , at the GP has previously been used as a biomarker for pathologies related to thromboembolic disease. This thesis investigates the potential adverse clotting characteristics induced by the presence of exhaust particulates using rheometric techniques. SAOS experiments conducted using a combined motor transducer (CMT) rheometer are susceptible to inertial artefacts at high frequencies, leading to potentially significant error in the reported GP. Herein, the development and evaluation of an enhanced rheometer inertia correction procedure (ERIC) is shown to allow valid GP data to be obtained post-acquisition at previously inaccessible frequencies. The potential impact of soot particulates on coagulation is likely to be small due to the weakly elastic gelling systems being studied, thus necessitating the use of the ERIC procedure to remove the presence of any inertial artefacts causing miscalculation of the GP. Fibrin gels were studied as model blood clots to assess the effects of the inclusion of soot particulates on the GP. The impact of the inclusion of increasing concentrations of soot solution on the GP proved inconclusive after the application of ERIC. However, in whole blood clots, the post-ERIC GP data indicated an increase in the density of the clot formed with increasing soot concentration, suggesting an elevated health risk as a possible result of interruption of the clotting cascade due to soot particulates. E-Thesis Swansea Rheology, gel point, particulate matter, fibrin gels, blood 11 11 2021 2021-11-11 10.23889/SUthesis.58624 COLLEGE NANME COLLEGE CODE Swansea University Curtis, Daniel J. ; Williams, P. Rhodri Doctoral Ph.D NRN 2021-11-11T16:54:24.3357190 2021-11-11T16:28:18.4311144 Faculty of Science and Engineering School of Engineering and Applied Sciences - Uncategorised REBECCA HUDSON 1 58624__21500__56053d9dbaca428697884594a9cf74f5.pdf Hudson_Rebecca_PhD_Thesis_Final_Redacted_Signature.pdf 2021-11-11T16:46:16.6722978 Output 6778317 application/pdf E-Thesis – open access true Copyright: The author, Rebecca Hudson, 2021. true eng
title Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques
spellingShingle Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques
REBECCA HUDSON
title_short Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques
title_full Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques
title_fullStr Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques
title_full_unstemmed Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques
title_sort Detection of Exhaust Particulate Induced Blood Clotting Anomalies using Rheometric Techniques
author_id_str_mv 0008e36b16fa5bbc35d0bc3e4d41af4b
author_id_fullname_str_mv 0008e36b16fa5bbc35d0bc3e4d41af4b_***_REBECCA HUDSON
author REBECCA HUDSON
author2 REBECCA HUDSON
format E-Thesis
publishDate 2021
institution Swansea University
doi_str_mv 10.23889/SUthesis.58624
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Uncategorised{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Uncategorised
document_store_str 1
active_str 0
description Characterisation of viscoelastic materials through exploitation of the frequency independent gel point (GP) can be used to study blood clotting anomalies. Information regarding the sol-gel transition can be obtained for gelling systems by employing small amplitude oscillatory shear (SAOS) measurements over a range of oscillatory shear frequencies. Analysis of the fractal dimension, , at the GP has previously been used as a biomarker for pathologies related to thromboembolic disease. This thesis investigates the potential adverse clotting characteristics induced by the presence of exhaust particulates using rheometric techniques. SAOS experiments conducted using a combined motor transducer (CMT) rheometer are susceptible to inertial artefacts at high frequencies, leading to potentially significant error in the reported GP. Herein, the development and evaluation of an enhanced rheometer inertia correction procedure (ERIC) is shown to allow valid GP data to be obtained post-acquisition at previously inaccessible frequencies. The potential impact of soot particulates on coagulation is likely to be small due to the weakly elastic gelling systems being studied, thus necessitating the use of the ERIC procedure to remove the presence of any inertial artefacts causing miscalculation of the GP. Fibrin gels were studied as model blood clots to assess the effects of the inclusion of soot particulates on the GP. The impact of the inclusion of increasing concentrations of soot solution on the GP proved inconclusive after the application of ERIC. However, in whole blood clots, the post-ERIC GP data indicated an increase in the density of the clot formed with increasing soot concentration, suggesting an elevated health risk as a possible result of interruption of the clotting cascade due to soot particulates.
published_date 2021-11-11T04:15:17Z
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score 11.02167

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