Journal article 1170 views
Influence of long-term oxygen therapy on heart rate and QT time-series in hypoxic patients with chronic obstructive pulmonary disease
Michael Lewis,
Joe Annandale,
Keir Lewis 
Clinical Physiology and Functional Imaging, Volume: 29, Issue: 6, Pages: 431 - 439
Swansea University Authors:
Michael Lewis, Keir Lewis
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DOI (Published version): 10.1111/j.1475-097X.2009.00891.x
Abstract
Influence of long-term oxygen therapy on heart rate and QT time-series in hypoxic patients with chronic obstructive pulmonary disease
| Published in: | Clinical Physiology and Functional Imaging |
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| Published: |
2009
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa5530 |
| Item Description: |
The novelty of this work was that it was the first to report cardiac benefits of long-term oxygen therapy (LTOT) in chronic obstructive pulmonary disease (COPD), demonstrated here through time-dependent reversal of autonomic nervous system depression. A rigorous pre-post clinical intervention study design and advanced time-series analysis methods provided evidence to support additional cardiac benefits of LTOT. The work led to further clinical collaborations to establish the cardio-pulmonary pathophysiology underlying COPD. This and companion works fostered the knowledge underpinning a major industrial collaboration with Haemair Ltd. (CIRP/A4B grant HE09COL1029) to empirically model a control system for an artificial lung device. |
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| College: |
Faculty of Science and Engineering |
| Issue: |
6 |
| Start Page: |
431 |
| End Page: |
439 |