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How can the MHC mediate social odor via the microbiota community? A deep dive into mechanisms

Nadine Schubert, Hazel Nichols Orcid Logo, Jamie C Winternitz

Behavioral Ecology, Volume: 32, Issue: 3, Pages: 359 - 373

Swansea University Author: Hazel Nichols Orcid Logo

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DOI (Published version): 10.1093/beheco/arab004

Abstract

Genes of the major histocompatibility complex (MHC) have long been linked to odor signaling and recently researchers’ attention has focused on MHC structuring of microbial communities and how this may in turn impact odor. However, understanding of the mechanisms through which the MHC could affect th...

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Published in: Behavioral Ecology
ISSN: 1045-2249 1465-7279
Published: Oxford University Press (OUP) 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa55992
first_indexed 2021-01-07T12:54:23Z
last_indexed 2025-01-09T19:58:05Z
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spelling 2024-12-20T11:11:36.8933556 v2 55992 2021-01-07 How can the MHC mediate social odor via the microbiota community? A deep dive into mechanisms 43ba12986bd7754484874c73eed0ebfe 0000-0002-4455-6065 Hazel Nichols Hazel Nichols true false 2021-01-07 BGPS Genes of the major histocompatibility complex (MHC) have long been linked to odor signaling and recently researchers’ attention has focused on MHC structuring of microbial communities and how this may in turn impact odor. However, understanding of the mechanisms through which the MHC could affect the microbiota to produce a chemical signal that is both reliable and strong enough to ensure unambiguous transmission of behaviorally important information remains poor. This is largely because empirical studies are rare, predictions are unclear, and the underlying immunological mechanisms governing MHC-microbiota interactions are often neglected. Here we review the immunological processes involving MHC class II (MHC-II) that could affect the commensal community. Focusing on immunological and medical research, we provide background knowledge for non-immunologists by describing key players within the vertebrate immune system relating to MHC-II molecules (which present extracellular-derived peptides, and thus interact with extracellular commensal microbes). We then systematically review the literature investigating MHC-odor-microbiota interactions in animals and identify areas for future research. These insights will help to design studies that are able to explore the role of MHC-II and the microbiota in the behavior of wild populations in their natural environment and consequently propel this research area forward. Journal Article Behavioral Ecology 32 3 359 373 Oxford University Press (OUP) 1045-2249 1465-7279 immune response, kin recognition, major histocompatibility complex, scent, systematic review, tolerance 4 6 2021 2021-06-04 10.1093/beheco/arab004 COLLEGE NANME Biosciences Geography and Physics School COLLEGE CODE BGPS Swansea University 2024-12-20T11:11:36.8933556 2021-01-07T12:48:53.6490779 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Nadine Schubert 1 Hazel Nichols 0000-0002-4455-6065 2 Jamie C Winternitz 3 55992__19221__4bb0779f2971452293f97c975c3bb84d.pdf 55992.pdf 2021-02-02T17:42:33.0309366 Output 1102960 application/pdf Accepted Manuscript true 2022-05-18T00:00:00.0000000 true eng 55992__19222__f8ef3a204ef641b181c7e98ecda07487.pdf 55992_Supplementary materia.pdf 2021-02-02T17:43:03.8713003 Output 498373 application/pdf Supplemental material true 2022-05-18T00:00:00.0000000 true eng
title How can the MHC mediate social odor via the microbiota community? A deep dive into mechanisms
spellingShingle How can the MHC mediate social odor via the microbiota community? A deep dive into mechanisms
Hazel Nichols
title_short How can the MHC mediate social odor via the microbiota community? A deep dive into mechanisms
title_full How can the MHC mediate social odor via the microbiota community? A deep dive into mechanisms
title_fullStr How can the MHC mediate social odor via the microbiota community? A deep dive into mechanisms
title_full_unstemmed How can the MHC mediate social odor via the microbiota community? A deep dive into mechanisms
title_sort How can the MHC mediate social odor via the microbiota community? A deep dive into mechanisms
author_id_str_mv 43ba12986bd7754484874c73eed0ebfe
author_id_fullname_str_mv 43ba12986bd7754484874c73eed0ebfe_***_Hazel Nichols
author Hazel Nichols
author2 Nadine Schubert
Hazel Nichols
Jamie C Winternitz
format Journal article
container_title Behavioral Ecology
container_volume 32
container_issue 3
container_start_page 359
publishDate 2021
institution Swansea University
issn 1045-2249
1465-7279
doi_str_mv 10.1093/beheco/arab004
publisher Oxford University Press (OUP)
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences
document_store_str 1
active_str 0
description Genes of the major histocompatibility complex (MHC) have long been linked to odor signaling and recently researchers’ attention has focused on MHC structuring of microbial communities and how this may in turn impact odor. However, understanding of the mechanisms through which the MHC could affect the microbiota to produce a chemical signal that is both reliable and strong enough to ensure unambiguous transmission of behaviorally important information remains poor. This is largely because empirical studies are rare, predictions are unclear, and the underlying immunological mechanisms governing MHC-microbiota interactions are often neglected. Here we review the immunological processes involving MHC class II (MHC-II) that could affect the commensal community. Focusing on immunological and medical research, we provide background knowledge for non-immunologists by describing key players within the vertebrate immune system relating to MHC-II molecules (which present extracellular-derived peptides, and thus interact with extracellular commensal microbes). We then systematically review the literature investigating MHC-odor-microbiota interactions in animals and identify areas for future research. These insights will help to design studies that are able to explore the role of MHC-II and the microbiota in the behavior of wild populations in their natural environment and consequently propel this research area forward.
published_date 2021-06-04T14:07:02Z
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