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Cholesterol metabolism pathways – are the intermediates more important than the products?

Yuqin Wang Orcid Logo, Eylan Yutuc Orcid Logo, William Griffiths Orcid Logo

The FEBS Journal, Volume: 288, Issue: 12, Pages: 3727 - 3745

Swansea University Authors: Yuqin Wang Orcid Logo, Eylan Yutuc Orcid Logo, William Griffiths Orcid Logo

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DOI (Published version): 10.1111/febs.15727

Abstract

Every cell in vertebrates possesses the machinery to synthesise cholesterol and to metabolise it. The major route of cholesterol metabolism is conversion to bile acids. Bile acids themselves are interesting molecules being ligands to nuclear and G protein-coupled receptors, but perhaps the intermedi...

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Published in: The FEBS Journal
ISSN: 1742-464X 1742-4658
Published: Wiley 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa56158
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first_indexed 2021-02-01T14:34:37Z
last_indexed 2021-08-13T03:22:50Z
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spelling 2021-08-12T13:07:17.4553619 v2 56158 2021-02-01 Cholesterol metabolism pathways – are the intermediates more important than the products? c92729b58622f9fdf6a0e7d8f4ce5081 0000-0002-3063-3066 Yuqin Wang Yuqin Wang true false 99332f073ce913a9b7d8b6441b17516d 0000-0001-9971-1950 Eylan Yutuc Eylan Yutuc true false 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2021-02-01 BMS Every cell in vertebrates possesses the machinery to synthesise cholesterol and to metabolise it. The major route of cholesterol metabolism is conversion to bile acids. Bile acids themselves are interesting molecules being ligands to nuclear and G protein-coupled receptors, but perhaps the intermediates in the bile acid biosynthesis pathways are even more interesting and equally important. Here we discuss the biological activity of the different intermediates generated in the various bile acid biosynthesis pathways. We put forward the hypothesis that the acidic pathway of bile acid biosynthesis has primary evolved to generate signalling molecules and its utilisation by hepatocytes provides an added bonus of producing bile acids to aid absorption of lipids in the intestine. Journal Article The FEBS Journal 288 12 3727 3745 Wiley 1742-464X 1742-4658 cholestenoic acids; COVID-19; G protein-coupled receptors; glutamate receptors; inborn errors of metabolism; massspectrometry; nuclear receptors; oxysterols; sterols 21 6 2021 2021-06-21 10.1111/febs.15727 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2021-08-12T13:07:17.4553619 2021-02-01T14:31:33.5492136 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Yuqin Wang 0000-0002-3063-3066 1 Eylan Yutuc 0000-0001-9971-1950 2 William Griffiths 0000-0002-4129-6616 3 56158__19434__38d776f147c94249bd140cfd1fa33ef3.pdf 56158.pdf 2021-03-04T19:12:27.3336594 Output 1608965 application/pdf Version of Record true © 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title Cholesterol metabolism pathways – are the intermediates more important than the products?
spellingShingle Cholesterol metabolism pathways – are the intermediates more important than the products?
Yuqin Wang
Eylan Yutuc
William Griffiths
title_short Cholesterol metabolism pathways – are the intermediates more important than the products?
title_full Cholesterol metabolism pathways – are the intermediates more important than the products?
title_fullStr Cholesterol metabolism pathways – are the intermediates more important than the products?
title_full_unstemmed Cholesterol metabolism pathways – are the intermediates more important than the products?
title_sort Cholesterol metabolism pathways – are the intermediates more important than the products?
author_id_str_mv c92729b58622f9fdf6a0e7d8f4ce5081
99332f073ce913a9b7d8b6441b17516d
3316b1d1b524be1831790933eed1c26e
author_id_fullname_str_mv c92729b58622f9fdf6a0e7d8f4ce5081_***_Yuqin Wang
99332f073ce913a9b7d8b6441b17516d_***_Eylan Yutuc
3316b1d1b524be1831790933eed1c26e_***_William Griffiths
author Yuqin Wang
Eylan Yutuc
William Griffiths
author2 Yuqin Wang
Eylan Yutuc
William Griffiths
format Journal article
container_title The FEBS Journal
container_volume 288
container_issue 12
container_start_page 3727
publishDate 2021
institution Swansea University
issn 1742-464X
1742-4658
doi_str_mv 10.1111/febs.15727
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description Every cell in vertebrates possesses the machinery to synthesise cholesterol and to metabolise it. The major route of cholesterol metabolism is conversion to bile acids. Bile acids themselves are interesting molecules being ligands to nuclear and G protein-coupled receptors, but perhaps the intermediates in the bile acid biosynthesis pathways are even more interesting and equally important. Here we discuss the biological activity of the different intermediates generated in the various bile acid biosynthesis pathways. We put forward the hypothesis that the acidic pathway of bile acid biosynthesis has primary evolved to generate signalling molecules and its utilisation by hepatocytes provides an added bonus of producing bile acids to aid absorption of lipids in the intestine.
published_date 2021-06-21T04:10:54Z
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score 11.037581

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