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Prevalence of faecal carriage of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli in veterinary hospital staff and students

Alexandra Royden, Emma Ormandy, Gina Pinchbeck, Ben Pascoe, Matthew Hitchings Orcid Logo, Samuel K Sheppard, Nicola J Williams

Veterinary Record Open, Volume: 6, Issue: 1, Start page: e000307

Swansea University Author: Matthew Hitchings Orcid Logo

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DOI (Published version): 10.1136/vetreco-2018-000307

Abstract

This study is the first to investigate prevalence of antimicrobial-resistant (AMR) and ESBL-producing faecal Escherichia coli within 84 veterinary hospital staff and student members across three UK veterinary hospitals. Longitudinal carriage was followed for six weeks in 27 of the participants. MDR...

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Published in: Veterinary Record Open
ISSN: 2052-6113
Published: 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa48073
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Abstract: This study is the first to investigate prevalence of antimicrobial-resistant (AMR) and ESBL-producing faecal Escherichia coli within 84 veterinary hospital staff and student members across three UK veterinary hospitals. Longitudinal carriage was followed for six weeks in 27 of the participants. MDR E. coli was detection was common (32.1 per cent; 95per cent CI 22.2 to 42.1 per cent) with a notably high prevalence of resistance to ciprofloxacin (11.9 per cent; 95 per cent CI 4.98 to 18.8 per cent). Extended-spectrum β-lactamase (ESBL) producing E coli were isolated from five samples (5.95 per cent: 95 per cent CI 0.89 to 11.0 per cent); two of these samples (E38 and S57) contained MDR ESBL-producing E coli, resistant to all antimicrobials tested. Two participants carried ESBL-producing E coli for the entire study period. Twenty-six participants (96.3 per cent; 95 per cent CI 89.2 to 100) carried ≥1 MDR E coli isolate during the six-week period, with seven participants (25.9 per cent) carrying ≥1 MDR isolate for at least five out of six weeks highlighting that whilst prevalence of ESBL-producing E coli is similar to asymptomatic in general populations, higher levels of carriage were observed longitudinally in our participants. This study highlights that veterinary hospital workers represent a high-risk population for carriage of MDR and ESBL-producing bacteria and that healthcare providers should be made aware of this.
College: Faculty of Medicine, Health and Life Sciences
Issue: 1
Start Page: e000307

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