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Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis

Ane Ruiz-de-Angulo, Marc Bilbao Asensio, James Cronin Orcid Logo, Stephen Evans Orcid Logo, Martin Clift Orcid Logo, Jordi Llop, Irene V.J. Feiner, Rhiannon Beadman, Kepa Zamacola Bascarán, Juan Mareque-Rivas Orcid Logo

iScience, Volume: 23, Issue: 9, Start page: 101499

Swansea University Authors: Marc Bilbao Asensio, James Cronin Orcid Logo, Stephen Evans Orcid Logo, Martin Clift Orcid Logo, Rhiannon Beadman, Juan Mareque-Rivas Orcid Logo

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DOI (Published version): 10.1016/j.isci.2020.101499

Abstract

Immunotherapy has yielded impressive results, but only for a minority of patients with cancer. Therefore, new approaches that potentiate immunotherapy are a pressing medical need. Ferroptosis is a newly described type of programmed cell death driven by iron-dependent phospholipid peroxidation via Fe...

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Published in: iScience
ISSN: 2589-0042
Published: Elsevier BV 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa55075
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spelling 2021-09-24T15:53:51.2931687 v2 55075 2020-08-26 Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis ae3834a12e3216058248bf0c83b90a4d Marc Bilbao Asensio Marc Bilbao Asensio true false 9cfd17551c0d1f7438895121e4fbb6e8 0000-0002-0590-9462 James Cronin James Cronin true false cfca981bdfb8492873a48cc1629def9a 0000-0002-5352-9800 Stephen Evans Stephen Evans true false 71bf49b157691e541950f5c3f49c9169 0000-0001-6133-3368 Martin Clift Martin Clift true false f1515bfd40b6dc901824c1bdf8d4a7c4 Rhiannon Beadman Rhiannon Beadman true false 14faad807724ffe1fb168c3fc225be0e 0000-0002-7405-3338 Juan Mareque-Rivas Juan Mareque-Rivas true false 2020-08-26 CHEM Immunotherapy has yielded impressive results, but only for a minority of patients with cancer. Therefore, new approaches that potentiate immunotherapy are a pressing medical need. Ferroptosis is a newly described type of programmed cell death driven by iron-dependent phospholipid peroxidation via Fenton chemistry. Here, we developed iron oxide-loaded nanovaccines (IONVs), which, chemically programmed to integrate iron catalysis, drug delivery, and tracking exploiting the characteristics of the tumor microenvironment (TME), improves immunotherapy and activation of ferroptosis. The IONVs trigger danger signals and use molecular disassembly and reversible covalent bonds for targeted antigen delivery and improved immunostimulatory capacity and catalytic iron for targeting tumor cell ferroptosis. IONV- and antibody-mediated TME modulation interfaced with imaging was important toward achieving complete eradication of aggressive and established tumors, eliciting long-lived protective antitumor immunity with no toxicities. This work establishes the feasibility of using nanoparticle iron catalytic activity as a versatile and effective feature for enhancing immunotherapy. Journal Article iScience 23 9 101499 Elsevier BV 2589-0042 Immunology, Biomaterials, Nanomaterials, Cancer Therapy 25 9 2020 2020-09-25 10.1016/j.isci.2020.101499 COLLEGE NANME Chemistry COLLEGE CODE CHEM Swansea University SU College/Department paid the OA fee College of Science August 2020 (APC), EPSRC, Spanish Ministry of Economy and Competitiveness (MINECO) EP/N509553/1, EP/R51312X/1, CTQ2017-87637-R 2021-09-24T15:53:51.2931687 2020-08-26T14:31:07.0247663 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Ane Ruiz-de-Angulo 1 Marc Bilbao Asensio 2 James Cronin 0000-0002-0590-9462 3 Stephen Evans 0000-0002-5352-9800 4 Martin Clift 0000-0001-6133-3368 5 Jordi Llop 6 Irene V.J. Feiner 7 Rhiannon Beadman 8 Kepa Zamacola Bascarán 9 Juan Mareque-Rivas 0000-0002-7405-3338 10 55075__18235__c63bbee6e66e480492e21010e21fcf4a.pdf 55075.pdf 2020-09-23T16:18:14.2641882 Output 8089959 application/pdf Version of Record true © 2020 The Authors. All article content, except where otherwise noted, is licensed under a Creative Commons Attribution Non-Commercial No Derivatives License (CC-BY-NC-ND 4.0) true eng http://creativecommons.org/licenses/by-nc-nd/4.0/
title Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis
spellingShingle Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis
Marc Bilbao Asensio
James Cronin
Stephen Evans
Martin Clift
Rhiannon Beadman
Juan Mareque-Rivas
title_short Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis
title_full Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis
title_fullStr Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis
title_full_unstemmed Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis
title_sort Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis
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author_id_fullname_str_mv ae3834a12e3216058248bf0c83b90a4d_***_Marc Bilbao Asensio
9cfd17551c0d1f7438895121e4fbb6e8_***_James Cronin
cfca981bdfb8492873a48cc1629def9a_***_Stephen Evans
71bf49b157691e541950f5c3f49c9169_***_Martin Clift
f1515bfd40b6dc901824c1bdf8d4a7c4_***_Rhiannon Beadman
14faad807724ffe1fb168c3fc225be0e_***_Juan Mareque-Rivas
author Marc Bilbao Asensio
James Cronin
Stephen Evans
Martin Clift
Rhiannon Beadman
Juan Mareque-Rivas
author2 Ane Ruiz-de-Angulo
Marc Bilbao Asensio
James Cronin
Stephen Evans
Martin Clift
Jordi Llop
Irene V.J. Feiner
Rhiannon Beadman
Kepa Zamacola Bascarán
Juan Mareque-Rivas
format Journal article
container_title iScience
container_volume 23
container_issue 9
container_start_page 101499
publishDate 2020
institution Swansea University
issn 2589-0042
doi_str_mv 10.1016/j.isci.2020.101499
publisher Elsevier BV
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
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description Immunotherapy has yielded impressive results, but only for a minority of patients with cancer. Therefore, new approaches that potentiate immunotherapy are a pressing medical need. Ferroptosis is a newly described type of programmed cell death driven by iron-dependent phospholipid peroxidation via Fenton chemistry. Here, we developed iron oxide-loaded nanovaccines (IONVs), which, chemically programmed to integrate iron catalysis, drug delivery, and tracking exploiting the characteristics of the tumor microenvironment (TME), improves immunotherapy and activation of ferroptosis. The IONVs trigger danger signals and use molecular disassembly and reversible covalent bonds for targeted antigen delivery and improved immunostimulatory capacity and catalytic iron for targeting tumor cell ferroptosis. IONV- and antibody-mediated TME modulation interfaced with imaging was important toward achieving complete eradication of aggressive and established tumors, eliciting long-lived protective antitumor immunity with no toxicities. This work establishes the feasibility of using nanoparticle iron catalytic activity as a versatile and effective feature for enhancing immunotherapy.
published_date 2020-09-25T04:09:02Z
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