Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: whole population cohort study in 46 million adults in England

Whiteley, William N; Ip, Samantha; Cooper, Jennifer A; Bolton, Thomas; Keene, Spencer; Walker, Venexia; Denholm, Rachel; Akbari, Ashley; Omigie, Efosa; Hollings, Sam; Angelantonio, Emanuele Di; Denaxas, Spiros; Wood, Angela; C, Jonathan A; Sudlow, Cathie; consortium), (CVD-COVID-UK

doi:10.1371/journal.pmed.1003926

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Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: whole population cohort study in 46 million adults in England

William N Whiteley

, Samantha Ip, Jennifer A Cooper

, Thomas Bolton, Spencer Keene

, Venexia Walker

, Rachel Denholm

, Ashley Akbari

, Efosa Omigie, Sam Hollings, Emanuele Di Angelantonio

, Spiros Denaxas

, Angela Wood

, Jonathan A C Sterne

, Cathie Sudlow

, (CVD-COVID-UK consortium)

PLOS Medicine

Swansea University Author: Ashley Akbari

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DOI (Published version): 10.1371/journal.pmed.1003926

Abstract

Thromboses in unusual locations after the Coronavirus Disease 2019 (COVID-19) vaccine ChAdOx1-S have been reported, although their frequency with vaccines of different types is uncertain at a population level. The aim of this study was to estimate the population-level risks of hospitalised thrombocy...

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Published in:	PLOS Medicine
ISSN:	1549-1676
Published:	Cold Spring Harbor Laboratory 2022
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa57688
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first_indexed	2021-09-17T15:55:59Z
last_indexed	2022-04-30T03:26:52Z
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spelling	2022-04-29T16:02:40.8238958 v2 57688 2021-08-24 Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: whole population cohort study in 46 million adults in England aa1b025ec0243f708bb5eb0a93d6fb52 0000-0003-0814-0801 Ashley Akbari Ashley Akbari true false 2021-08-24 HDAT Thromboses in unusual locations after the Coronavirus Disease 2019 (COVID-19) vaccine ChAdOx1-S have been reported, although their frequency with vaccines of different types is uncertain at a population level. The aim of this study was to estimate the population-level risks of hospitalised thrombocytopenia and major arterial and venous thromboses after COVID-19 vaccination. Journal Article PLOS Medicine 0 Cold Spring Harbor Laboratory 1549-1676 22 2 2022 2022-02-22 10.1371/journal.pmed.1003926 Preprint article before certification by peer review: http://dx.doi.org/10.1101/2021.08.18.21262222 COLLEGE NANME Health Data Science COLLEGE CODE HDAT Swansea University SU Library paid the OA fee (TA Institutional Deal) This work uses data provided by patients and collected by the NHS as part of their care and support. We would also like to acknowledge all data providers who make anonymised data available for research. 2022-04-29T16:02:40.8238958 2021-08-24T23:04:14.2676923 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine William N Whiteley 0000-0002-4816-8991 1 Samantha Ip 2 Jennifer A Cooper 0000-0001-9364-7353 3 Thomas Bolton 4 Spencer Keene 0000-0003-0622-6476 5 Venexia Walker 0000-0001-5064-446x 6 Rachel Denholm 0000-0002-8067-5440 7 Ashley Akbari 0000-0003-0814-0801 8 Efosa Omigie 9 Sam Hollings 10 Emanuele Di Angelantonio 0000-0001-8776-6719 11 Spiros Denaxas 0000-0001-9612-7791 12 Angela Wood 0000-0002-7937-304x 13 Jonathan A C Sterne 0000-0001-8496-6053 14 Cathie Sudlow 0000-0002-7725-7520 15 (CVD-COVID-UK consortium) 16 57688__23941__69a222d696ec4cd991ed01d7cb47ee8e.pdf 57688.VOR.pdf 2022-04-29T15:58:51.6535936 Output 1352580 application/pdf Version of Record true Copyright: © 2022 Whiteley et al. This is an open access article distributed under the terms of the Creative Commons Attribution License. true eng http://creativecommons.org/licenses/by/4.0/
title	Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: whole population cohort study in 46 million adults in England
spellingShingle	Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: whole population cohort study in 46 million adults in England Ashley Akbari
title_short	Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: whole population cohort study in 46 million adults in England
title_full	Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: whole population cohort study in 46 million adults in England
title_fullStr	Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: whole population cohort study in 46 million adults in England
title_full_unstemmed	Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: whole population cohort study in 46 million adults in England
title_sort	Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: whole population cohort study in 46 million adults in England
author_id_str_mv	aa1b025ec0243f708bb5eb0a93d6fb52
author_id_fullname_str_mv	aa1b025ec0243f708bb5eb0a93d6fb52_***_Ashley Akbari
author	Ashley Akbari
author2	William N Whiteley Samantha Ip Jennifer A Cooper Thomas Bolton Spencer Keene Venexia Walker Rachel Denholm Ashley Akbari Efosa Omigie Sam Hollings Emanuele Di Angelantonio Spiros Denaxas Angela Wood Jonathan A C Sterne Cathie Sudlow (CVD-COVID-UK consortium)
format	Journal article
container_title	PLOS Medicine
container_volume	0
publishDate	2022
institution	Swansea University
issn	1549-1676
doi_str_mv	10.1371/journal.pmed.1003926
publisher	Cold Spring Harbor Laboratory
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description	Thromboses in unusual locations after the Coronavirus Disease 2019 (COVID-19) vaccine ChAdOx1-S have been reported, although their frequency with vaccines of different types is uncertain at a population level. The aim of this study was to estimate the population-level risks of hospitalised thrombocytopenia and major arterial and venous thromboses after COVID-19 vaccination.
published_date	2022-02-22T04:13:36Z
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Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: whole population cohort study in 46 million adults in England

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