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AFM-detected apoptosis of hepatocellular carcinoma cells induced by American ginseng root water extract

Yingmin Qu, Zuobin Wang, Feihu Zhao Orcid Logo, Jinyun Liu, Wenxiao Zhang, Jingmei Li, Zhengxun Song, Hongmei Xu

Micron, Volume: 104, Pages: 1 - 7

Swansea University Author: Feihu Zhao Orcid Logo

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DOI (Published version): 10.1016/j.micron.2017.10.003

Abstract

American ginseng as a common and traditional herbal medicine has been used in cancer treatment for many years. However, the effect of American ginseng on the cancer cell response (i.e. apoptosis) has not been fully understood yet. Previous studies demonstrated that cellular apoptosis was associated...

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Published in: Micron
ISSN: 0968-4328
Published: 2018
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa51683
first_indexed 2019-09-04T20:46:37Z
last_indexed 2019-10-11T14:23:31Z
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spelling 2019-10-11T11:17:01.8773252 v2 51683 2019-09-04 AFM-detected apoptosis of hepatocellular carcinoma cells induced by American ginseng root water extract 1c6e79b6edd08c88a8d17a241cd78630 0000-0003-0515-6808 Feihu Zhao Feihu Zhao true false 2019-09-04 EAAS American ginseng as a common and traditional herbal medicine has been used in cancer treatment for many years. However, the effect of American ginseng on the cancer cell response (i.e. apoptosis) has not been fully understood yet. Previous studies demonstrated that cellular apoptosis was associated with the changes of mechanical and morphological properties. Therefore, in this study, mechanical and morphological characterizations were carried out by both atomic force microscope (AFM) and inverted optical microscope to investigate the apoptosis of hepatocellular carcinoma (SMMC-7721) cells affected by American ginseng root water extract (AGRWE). The results showed that the cells treated with AGRWE exhibited significantly larger surface roughness, height and elastic modulus values than control group. Moreover, those parameters were upregulated under the higher concentration of AGRWE and longer culture time. Consequently, it indicates that the mechanical and morphological properties can be used as the apoptotic characteristics of SMMC-7721 cells. Also, the increased surface roughness and elastic modulus of cells under the AGRWE treatment have shown that the apoptosis of SMMC-7721 cells can be enhanced by AGRWE. This will provide an important implication for hepatocelluar carcinoma treatment and drug development. Journal Article Micron 104 1 7 0968-4328 American ginseng, Atomic force microscope (AFM), Cell apoptosis, Cellular stiffness, SMMC-7721 cells 31 1 2018 2018-01-31 10.1016/j.micron.2017.10.003 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University 2019-10-11T11:17:01.8773252 2019-09-04T15:40:50.8805311 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Yingmin Qu 1 Zuobin Wang 2 Feihu Zhao 0000-0003-0515-6808 3 Jinyun Liu 4 Wenxiao Zhang 5 Jingmei Li 6 Zhengxun Song 7 Hongmei Xu 8
title AFM-detected apoptosis of hepatocellular carcinoma cells induced by American ginseng root water extract
spellingShingle AFM-detected apoptosis of hepatocellular carcinoma cells induced by American ginseng root water extract
Feihu Zhao
title_short AFM-detected apoptosis of hepatocellular carcinoma cells induced by American ginseng root water extract
title_full AFM-detected apoptosis of hepatocellular carcinoma cells induced by American ginseng root water extract
title_fullStr AFM-detected apoptosis of hepatocellular carcinoma cells induced by American ginseng root water extract
title_full_unstemmed AFM-detected apoptosis of hepatocellular carcinoma cells induced by American ginseng root water extract
title_sort AFM-detected apoptosis of hepatocellular carcinoma cells induced by American ginseng root water extract
author_id_str_mv 1c6e79b6edd08c88a8d17a241cd78630
author_id_fullname_str_mv 1c6e79b6edd08c88a8d17a241cd78630_***_Feihu Zhao
author Feihu Zhao
author2 Yingmin Qu
Zuobin Wang
Feihu Zhao
Jinyun Liu
Wenxiao Zhang
Jingmei Li
Zhengxun Song
Hongmei Xu
format Journal article
container_title Micron
container_volume 104
container_start_page 1
publishDate 2018
institution Swansea University
issn 0968-4328
doi_str_mv 10.1016/j.micron.2017.10.003
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 0
active_str 0
description American ginseng as a common and traditional herbal medicine has been used in cancer treatment for many years. However, the effect of American ginseng on the cancer cell response (i.e. apoptosis) has not been fully understood yet. Previous studies demonstrated that cellular apoptosis was associated with the changes of mechanical and morphological properties. Therefore, in this study, mechanical and morphological characterizations were carried out by both atomic force microscope (AFM) and inverted optical microscope to investigate the apoptosis of hepatocellular carcinoma (SMMC-7721) cells affected by American ginseng root water extract (AGRWE). The results showed that the cells treated with AGRWE exhibited significantly larger surface roughness, height and elastic modulus values than control group. Moreover, those parameters were upregulated under the higher concentration of AGRWE and longer culture time. Consequently, it indicates that the mechanical and morphological properties can be used as the apoptotic characteristics of SMMC-7721 cells. Also, the increased surface roughness and elastic modulus of cells under the AGRWE treatment have shown that the apoptosis of SMMC-7721 cells can be enhanced by AGRWE. This will provide an important implication for hepatocelluar carcinoma treatment and drug development.
published_date 2018-01-31T13:54:11Z
_version_ 1821413895096500224
score 11.048171

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