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Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells

Aruna Prasopthum, Zexing Deng, Ilyas Khan Orcid Logo, Zhanhai Yin, Baolin Guo, Jing Yang

Biomaterials Science, Volume: 8, Issue: 15, Pages: 4287 - 4298

Swansea University Author: Ilyas Khan Orcid Logo

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DOI (Published version): 10.1039/d0bm00621a

Abstract

Degradable and electroactive polymers have been widely used for various biomedical applications including biosensors, tissue engineering and regenerative medicine. However, the poor processability of these polymers hinders the fabrication of electroactive polymer structures into complex desirable ge...

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Published in: Biomaterials Science
ISSN: 2047-4830 2047-4849
Published: Royal Society of Chemistry (RSC) 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa54499
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first_indexed 2020-06-17T19:09:03Z
last_indexed 2020-08-18T03:18:25Z
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spelling 2020-08-17T11:08:11.7086652 v2 54499 2020-06-17 Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells 2536d955ff70e7b77063a8efe9103161 0000-0002-3886-1987 Ilyas Khan Ilyas Khan true false 2020-06-17 BMS Degradable and electroactive polymers have been widely used for various biomedical applications including biosensors, tissue engineering and regenerative medicine. However, the poor processability of these polymers hinders the fabrication of electroactive polymer structures into complex desirable geometries. Herein, a block copolymer of tetraaniline (TA) and PCL, tetraaniline-b-polycaprolactone-b-tetraaniline (TPT) (possessing ~33% TA content), was synthesised and fabricated for the first time into a 3D printed electroactive biodegradable scaffold by direct-ink writing. This printable polymer ink was further formulated by the blending of TPT with high molecular weight PCL and directly 3D printed to generate a mechanically robust electroactive scaffold. The presence of TA content at 2.5% and 5% weight in relation to total PCL weight rendered the scaffold surface electrically and biologically active, in which fibronectin absorption and chondrogenic differentiation of chondroprogenitor cells over 28 days were enhanced, when compared to 0% TA. Our work demonstrates the formulation of a poorly processible materials (i.e., conductive polymers) into bio-inks able to produce 3D printed scaffolds and highlights the potential use of degradable and electroactive materials for cartilage tissue regeneration. Journal Article Biomaterials Science 8 15 4287 4298 Royal Society of Chemistry (RSC) 2047-4830 2047-4849 26 6 2020 2020-06-26 10.1039/d0bm00621a COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2020-08-17T11:08:11.7086652 2020-06-17T16:45:00.5423693 Aruna Prasopthum 1 Zexing Deng 2 Ilyas Khan 0000-0002-3886-1987 3 Zhanhai Yin 4 Baolin Guo 5 Jing Yang 6 54499__17953__c193fa7900274106ae06f66932535863.pdf 54499.pdf 2020-08-17T11:05:46.8445050 Output 2506335 application/pdf Version of Record true This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. true eng http://creativecommons.org/licenses/by/3.0/
title Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells
spellingShingle Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells
Ilyas Khan
title_short Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells
title_full Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells
title_fullStr Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells
title_full_unstemmed Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells
title_sort Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells
author_id_str_mv 2536d955ff70e7b77063a8efe9103161
author_id_fullname_str_mv 2536d955ff70e7b77063a8efe9103161_***_Ilyas Khan
author Ilyas Khan
author2 Aruna Prasopthum
Zexing Deng
Ilyas Khan
Zhanhai Yin
Baolin Guo
Jing Yang
format Journal article
container_title Biomaterials Science
container_volume 8
container_issue 15
container_start_page 4287
publishDate 2020
institution Swansea University
issn 2047-4830
2047-4849
doi_str_mv 10.1039/d0bm00621a
publisher Royal Society of Chemistry (RSC)
document_store_str 1
active_str 0
description Degradable and electroactive polymers have been widely used for various biomedical applications including biosensors, tissue engineering and regenerative medicine. However, the poor processability of these polymers hinders the fabrication of electroactive polymer structures into complex desirable geometries. Herein, a block copolymer of tetraaniline (TA) and PCL, tetraaniline-b-polycaprolactone-b-tetraaniline (TPT) (possessing ~33% TA content), was synthesised and fabricated for the first time into a 3D printed electroactive biodegradable scaffold by direct-ink writing. This printable polymer ink was further formulated by the blending of TPT with high molecular weight PCL and directly 3D printed to generate a mechanically robust electroactive scaffold. The presence of TA content at 2.5% and 5% weight in relation to total PCL weight rendered the scaffold surface electrically and biologically active, in which fibronectin absorption and chondrogenic differentiation of chondroprogenitor cells over 28 days were enhanced, when compared to 0% TA. Our work demonstrates the formulation of a poorly processible materials (i.e., conductive polymers) into bio-inks able to produce 3D printed scaffolds and highlights the potential use of degradable and electroactive materials for cartilage tissue regeneration.
published_date 2020-06-26T04:08:04Z
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score 11.037603

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