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Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data
,
Shanthi Ameratunga,
Mariana Brussoni,
Fiona E. Lecky,
Clare Bradley,
Ben Beck,
Jane Lyons,
Amy Schneeberg,
James E. Harrison,
Belinda Gabbe
International Journal of Environmental Research and Public Health, Volume: 18, Issue: 19, Start page: 10156
Swansea University Authors:
Ronan Lyons , Jane Lyons, Belinda Gabbe
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DOI (Published version): 10.3390/ijerph181910156
Abstract
Background: Injury is a leading contributor to the global disease burden in children, affecting their health-related quality of life (HRQoL)—yet valid estimates of burden are absent. Methods: This study pooled longitudinal data from five cohort studies of pediatric injury survivors (5–17 years) at b...
| Published in: | International Journal of Environmental Research and Public Health |
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| ISSN: | 1660-4601 |
| Published: |
MDPI AG
2021
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa58149 |
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| Abstract: |
Background: Injury is a leading contributor to the global disease burden in children, affecting their health-related quality of life (HRQoL)—yet valid estimates of burden are absent. Methods: This study pooled longitudinal data from five cohort studies of pediatric injury survivors (5–17 years) at baseline, 1-, 4-, 6-, 12-, and 24- months (n = 2334). HRQoL post-injury was measured using the 3-level EQ-5D utility score (EQ-5D) and five health states (mobility, self-care, activity, pain, anxiety and depression (anxiety)). Results: Mean EQ-5D post-injury did not return to baseline level (0.95) by 24 months (0.88) and was lower for females over time (−0.04, 95%CI −0.05, −0.02). A decreased adjusted risk ratio over time (ARR) was observed for intentional injuries (pain: 0.85, 95%CI 0.73,0.98; anxiety: 0.62, 95%CI 0.49,0.78); spinal cord injuries (mobility: 0.61, 95%CI 0.45,0.83), self-care: 0.76, 95%CI 0.63,0.91, activity: 0.64, 95%CI 0.47,0.88); moderate/severe traumatic brain injury (activity: 0.83, 95%CI 0.71,0.96). ARRs were also low for certain fractures, with various health states affected. Conclusions: HRQoL outcomes over time for children and adolescents post-injury differed across key demographic and injury related attributes. HRQoL did not reach levels consistent with full health by 24 months with recovery plateauing from 6 to 24 months. Tailored interventions are required to respond to the varying post-injury recovery trajectories in this population. |
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| Keywords: |
health-related quality of life, health outcomes, disability, trauma, injury, EQ-5D, children, pediatric, adolescents |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
National Health and Medical Research Council of Australia Grant: NHMRC-APP1142325 Grant: (#0010009) Grant: NA Grant: NA Grant: NA Grant: NA Grant: (FT170100048) Canadian Institutes of Health Research Grant: (#TIR-104028) Michael Smith Foundation for Health Research Grant: NA |
| Issue: |
19 |
| Start Page: |
10156 |