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Transport of solid bodies along tubular membrane tethers

Rob Daniels Orcid Logo

PLOS ONE, Volume: 14, Issue: 1, Start page: e0210259

Swansea University Author: Rob Daniels Orcid Logo

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DOI (Published version): 10.1371/journal.pone.0210259

Abstract

We study the crucial role of membrane fluctuations in maintaining a narrow gap between a fluid membrane tube and an enclosed solid particle. Solvent flows can occur in this gap, hence giving rise to a finite particle mobility along the tube. While our study has relevance for how cells are able to tr...

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Published in: PLOS ONE
ISSN: 1932-6203
Published: 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa48060
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first_indexed 2019-01-07T20:00:53Z
last_indexed 2020-08-06T03:11:10Z
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spelling 2020-08-05T15:40:06.4230805 v2 48060 2019-01-07 Transport of solid bodies along tubular membrane tethers 23f38c3bb732d4378986bdfaf7b6ee51 0000-0002-6933-8144 Rob Daniels Rob Daniels true false 2019-01-07 MEDE We study the crucial role of membrane fluctuations in maintaining a narrow gap between a fluid membrane tube and an enclosed solid particle. Solvent flows can occur in this gap, hence giving rise to a finite particle mobility along the tube. While our study has relevance for how cells are able to transport large organelles or other cargo along connecting membrane tubes, known as tunneling nanotubes, our calculations are also framed so that they can be tested by a specific in vitro experiment: A tubular membrane tether can be pulled from a membrane reservoir, such as an aspirated Giant Unilamellar Vesicle (GUV), e.g. using a conjugated bead that binds to the membrane and is held in a laser trap. We compute the subsequent mobility of colloidal particles trapped in the tube, focusing on the case when the particle is large compared to the equilibrium tube radius. We predict that the particle mobility should scale as ∼ σ−2/3, with σ the membrane tension. Journal Article PLOS ONE 14 1 e0210259 1932-6203 16 1 2019 2019-01-16 10.1371/journal.pone.0210259 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2020-08-05T15:40:06.4230805 2019-01-07T14:10:25.5419506 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Rob Daniels 0000-0002-6933-8144 1 48060__17498__9c2f52c88dde4d05ba8b5780ef8f2fcd.pdf 48026.pdf 2020-06-15T16:36:01.2316551 Output 638267 application/pdf Version of Record true Published under Creative Commons License Attribution 4.0 International (CC BY 4.0) true https://creativecommons.org/licenses/by/4.0/
title Transport of solid bodies along tubular membrane tethers
spellingShingle Transport of solid bodies along tubular membrane tethers
Rob Daniels
title_short Transport of solid bodies along tubular membrane tethers
title_full Transport of solid bodies along tubular membrane tethers
title_fullStr Transport of solid bodies along tubular membrane tethers
title_full_unstemmed Transport of solid bodies along tubular membrane tethers
title_sort Transport of solid bodies along tubular membrane tethers
author_id_str_mv 23f38c3bb732d4378986bdfaf7b6ee51
author_id_fullname_str_mv 23f38c3bb732d4378986bdfaf7b6ee51_***_Rob Daniels
author Rob Daniels
author2 Rob Daniels
format Journal article
container_title PLOS ONE
container_volume 14
container_issue 1
container_start_page e0210259
publishDate 2019
institution Swansea University
issn 1932-6203
doi_str_mv 10.1371/journal.pone.0210259
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 1
active_str 0
description We study the crucial role of membrane fluctuations in maintaining a narrow gap between a fluid membrane tube and an enclosed solid particle. Solvent flows can occur in this gap, hence giving rise to a finite particle mobility along the tube. While our study has relevance for how cells are able to transport large organelles or other cargo along connecting membrane tubes, known as tunneling nanotubes, our calculations are also framed so that they can be tested by a specific in vitro experiment: A tubular membrane tether can be pulled from a membrane reservoir, such as an aspirated Giant Unilamellar Vesicle (GUV), e.g. using a conjugated bead that binds to the membrane and is held in a laser trap. We compute the subsequent mobility of colloidal particles trapped in the tube, focusing on the case when the particle is large compared to the equilibrium tube radius. We predict that the particle mobility should scale as ∼ σ−2/3, with σ the membrane tension.
published_date 2019-01-16T03:58:21Z
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score 11.014067

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