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Neuro‐oxysterols and neuro‐sterols as ligands to nuclear receptors, GPCRs, ligand‐gated ion channels and other protein receptors

Yuqin Wang Orcid Logo, Eylan Yutuc Orcid Logo, William Griffiths Orcid Logo

British Journal of Pharmacology, Volume: 178, Issue: 16, Pages: 3176 - 3193

Swansea University Authors: Yuqin Wang Orcid Logo, Eylan Yutuc Orcid Logo, William Griffiths Orcid Logo

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DOI (Published version): 10.1111/bph.15191

Abstract

The brain is the most cholesterol rich organ in the body containing about 25% of the body’s free cholesterol. Cholesterol cannot pass the blood brain barrier and be imported or exported, instead it is synthesised in situ and metabolised to oxysterols, oxidised forms of cholesterol, which can pass th...

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Published in: British Journal of Pharmacology
ISSN: 0007-1188 1476-5381
Published: Wiley 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa54644
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last_indexed 2021-09-18T03:16:11Z
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spelling 2021-09-17T13:26:40.8893602 v2 54644 2020-07-05 Neuro‐oxysterols and neuro‐sterols as ligands to nuclear receptors, GPCRs, ligand‐gated ion channels and other protein receptors c92729b58622f9fdf6a0e7d8f4ce5081 0000-0002-3063-3066 Yuqin Wang Yuqin Wang true false 99332f073ce913a9b7d8b6441b17516d 0000-0001-9971-1950 Eylan Yutuc Eylan Yutuc true false 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2020-07-05 MEDS The brain is the most cholesterol rich organ in the body containing about 25% of the body’s free cholesterol. Cholesterol cannot pass the blood brain barrier and be imported or exported, instead it is synthesised in situ and metabolised to oxysterols, oxidised forms of cholesterol, which can pass the blood brain barrier. 24S-Hydroxycholesterol is the dominant oxysterol in brain after parturition but during development a myriad of other oxysterols are produced which persist as minor oxysterols after birth. During both development and in later life, oxysterols and other sterols interact with a variety of different receptors, including nuclear receptors, membrane bound G protein-coupled receptors, the oxysterol/sterol sensing proteins INSIG and SCAP, and the ligand-gated ion channel N-methyl-D-aspartate receptors found in nerve cells. In this review we summarise the different oxysterols and sterols found in the central nervous system whose biological activity is transmitted via these different classes of protein receptors. Journal Article British Journal of Pharmacology 178 16 3176 3193 Wiley 0007-1188 1476-5381 24S-hydroxycholesterol, 24S,25-epoxycholesterol, brain, cholesterol, G protein-coupledreceptor, nuclear receptor, oxysterol 1 8 2021 2021-08-01 10.1111/bph.15191 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University UKRI, BBSRC Michael J. Fox Foundation for Parkinson's Research Wiley TA deal (Library). BB/S019588/1, BB/N015932/1, BB/L001942/1, BB/I001735/1, 16231, 2021-09-17T13:26:40.8893602 2020-07-05T16:26:26.0081445 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Yuqin Wang 0000-0002-3063-3066 1 Eylan Yutuc 0000-0001-9971-1950 2 William Griffiths 0000-0002-4129-6616 3 54644__17886__58236831afa1470e9b0d12dc77841d86.pdf Wamg BJP 2020.pdf 2020-08-10T09:04:27.3453828 Output 4211870 application/pdf Version of Record true Released under the terms of a Creative Commons Attribution License (CC-BY). true eng http://creativecommons.org/licenses/by/4.0/
title Neuro‐oxysterols and neuro‐sterols as ligands to nuclear receptors, GPCRs, ligand‐gated ion channels and other protein receptors
spellingShingle Neuro‐oxysterols and neuro‐sterols as ligands to nuclear receptors, GPCRs, ligand‐gated ion channels and other protein receptors
Yuqin Wang
Eylan Yutuc
William Griffiths
title_short Neuro‐oxysterols and neuro‐sterols as ligands to nuclear receptors, GPCRs, ligand‐gated ion channels and other protein receptors
title_full Neuro‐oxysterols and neuro‐sterols as ligands to nuclear receptors, GPCRs, ligand‐gated ion channels and other protein receptors
title_fullStr Neuro‐oxysterols and neuro‐sterols as ligands to nuclear receptors, GPCRs, ligand‐gated ion channels and other protein receptors
title_full_unstemmed Neuro‐oxysterols and neuro‐sterols as ligands to nuclear receptors, GPCRs, ligand‐gated ion channels and other protein receptors
title_sort Neuro‐oxysterols and neuro‐sterols as ligands to nuclear receptors, GPCRs, ligand‐gated ion channels and other protein receptors
author_id_str_mv c92729b58622f9fdf6a0e7d8f4ce5081
99332f073ce913a9b7d8b6441b17516d
3316b1d1b524be1831790933eed1c26e
author_id_fullname_str_mv c92729b58622f9fdf6a0e7d8f4ce5081_***_Yuqin Wang
99332f073ce913a9b7d8b6441b17516d_***_Eylan Yutuc
3316b1d1b524be1831790933eed1c26e_***_William Griffiths
author Yuqin Wang
Eylan Yutuc
William Griffiths
author2 Yuqin Wang
Eylan Yutuc
William Griffiths
format Journal article
container_title British Journal of Pharmacology
container_volume 178
container_issue 16
container_start_page 3176
publishDate 2021
institution Swansea University
issn 0007-1188
1476-5381
doi_str_mv 10.1111/bph.15191
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description The brain is the most cholesterol rich organ in the body containing about 25% of the body’s free cholesterol. Cholesterol cannot pass the blood brain barrier and be imported or exported, instead it is synthesised in situ and metabolised to oxysterols, oxidised forms of cholesterol, which can pass the blood brain barrier. 24S-Hydroxycholesterol is the dominant oxysterol in brain after parturition but during development a myriad of other oxysterols are produced which persist as minor oxysterols after birth. During both development and in later life, oxysterols and other sterols interact with a variety of different receptors, including nuclear receptors, membrane bound G protein-coupled receptors, the oxysterol/sterol sensing proteins INSIG and SCAP, and the ligand-gated ion channel N-methyl-D-aspartate receptors found in nerve cells. In this review we summarise the different oxysterols and sterols found in the central nervous system whose biological activity is transmitted via these different classes of protein receptors.
published_date 2021-08-01T07:55:18Z
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