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Electromechanical vibration of microtubules and its application in biosensors

Si Li, Chengyuan Wang Orcid Logo, Perumal Nithiarasu Orcid Logo

Journal of The Royal Society Interface, Volume: 16, Issue: 151, Start page: 20180826

Swansea University Authors: Chengyuan Wang Orcid Logo, Perumal Nithiarasu Orcid Logo

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DOI (Published version): 10.1098/rsif.2018.0826

Abstract

An electric field (EF) has the potential to excite the vibration of polarized microtubules (MTs) and thus enable their use as a biosensor for the biophysical properties of MTs or cells. To facilitate the development, this paper aims to capture the EF-induced vibration modes and the associated freque...

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Published in: Journal of The Royal Society Interface
ISSN: 1742-5689 1742-5662
Published: 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa48679
first_indexed 2019-02-04T20:02:38Z
last_indexed 2019-03-26T12:21:57Z
id cronfa48679
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spelling 2019-03-25T16:42:39.5103791 v2 48679 2019-02-04 Electromechanical vibration of microtubules and its application in biosensors fdea93ab99f51d0b3921d3601876c1e5 0000-0002-1001-2537 Chengyuan Wang Chengyuan Wang true false 3b28bf59358fc2b9bd9a46897dbfc92d 0000-0002-4901-2980 Perumal Nithiarasu Perumal Nithiarasu true false 2019-02-04 ACEM An electric field (EF) has the potential to excite the vibration of polarized microtubules (MTs) and thus enable their use as a biosensor for the biophysical properties of MTs or cells. To facilitate the development, this paper aims to capture the EF-induced vibration modes and the associated frequency for MTs. The analyses were carried out based on a molecular structural mechanics model accounting for the structural details of MTs. Transverse vibration, radial breathing vibration and axial vibration were achieved for MTs subject to a transverse or an axial EF. The frequency shift and stiffness alteration of MTs were also examined due to the possible changes of the tubulin interactions in physiological or pathological processes. The strong correlation achieved between the tubulin interaction and MT vibration excited by EF provides a new avenue to a non-contacting technique for the structural or property changes in MTs, where frequency shift is used as a biomarker. This technique can be used for individual MTs and is possible for those in cells when the cytosol damping on MT vibrations is largely reduced by the unique features of MT–cytosol interface. Journal Article Journal of The Royal Society Interface 16 151 20180826 1742-5689 1742-5662 28 2 2019 2019-02-28 10.1098/rsif.2018.0826 COLLEGE NANME Aerospace, Civil, Electrical, and Mechanical Engineering COLLEGE CODE ACEM Swansea University 2019-03-25T16:42:39.5103791 2019-02-04T13:42:51.9116045 Si Li 1 Chengyuan Wang 0000-0002-1001-2537 2 Perumal Nithiarasu 0000-0002-4901-2980 3 0048679-04022019134516.pdf li2019(3).pdf 2019-02-04T13:45:16.3630000 Output 1963135 application/pdf Accepted Manuscript true 2019-02-12T00:00:00.0000000 true eng
title Electromechanical vibration of microtubules and its application in biosensors
spellingShingle Electromechanical vibration of microtubules and its application in biosensors
Chengyuan Wang
Perumal Nithiarasu
title_short Electromechanical vibration of microtubules and its application in biosensors
title_full Electromechanical vibration of microtubules and its application in biosensors
title_fullStr Electromechanical vibration of microtubules and its application in biosensors
title_full_unstemmed Electromechanical vibration of microtubules and its application in biosensors
title_sort Electromechanical vibration of microtubules and its application in biosensors
author_id_str_mv fdea93ab99f51d0b3921d3601876c1e5
3b28bf59358fc2b9bd9a46897dbfc92d
author_id_fullname_str_mv fdea93ab99f51d0b3921d3601876c1e5_***_Chengyuan Wang
3b28bf59358fc2b9bd9a46897dbfc92d_***_Perumal Nithiarasu
author Chengyuan Wang
Perumal Nithiarasu
author2 Si Li
Chengyuan Wang
Perumal Nithiarasu
format Journal article
container_title Journal of The Royal Society Interface
container_volume 16
container_issue 151
container_start_page 20180826
publishDate 2019
institution Swansea University
issn 1742-5689
1742-5662
doi_str_mv 10.1098/rsif.2018.0826
document_store_str 1
active_str 0
description An electric field (EF) has the potential to excite the vibration of polarized microtubules (MTs) and thus enable their use as a biosensor for the biophysical properties of MTs or cells. To facilitate the development, this paper aims to capture the EF-induced vibration modes and the associated frequency for MTs. The analyses were carried out based on a molecular structural mechanics model accounting for the structural details of MTs. Transverse vibration, radial breathing vibration and axial vibration were achieved for MTs subject to a transverse or an axial EF. The frequency shift and stiffness alteration of MTs were also examined due to the possible changes of the tubulin interactions in physiological or pathological processes. The strong correlation achieved between the tubulin interaction and MT vibration excited by EF provides a new avenue to a non-contacting technique for the structural or property changes in MTs, where frequency shift is used as a biomarker. This technique can be used for individual MTs and is possible for those in cells when the cytosol damping on MT vibrations is largely reduced by the unique features of MT–cytosol interface.
published_date 2019-02-28T13:46:25Z
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score 11.048064

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