Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements

Arora, Hari; Mitchell, Ria; Johnston, Richard; Manolesos, Marinos; Howells, David; Sherwood, Joseph; Bodey, Andrew; Wanelik, Kaz

doi:10.3390/ma14020439

Journal article 1079 views 138 downloads

Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements

Hari Arora

, Ria Mitchell

, Richard Johnston

, Marinos Manolesos

, David Howells, Joseph Sherwood, Andrew Bodey, Kaz Wanelik

Materials, Volume: 14, Issue: 2, Start page: 439

Swansea University Authors: Hari Arora , Ria Mitchell , Richard Johnston , Marinos Manolesos , David Howells

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DOI (Published version): 10.3390/ma14020439

Abstract

Abstract: The mechanics of breathing is a fascinating and vital process. The lung has complexities andsubtle heterogeneities in structure across length scales that influence mechanics and function. Thisstudy establishes an experimental pipeline for capturing alveolar deformations during a respirator...

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Published in:	Materials
ISSN:	1996-1944
Published:	MDPI AG 2021
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa56090

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last_indexed	2021-02-20T04:19:08Z
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The lung has complexities andsubtle heterogeneities in structure across length scales that influence mechanics and function. Thisstudy establishes an experimental pipeline for capturing alveolar deformations during a respiratorycycle using synchrotron radiation micro-computed tomography (SR-micro-CT). Rodent lungs weremechanically ventilated and imaged at various time points during the respiratory cycle. PressureVolume (P-V) characteristics were recorded to capture any changes in overall lung mechanicalbehaviour during the experiment. A sequence of tomograms was collected from the lungs within theintact thoracic cavity. Digital volume correlation (DVC) was used to compute the three-dimensionalstrain field at the alveolar level from the time sequence of reconstructed tomograms. Regionaldifferences in ventilation were highlighted during the respiratory cycle, relating the local strainswithin the lung tissue to the global ventilation measurements. Strains locally reached approximately150% compared to the averaged regional deformations of approximately 80–100%. Redistribution ofair within the lungs was observed during cycling. Regions which were relatively poorly ventilated(low deformations compared to its neighbouring region) were deforming more uniformly at laterstages of the experiment (consistent with its neighbouring region). Such heterogenous phenomena arecommon in everyday breathing. In pathological lungs, some of these non-uniformities in deformationbehaviour can become exaggerated, leading to poor function or further damage. The techniquepresented can help characterize the multiscale biomechanical nature of a given pathology to improvepatient management strategies, considering both the local and global lung mechanics.</abstract><type>Journal Article</type><journal>Materials</journal><volume>14</volume><journalNumber>2</journalNumber><paginationStart>439</paginationStart><paginationEnd/><publisher>MDPI AG</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>1996-1944</issnElectronic><keywords>lung mechanics; micro-CT; synchrotron; digital volume correlation; alveoli</keywords><publishedDay>18</publishedDay><publishedMonth>1</publishedMonth><publishedYear>2021</publishedYear><publishedDate>2021-01-18</publishedDate><doi>10.3390/ma14020439</doi><url/><notes/><college>COLLEGE NANME</college><department>Engineering and Applied Sciences School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>EAAS</DepartmentCode><institution>Swansea University</institution><apcterm/><funders>UKRI Block Grant, EP/M028267/1</funders><lastEdited>2021-02-19T09:01:49.8436993</lastEdited><Created>2021-01-21T14:03:17.0688421</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Materials Science and Engineering</level></path><authors><author><firstname>Hari</firstname><surname>Arora</surname><orcid>0000-0002-9790-0907</orcid><order>1</order></author><author><firstname>Ria</firstname><surname>Mitchell</surname><orcid>0000-0002-6328-3998</orcid><order>2</order></author><author><firstname>Richard</firstname><surname>Johnston</surname><orcid>0000-0003-1977-6418</orcid><order>3</order></author><author><firstname>Marinos</firstname><surname>Manolesos</surname><orcid>0000-0002-5506-6061</orcid><order>4</order></author><author><firstname>David</firstname><surname>Howells</surname><order>5</order></author><author><firstname>Joseph</firstname><surname>Sherwood</surname><order>6</order></author><author><firstname>Andrew</firstname><surname>Bodey</surname><order>7</order></author><author><firstname>Kaz</firstname><surname>Wanelik</surname><order>8</order></author></authors><documents><document><filename>56090__19145__6f4254334fa347c4aa0c1b46a645327e.pdf</filename><originalFilename>materials-14-00439.pdf</originalFilename><uploaded>2021-01-21T14:08:49.5311720</uploaded><type>Output</type><contentLength>11833144</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>Copyright: © 2021 by the authors. 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spelling	2021-02-19T09:01:49.8436993 v2 56090 2021-01-21 Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements ed7371c768e9746008a6807f9f7a1555 0000-0002-9790-0907 Hari Arora Hari Arora true false fcfffafbafb0036c483338f839df45e5 0000-0002-6328-3998 Ria Mitchell Ria Mitchell true false 23282e7acce87dd926b8a62ae410a393 0000-0003-1977-6418 Richard Johnston Richard Johnston true false 44a3e0d351ccd7a8365d5fc7c50c8778 0000-0002-5506-6061 Marinos Manolesos Marinos Manolesos true false 1e204d7456909eaa1bcd19f5d7415134 David Howells David Howells true false 2021-01-21 EAAS Abstract: The mechanics of breathing is a fascinating and vital process. The lung has complexities andsubtle heterogeneities in structure across length scales that influence mechanics and function. Thisstudy establishes an experimental pipeline for capturing alveolar deformations during a respiratorycycle using synchrotron radiation micro-computed tomography (SR-micro-CT). Rodent lungs weremechanically ventilated and imaged at various time points during the respiratory cycle. PressureVolume (P-V) characteristics were recorded to capture any changes in overall lung mechanicalbehaviour during the experiment. A sequence of tomograms was collected from the lungs within theintact thoracic cavity. Digital volume correlation (DVC) was used to compute the three-dimensionalstrain field at the alveolar level from the time sequence of reconstructed tomograms. Regionaldifferences in ventilation were highlighted during the respiratory cycle, relating the local strainswithin the lung tissue to the global ventilation measurements. Strains locally reached approximately150% compared to the averaged regional deformations of approximately 80–100%. Redistribution ofair within the lungs was observed during cycling. Regions which were relatively poorly ventilated(low deformations compared to its neighbouring region) were deforming more uniformly at laterstages of the experiment (consistent with its neighbouring region). Such heterogenous phenomena arecommon in everyday breathing. In pathological lungs, some of these non-uniformities in deformationbehaviour can become exaggerated, leading to poor function or further damage. The techniquepresented can help characterize the multiscale biomechanical nature of a given pathology to improvepatient management strategies, considering both the local and global lung mechanics. Journal Article Materials 14 2 439 MDPI AG 1996-1944 lung mechanics; micro-CT; synchrotron; digital volume correlation; alveoli 18 1 2021 2021-01-18 10.3390/ma14020439 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University UKRI Block Grant, EP/M028267/1 2021-02-19T09:01:49.8436993 2021-01-21T14:03:17.0688421 Faculty of Science and Engineering School of Engineering and Applied Sciences - Materials Science and Engineering Hari Arora 0000-0002-9790-0907 1 Ria Mitchell 0000-0002-6328-3998 2 Richard Johnston 0000-0003-1977-6418 3 Marinos Manolesos 0000-0002-5506-6061 4 David Howells 5 Joseph Sherwood 6 Andrew Bodey 7 Kaz Wanelik 8 56090__19145__6f4254334fa347c4aa0c1b46a645327e.pdf materials-14-00439.pdf 2021-01-21T14:08:49.5311720 Output 11833144 application/pdf Version of Record true Copyright: © 2021 by the authors. Distributed under the terms of a Creative Commons Attribution 4.0 (CC-BY)License. true eng https://creativecommons.org/licenses/by/4.0/
title	Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements
spellingShingle	Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements Hari Arora Ria Mitchell Richard Johnston Marinos Manolesos David Howells
title_short	Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements
title_full	Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements
title_fullStr	Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements
title_full_unstemmed	Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements
title_sort	Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements
author_id_str_mv	ed7371c768e9746008a6807f9f7a1555 fcfffafbafb0036c483338f839df45e5 23282e7acce87dd926b8a62ae410a393 44a3e0d351ccd7a8365d5fc7c50c8778 1e204d7456909eaa1bcd19f5d7415134
author_id_fullname_str_mv	ed7371c768e9746008a6807f9f7a1555_*_Hari Arora fcfffafbafb0036c483338f839df45e5__Ria Mitchell 23282e7acce87dd926b8a62ae410a393__Richard Johnston 44a3e0d351ccd7a8365d5fc7c50c8778__Marinos Manolesos 1e204d7456909eaa1bcd19f5d7415134_**_David Howells
author	Hari Arora Ria Mitchell Richard Johnston Marinos Manolesos David Howells
author2	Hari Arora Ria Mitchell Richard Johnston Marinos Manolesos David Howells Joseph Sherwood Andrew Bodey Kaz Wanelik
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issn	1996-1944
doi_str_mv	10.3390/ma14020439
publisher	MDPI AG
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description	Abstract: The mechanics of breathing is a fascinating and vital process. The lung has complexities andsubtle heterogeneities in structure across length scales that influence mechanics and function. Thisstudy establishes an experimental pipeline for capturing alveolar deformations during a respiratorycycle using synchrotron radiation micro-computed tomography (SR-micro-CT). Rodent lungs weremechanically ventilated and imaged at various time points during the respiratory cycle. PressureVolume (P-V) characteristics were recorded to capture any changes in overall lung mechanicalbehaviour during the experiment. A sequence of tomograms was collected from the lungs within theintact thoracic cavity. Digital volume correlation (DVC) was used to compute the three-dimensionalstrain field at the alveolar level from the time sequence of reconstructed tomograms. Regionaldifferences in ventilation were highlighted during the respiratory cycle, relating the local strainswithin the lung tissue to the global ventilation measurements. Strains locally reached approximately150% compared to the averaged regional deformations of approximately 80–100%. Redistribution ofair within the lungs was observed during cycling. Regions which were relatively poorly ventilated(low deformations compared to its neighbouring region) were deforming more uniformly at laterstages of the experiment (consistent with its neighbouring region). Such heterogenous phenomena arecommon in everyday breathing. In pathological lungs, some of these non-uniformities in deformationbehaviour can become exaggerated, leading to poor function or further damage. The techniquepresented can help characterize the multiscale biomechanical nature of a given pathology to improvepatient management strategies, considering both the local and global lung mechanics.
published_date	2021-01-18T14:03:00Z
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Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements

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