Journal article 863 views 426 downloads
The neuroscience of sadness: A multidisciplinary synthesis and collaborative review
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Rashmi Raghvani,
Moji Aghajani,
Sandra Baez,
Catherine Belzung,
Linda Booij,
Geraldo Busatto,
Julian Chiarella,
Cynthia HY Fu,
Agustin Ibanez,
Belinda J. Liddell,
Leroy Lowe,
Brenda W.J.H. Penninx,
Pedro Rosa,
Andrew Kemp
Neuroscience & Biobehavioral Reviews, Volume: 111, Pages: 199 - 228
Swansea University Authors:
Claire Williams , Rashmi Raghvani, Andrew Kemp
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DOI (Published version): 10.1016/j.neubiorev.2020.01.006
Abstract
Sadness is typically characterized by raised inner eyebrows, lowered corners of the mouth, reduced walking speed, and slumped posture. Ancient subcortical circuitry provides a neuroanatomical foundation, extending from dorsal periaqueductal grey to subgenual anterior cingulate, the latter of which i...
| Published in: | Neuroscience & Biobehavioral Reviews |
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| ISSN: | 0149-7634 |
| Published: |
Elsevier BV
2020
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa53116 |
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| Abstract: |
Sadness is typically characterized by raised inner eyebrows, lowered corners of the mouth, reduced walking speed, and slumped posture. Ancient subcortical circuitry provides a neuroanatomical foundation, extending from dorsal periaqueductal grey to subgenual anterior cingulate, the latter of which is now a treatment target in disorders of sadness. Electrophysiological studies further emphasize a role for reduced left relative to right frontal asymmetry in sadness, underpinning interest in the transcranial stimulation of left dorsolateral prefrontal cortex as an antidepressant target. Neuroimaging studies – including meta-analyses – indicate that sadness is associated with reduced cortical activation, which may contribute to reduced parasympathetic inhibitory control over medullary cardioacceleratory circuits. Reduced cardiac control may – in part – contribute to epidemiological reports of reduced life expectancy in affective disorders, effects equivalent to heavy smoking. We suggest that the field may be moving toward a theoretical consensus, in which different models relating to basic emotion theory and psychological constructionism may be considered as complementary, working at different levels of the phylogenetic hierarchy. |
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| Keywords: |
Sadness, Major Depressive Disorder, Basic Emotions, Psychological Constructionism, Genetics, Psychophysiology, Neuroimaging, Affective Neuroscience, Heart Rate Variability, GENIAL model, Health and wellbeing, Vagal function |
| Start Page: |
199 |
| End Page: |
228 |