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Prevalence of faecal carriage of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli in veterinary hospital staff and students

Alexandra Royden, Emma Ormandy, Gina Pinchbeck, Ben Pascoe, Matthew Hitchings Orcid Logo, Samuel K Sheppard, Nicola J Williams

Veterinary Record Open, Volume: 6, Issue: 1, Start page: e000307

Swansea University Author: Matthew Hitchings Orcid Logo

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DOI (Published version): 10.1136/vetreco-2018-000307

Abstract

This study is the first to investigate prevalence of antimicrobial-resistant (AMR) and ESBL-producing faecal Escherichia coli within 84 veterinary hospital staff and student members across three UK veterinary hospitals. Longitudinal carriage was followed for six weeks in 27 of the participants. MDR...

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Published in: Veterinary Record Open
ISSN: 2052-6113
Published: 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa48073
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spelling 2019-01-18T14:18:07.0380631 v2 48073 2019-01-08 Prevalence of faecal carriage of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli in veterinary hospital staff and students be98847c72c14a731c4a6b7bc02b3bcf 0000-0002-5527-4709 Matthew Hitchings Matthew Hitchings true false 2019-01-08 BMS This study is the first to investigate prevalence of antimicrobial-resistant (AMR) and ESBL-producing faecal Escherichia coli within 84 veterinary hospital staff and student members across three UK veterinary hospitals. Longitudinal carriage was followed for six weeks in 27 of the participants. MDR E. coli was detection was common (32.1 per cent; 95per cent CI 22.2 to 42.1 per cent) with a notably high prevalence of resistance to ciprofloxacin (11.9 per cent; 95 per cent CI 4.98 to 18.8 per cent). Extended-spectrum β-lactamase (ESBL) producing E coli were isolated from five samples (5.95 per cent: 95 per cent CI 0.89 to 11.0 per cent); two of these samples (E38 and S57) contained MDR ESBL-producing E coli, resistant to all antimicrobials tested. Two participants carried ESBL-producing E coli for the entire study period. Twenty-six participants (96.3 per cent; 95 per cent CI 89.2 to 100) carried ≥1 MDR E coli isolate during the six-week period, with seven participants (25.9 per cent) carrying ≥1 MDR isolate for at least five out of six weeks highlighting that whilst prevalence of ESBL-producing E coli is similar to asymptomatic in general populations, higher levels of carriage were observed longitudinally in our participants. This study highlights that veterinary hospital workers represent a high-risk population for carriage of MDR and ESBL-producing bacteria and that healthcare providers should be made aware of this. Journal Article Veterinary Record Open 6 1 e000307 2052-6113 7 1 2019 2019-01-07 10.1136/vetreco-2018-000307 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2019-01-18T14:18:07.0380631 2019-01-08T10:05:00.9598230 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Alexandra Royden 1 Emma Ormandy 2 Gina Pinchbeck 3 Ben Pascoe 4 Matthew Hitchings 0000-0002-5527-4709 5 Samuel K Sheppard 6 Nicola J Williams 7 0048073-18012019141640.pdf 48073.pdf 2019-01-18T14:16:40.4600000 Output 922339 application/pdf Version of Record true 2019-01-17T00:00:00.0000000 Released under the terms of a Creative Commons Attribution License (CC-BY). true eng
title Prevalence of faecal carriage of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli in veterinary hospital staff and students
spellingShingle Prevalence of faecal carriage of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli in veterinary hospital staff and students
Matthew Hitchings
title_short Prevalence of faecal carriage of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli in veterinary hospital staff and students
title_full Prevalence of faecal carriage of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli in veterinary hospital staff and students
title_fullStr Prevalence of faecal carriage of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli in veterinary hospital staff and students
title_full_unstemmed Prevalence of faecal carriage of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli in veterinary hospital staff and students
title_sort Prevalence of faecal carriage of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli in veterinary hospital staff and students
author_id_str_mv be98847c72c14a731c4a6b7bc02b3bcf
author_id_fullname_str_mv be98847c72c14a731c4a6b7bc02b3bcf_***_Matthew Hitchings
author Matthew Hitchings
author2 Alexandra Royden
Emma Ormandy
Gina Pinchbeck
Ben Pascoe
Matthew Hitchings
Samuel K Sheppard
Nicola J Williams
format Journal article
container_title Veterinary Record Open
container_volume 6
container_issue 1
container_start_page e000307
publishDate 2019
institution Swansea University
issn 2052-6113
doi_str_mv 10.1136/vetreco-2018-000307
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description This study is the first to investigate prevalence of antimicrobial-resistant (AMR) and ESBL-producing faecal Escherichia coli within 84 veterinary hospital staff and student members across three UK veterinary hospitals. Longitudinal carriage was followed for six weeks in 27 of the participants. MDR E. coli was detection was common (32.1 per cent; 95per cent CI 22.2 to 42.1 per cent) with a notably high prevalence of resistance to ciprofloxacin (11.9 per cent; 95 per cent CI 4.98 to 18.8 per cent). Extended-spectrum β-lactamase (ESBL) producing E coli were isolated from five samples (5.95 per cent: 95 per cent CI 0.89 to 11.0 per cent); two of these samples (E38 and S57) contained MDR ESBL-producing E coli, resistant to all antimicrobials tested. Two participants carried ESBL-producing E coli for the entire study period. Twenty-six participants (96.3 per cent; 95 per cent CI 89.2 to 100) carried ≥1 MDR E coli isolate during the six-week period, with seven participants (25.9 per cent) carrying ≥1 MDR isolate for at least five out of six weeks highlighting that whilst prevalence of ESBL-producing E coli is similar to asymptomatic in general populations, higher levels of carriage were observed longitudinally in our participants. This study highlights that veterinary hospital workers represent a high-risk population for carriage of MDR and ESBL-producing bacteria and that healthcare providers should be made aware of this.
published_date 2019-01-07T03:58:22Z
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