The neuroscience of sadness: A multidisciplinary synthesis and collaborative review

Arias, Juan A.; Williams, Claire; Raghvani, Rashmi; Aghajani, Moji; Baez, Sandra; Belzung, Catherine; Booij, Linda; Busatto, Geraldo; Chiarella, Julian; Fu, Cynthia HY; Ibanez, Agustin; Liddell, Belinda J.; Lowe, Leroy; Penninx, Brenda W.J.H.; Rosa, Pedro; Kemp, Andrew

doi:10.1016/j.neubiorev.2020.01.006

Journal article 863 views 426 downloads

The neuroscience of sadness: A multidisciplinary synthesis and collaborative review

Juan A. Arias, Claire Williams

, Rashmi Raghvani, Moji Aghajani, Sandra Baez, Catherine Belzung, Linda Booij, Geraldo Busatto, Julian Chiarella, Cynthia HY Fu, Agustin Ibanez, Belinda J. Liddell, Leroy Lowe, Brenda W.J.H. Penninx, Pedro Rosa, Andrew Kemp

Neuroscience & Biobehavioral Reviews, Volume: 111, Pages: 199 - 228

Swansea University Authors: Claire Williams , Rashmi Raghvani, Andrew Kemp

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DOI (Published version): 10.1016/j.neubiorev.2020.01.006

Abstract

Sadness is typically characterized by raised inner eyebrows, lowered corners of the mouth, reduced walking speed, and slumped posture. Ancient subcortical circuitry provides a neuroanatomical foundation, extending from dorsal periaqueductal grey to subgenual anterior cingulate, the latter of which i...

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Published in:	Neuroscience & Biobehavioral Reviews
ISSN:	0149-7634
Published:	Elsevier BV 2020
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URI:	https://cronfa.swan.ac.uk/Record/cronfa53116
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first_indexed	2020-01-06T21:23:18Z
last_indexed	2020-05-18T19:07:20Z
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Ancient subcortical circuitry provides a neuroanatomical foundation, extending from dorsal periaqueductal grey to subgenual anterior cingulate, the latter of which is now a treatment target in disorders of sadness. Electrophysiological studies further emphasize a role for reduced left relative to right frontal asymmetry in sadness, underpinning interest in the transcranial stimulation of left dorsolateral prefrontal cortex as an antidepressant target. Neuroimaging studies – including meta-analyses – indicate that sadness is associated with reduced cortical activation, which may contribute to reduced parasympathetic inhibitory control over medullary cardioacceleratory circuits. Reduced cardiac control may – in part – contribute to epidemiological reports of reduced life expectancy in affective disorders, effects equivalent to heavy smoking. 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spelling	2020-05-18T17:35:59.1815398 v2 53116 2020-01-06 The neuroscience of sadness: A multidisciplinary synthesis and collaborative review 21dc2ebf100cf324becc27e8db6fde8d 0000-0002-0791-744X Claire Williams Claire Williams true false a701b02576f9088554a73bfc4595a821 Rashmi Raghvani Rashmi Raghvani true false dfd05900f0e2409d3f67dca227c59a93 0000-0003-1146-3791 Andrew Kemp Andrew Kemp true false 2020-01-06 HPS Sadness is typically characterized by raised inner eyebrows, lowered corners of the mouth, reduced walking speed, and slumped posture. Ancient subcortical circuitry provides a neuroanatomical foundation, extending from dorsal periaqueductal grey to subgenual anterior cingulate, the latter of which is now a treatment target in disorders of sadness. Electrophysiological studies further emphasize a role for reduced left relative to right frontal asymmetry in sadness, underpinning interest in the transcranial stimulation of left dorsolateral prefrontal cortex as an antidepressant target. Neuroimaging studies – including meta-analyses – indicate that sadness is associated with reduced cortical activation, which may contribute to reduced parasympathetic inhibitory control over medullary cardioacceleratory circuits. Reduced cardiac control may – in part – contribute to epidemiological reports of reduced life expectancy in affective disorders, effects equivalent to heavy smoking. We suggest that the field may be moving toward a theoretical consensus, in which different models relating to basic emotion theory and psychological constructionism may be considered as complementary, working at different levels of the phylogenetic hierarchy. Journal Article Neuroscience & Biobehavioral Reviews 111 199 228 Elsevier BV 0149-7634 Sadness, Major Depressive Disorder, Basic Emotions, Psychological Constructionism, Genetics, Psychophysiology, Neuroimaging, Affective Neuroscience, Heart Rate Variability, GENIAL model, Health and wellbeing, Vagal function 1 4 2020 2020-04-01 10.1016/j.neubiorev.2020.01.006 COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University 2020-05-18T17:35:59.1815398 2020-01-06T15:25:44.6304616 Juan A. Arias 1 Claire Williams 0000-0002-0791-744X 2 Rashmi Raghvani 3 Moji Aghajani 4 Sandra Baez 5 Catherine Belzung 6 Linda Booij 7 Geraldo Busatto 8 Julian Chiarella 9 Cynthia HY Fu 10 Agustin Ibanez 11 Belinda J. Liddell 12 Leroy Lowe 13 Brenda W.J.H. Penninx 14 Pedro Rosa 15 Andrew Kemp 0000-0003-1146-3791 16 53116__16589__7af1e90483394ebba15f82e0d59035bd.pdf 53116.pdf 2020-02-17T15:24:05.5248543 Output 4057885 application/pdf Version of Record true This is an open access article under the CC BY-NC-ND license. true http://creativecommons.org/licenses/BY-NC-ND/4.0/
title	The neuroscience of sadness: A multidisciplinary synthesis and collaborative review
spellingShingle	The neuroscience of sadness: A multidisciplinary synthesis and collaborative review Claire Williams Rashmi Raghvani Andrew Kemp
title_short	The neuroscience of sadness: A multidisciplinary synthesis and collaborative review
title_full	The neuroscience of sadness: A multidisciplinary synthesis and collaborative review
title_fullStr	The neuroscience of sadness: A multidisciplinary synthesis and collaborative review
title_full_unstemmed	The neuroscience of sadness: A multidisciplinary synthesis and collaborative review
title_sort	The neuroscience of sadness: A multidisciplinary synthesis and collaborative review
author_id_str_mv	21dc2ebf100cf324becc27e8db6fde8d a701b02576f9088554a73bfc4595a821 dfd05900f0e2409d3f67dca227c59a93
author_id_fullname_str_mv	21dc2ebf100cf324becc27e8db6fde8d_*_Claire Williams a701b02576f9088554a73bfc4595a821__Rashmi Raghvani dfd05900f0e2409d3f67dca227c59a93_**_Andrew Kemp
author	Claire Williams Rashmi Raghvani Andrew Kemp
author2	Juan A. Arias Claire Williams Rashmi Raghvani Moji Aghajani Sandra Baez Catherine Belzung Linda Booij Geraldo Busatto Julian Chiarella Cynthia HY Fu Agustin Ibanez Belinda J. Liddell Leroy Lowe Brenda W.J.H. Penninx Pedro Rosa Andrew Kemp
format	Journal article
container_title	Neuroscience & Biobehavioral Reviews
container_volume	111
container_start_page	199
publishDate	2020
institution	Swansea University
issn	0149-7634
doi_str_mv	10.1016/j.neubiorev.2020.01.006
publisher	Elsevier BV
document_store_str	1
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description	Sadness is typically characterized by raised inner eyebrows, lowered corners of the mouth, reduced walking speed, and slumped posture. Ancient subcortical circuitry provides a neuroanatomical foundation, extending from dorsal periaqueductal grey to subgenual anterior cingulate, the latter of which is now a treatment target in disorders of sadness. Electrophysiological studies further emphasize a role for reduced left relative to right frontal asymmetry in sadness, underpinning interest in the transcranial stimulation of left dorsolateral prefrontal cortex as an antidepressant target. Neuroimaging studies – including meta-analyses – indicate that sadness is associated with reduced cortical activation, which may contribute to reduced parasympathetic inhibitory control over medullary cardioacceleratory circuits. Reduced cardiac control may – in part – contribute to epidemiological reports of reduced life expectancy in affective disorders, effects equivalent to heavy smoking. We suggest that the field may be moving toward a theoretical consensus, in which different models relating to basic emotion theory and psychological constructionism may be considered as complementary, working at different levels of the phylogenetic hierarchy.
published_date	2020-04-01T04:05:56Z
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The neuroscience of sadness: A multidisciplinary synthesis and collaborative review

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