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Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo

Paul Rees Orcid Logo, Guillermo Bauza‐Mayol, Marcos Quintela Vazquez, Ava Brozovich, Michael Hopson, Shazad Shaikh, Fernando Cabrera, Aaron Shi, Federica Banche Niclot, Francesca Paradiso, Emman Thomson, Thomas Jovic, Paul Rees, Ennio Tasciotti, Lewis Francis Orcid Logo, Patrick Mcculloch, Francesca Taraballi

Advanced Healthcare Materials, Volume: 11, Issue: 1, Start page: 2101127

Swansea University Authors: Paul Rees Orcid Logo, Marcos Quintela Vazquez, Emman Thomson, Thomas Jovic, Lewis Francis Orcid Logo

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DOI (Published version): 10.1002/adhm.202101127

Abstract

Focal chondral lesions of the knee are the most frequent type of trauma in younger patients and are associated with a high risk of developing early posttraumatic osteoarthritis. The only current clinical solutions include microfracture, osteochondral grafting, and autologous chondrocyte implantation...

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Published in: Advanced Healthcare Materials
ISSN: 2192-2640 2192-2659
Published: Wiley 2021
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spelling 2022-10-31T17:48:02.2153477 v2 58476 2021-10-27 Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo 537a2fe031a796a3bde99679ee8c24f5 0000-0002-7715-6914 Paul Rees Paul Rees true false 29d006fa16d293ca29762fce9c356f8e Marcos Quintela Vazquez Marcos Quintela Vazquez true false dc9e7718f6f8bb11d3df1d0cd8245318 Emman Thomson Emman Thomson true false 7d95ed2bceb18fc0fdfd4048277c6eed Thomas Jovic Thomas Jovic true false 10f61f9c1248951c1a33f6a89498f37d 0000-0002-7803-7714 Lewis Francis Lewis Francis true false 2021-10-27 MEDE Focal chondral lesions of the knee are the most frequent type of trauma in younger patients and are associated with a high risk of developing early posttraumatic osteoarthritis. The only current clinical solutions include microfracture, osteochondral grafting, and autologous chondrocyte implantation. Cartilage tissue engineering based on biomimetic scaffolds has become an appealing strategy to repair cartilage defects. Here, a chondrogenic collagen-chondroitin sulfate scaffold is tested in an orthotopic Lapine in vivo model to understand the beneficial effects of the immunomodulatory biomaterial on the full chondral defect. Using a combination of noninvasive imaging techniques, histological and whole transcriptome analysis, the scaffolds are shown to enhance the formation of cartilaginous tissue and suppression of host cartilage degeneration, while also supporting tissue integration and increased tissue regeneration over a 12 weeks recovery period. The results presented suggest that biomimetic materials could be a clinical solution for cartilage tissue repair, due to their ability to modulate the immune environment in favor of regenerative processes and suppression of cartilage degeneration. Journal Article Advanced Healthcare Materials 11 1 2101127 Wiley 2192-2640 2192-2659 cartilage repair; osteoarthritis; scaffolds; tissue engineering 28 10 2021 2021-10-28 10.1002/adhm.202101127 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University Cullen Trust for Health Care Foundation. Grant Number: 18130014; Houston Methodist Hospital 2022-10-31T17:48:02.2153477 2021-10-27T13:54:37.5124300 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Paul Rees 0000-0002-7715-6914 1 Guillermo Bauza‐Mayol 2 Marcos Quintela Vazquez 3 Ava Brozovich 4 Michael Hopson 5 Shazad Shaikh 6 Fernando Cabrera 7 Aaron Shi 8 Federica Banche Niclot 9 Francesca Paradiso 10 Emman Thomson 11 Thomas Jovic 12 Paul Rees 13 Ennio Tasciotti 14 Lewis Francis 0000-0002-7803-7714 15 Patrick Mcculloch 16 Francesca Taraballi 17 58476__21368__9508b820b4344c87b2f37165302b9ea3.pdf 58476.pdf 2021-10-29T13:15:48.3300117 Output 7915588 application/pdf Version of Record true © 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo
spellingShingle Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo
Paul Rees
Marcos Quintela Vazquez
Emman Thomson
Thomas Jovic
Lewis Francis
title_short Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo
title_full Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo
title_fullStr Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo
title_full_unstemmed Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo
title_sort Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo
author_id_str_mv 537a2fe031a796a3bde99679ee8c24f5
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7d95ed2bceb18fc0fdfd4048277c6eed
10f61f9c1248951c1a33f6a89498f37d
author_id_fullname_str_mv 537a2fe031a796a3bde99679ee8c24f5_***_Paul Rees
29d006fa16d293ca29762fce9c356f8e_***_Marcos Quintela Vazquez
dc9e7718f6f8bb11d3df1d0cd8245318_***_Emman Thomson
7d95ed2bceb18fc0fdfd4048277c6eed_***_Thomas Jovic
10f61f9c1248951c1a33f6a89498f37d_***_Lewis Francis
author Paul Rees
Marcos Quintela Vazquez
Emman Thomson
Thomas Jovic
Lewis Francis
author2 Paul Rees
Guillermo Bauza‐Mayol
Marcos Quintela Vazquez
Ava Brozovich
Michael Hopson
Shazad Shaikh
Fernando Cabrera
Aaron Shi
Federica Banche Niclot
Francesca Paradiso
Emman Thomson
Thomas Jovic
Paul Rees
Ennio Tasciotti
Lewis Francis
Patrick Mcculloch
Francesca Taraballi
format Journal article
container_title Advanced Healthcare Materials
container_volume 11
container_issue 1
container_start_page 2101127
publishDate 2021
institution Swansea University
issn 2192-2640
2192-2659
doi_str_mv 10.1002/adhm.202101127
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
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description Focal chondral lesions of the knee are the most frequent type of trauma in younger patients and are associated with a high risk of developing early posttraumatic osteoarthritis. The only current clinical solutions include microfracture, osteochondral grafting, and autologous chondrocyte implantation. Cartilage tissue engineering based on biomimetic scaffolds has become an appealing strategy to repair cartilage defects. Here, a chondrogenic collagen-chondroitin sulfate scaffold is tested in an orthotopic Lapine in vivo model to understand the beneficial effects of the immunomodulatory biomaterial on the full chondral defect. Using a combination of noninvasive imaging techniques, histological and whole transcriptome analysis, the scaffolds are shown to enhance the formation of cartilaginous tissue and suppression of host cartilage degeneration, while also supporting tissue integration and increased tissue regeneration over a 12 weeks recovery period. The results presented suggest that biomimetic materials could be a clinical solution for cartilage tissue repair, due to their ability to modulate the immune environment in favor of regenerative processes and suppression of cartilage degeneration.
published_date 2021-10-28T04:15:02Z
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