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A study of temperature control in different designs of emergency drug transport bags

J. Dingley, N. Thatcher, D. Williams, John Dingley

Anaesthesia, Volume: 74, Pages: 868 - 874

Swansea University Author: John Dingley

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DOI (Published version): 10.1111/anae.14665

Abstract

We examined whether low melting point phase-change waxes might be used in the design of emergency drugtransport bags to reduce the known temperature extremes their contents can be exposed to. Two custom-made hollow-walled drug containers were placed within a pair of drug transport bags to three day/...

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Published in: Anaesthesia
ISSN: 0003-2409 1365-2044
Published: New Jersey, United States Wiley 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa50532
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first_indexed 2019-06-05T11:07:45Z
last_indexed 2019-08-13T15:26:37Z
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2019-08-13T11:06:43.5449645</datestamp><bib-version>v2</bib-version><id>50532</id><entry>2019-05-24</entry><title>A study of temperature control in different designs of emergency drug transport bags</title><swanseaauthors><author><sid>1283ffdd09b091ec57ec3e235a48cfcc</sid><firstname>John</firstname><surname>Dingley</surname><name>John Dingley</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2019-05-24</date><deptcode>PMSC</deptcode><abstract>We examined whether low melting point phase-change waxes might be used in the design of emergency drugtransport bags to reduce the known temperature extremes their contents can be exposed to. Two custom-made hollow-walled drug containers were placed within a pair of drug transport bags to three day/nightcycles which included periods of direct radiant sunlight. The wall cavities of one container contained air, whereas those of theother contained a paraffin wax with a melting point of 44&#x2013;46 &#xB0;C and a high latent heat of fusion (i.e. until fully melted, itstemperature will not increase further). We collected 25,920 sets of temperature data at six locations within and around both containers. We foundthat 97.8% and 84.7% of ampoule temperatures within the wax and air cavity containers, respectively, werewithin a target range of 15&#x2013;40 &#xB0;C over the study duration (Levene statisticW = 4279.1; Levene&#x2019;s test for equalityof variance, p &lt; 0.001). The temperature of the ampoules in the wax cavity container only exceeded 40 &#xB0;C for 1.7% of thetime. Even when they did so, their temperature was attenuated to 40.3 &#xB0;C, despite an ambient air temperatureof &gt; 40 &#xB0;C for 6.4% of the time (peak 46.9 &#xB0;C) and a bag surface temperature of &gt; 40 &#xB0;C for 17.2% of the time(peak 64.4 &#xB0;C). In contrast, the ampoule temperature within the air cavity container was above 40 &#xB0;C for 17.1% of thetime (peak 54.1 &#xB0;C). We suggest that the latent heat of fusion of phase-change materials may be used to improve the design of drugtransport bags to mitigate any temperature changes in the drugs stored within.</abstract><type>Journal Article</type><journal>Anaesthesia</journal><volume>74</volume><paginationStart>868</paginationStart><paginationEnd>874</paginationEnd><publisher>Wiley</publisher><placeOfPublication>New Jersey, United States</placeOfPublication><issnPrint>0003-2409</issnPrint><issnElectronic>1365-2044</issnElectronic><keywords>Drug transport, Drug storage, Emergency Medical Team, Thermal stability.</keywords><publishedDay>1</publishedDay><publishedMonth>6</publishedMonth><publishedYear>2019</publishedYear><publishedDate>2019-06-01</publishedDate><doi>10.1111/anae.14665</doi><url/><notes/><college>COLLEGE NANME</college><department>Medicine</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>PMSC</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2019-08-13T11:06:43.5449645</lastEdited><Created>2019-05-24T19:55:18.6388843</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>J.</firstname><surname>Dingley</surname><order>1</order></author><author><firstname>N.</firstname><surname>Thatcher</surname><order>2</order></author><author><firstname>D.</firstname><surname>Williams</surname><order>3</order></author><author><firstname>John</firstname><surname>Dingley</surname><order>4</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2019-08-13T11:06:43.5449645 v2 50532 2019-05-24 A study of temperature control in different designs of emergency drug transport bags 1283ffdd09b091ec57ec3e235a48cfcc John Dingley John Dingley true false 2019-05-24 PMSC We examined whether low melting point phase-change waxes might be used in the design of emergency drugtransport bags to reduce the known temperature extremes their contents can be exposed to. Two custom-made hollow-walled drug containers were placed within a pair of drug transport bags to three day/nightcycles which included periods of direct radiant sunlight. The wall cavities of one container contained air, whereas those of theother contained a paraffin wax with a melting point of 44–46 °C and a high latent heat of fusion (i.e. until fully melted, itstemperature will not increase further). We collected 25,920 sets of temperature data at six locations within and around both containers. We foundthat 97.8% and 84.7% of ampoule temperatures within the wax and air cavity containers, respectively, werewithin a target range of 15–40 °C over the study duration (Levene statisticW = 4279.1; Levene’s test for equalityof variance, p < 0.001). The temperature of the ampoules in the wax cavity container only exceeded 40 °C for 1.7% of thetime. Even when they did so, their temperature was attenuated to 40.3 °C, despite an ambient air temperatureof > 40 °C for 6.4% of the time (peak 46.9 °C) and a bag surface temperature of > 40 °C for 17.2% of the time(peak 64.4 °C). In contrast, the ampoule temperature within the air cavity container was above 40 °C for 17.1% of thetime (peak 54.1 °C). We suggest that the latent heat of fusion of phase-change materials may be used to improve the design of drugtransport bags to mitigate any temperature changes in the drugs stored within. Journal Article Anaesthesia 74 868 874 Wiley New Jersey, United States 0003-2409 1365-2044 Drug transport, Drug storage, Emergency Medical Team, Thermal stability. 1 6 2019 2019-06-01 10.1111/anae.14665 COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University 2019-08-13T11:06:43.5449645 2019-05-24T19:55:18.6388843 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine J. Dingley 1 N. Thatcher 2 D. Williams 3 John Dingley 4
title A study of temperature control in different designs of emergency drug transport bags
spellingShingle A study of temperature control in different designs of emergency drug transport bags
John Dingley
title_short A study of temperature control in different designs of emergency drug transport bags
title_full A study of temperature control in different designs of emergency drug transport bags
title_fullStr A study of temperature control in different designs of emergency drug transport bags
title_full_unstemmed A study of temperature control in different designs of emergency drug transport bags
title_sort A study of temperature control in different designs of emergency drug transport bags
author_id_str_mv 1283ffdd09b091ec57ec3e235a48cfcc
author_id_fullname_str_mv 1283ffdd09b091ec57ec3e235a48cfcc_***_John Dingley
author John Dingley
author2 J. Dingley
N. Thatcher
D. Williams
John Dingley
format Journal article
container_title Anaesthesia
container_volume 74
container_start_page 868
publishDate 2019
institution Swansea University
issn 0003-2409
1365-2044
doi_str_mv 10.1111/anae.14665
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
active_str 0
description We examined whether low melting point phase-change waxes might be used in the design of emergency drugtransport bags to reduce the known temperature extremes their contents can be exposed to. Two custom-made hollow-walled drug containers were placed within a pair of drug transport bags to three day/nightcycles which included periods of direct radiant sunlight. The wall cavities of one container contained air, whereas those of theother contained a paraffin wax with a melting point of 44–46 °C and a high latent heat of fusion (i.e. until fully melted, itstemperature will not increase further). We collected 25,920 sets of temperature data at six locations within and around both containers. We foundthat 97.8% and 84.7% of ampoule temperatures within the wax and air cavity containers, respectively, werewithin a target range of 15–40 °C over the study duration (Levene statisticW = 4279.1; Levene’s test for equalityof variance, p < 0.001). The temperature of the ampoules in the wax cavity container only exceeded 40 °C for 1.7% of thetime. Even when they did so, their temperature was attenuated to 40.3 °C, despite an ambient air temperatureof > 40 °C for 6.4% of the time (peak 46.9 °C) and a bag surface temperature of > 40 °C for 17.2% of the time(peak 64.4 °C). In contrast, the ampoule temperature within the air cavity container was above 40 °C for 17.1% of thetime (peak 54.1 °C). We suggest that the latent heat of fusion of phase-change materials may be used to improve the design of drugtransport bags to mitigate any temperature changes in the drugs stored within.
published_date 2019-06-01T04:02:01Z
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score 11.013619

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