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Biomimetic Peptide Nanowires Designed for Conductivity

Rhiannon Creasy, Bernard Mostert Orcid Logo, Armin Solemanifar, Tuan Nguyen, Bernardino Virdis, Stefano Freguia, Bronwyn Laycock

ACS Omega, Volume: 4, Issue: 1, Pages: 1748 - 1756

Swansea University Author: Bernard Mostert Orcid Logo

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DOI (Published version): 10.1021/acsomega.8b02231

Abstract

The filamentous peptide-based nanowires produced by some dissimilatory metal-reducing bacteria, such as Geobacter sulfurreducens, display excellent natural conductivity. Their mechanism of conduction is assumed to be a combination of delocalized electrons through closely aligned aromatic amino acids...

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Published in: ACS Omega
Published: ACS Publications 2019
Online Access: https://pubs.acs.org/doi/10.1021/acsomega.8b02231
URI: https://cronfa.swan.ac.uk/Record/cronfa48387
first_indexed 2019-01-23T14:02:09Z
last_indexed 2019-02-04T20:02:00Z
id cronfa48387
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spelling 2019-02-04T15:24:09.2292164 v2 48387 2019-01-23 Biomimetic Peptide Nanowires Designed for Conductivity a353503c976a7338c7708a32e82f451f 0000-0002-9590-2124 Bernard Mostert Bernard Mostert true false 2019-01-23 BGPS The filamentous peptide-based nanowires produced by some dissimilatory metal-reducing bacteria, such as Geobacter sulfurreducens, display excellent natural conductivity. Their mechanism of conduction is assumed to be a combination of delocalized electrons through closely aligned aromatic amino acids and hopping/charge transfer. The proteins that form these microbial nanowires are structured from a coiled-coil, for which the design rules have been reported in the literature. Furthermore, at least one biomimetic system using related synthetic peptides has shown that the incorporation of aromatic residues can be used to enhance conductivity of peptide fibers. Herein, the de novo design of peptide sequences is used to enhance the conductivity of peptide gels, as inspired by microbial nanowires. A critical factor hampering investigations in both microbiology and materials development is inconsistent reporting of biomaterial conductivity measurements, with consistent methodologies needed for such investigations. We have reported a method herein to analyze non-Ohmic behavior using existing parameters, which is a statistically insightful approach for detecting small changes in biologically based samples. Aromatic residues were found to contribute to peptide gel conductivity, with the importance of the peptide confirmation and fibril assembly demonstrated both experimentally and computationally. This is a small step (in combination with parallel research under way by other researchers) toward developing effective peptide-based conducting nanowires, opening the door to the use of electronics in water and physiological environments for bioelectronic and bioenergy applications. Journal Article ACS Omega 4 1 1748 1756 ACS Publications Bioelectronics, Biomimetic, Nanowires, Conductivity, Geobacter sulfurreducens 31 1 2019 2019-01-31 10.1021/acsomega.8b02231 https://pubs.acs.org/doi/10.1021/acsomega.8b02231 COLLEGE NANME Biosciences Geography and Physics School COLLEGE CODE BGPS Swansea University 2019-02-04T15:24:09.2292164 2019-01-23T10:21:34.2796186 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Rhiannon Creasy 1 Bernard Mostert 0000-0002-9590-2124 2 Armin Solemanifar 3 Tuan Nguyen 4 Bernardino Virdis 5 Stefano Freguia 6 Bronwyn Laycock 7 0048387-23012019103217.pdf Creasy2019.pdf 2019-01-23T10:32:17.9370000 Output 4713313 application/pdf Version of Record true 2019-01-23T00:00:00.0000000 This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. true eng
title Biomimetic Peptide Nanowires Designed for Conductivity
spellingShingle Biomimetic Peptide Nanowires Designed for Conductivity
Bernard Mostert
title_short Biomimetic Peptide Nanowires Designed for Conductivity
title_full Biomimetic Peptide Nanowires Designed for Conductivity
title_fullStr Biomimetic Peptide Nanowires Designed for Conductivity
title_full_unstemmed Biomimetic Peptide Nanowires Designed for Conductivity
title_sort Biomimetic Peptide Nanowires Designed for Conductivity
author_id_str_mv a353503c976a7338c7708a32e82f451f
author_id_fullname_str_mv a353503c976a7338c7708a32e82f451f_***_Bernard Mostert
author Bernard Mostert
author2 Rhiannon Creasy
Bernard Mostert
Armin Solemanifar
Tuan Nguyen
Bernardino Virdis
Stefano Freguia
Bronwyn Laycock
format Journal article
container_title ACS Omega
container_volume 4
container_issue 1
container_start_page 1748
publishDate 2019
institution Swansea University
doi_str_mv 10.1021/acsomega.8b02231
publisher ACS Publications
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
url https://pubs.acs.org/doi/10.1021/acsomega.8b02231
document_store_str 1
active_str 0
description The filamentous peptide-based nanowires produced by some dissimilatory metal-reducing bacteria, such as Geobacter sulfurreducens, display excellent natural conductivity. Their mechanism of conduction is assumed to be a combination of delocalized electrons through closely aligned aromatic amino acids and hopping/charge transfer. The proteins that form these microbial nanowires are structured from a coiled-coil, for which the design rules have been reported in the literature. Furthermore, at least one biomimetic system using related synthetic peptides has shown that the incorporation of aromatic residues can be used to enhance conductivity of peptide fibers. Herein, the de novo design of peptide sequences is used to enhance the conductivity of peptide gels, as inspired by microbial nanowires. A critical factor hampering investigations in both microbiology and materials development is inconsistent reporting of biomaterial conductivity measurements, with consistent methodologies needed for such investigations. We have reported a method herein to analyze non-Ohmic behavior using existing parameters, which is a statistically insightful approach for detecting small changes in biologically based samples. Aromatic residues were found to contribute to peptide gel conductivity, with the importance of the peptide confirmation and fibril assembly demonstrated both experimentally and computationally. This is a small step (in combination with parallel research under way by other researchers) toward developing effective peptide-based conducting nanowires, opening the door to the use of electronics in water and physiological environments for bioelectronic and bioenergy applications.
published_date 2019-01-31T13:45:39Z
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