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Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months

Sarah Prior Orcid Logo, Rachel Churm Orcid Logo, Thinzar Min, Gareth Dunseath Orcid Logo, J. D. Barry, Jeffrey Stephens Orcid Logo

Obesity Surgery, Volume: 30, Issue: 6, Pages: 2243 - 2250

Swansea University Authors: Sarah Prior Orcid Logo, Rachel Churm Orcid Logo, Thinzar Min, Gareth Dunseath Orcid Logo, Jeffrey Stephens Orcid Logo

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DOI (Published version): 10.1007/s11695-020-04457-9

Abstract

BackgroundBariatric surgery is an effective treatment for morbid obesity and glycaemic dysfunction.ObjectivesThe aim of the work was to examine both the static and dynamic changes of glucose-insulin homeostasis and incretin hormone response following sleeve gastrectomy (SG) in a sample of 55 partici...

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Published in: Obesity Surgery
ISSN: 0960-8923 1708-0428
Published: Springer Science and Business Media LLC 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa53472
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The focus was on a sample of patients with impaired glucose tolerance and type 2 diabetes (T2D).SettingMorriston Hospital, UK.MethodsProspective study comprising of 55 participants with impaired glucose homeostasis and T2D undergoing SG (mean body mass index [BMI] 50.4 kg/m2, mean glycated haemoglobin [A1C] 7.4%). Serial measurements of glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic hormone (GIP) were performed during oral glucose tolerance testing preoperatively and 1 and 6 months postoperatively. Areas under the curve (AUC) were examined at 30, 60, and 120 min.ResultsWe observed significant improvements in measures of obesity, as well as static and dynamic measures of glucose, insulin, C-peptide and HOMA. Furthermore, significant increases in GLP-1 response as early as 6 months postoperatively were also seen.ConclusionsTo our knowledge, no study has examined the detailed dynamic changes in glucose and insulin homeostasis in this number of participants undergoing SG in relation to incretin hormones GIP and GLP-1. 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spelling 2020-10-23T11:44:14.3912135 v2 53472 2020-02-07 Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months cdda101035997acfaa6fdf17097f52b2 0000-0001-8703-8092 Sarah Prior Sarah Prior true false c6cd8267ff0b13f2ea333bbfefdae144 0000-0001-9855-6282 Rachel Churm Rachel Churm true false 27cba511a4800fefddb6885ffffdb8b2 Thinzar Min Thinzar Min true false fccbba9edcaee08a839a3c5cff8cbe19 0000-0001-6022-862X Gareth Dunseath Gareth Dunseath true false 5219d126f97f8f884bdb622099bd41de 0000-0003-2228-086X Jeffrey Stephens Jeffrey Stephens true false 2020-02-07 BMS BackgroundBariatric surgery is an effective treatment for morbid obesity and glycaemic dysfunction.ObjectivesThe aim of the work was to examine both the static and dynamic changes of glucose-insulin homeostasis and incretin hormone response following sleeve gastrectomy (SG) in a sample of 55 participants preoperatively and 1 month and 6 months postoperatively. The focus was on a sample of patients with impaired glucose tolerance and type 2 diabetes (T2D).SettingMorriston Hospital, UK.MethodsProspective study comprising of 55 participants with impaired glucose homeostasis and T2D undergoing SG (mean body mass index [BMI] 50.4 kg/m2, mean glycated haemoglobin [A1C] 7.4%). Serial measurements of glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic hormone (GIP) were performed during oral glucose tolerance testing preoperatively and 1 and 6 months postoperatively. Areas under the curve (AUC) were examined at 30, 60, and 120 min.ResultsWe observed significant improvements in measures of obesity, as well as static and dynamic measures of glucose, insulin, C-peptide and HOMA. Furthermore, significant increases in GLP-1 response as early as 6 months postoperatively were also seen.ConclusionsTo our knowledge, no study has examined the detailed dynamic changes in glucose and insulin homeostasis in this number of participants undergoing SG in relation to incretin hormones GIP and GLP-1. This current study supports the role of SG for the treatment of obesity-related glucose dysregulation. Journal Article Obesity Surgery 30 6 2243 2250 Springer Science and Business Media LLC 0960-8923 1708-0428 Type 2 diabetes; Impaired glucose tolerance; Incretin; Sleeve gastrectomy 1 6 2020 2020-06-01 10.1007/s11695-020-04457-9 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2020-10-23T11:44:14.3912135 2020-02-07T15:05:27.7413617 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Sarah Prior 0000-0001-8703-8092 1 Rachel Churm 0000-0001-9855-6282 2 Thinzar Min 3 Gareth Dunseath 0000-0001-6022-862X 4 J. D. Barry 5 Jeffrey Stephens 0000-0003-2228-086X 6 53472__16677__9dd8011dbb724234908995c5123ca5e0.pdf 53472.pdf 2020-02-24T15:29:08.4583679 Output 479850 application/pdf Version of Record true Released under the terms of a Creative Commons Attribution 4.0 International License (CC-BY). true eng http://creativecommons.org/licenses/by/4.0/
title Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months
spellingShingle Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months
Sarah Prior
Rachel Churm
Thinzar Min
Gareth Dunseath
Jeffrey Stephens
title_short Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months
title_full Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months
title_fullStr Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months
title_full_unstemmed Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months
title_sort Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months
author_id_str_mv cdda101035997acfaa6fdf17097f52b2
c6cd8267ff0b13f2ea333bbfefdae144
27cba511a4800fefddb6885ffffdb8b2
fccbba9edcaee08a839a3c5cff8cbe19
5219d126f97f8f884bdb622099bd41de
author_id_fullname_str_mv cdda101035997acfaa6fdf17097f52b2_***_Sarah Prior
c6cd8267ff0b13f2ea333bbfefdae144_***_Rachel Churm
27cba511a4800fefddb6885ffffdb8b2_***_Thinzar Min
fccbba9edcaee08a839a3c5cff8cbe19_***_Gareth Dunseath
5219d126f97f8f884bdb622099bd41de_***_Jeffrey Stephens
author Sarah Prior
Rachel Churm
Thinzar Min
Gareth Dunseath
Jeffrey Stephens
author2 Sarah Prior
Rachel Churm
Thinzar Min
Gareth Dunseath
J. D. Barry
Jeffrey Stephens
format Journal article
container_title Obesity Surgery
container_volume 30
container_issue 6
container_start_page 2243
publishDate 2020
institution Swansea University
issn 0960-8923
1708-0428
doi_str_mv 10.1007/s11695-020-04457-9
publisher Springer Science and Business Media LLC
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description BackgroundBariatric surgery is an effective treatment for morbid obesity and glycaemic dysfunction.ObjectivesThe aim of the work was to examine both the static and dynamic changes of glucose-insulin homeostasis and incretin hormone response following sleeve gastrectomy (SG) in a sample of 55 participants preoperatively and 1 month and 6 months postoperatively. The focus was on a sample of patients with impaired glucose tolerance and type 2 diabetes (T2D).SettingMorriston Hospital, UK.MethodsProspective study comprising of 55 participants with impaired glucose homeostasis and T2D undergoing SG (mean body mass index [BMI] 50.4 kg/m2, mean glycated haemoglobin [A1C] 7.4%). Serial measurements of glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic hormone (GIP) were performed during oral glucose tolerance testing preoperatively and 1 and 6 months postoperatively. Areas under the curve (AUC) were examined at 30, 60, and 120 min.ResultsWe observed significant improvements in measures of obesity, as well as static and dynamic measures of glucose, insulin, C-peptide and HOMA. Furthermore, significant increases in GLP-1 response as early as 6 months postoperatively were also seen.ConclusionsTo our knowledge, no study has examined the detailed dynamic changes in glucose and insulin homeostasis in this number of participants undergoing SG in relation to incretin hormones GIP and GLP-1. This current study supports the role of SG for the treatment of obesity-related glucose dysregulation.
published_date 2020-06-01T04:06:24Z
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