Journal article 21419 views 146 downloads
Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis
,
Stephen Evans ,
Martin Clift ,
Jordi Llop,
Irene V.J. Feiner,
Rhiannon Beadman,
Kepa Zamacola Bascarán,
Juan Mareque-Rivas
iScience, Volume: 23, Issue: 9, Start page: 101499
Swansea University Authors:
Marc Bilbao Asensio, James Cronin , Stephen Evans , Martin Clift , Rhiannon Beadman, Juan Mareque-Rivas
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DOI (Published version): 10.1016/j.isci.2020.101499
Abstract
Immunotherapy has yielded impressive results, but only for a minority of patients with cancer. Therefore, new approaches that potentiate immunotherapy are a pressing medical need. Ferroptosis is a newly described type of programmed cell death driven by iron-dependent phospholipid peroxidation via Fe...
| Published in: | iScience |
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| ISSN: | 2589-0042 |
| Published: |
Elsevier BV
2020
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa55075 |
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| Abstract: |
Immunotherapy has yielded impressive results, but only for a minority of patients with cancer. Therefore, new approaches that potentiate immunotherapy are a pressing medical need. Ferroptosis is a newly described type of programmed cell death driven by iron-dependent phospholipid peroxidation via Fenton chemistry. Here, we developed iron oxide-loaded nanovaccines (IONVs), which, chemically programmed to integrate iron catalysis, drug delivery, and tracking exploiting the characteristics of the tumor microenvironment (TME), improves immunotherapy and activation of ferroptosis. The IONVs trigger danger signals and use molecular disassembly and reversible covalent bonds for targeted antigen delivery and improved immunostimulatory capacity and catalytic iron for targeting tumor cell ferroptosis. IONV- and antibody-mediated TME modulation interfaced with imaging was important toward achieving complete eradication of aggressive and established tumors, eliciting long-lived protective antitumor immunity with no toxicities. This work establishes the feasibility of using nanoparticle iron catalytic activity as a versatile and effective feature for enhancing immunotherapy. |
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| Keywords: |
Immunology, Biomaterials, Nanomaterials, Cancer Therapy |
| College: |
Faculty of Science and Engineering |
| Funders: |
College of Science August 2020 (APC), EPSRC, Spanish Ministry of Economy and Competitiveness (MINECO) |
| Issue: |
9 |
| Start Page: |
101499 |