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Investigating the Measurement of Physical Activity and Associated Factors in Youth and Adults with Cystic Fibrosis / MAYARA BIANCHIM

Swansea University Author: MAYARA BIANCHIM

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DOI (Published version): 10.23889/SUthesis.58596

Abstract

Cystic Fibrosis (CF) is a multisystemic condition that affects almost every organ in the body, but especially the lungs. Regular physical activity (PA) can significantly slow disease progression and has become a crucial part of CF care. Previous research evaluating PA in CF has been hindered by the...

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Published: Swansea 2021
Institution: Swansea University
Degree level: Doctoral
Degree name: Ph.D
Supervisor: Mackintosh, Kelly ; McNarry, Melitta
URI: https://cronfa.swan.ac.uk/Record/cronfa58596
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first_indexed 2021-11-10T10:48:24Z
last_indexed 2021-11-11T04:26:07Z
id cronfa58596
recordtype RisThesis
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spelling 2021-11-10T11:39:46.3910374 v2 58596 2021-11-10 Investigating the Measurement of Physical Activity and Associated Factors in Youth and Adults with Cystic Fibrosis e9a4027c1fe73d418de77829a74d7259 MAYARA BIANCHIM MAYARA BIANCHIM true false 2021-11-10 Cystic Fibrosis (CF) is a multisystemic condition that affects almost every organ in the body, but especially the lungs. Regular physical activity (PA) can significantly slow disease progression and has become a crucial part of CF care. Previous research evaluating PA in CF has been hindered by the use of cut-points developed for healthy populations and the investigation of collinear movement behaviours as independent entities, both of which are likely to have confounded their findings and any subsequent inferences regarding associated health outcomes. Therefore, the overall aim of this thesis was to investigate the measurement and analysis of PA in those with CF. An initial systematic review provided recommendations for research calibrating accelerometry in paediatric clinical populations, highlighting that the pathophysiology of the condition must be accounted for and that the protocol should include a broad range of activities varying in intensity (Chapter 4). Subsequently, Chapter 5 developed and cross-validated raw acceleration CF-specific cut-points in youth which were then further assessed in Chapter 6, demonstrating that the CF-specific thresholds were associated with higher levels of moderate-to-vigorous physical activity (MVPA) and sedentary time (SED) and lower levels of light PA compared to generic cut-points. Furthermore, lung function was associated with light PA when using condition-specific thresholds. Further investigation of the relationship between PA and health in Chapter 7 found that reallocating time from sedentary to any other behaviour was beneficial for lung function, with the greatest improvements observed when SED was reallocated to sleep or MVPA. Finally, Chapter 8 developed and validated machine learning algorithms that achieved excellent accuracy to classify PA types and intensities in youth with CF. In conclusion, these findings significantly advance the assessment of PA, enhancing our understanding of the relationship between PA and health in CF and informing future condition-specific PA guidelines, care strategies and interventions. E-Thesis Swansea Physical Activity, Cystic Fibrosis, Lung Function, Accelerometry, Machine Learning, Compositional Analysis 10 11 2021 2021-11-10 10.23889/SUthesis.58596 COLLEGE NANME COLLEGE CODE Swansea University Mackintosh, Kelly ; McNarry, Melitta Doctoral Ph.D SRC Cystic Fibrosis Trust 2021-11-10T11:39:46.3910374 2021-11-10T10:44:13.9394398 Faculty of Science and Engineering School of Engineering and Applied Sciences - Uncategorised MAYARA BIANCHIM 1 Under embargo Under embargo 2021-11-10T11:31:03.0609873 Output 10550135 application/pdf E-Thesis – open access true 2024-01-01T00:00:00.0000000 Copyright: The author, Mayara Silveira Bianchim, 2021. true eng
title Investigating the Measurement of Physical Activity and Associated Factors in Youth and Adults with Cystic Fibrosis
spellingShingle Investigating the Measurement of Physical Activity and Associated Factors in Youth and Adults with Cystic Fibrosis
MAYARA BIANCHIM
title_short Investigating the Measurement of Physical Activity and Associated Factors in Youth and Adults with Cystic Fibrosis
title_full Investigating the Measurement of Physical Activity and Associated Factors in Youth and Adults with Cystic Fibrosis
title_fullStr Investigating the Measurement of Physical Activity and Associated Factors in Youth and Adults with Cystic Fibrosis
title_full_unstemmed Investigating the Measurement of Physical Activity and Associated Factors in Youth and Adults with Cystic Fibrosis
title_sort Investigating the Measurement of Physical Activity and Associated Factors in Youth and Adults with Cystic Fibrosis
author_id_str_mv e9a4027c1fe73d418de77829a74d7259
author_id_fullname_str_mv e9a4027c1fe73d418de77829a74d7259_***_MAYARA BIANCHIM
author MAYARA BIANCHIM
author2 MAYARA BIANCHIM
format E-Thesis
publishDate 2021
institution Swansea University
doi_str_mv 10.23889/SUthesis.58596
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Uncategorised{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Uncategorised
document_store_str 0
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description Cystic Fibrosis (CF) is a multisystemic condition that affects almost every organ in the body, but especially the lungs. Regular physical activity (PA) can significantly slow disease progression and has become a crucial part of CF care. Previous research evaluating PA in CF has been hindered by the use of cut-points developed for healthy populations and the investigation of collinear movement behaviours as independent entities, both of which are likely to have confounded their findings and any subsequent inferences regarding associated health outcomes. Therefore, the overall aim of this thesis was to investigate the measurement and analysis of PA in those with CF. An initial systematic review provided recommendations for research calibrating accelerometry in paediatric clinical populations, highlighting that the pathophysiology of the condition must be accounted for and that the protocol should include a broad range of activities varying in intensity (Chapter 4). Subsequently, Chapter 5 developed and cross-validated raw acceleration CF-specific cut-points in youth which were then further assessed in Chapter 6, demonstrating that the CF-specific thresholds were associated with higher levels of moderate-to-vigorous physical activity (MVPA) and sedentary time (SED) and lower levels of light PA compared to generic cut-points. Furthermore, lung function was associated with light PA when using condition-specific thresholds. Further investigation of the relationship between PA and health in Chapter 7 found that reallocating time from sedentary to any other behaviour was beneficial for lung function, with the greatest improvements observed when SED was reallocated to sleep or MVPA. Finally, Chapter 8 developed and validated machine learning algorithms that achieved excellent accuracy to classify PA types and intensities in youth with CF. In conclusion, these findings significantly advance the assessment of PA, enhancing our understanding of the relationship between PA and health in CF and informing future condition-specific PA guidelines, care strategies and interventions.
published_date 2021-11-10T04:15:15Z
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score 11.013776

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