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Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo
,
Guillermo Bauza‐Mayol,
Marcos Quintela Vazquez,
Ava Brozovich,
Michael Hopson,
Shazad Shaikh,
Fernando Cabrera,
Aaron Shi,
Federica Banche Niclot,
Francesca Paradiso,
Emman Thomson,
Thomas Jovic,
Paul Rees,
Ennio Tasciotti,
Lewis Francis ,
Patrick Mcculloch,
Francesca Taraballi
Advanced Healthcare Materials, Volume: 11, Issue: 1, Start page: 2101127
Swansea University Authors:
Paul Rees , Marcos Quintela Vazquez, Emman Thomson, Thomas Jovic, Lewis Francis
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DOI (Published version): 10.1002/adhm.202101127
Abstract
Focal chondral lesions of the knee are the most frequent type of trauma in younger patients and are associated with a high risk of developing early posttraumatic osteoarthritis. The only current clinical solutions include microfracture, osteochondral grafting, and autologous chondrocyte implantation...
| Published in: | Advanced Healthcare Materials |
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| ISSN: | 2192-2640 2192-2659 |
| Published: |
Wiley
2021
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa58476 |
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| Abstract: |
Focal chondral lesions of the knee are the most frequent type of trauma in younger patients and are associated with a high risk of developing early posttraumatic osteoarthritis. The only current clinical solutions include microfracture, osteochondral grafting, and autologous chondrocyte implantation. Cartilage tissue engineering based on biomimetic scaffolds has become an appealing strategy to repair cartilage defects. Here, a chondrogenic collagen-chondroitin sulfate scaffold is tested in an orthotopic Lapine in vivo model to understand the beneficial effects of the immunomodulatory biomaterial on the full chondral defect. Using a combination of noninvasive imaging techniques, histological and whole transcriptome analysis, the scaffolds are shown to enhance the formation of cartilaginous tissue and suppression of host cartilage degeneration, while also supporting tissue integration and increased tissue regeneration over a 12 weeks recovery period. The results presented suggest that biomimetic materials could be a clinical solution for cartilage tissue repair, due to their ability to modulate the immune environment in favor of regenerative processes and suppression of cartilage degeneration. |
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| Keywords: |
cartilage repair; osteoarthritis; scaffolds; tissue engineering |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
Cullen Trust for Health Care Foundation. Grant Number: 18130014; Houston Methodist Hospital |
| Issue: |
1 |
| Start Page: |
2101127 |