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Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data

Joanna F. Dipnall, Frederick P. Rivara, Ronan Lyons Orcid Logo, Shanthi Ameratunga, Mariana Brussoni, Fiona E. Lecky, Clare Bradley, Ben Beck, Jane Lyons, Amy Schneeberg, James E. Harrison, Belinda Gabbe Orcid Logo

International Journal of Environmental Research and Public Health, Volume: 18, Issue: 19, Start page: 10156

Swansea University Authors: Ronan Lyons Orcid Logo, Jane Lyons, Belinda Gabbe Orcid Logo

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DOI (Published version): 10.3390/ijerph181910156

Abstract

Background: Injury is a leading contributor to the global disease burden in children, affecting their health-related quality of life (HRQoL)—yet valid estimates of burden are absent. Methods: This study pooled longitudinal data from five cohort studies of pediatric injury survivors (5–17 years) at b...

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Published in: International Journal of Environmental Research and Public Health
ISSN: 1660-4601
Published: MDPI AG 2021
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Methods: This study pooled longitudinal data from five cohort studies of pediatric injury survivors (5&#x2013;17 years) at baseline, 1-, 4-, 6-, 12-, and 24- months (n = 2334). HRQoL post-injury was measured using the 3-level EQ-5D utility score (EQ-5D) and five health states (mobility, self-care, activity, pain, anxiety and depression (anxiety)). Results: Mean EQ-5D post-injury did not return to baseline level (0.95) by 24 months (0.88) and was lower for females over time (&#x2212;0.04, 95%CI &#x2212;0.05, &#x2212;0.02). A decreased adjusted risk ratio over time (ARR) was observed for intentional injuries (pain: 0.85, 95%CI 0.73,0.98; anxiety: 0.62, 95%CI 0.49,0.78); spinal cord injuries (mobility: 0.61, 95%CI 0.45,0.83), self-care: 0.76, 95%CI 0.63,0.91, activity: 0.64, 95%CI 0.47,0.88); moderate/severe traumatic brain injury (activity: 0.83, 95%CI 0.71,0.96). ARRs were also low for certain fractures, with various health states affected. Conclusions: HRQoL outcomes over time for children and adolescents post-injury differed across key demographic and injury related attributes. HRQoL did not reach levels consistent with full health by 24 months with recovery plateauing from 6 to 24 months. 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spelling 2021-10-25T16:00:09.1760442 v2 58149 2021-09-29 Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data 83efcf2a9dfcf8b55586999d3d152ac6 0000-0001-5225-000X Ronan Lyons Ronan Lyons true false 1b74fa5125a88451c52c45bcf20e0b47 Jane Lyons Jane Lyons true false 4bdcc94332b2bd10530c5e71ceb04f14 0000-0001-7096-7688 Belinda Gabbe Belinda Gabbe true false 2021-09-29 HDAT Background: Injury is a leading contributor to the global disease burden in children, affecting their health-related quality of life (HRQoL)—yet valid estimates of burden are absent. Methods: This study pooled longitudinal data from five cohort studies of pediatric injury survivors (5–17 years) at baseline, 1-, 4-, 6-, 12-, and 24- months (n = 2334). HRQoL post-injury was measured using the 3-level EQ-5D utility score (EQ-5D) and five health states (mobility, self-care, activity, pain, anxiety and depression (anxiety)). Results: Mean EQ-5D post-injury did not return to baseline level (0.95) by 24 months (0.88) and was lower for females over time (−0.04, 95%CI −0.05, −0.02). A decreased adjusted risk ratio over time (ARR) was observed for intentional injuries (pain: 0.85, 95%CI 0.73,0.98; anxiety: 0.62, 95%CI 0.49,0.78); spinal cord injuries (mobility: 0.61, 95%CI 0.45,0.83), self-care: 0.76, 95%CI 0.63,0.91, activity: 0.64, 95%CI 0.47,0.88); moderate/severe traumatic brain injury (activity: 0.83, 95%CI 0.71,0.96). ARRs were also low for certain fractures, with various health states affected. Conclusions: HRQoL outcomes over time for children and adolescents post-injury differed across key demographic and injury related attributes. HRQoL did not reach levels consistent with full health by 24 months with recovery plateauing from 6 to 24 months. Tailored interventions are required to respond to the varying post-injury recovery trajectories in this population. Journal Article International Journal of Environmental Research and Public Health 18 19 10156 MDPI AG 1660-4601 health-related quality of life, health outcomes, disability, trauma, injury, EQ-5D, children, pediatric, adolescents 27 9 2021 2021-09-27 10.3390/ijerph181910156 COLLEGE NANME Health Data Science COLLEGE CODE HDAT Swansea University National Health and Medical Research Council of Australia Grant: NHMRC-APP1142325 Grant: (#0010009) Grant: NA Grant: NA Grant: NA Grant: NA Grant: (FT170100048) Canadian Institutes of Health Research Grant: (#TIR-104028) Michael Smith Foundation for Health Research Grant: NA 2021-10-25T16:00:09.1760442 2021-09-29T15:31:38.2959977 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Joanna F. Dipnall 1 Frederick P. Rivara 2 Ronan Lyons 0000-0001-5225-000X 3 Shanthi Ameratunga 4 Mariana Brussoni 5 Fiona E. Lecky 6 Clare Bradley 7 Ben Beck 8 Jane Lyons 9 Amy Schneeberg 10 James E. Harrison 11 Belinda Gabbe 0000-0001-7096-7688 12 58149__21055__2fc35aa9f5ea4fe5b5e8afc5b5b6a7ac.pdf ijerph-18-10156-v3.pdf 2021-09-29T15:31:38.2956912 Output 7059302 application/pdf Version of Record true © 2021 by the authors. Distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license true eng https://creativecommons.org/licenses/by/4.0/
title Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data
spellingShingle Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data
Ronan Lyons
Jane Lyons
Belinda Gabbe
title_short Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data
title_full Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data
title_fullStr Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data
title_full_unstemmed Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data
title_sort Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data
author_id_str_mv 83efcf2a9dfcf8b55586999d3d152ac6
1b74fa5125a88451c52c45bcf20e0b47
4bdcc94332b2bd10530c5e71ceb04f14
author_id_fullname_str_mv 83efcf2a9dfcf8b55586999d3d152ac6_***_Ronan Lyons
1b74fa5125a88451c52c45bcf20e0b47_***_Jane Lyons
4bdcc94332b2bd10530c5e71ceb04f14_***_Belinda Gabbe
author Ronan Lyons
Jane Lyons
Belinda Gabbe
author2 Joanna F. Dipnall
Frederick P. Rivara
Ronan Lyons
Shanthi Ameratunga
Mariana Brussoni
Fiona E. Lecky
Clare Bradley
Ben Beck
Jane Lyons
Amy Schneeberg
James E. Harrison
Belinda Gabbe
format Journal article
container_title International Journal of Environmental Research and Public Health
container_volume 18
container_issue 19
container_start_page 10156
publishDate 2021
institution Swansea University
issn 1660-4601
doi_str_mv 10.3390/ijerph181910156
publisher MDPI AG
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description Background: Injury is a leading contributor to the global disease burden in children, affecting their health-related quality of life (HRQoL)—yet valid estimates of burden are absent. Methods: This study pooled longitudinal data from five cohort studies of pediatric injury survivors (5–17 years) at baseline, 1-, 4-, 6-, 12-, and 24- months (n = 2334). HRQoL post-injury was measured using the 3-level EQ-5D utility score (EQ-5D) and five health states (mobility, self-care, activity, pain, anxiety and depression (anxiety)). Results: Mean EQ-5D post-injury did not return to baseline level (0.95) by 24 months (0.88) and was lower for females over time (−0.04, 95%CI −0.05, −0.02). A decreased adjusted risk ratio over time (ARR) was observed for intentional injuries (pain: 0.85, 95%CI 0.73,0.98; anxiety: 0.62, 95%CI 0.49,0.78); spinal cord injuries (mobility: 0.61, 95%CI 0.45,0.83), self-care: 0.76, 95%CI 0.63,0.91, activity: 0.64, 95%CI 0.47,0.88); moderate/severe traumatic brain injury (activity: 0.83, 95%CI 0.71,0.96). ARRs were also low for certain fractures, with various health states affected. Conclusions: HRQoL outcomes over time for children and adolescents post-injury differed across key demographic and injury related attributes. HRQoL did not reach levels consistent with full health by 24 months with recovery plateauing from 6 to 24 months. Tailored interventions are required to respond to the varying post-injury recovery trajectories in this population.
published_date 2021-09-27T04:14:26Z
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