Journal article 851 views
Biofilm Formation in Medical Device-Related Infection
,
Angharad Davies ,
M.A. Horstkotte,
J.K.-M. Knobloch
The International Journal of Artificial Organs, Volume: 29, Issue: 4, Pages: 343 - 359
Swansea University Authors:
Dietrich Mack, Llinos Harris , Angharad Davies
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1177/039139880602900404
Abstract
Medical device-associated infections, most frequently caused by coagulase-negative staphylococci, especially Staphylococcus epidermidis, are of increasing importance in modern medicine. Regularly, antimicrobial therapy fails without removal of the implanted device. The most important factor in the p...
| Published in: | The International Journal of Artificial Organs |
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| ISSN: | 0391-3988 1724-6040 |
| Published: |
SAGE Publications
2006
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa57859 |
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| Abstract: |
Medical device-associated infections, most frequently caused by coagulase-negative staphylococci, especially Staphylococcus epidermidis, are of increasing importance in modern medicine. Regularly, antimicrobial therapy fails without removal of the implanted device. The most important factor in the pathogenesis of medical device-associated staphylococcal infections is the formation of adherent, multilayered bacterial biofilms. There is urgent need for an increased understanding of the functional factors involved in biofilm formation, the regulation of their expression, and the interaction of those potential virulence factors in device related infection with the host. Significant progress has been made in recent years which may ultimately lead to new rational approaches for better preventive, therapeutic, and diagnostic measures. |
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| Keywords: |
Polysaccharide intercellular adhesin, Primary attachment, Biofilm accumulation, Staphylococcus epidermidis, Staphylococcal virulence, Alternative sigma factor σB, Adhesion, Implants |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
4 |
| Start Page: |
343 |
| End Page: |
359 |