Journal article 1008 views 122 downloads
Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months
,
Rachel Churm ,
Thinzar Min,
Gareth Dunseath ,
J. D. Barry,
Jeffrey Stephens
Obesity Surgery, Volume: 30, Issue: 6, Pages: 2243 - 2250
Swansea University Authors:
Sarah Prior , Rachel Churm , Thinzar Min, Gareth Dunseath , Jeffrey Stephens
-
PDF | Version of Record
Released under the terms of a Creative Commons Attribution 4.0 International License (CC-BY).
Download (468.6KB)
DOI (Published version): 10.1007/s11695-020-04457-9
Abstract
BackgroundBariatric surgery is an effective treatment for morbid obesity and glycaemic dysfunction.ObjectivesThe aim of the work was to examine both the static and dynamic changes of glucose-insulin homeostasis and incretin hormone response following sleeve gastrectomy (SG) in a sample of 55 partici...
| Published in: | Obesity Surgery |
|---|---|
| ISSN: | 0960-8923 1708-0428 |
| Published: |
Springer Science and Business Media LLC
2020
|
| Online Access: |
Check full text
|
| URI: | https://cronfa.swan.ac.uk/Record/cronfa53472 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract: |
BackgroundBariatric surgery is an effective treatment for morbid obesity and glycaemic dysfunction.ObjectivesThe aim of the work was to examine both the static and dynamic changes of glucose-insulin homeostasis and incretin hormone response following sleeve gastrectomy (SG) in a sample of 55 participants preoperatively and 1 month and 6 months postoperatively. The focus was on a sample of patients with impaired glucose tolerance and type 2 diabetes (T2D).SettingMorriston Hospital, UK.MethodsProspective study comprising of 55 participants with impaired glucose homeostasis and T2D undergoing SG (mean body mass index [BMI] 50.4 kg/m2, mean glycated haemoglobin [A1C] 7.4%). Serial measurements of glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic hormone (GIP) were performed during oral glucose tolerance testing preoperatively and 1 and 6 months postoperatively. Areas under the curve (AUC) were examined at 30, 60, and 120 min.ResultsWe observed significant improvements in measures of obesity, as well as static and dynamic measures of glucose, insulin, C-peptide and HOMA. Furthermore, significant increases in GLP-1 response as early as 6 months postoperatively were also seen.ConclusionsTo our knowledge, no study has examined the detailed dynamic changes in glucose and insulin homeostasis in this number of participants undergoing SG in relation to incretin hormones GIP and GLP-1. This current study supports the role of SG for the treatment of obesity-related glucose dysregulation. |
|---|---|
| Keywords: |
Type 2 diabetes; Impaired glucose tolerance; Incretin; Sleeve gastrectomy |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
6 |
| Start Page: |
2243 |
| End Page: |
2250 |