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Time-resolved in situ synchrotron-microCT: 4D deformation of bone and bone analogues using digital volume correlation

Marta Peña Fernández, Alexander P. Kao, Roxane Bonithon, David Howells, Andrew J. Bodey, Kazimir Wanelik, Frank Witte, Richard Johnston Orcid Logo, Hari Arora Orcid Logo, Gianluca Tozzi

Acta Biomaterialia, Volume: 131, Pages: 424 - 439

Swansea University Authors: David Howells, Richard Johnston Orcid Logo, Hari Arora Orcid Logo

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DOI (Published version): 10.1016/j.actbio.2021.06.014

Abstract

Digital volume correlation (DVC) in combination with high-resolution micro-computed tomography (microCT) imaging and in situ mechanical testing is gaining popularity for quantifying 3D full-field strains in bone and biomaterials. However, traditional in situ time-lapsed (i.e., interrupted) mechanica...

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Published in: Acta Biomaterialia
ISSN: 1742-7061
Published: Elsevier BV 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa57047
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However, traditional in situ time-lapsed (i.e., interrupted) mechanical testing cannot fully capture the dynamic strain mechanisms in viscoelastic biological materials. The aim of this study was to investigate the time-resolved deformation of bone structures and analogues via continuous in situ synchrotron-radiation microCT (SR-microCT) compression and DVC to gain a better insight into their structure-function relationships. Fast SR-microCT imaging enabled the deformation behaviour to be captured with high temporal and spatial resolution. Time-resolved DVC highlighted the relationship between local strains and damage initiation and progression in the different biostructures undergoing plastic deformation, bending and/or buckling of their main microstructural elements. The results showed that SR-microCT continuous mechanical testing complemented and enhanced the information obtained from time-lapsed testing, which may underestimate the 3D strain magnitudes as a result of the stress relaxation occurring in between steps before image acquisition in porous biomaterials. 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spelling 2022-10-31T18:53:55.9350753 v2 57047 2021-06-08 Time-resolved in situ synchrotron-microCT: 4D deformation of bone and bone analogues using digital volume correlation 1e204d7456909eaa1bcd19f5d7415134 David Howells David Howells true false 23282e7acce87dd926b8a62ae410a393 0000-0003-1977-6418 Richard Johnston Richard Johnston true false ed7371c768e9746008a6807f9f7a1555 0000-0002-9790-0907 Hari Arora Hari Arora true false 2021-06-08 Digital volume correlation (DVC) in combination with high-resolution micro-computed tomography (microCT) imaging and in situ mechanical testing is gaining popularity for quantifying 3D full-field strains in bone and biomaterials. However, traditional in situ time-lapsed (i.e., interrupted) mechanical testing cannot fully capture the dynamic strain mechanisms in viscoelastic biological materials. The aim of this study was to investigate the time-resolved deformation of bone structures and analogues via continuous in situ synchrotron-radiation microCT (SR-microCT) compression and DVC to gain a better insight into their structure-function relationships. Fast SR-microCT imaging enabled the deformation behaviour to be captured with high temporal and spatial resolution. Time-resolved DVC highlighted the relationship between local strains and damage initiation and progression in the different biostructures undergoing plastic deformation, bending and/or buckling of their main microstructural elements. The results showed that SR-microCT continuous mechanical testing complemented and enhanced the information obtained from time-lapsed testing, which may underestimate the 3D strain magnitudes as a result of the stress relaxation occurring in between steps before image acquisition in porous biomaterials. Altogether, the findings of this study highlight the importance of time-resolved in situ experiments to fully characterise the time-dependent mechanical behaviour of biological tissues and biomaterials and to further explore their micromechanics under physiologically relevant conditions. Journal Article Acta Biomaterialia 131 424 439 Elsevier BV 1742-7061 Bone, time-resolved SR-microCT, continuous in situ mechanics, digital volume correlation, time-dependent behaviour 1 9 2021 2021-09-01 10.1016/j.actbio.2021.06.014 COLLEGE NANME COLLEGE CODE Swansea University 2022-10-31T18:53:55.9350753 2021-06-08T09:19:21.2923437 Faculty of Science and Engineering School of Engineering and Applied Sciences - Materials Science and Engineering Marta Peña Fernández 1 Alexander P. Kao 2 Roxane Bonithon 3 David Howells 4 Andrew J. Bodey 5 Kazimir Wanelik 6 Frank Witte 7 Richard Johnston 0000-0003-1977-6418 8 Hari Arora 0000-0002-9790-0907 9 Gianluca Tozzi 10 57047__20073__5d4dc91ded3e4c5b8ddf07901e73b707.pdf 57047.pdf 2021-06-08T09:23:31.4649742 Output 6537005 application/pdf Accepted Manuscript true 2022-06-12T00:00:00.0000000 ©2021 All rights reserved. All article content, except where otherwise noted, is licensed under a Creative Commons Attribution Non-Commercial No Derivatives License (CC-BY-NC-ND) true eng http://creativecommons.org/licenses/by-nc-nd/4.0/
title Time-resolved in situ synchrotron-microCT: 4D deformation of bone and bone analogues using digital volume correlation
spellingShingle Time-resolved in situ synchrotron-microCT: 4D deformation of bone and bone analogues using digital volume correlation
David Howells
Richard Johnston
Hari Arora
title_short Time-resolved in situ synchrotron-microCT: 4D deformation of bone and bone analogues using digital volume correlation
title_full Time-resolved in situ synchrotron-microCT: 4D deformation of bone and bone analogues using digital volume correlation
title_fullStr Time-resolved in situ synchrotron-microCT: 4D deformation of bone and bone analogues using digital volume correlation
title_full_unstemmed Time-resolved in situ synchrotron-microCT: 4D deformation of bone and bone analogues using digital volume correlation
title_sort Time-resolved in situ synchrotron-microCT: 4D deformation of bone and bone analogues using digital volume correlation
author_id_str_mv 1e204d7456909eaa1bcd19f5d7415134
23282e7acce87dd926b8a62ae410a393
ed7371c768e9746008a6807f9f7a1555
author_id_fullname_str_mv 1e204d7456909eaa1bcd19f5d7415134_***_David Howells
23282e7acce87dd926b8a62ae410a393_***_Richard Johnston
ed7371c768e9746008a6807f9f7a1555_***_Hari Arora
author David Howells
Richard Johnston
Hari Arora
author2 Marta Peña Fernández
Alexander P. Kao
Roxane Bonithon
David Howells
Andrew J. Bodey
Kazimir Wanelik
Frank Witte
Richard Johnston
Hari Arora
Gianluca Tozzi
format Journal article
container_title Acta Biomaterialia
container_volume 131
container_start_page 424
publishDate 2021
institution Swansea University
issn 1742-7061
doi_str_mv 10.1016/j.actbio.2021.06.014
publisher Elsevier BV
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Materials Science and Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Materials Science and Engineering
document_store_str 1
active_str 0
description Digital volume correlation (DVC) in combination with high-resolution micro-computed tomography (microCT) imaging and in situ mechanical testing is gaining popularity for quantifying 3D full-field strains in bone and biomaterials. However, traditional in situ time-lapsed (i.e., interrupted) mechanical testing cannot fully capture the dynamic strain mechanisms in viscoelastic biological materials. The aim of this study was to investigate the time-resolved deformation of bone structures and analogues via continuous in situ synchrotron-radiation microCT (SR-microCT) compression and DVC to gain a better insight into their structure-function relationships. Fast SR-microCT imaging enabled the deformation behaviour to be captured with high temporal and spatial resolution. Time-resolved DVC highlighted the relationship between local strains and damage initiation and progression in the different biostructures undergoing plastic deformation, bending and/or buckling of their main microstructural elements. The results showed that SR-microCT continuous mechanical testing complemented and enhanced the information obtained from time-lapsed testing, which may underestimate the 3D strain magnitudes as a result of the stress relaxation occurring in between steps before image acquisition in porous biomaterials. Altogether, the findings of this study highlight the importance of time-resolved in situ experiments to fully characterise the time-dependent mechanical behaviour of biological tissues and biomaterials and to further explore their micromechanics under physiologically relevant conditions.
published_date 2021-09-01T07:58:29Z
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