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Biofilm Formation in Medical Device-Related Infection

Dietrich Mack, H. Rohde, Llinos Harris Orcid Logo, Angharad Davies Orcid Logo, M.A. Horstkotte, J.K.-M. Knobloch

The International Journal of Artificial Organs, Volume: 29, Issue: 4, Pages: 343 - 359

Swansea University Authors: Dietrich Mack, Llinos Harris Orcid Logo, Angharad Davies Orcid Logo

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DOI (Published version): 10.1177/039139880602900404

Abstract

Medical device-associated infections, most frequently caused by coagulase-negative staphylococci, especially Staphylococcus epidermidis, are of increasing importance in modern medicine. Regularly, antimicrobial therapy fails without removal of the implanted device. The most important factor in the p...

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Published in: The International Journal of Artificial Organs
ISSN: 0391-3988 1724-6040
Published: SAGE Publications 2006
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URI: https://cronfa.swan.ac.uk/Record/cronfa57859
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last_indexed 2021-09-30T03:21:59Z
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spelling 2021-09-29T15:36:13.6231979 v2 57859 2021-09-10 Biofilm Formation in Medical Device-Related Infection c6afa8ec5adb139f55d50550e0d9f03f Dietrich Mack Dietrich Mack true false dc70f9d4badbbdb5d467fd321986d173 0000-0002-0295-3038 Llinos Harris Llinos Harris true false 62586459693e05b2e1063967e76883f1 0000-0003-4190-8894 Angharad Davies Angharad Davies true false 2021-09-10 Medical device-associated infections, most frequently caused by coagulase-negative staphylococci, especially Staphylococcus epidermidis, are of increasing importance in modern medicine. Regularly, antimicrobial therapy fails without removal of the implanted device. The most important factor in the pathogenesis of medical device-associated staphylococcal infections is the formation of adherent, multilayered bacterial biofilms. There is urgent need for an increased understanding of the functional factors involved in biofilm formation, the regulation of their expression, and the interaction of those potential virulence factors in device related infection with the host. Significant progress has been made in recent years which may ultimately lead to new rational approaches for better preventive, therapeutic, and diagnostic measures. Journal Article The International Journal of Artificial Organs 29 4 343 359 SAGE Publications 0391-3988 1724-6040 Polysaccharide intercellular adhesin, Primary attachment, Biofilm accumulation, Staphylococcus epidermidis, Staphylococcal virulence, Alternative sigma factor σB, Adhesion, Implants 1 4 2006 2006-04-01 10.1177/039139880602900404 COLLEGE NANME COLLEGE CODE Swansea University 2021-09-29T15:36:13.6231979 2021-09-10T23:23:50.3380652 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Dietrich Mack 1 H. Rohde 2 Llinos Harris 0000-0002-0295-3038 3 Angharad Davies 0000-0003-4190-8894 4 M.A. Horstkotte 5 J.K.-M. Knobloch 6
title Biofilm Formation in Medical Device-Related Infection
spellingShingle Biofilm Formation in Medical Device-Related Infection
Dietrich Mack
Llinos Harris
Angharad Davies
title_short Biofilm Formation in Medical Device-Related Infection
title_full Biofilm Formation in Medical Device-Related Infection
title_fullStr Biofilm Formation in Medical Device-Related Infection
title_full_unstemmed Biofilm Formation in Medical Device-Related Infection
title_sort Biofilm Formation in Medical Device-Related Infection
author_id_str_mv c6afa8ec5adb139f55d50550e0d9f03f
dc70f9d4badbbdb5d467fd321986d173
62586459693e05b2e1063967e76883f1
author_id_fullname_str_mv c6afa8ec5adb139f55d50550e0d9f03f_***_Dietrich Mack
dc70f9d4badbbdb5d467fd321986d173_***_Llinos Harris
62586459693e05b2e1063967e76883f1_***_Angharad Davies
author Dietrich Mack
Llinos Harris
Angharad Davies
author2 Dietrich Mack
H. Rohde
Llinos Harris
Angharad Davies
M.A. Horstkotte
J.K.-M. Knobloch
format Journal article
container_title The International Journal of Artificial Organs
container_volume 29
container_issue 4
container_start_page 343
publishDate 2006
institution Swansea University
issn 0391-3988
1724-6040
doi_str_mv 10.1177/039139880602900404
publisher SAGE Publications
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
active_str 0
description Medical device-associated infections, most frequently caused by coagulase-negative staphylococci, especially Staphylococcus epidermidis, are of increasing importance in modern medicine. Regularly, antimicrobial therapy fails without removal of the implanted device. The most important factor in the pathogenesis of medical device-associated staphylococcal infections is the formation of adherent, multilayered bacterial biofilms. There is urgent need for an increased understanding of the functional factors involved in biofilm formation, the regulation of their expression, and the interaction of those potential virulence factors in device related infection with the host. Significant progress has been made in recent years which may ultimately lead to new rational approaches for better preventive, therapeutic, and diagnostic measures.
published_date 2006-04-01T20:04:54Z
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score 11.04748

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